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Pattern recognition receptors (PRRs) are host sensors that activate the immune response against infectious agents. However, it is unclear whether PRR single-nucleotide polymorphisms (SNPs) are associated with the occurrence of CMV DNAemia in subjects coinfected with HIV and CMV. HIV\/CMV-coinfected patients with and without CMV DNAemia were recruited for this study. The <jats:italic>DDX58<\/jats:italic> rs10813831 and <jats:italic>IFIH1<\/jats:italic> (rs3747517 and rs1990760) polymorphisms were genotyped using the TaqMan Allelic Discrimination Assay, whereas the <jats:italic>DDX58<\/jats:italic> rs12006123 and <jats:italic>TLR3<\/jats:italic> (rs3775291 and rs3775296) SNPs were analyzed using a polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. A mutation present in at least one allele of the <jats:italic>DDX58<\/jats:italic> rs12006123 SNP occurred at least two times more frequently in HIV\/CMV-coinfected patients with CMV DNAemia than in coinfected subjects without CMV DNAemia (OR, 2.50; 95% CI, 1.33\u20134.68; <jats:italic>p<\/jats:italic>\u2009=\u20090.004, in the dominant model). A higher level of CMV DNAemia was observed in subjects who had the heterozygous (GA) or homozygous recessive (AA) genotype for the <jats:italic>DDX58<\/jats:italic> rs12006123 SNP compared with those who had the wild-type (GG) genotype (<jats:italic>p<\/jats:italic>\u2009=\u20090.0003). Moreover, in subjects with a mutation detected in at least one allele of the <jats:italic>DDX58<\/jats:italic> rs12006123 SNP, a lower serum IFN-\u03b2 concentration was found compared with those who had a wild-type (GG) genotype for this polymorphism (<jats:italic>p<\/jats:italic>\u2009=\u20090.024). The <jats:italic>DDX58<\/jats:italic> rs12006123 SNP is associated with CMV DNAemia in HIV\/CMV-coinfected patients.<\/jats:p>","DOI":"10.1007\/s00705-024-06114-3","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T13:02:59Z","timestamp":1727442179000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polymorphisms in the genes encoding RLR and TLR3 and CMV DNAemia in subjects coinfected with human immunodeficiency virus and cytomegalovirus"],"prefix":"10.1007","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-043X","authenticated-orcid":false,"given":"Agnieszka","family":"Jab\u0142o\u0144ska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7282-1225","authenticated-orcid":false,"given":"El\u017cbieta","family":"Jab\u0142onowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4851-2190","authenticated-orcid":false,"given":"Miros\u0142awa","family":"Studzi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0320-0281","authenticated-orcid":false,"given":"Juliusz","family":"Kamerys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9446-0136","authenticated-orcid":false,"given":"Edyta","family":"Paradowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"6114_CR1","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1093\/cid\/ciw076","volume":"62","author":"F Caby","year":"2016","unstructured":"Caby F, Guihot A, Lambert-Niclot S, Guiguet M, Boutolleau D, Agher R, Valantin MA, Tubiana R, Calvez V, Marcelin AG, Carcelain G, Autran B, Costagliola D, Katlama C (2016) Determinants of a Low CD4\/CD8 Ratio in HIV-1-Infected Individuals Despite Long-term Viral Suppression. 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Approval was granted by the ethics committee of the Medical University of Lodz (RNN\/211\/06\/KE and RNN\/33\/17\/KE).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"211"}}