{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:34:07Z","timestamp":1790166847977,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["SQ2022YFD1800105"],"award-info":[{"award-number":["SQ2022YFD1800105"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["32030107"],"award-info":[{"award-number":["32030107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s00705-023-05780-z","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T14:02:18Z","timestamp":1685109738000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Japanese encephalitis virus induces apoptosis by activating the RIG-1 signaling pathway"],"prefix":"10.1007","volume":"168","author":[{"given":"Mingxing","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanpo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5776-2127","authenticated-orcid":false,"given":"Changqin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"issue":"9","key":"5780_CR1","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/sj.onc.1210220","volume":"26","author":"JM Adams","year":"2007","unstructured":"Adams JM, Cory S (2007) The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26(9):1324\u20131337. https:\/\/doi.org\/10.1038\/sj.onc.1210220","journal-title":"Oncogene"},{"issue":"6","key":"5780_CR2","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/leu.2014.17","volume":"28","author":"LJ Bendall","year":"2014","unstructured":"Bendall LJ, Green DR (2014) Autopsy of a cell. Leukemia 28(6):1341\u20131343. https:\/\/doi.org\/10.1038\/leu.2014.17","journal-title":"Leukemia"},{"issue":"1","key":"5780_CR3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nrn2038","volume":"8","author":"ML Block","year":"2007","unstructured":"Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8(1):57\u201369. https:\/\/doi.org\/10.1038\/nrn2038","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"5780_CR4","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.cell.2009.01.035","volume":"136","author":"RW Carthew","year":"2009","unstructured":"Carthew RW, Sontheimer EJ (2009) Origins and mechanisms of miRNAs and siRNAs. Cell 136(4):642\u2013655. https:\/\/doi.org\/10.1016\/j.cell.2009.01.035","journal-title":"Cell"},{"issue":"10","key":"5780_CR5","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1038\/emboj.2010.50","volume":"29","author":"S Chattopadhyay","year":"2010","unstructured":"Chattopadhyay S, Marques JT, Yamashita M, Peters KL, Smith K, Desai A, Williams BR, Sen GC (2010) Viral apoptosis is induced by IRF-3-mediated activation of Bax. EMBO J 29(10):1762\u20131773. https:\/\/doi.org\/10.1038\/emboj.2010.50","journal-title":"EMBO J"},{"issue":"1","key":"5780_CR6","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm3722","volume":"15","author":"PE Czabotar","year":"2014","unstructured":"Czabotar PE, Lessene G, Strasser A, Adams JM (2014) Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol 15(1):49\u201363. https:\/\/doi.org\/10.1038\/nrm3722","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5780_CR7","doi-asserted-by":"publisher","unstructured":"Ghosh D, Basu A (2009) Japanese encephalitis-a pathological and clinical perspective. PLoS Negl Trop Dis 3(9):e437. https:\/\/doi.org\/10.1371\/journal.pntd.0000437","DOI":"10.1371\/journal.pntd.0000437"},{"issue":"5","key":"5780_CR8","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/glia.20474","volume":"55","author":"A Ghoshal","year":"2007","unstructured":"Ghoshal A, Das S, Ghosh S, Mishra MK, Sharma V, Koli P, Sen E, Basu A (2007) Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis. Glia 55(5):483\u2013496. https:\/\/doi.org\/10.1002\/glia.20474","journal-title":"Glia"},{"key":"5780_CR9","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.vetmic.2018.05.008","volume":"220","author":"F Guo","year":"2018","unstructured":"Guo F, Yu X, Xu A, Xu J, Wang Q, Guo Y, Wu X, Tang Y, Ding Z, Zhang Y, Gong T, Pan Z, Li S, Kong L (2018) Japanese encephalitis virus induces apoptosis by inhibiting Foxo signaling pathway. Vet Microbiol 220:73\u201382. https:\/\/doi.org\/10.1016\/j.vetmic.2018.05.008","journal-title":"Vet Microbiol"},{"issue":"3","key":"5780_CR10","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s00705-015-2715-5","volume":"161","author":"M Huang","year":"2016","unstructured":"Huang M, Xu A, Wu X, Zhang Y, Guo Y, Guo F, Pan Z, Kong L (2016) Japanese encephalitis virus induces apoptosis by the IRE1\/JNK pathway of ER stress response in BHK-21 cells. Arch Virol 161(3):699\u2013703. https:\/\/doi.org\/10.1007\/s00705-015-2715-5","journal-title":"Arch Virol"},{"key":"5780_CR11","doi-asserted-by":"publisher","first-page":"787023","DOI":"10.1155\/2014\/787023","volume":"2014","author":"R Jiang","year":"2014","unstructured":"Jiang R, Ye J, Zhu B, Song Y, Chen H, Cao S (2014) Roles of TLR3 and RIG-I in mediating the inflammatory response in mouse microglia following Japanese encephalitis virus infection. J Immunol Res 2014:787023. https:\/\/doi.org\/10.1155\/2014\/787023","journal-title":"J Immunol Res"},{"issue":"14","key":"5780_CR12","doi-asserted-by":"publisher","first-page":"9320","DOI":"10.1128\/JVI.79.14.9320-9324.2005","volume":"79","author":"JR Kirshner","year":"2005","unstructured":"Kirshner JR, Karpova AY, Kops M, Howley PM (2005) Identification of TRAIL as an interferon regulatory factor 3 transcriptional target. J Virol 79(14):9320\u20139324. https:\/\/doi.org\/10.1128\/JVI.79.14.9320-9324.2005","journal-title":"J Virol"},{"issue":"1","key":"5780_CR13","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/sj.cdd.4402060","volume":"14","author":"S Kumar","year":"2007","unstructured":"Kumar S (2007) Caspase function in programmed cell death. Cell Death Differ 14(1):32\u201343. https:\/\/doi.org\/10.1038\/sj.cdd.4402060","journal-title":"Cell Death Differ"},{"key":"5780_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122510","author":"SH Lee","year":"2017","unstructured":"Lee SH, Choi BY, Lee SH, Kho AR, Jeong JH, Hong DK, Suh SW (2017) Administration of protocatechuic acid reduces traumatic brain injury-induced neuronal death. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms18122510","journal-title":"Int J Mol Sci"},{"issue":"1\u20132","key":"5780_CR15","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jviromet.2010.04.015","volume":"168","author":"Y Li","year":"2010","unstructured":"Li Y, Hou L, Ye J, Liu X, Dan H, Jin M, Chen H, Cao S (2010) Development of a convenient immunochromatographic strip for the diagnosis of infection with Japanese encephalitis virus in swine. J Virol Methods 168(1\u20132):51\u201356. https:\/\/doi.org\/10.1016\/j.jviromet.2010.04.015","journal-title":"J Virol Methods"},{"issue":"5","key":"5780_CR16","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1080\/15548627.2017.1290751","volume":"13","author":"P Mokarram","year":"2017","unstructured":"Mokarram P, Albokashy M, Zarghooni M, Moosavi MA, Sepehri Z, Chen QM, Hudecki A, Sargazi A, Alizadeh J, Moghadam AR, Hashemi M, Movassagh H, Klonisch T, Owji AA, Los MJ, Ghavami S (2017) New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets. Autophagy 13(5):781\u2013819. https:\/\/doi.org\/10.1080\/15548627.2017.1290751","journal-title":"Autophagy"},{"key":"5780_CR17","doi-asserted-by":"publisher","first-page":"103277","DOI":"10.1016\/j.critrevonc.2021.103277","volume":"160","author":"A Rodrigues","year":"2021","unstructured":"Rodrigues A, Costa R, Silva S, Dias I, Dias RB, Bezerra DP (2021) Cell signaling pathways as molecular targets to eliminate AML stem cells. Crit Rev Oncol Hematol 160:103277. https:\/\/doi.org\/10.1016\/j.critrevonc.2021.103277","journal-title":"Crit Rev Oncol Hematol"},{"issue":"4","key":"5780_CR18","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s40506-020-00242-5","volume":"12","author":"V Satchidanandam","year":"2020","unstructured":"Satchidanandam V (2020) Japanese encephalitis vaccines. Curr Treat Opt Infect Dis 12(4):375\u2013386. https:\/\/doi.org\/10.1007\/s40506-020-00242-5","journal-title":"Curr Treat Opt Infect Dis"},{"key":"5780_CR19","unstructured":"Shao L (2013) Preparation and characterization of Japanese encephalitis virus NS5 and E protein mab.dissertation, Huazhong Agricultural University"},{"key":"5780_CR20","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00887-19","author":"Q Wang","year":"2019","unstructured":"Wang Q, Xin X, Wang T, Wan J, Ou Y, Yang Z, Yu Q, Zhu L, Guo Y, Wu Y, Ding Z, Zhang Y, Pan Z, Tang Y, Li S, Kong L (2019) Japanese encephalitis virus induces apoptosis and encephalitis by activating the PERK pathway. J Virol. https:\/\/doi.org\/10.1128\/JVI.00887-19","journal-title":"J Virol"},{"issue":"448","key":"5780_CR21","doi-asserted-by":"publisher","first-page":"a98","DOI":"10.1126\/scisignal.aaf5132","volume":"9","author":"J Ye","year":"2016","unstructured":"Ye J, Zhang H, He W, Zhu B, Zhou D, Chen Z, Ashraf U, Wei Y, Liu Z, Fu ZF, Chen H, Cao S (2016) Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus. Sci Signal 9(448):a98. https:\/\/doi.org\/10.1126\/scisignal.aaf5132","journal-title":"Sci Signal"},{"key":"5780_CR22","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00039-17","author":"J Ye","year":"2017","unstructured":"Ye J, Chen Z, Li Y, Zhao Z, He W, Zohaib A, Song Y, Deng C, Zhang B, Chen H, Cao S (2017) Japanese encephalitis virus NS5 inhibits type I interferon (IFN) production by blocking the nuclear translocation of IFN regulatory factor 3 and NF-kappaB. J Virol. https:\/\/doi.org\/10.1128\/JVI.00039-17","journal-title":"J Virol"},{"issue":"23","key":"5780_CR23","doi-asserted-by":"publisher","first-page":"11868","DOI":"10.1128\/JVI.00879-06","volume":"80","author":"CY Yu","year":"2006","unstructured":"Yu CY, Hsu YW, Liao CL, Lin YL (2006) Flavivirus infection activates the XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress. J Virol 80(23):11868\u201311880. https:\/\/doi.org\/10.1128\/JVI.00879-06","journal-title":"J Virol"},{"key":"5780_CR24","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.meegid.2015.03.037","volume":"32","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Jing J, Li X, Wang J, Feng X, Cao R, Chen P (2015) Integration analysis of miRNA and mRNA expression profiles in swine testis cells infected with Japanese encephalitis virus. Infect Genet Evol 32:342\u2013347. https:\/\/doi.org\/10.1016\/j.meegid.2015.03.037","journal-title":"Infect Genet Evol"},{"issue":"02","key":"5780_CR25","first-page":"506","volume":"52","author":"J Zhang","year":"2021","unstructured":"Zhang J, Gao M, Liu Z, Gu C (2021) Effects of autophagy regulators on apoptosis in the brain of mice infected with Japanese encephalitis virus. Acta Vet Zootech Sin 52(02):506\u2013514","journal-title":"Acta Vet Zootech Sin"},{"issue":"5","key":"5780_CR26","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.4049\/jimmunol.1500370","volume":"195","author":"B Zhu","year":"2015","unstructured":"Zhu B, Ye J, Nie Y, Ashraf U, Zohaib A, Duan X, Fu ZF, Song Y, Chen H, Cao S (2015) MicroRNA-15b modulates japanese encephalitis virus-mediated inflammation via targeting RNF125. J Immunol 195(5):2251\u20132262. https:\/\/doi.org\/10.4049\/jimmunol.1500370","journal-title":"J Immunol"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-023-05780-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00705-023-05780-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-023-05780-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T03:14:04Z","timestamp":1686539644000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00705-023-05780-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,26]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["5780"],"URL":"https:\/\/doi.org\/10.1007\/s00705-023-05780-z","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,26]]},"assertion":[{"value":"22 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have not disclosed any competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors confirm that the ethical policies of the journal, as noted on the journal's author guidelines page, have been adhered to. No ethical approval was required, as no animal trials were conducted in this research article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal welfare statement"}}],"article-number":"169"}}