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To overcome the challenge of viral adaptation and evolution, increased vigilance is required. Particularly, antiviral drugs derived from new, natural sources provide an attractive strategy for controlling problematic viral diseases. In this antiviral study, we discovered a previously unknown bacterium,\n                    <jats:italic>Mameliella<\/jats:italic>\n                    sp. M20D2D8, by conducting an antiviral screening of marine microorganisms. An extract from M20D2D8 exhibited antiviral activity with low cytotoxicity and was found to be effective\n                    <jats:italic>in vitro<\/jats:italic>\n                    against multiple influenza virus strains: A\/PR8 (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20092.93 \u00b5g\/mL, SI\u2009=\u2009294.85), A\/Phil82 (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20091.42 \u00b5g\/mL, SI\u2009=\u2009608.38), and B\/Yamagata (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20091.59 \u00b5g\/mL, SI\u2009=\u2009543.33). The antiviral action was found to occur in the post-entry stages of viral replication and to suppress viral replication by inducing apoptosis in infected cells. Moreover, it efficiently suppressed viral genome replication, protein synthesis, and infectivity in MDCK and A549 cells. Our findings highlight the antiviral capabilities of a novel marine bacterium, which could potentially be useful in the development of drugs for controlling viral diseases.\n                  <\/jats:p>","DOI":"10.1007\/s00705-024-05979-8","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T14:02:26Z","timestamp":1707314546000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification and characterization of a marine bacterium extract from Mameliella sp. M20D2D8 with antiviral effects against influenza A and B viruses"],"prefix":"10.1007","volume":"169","author":[{"given":"Hyo-Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Gyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeong-Seo","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Bin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Min","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Seon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Hyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Jip","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong-Bin","family":"Baek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-0324","authenticated-orcid":false,"given":"Sang-Ik","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"5979_CR1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/j.1365-2796.2006.01711.x","volume":"260","author":"JL Heeney","year":"2006","unstructured":"Heeney JL (2006) Zoonotic viral diseases and the frontier of early diagnosis, control and prevention. 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