{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:23:50Z","timestamp":1772119430468,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573861"],"award-info":[{"award-number":["81573861"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s00705-025-06247-z","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T13:28:20Z","timestamp":1739453300000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A novel SIV-infection animal model based on nude mice inoculated with MT-2 cells"],"prefix":"10.1007","volume":"170","author":[{"given":"Lei","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenguan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minyi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yatian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haolan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-1585","authenticated-orcid":false,"given":"Jinyang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"6247_CR1","unstructured":"Statistics GHA (2022) Global HIV & AIDS statistics? Fact sheet. https:\/\/www.unaids.org\/en\/resources\/fact-sheet. Accessed 2022-10-18 2022"},{"issue":"12","key":"6247_CR2","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/nrmicro2911","volume":"10","author":"T Hatziioannou","year":"2012","unstructured":"Hatziioannou T, Evans DT (2012) Animal models for HIV\/AIDS research. NAT REV MICROBIOL 10(12):852\u2013867. https:\/\/doi.org\/10.1038\/nrmicro2911","journal-title":"NAT REV MICROBIOL"},{"issue":"4873","key":"6247_CR3","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1126\/science.241.4873.1632","volume":"241","author":"JM Mccune","year":"1988","unstructured":"Mccune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL (1988) The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function. Science 241(4873):1632\u20131639. https:\/\/doi.org\/10.1126\/science.241.4873.1632","journal-title":"Science"},{"issue":"4886","key":"6247_CR4","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1126\/science.3201256","volume":"242","author":"R Namikawa","year":"1988","unstructured":"Namikawa R, Kaneshima H, Lieberman M, Weissman IL, Mccune JM (1988) Infection of the SCID-hu mouse by HIV-1. Science 242(4886):1684\u20131686. https:\/\/doi.org\/10.1126\/science.3201256","journal-title":"Science"},{"issue":"6187","key":"6247_CR5","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/335256a0","volume":"335","author":"DE Mosier","year":"1988","unstructured":"Mosier DE, Gulizia RJ, Baird SM, Wilson DB (1988) Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335(6187):256\u2013259. https:\/\/doi.org\/10.1038\/335256a0","journal-title":"Nature"},{"issue":"3","key":"6247_CR6","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s13365-014-0299-6","volume":"21","author":"JB Honeycutt","year":"2015","unstructured":"Honeycutt JB, Sheridan PA, Matsushima GK, Garcia JV (2015) Humanized mouse models for HIV-1 infection of the CNS. J NEUROVIROL 21(3):301\u2013309. https:\/\/doi.org\/10.1007\/s13365-014-0299-6","journal-title":"J NEUROVIROL"},{"issue":"10","key":"6247_CR7","doi-asserted-by":"publisher","first-page":"6477","DOI":"10.4049\/jimmunol.174.10.6477","volume":"174","author":"LD Shultz","year":"2005","unstructured":"Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S, Kotb M, Gillies SD, King M, Mangada J, Greiner DL, Handgretinger R (2005) Human lymphoid and myeloid cell development in NOD\/LtSz-scid IL2R??Null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174(10):6477\u20136489. https:\/\/doi.org\/10.4049\/jimmunol.174.10.6477","journal-title":"J Immunol"},{"issue":"9","key":"6247_CR8","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1182\/blood-2001-12-0207","volume":"100","author":"M Ito","year":"2002","unstructured":"Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, Ueyama Y, Koyanagi Y, Sugamura K, Tsuji K, Heike T, Nakahata T (2002) NOD\/SCID\/??Cnull mouse: An excellent recipient mouse model for engraftment of human cells. Blood 100(9):3175\u20133182. https:\/\/doi.org\/10.1182\/blood-2001-12-0207","journal-title":"Blood"},{"key":"6247_CR9","doi-asserted-by":"publisher","unstructured":"Satheesan S, Li H, Burnett JC, Takahashi M, Li S, Wu SX, Synold TW, Rossi JJ, Zhou J (2018) HIV replication and latency in a humanized NSG mouse model during suppressive oral combinational antiretroviral therapy. J Virol 92(7). https:\/\/doi.org\/10.1128\/JVI.02118-17","DOI":"10.1128\/JVI.02118-17"},{"key":"6247_CR10","doi-asserted-by":"publisher","unstructured":"Zhang J, Lohani SC, Cheng Y, Wang T, Guo L, Kim W, Gorantla S, Li Q (2021) Human microglia extensively reconstitute in Humanized-BLT mice with human interleukin-34 transgene and support HIV-1 brain infection. Front Immunol 12. https:\/\/doi.org\/10.3389\/fimmu.2021.672415","DOI":"10.3389\/fimmu.2021.672415"},{"issue":"2","key":"6247_CR11","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1046\/j.1365-2141.1998.00980.x","volume":"103","author":"JP Goldman","year":"1998","unstructured":"Goldman JP, Blundell MP, Lopes L, Kinnon C, DI Santo JP, Thrasher AJ (1998) Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor?? Chain. BRIT J HAEMATOL 103(2):335\u2013342. https:\/\/doi.org\/10.1046\/j.1365-2141.1998.00980.x","journal-title":"BRIT J HAEMATOL"},{"key":"6247_CR12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jviromet.2014.01.004","volume":"203","author":"H Liu","year":"2014","unstructured":"Liu H, Wu Y, Liu C, He J (2014) A single-tube nucleotide isolation reagent for the quantitative PCR detection of virus in body fluids. J VIROL METHODS 203:81\u201387. https:\/\/doi.org\/10.1016\/j.jviromet.2014.01.004","journal-title":"J VIROL METHODS"},{"issue":"6431","key":"6247_CR13","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/363728a0","volume":"363","author":"ML Bonyhadi","year":"1993","unstructured":"Bonyhadi ML, Rabin L, Salimi S, Brown DA, Kosek J, Mccune JM, Kaneshima H (1993) HIV induces thymus depletion in vivo. Nature 363(6431):728\u2013732. https:\/\/doi.org\/10.1038\/363728a0","journal-title":"Nature"},{"issue":"4942","key":"6247_CR14","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1126\/science.2300816","volume":"247","author":"JM Mccune","year":"1990","unstructured":"Mccune JM, Namikawa R, Shih C, Rabin L, Kaneshima H (1990) Suppression of HIV infection in AZT-Treated SCID-hu mice. Science 247(4942):564\u2013566. https:\/\/doi.org\/10.1126\/science.2300816","journal-title":"Science"},{"issue":"2","key":"6247_CR15","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/nri2017","volume":"7","author":"LD Shultz","year":"2007","unstructured":"Shultz LD, Ishikawa F, Greiner DL (2007) Humanized mice in translational biomedical research. NAT REV IMMUNOL 7(2):118\u2013130. https:\/\/doi.org\/10.1038\/nri2017","journal-title":"NAT REV IMMUNOL"},{"issue":"6","key":"6247_CR16","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1128\/JVI.02010-06","volume":"81","author":"S Gorantla","year":"2007","unstructured":"Gorantla S, Sneller H, Walters L, Sharp JG, Pirruccello SJ, West JT, Wood C, Dewhurst S, Gendelman HE, Poluektova L (2007) Human immunodeficiency virus type 1 pathobiology studied in humanized BALB\/c-Rag2-\/-gammac-\/- mice. J VIROL 81(6):2700\u20132712","journal-title":"J VIROL"},{"issue":"17","key":"6247_CR17","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1097\/QAD.0b013e328357f5ad","volume":"26","author":"PK Dash","year":"2012","unstructured":"Dash PK, Gendelman HE, Roy U, Balkundi S, Alnouti Y, Mosley RL, Gelbard HA, Mcmillan J, Gorantla S, Poluektova LY (2012) Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice. AIDS 26(17):2135\u20132144. https:\/\/doi.org\/10.1097\/QAD.0b013e328357f5ad","journal-title":"AIDS"},{"key":"6247_CR18","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.antiviral.2015.05.009","volume":"120","author":"P Puligujja","year":"2015","unstructured":"Puligujja P, Ara Nga M, Dash P, Palandri D, Mosley RL, Gorantla S, Poluektova L, Mcmillan J, Gendelman HE (2015) Pharmacodynamics of folic acid receptor targeted antiretroviral nanotherapy in HIV-1-infected humanized mice. ANTIVIR RES 120:85\u201388. https:\/\/doi.org\/10.1016\/j.antiviral.2015.05.009","journal-title":"ANTIVIR RES"},{"key":"6247_CR19","doi-asserted-by":"publisher","unstructured":"Feng T, Qin H, Wang L, Benveniste EN, Elson CO, Cong Y (2011) Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production. Journal of immunology (Baltimore, Md.: 1950) 186(11):6313\u20136318. https:\/\/doi.org\/10.4049\/jimmunol.1001454","DOI":"10.4049\/jimmunol.1001454"},{"issue":"7","key":"6247_CR20","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1016\/j.cell.2020.05.053","volume":"181","author":"N Koundouros","year":"2020","unstructured":"Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry NJS, Magee DJ, Anjomani Virmouni S, Elder GA, Tyson AL, Ria D, van Weverwijk ML, Soares A, Isacke RF, Nicholson CM, Glen JK, Takats RC, Poulogiannis Z G (2020) Metabolic fingerprinting links oncogenic PIK3CA with enhanced arachidonic Acid-Derived eicosanoids. Cell 181(7):1596\u20131611. https:\/\/doi.org\/10.1016\/j.cell.2020.05.053","journal-title":"Cell"},{"issue":"6","key":"6247_CR21","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.4049\/jimmunol.1900889","volume":"204","author":"Haj AK","year":"2020","unstructured":"Haj AK, Breitbach ME, Baker DA, Mohns MS, Moreno GK, Wilson NA, Lyamichev V, Patel J, Weisgrau KL, Dudley DM, O'Connor DH (2020) High-Throughput identification of MHC class i binding peptides using an ultradense peptide array. J Immunol (Baltim Md 1950) 204(6):1689\u20131696. https:\/\/doi.org\/10.4049\/jimmunol.1900889","journal-title":"J Immunol (Baltim Md 1950)"},{"issue":"5S","key":"6247_CR22","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1097\/INF.0000000000002774","volume":"40","author":"JF Mangold","year":"2021","unstructured":"Mangold JF, Goswami R, Nelson AN, Martinez DR, Fouda GG, Permar SR (2021) Maternal intervention to prevent Mother-to-Child transmission of HIV: Moving beyond antiretroviral therapy. Pediatr Infect Dis J 40(5S):S5\u2013S10. https:\/\/doi.org\/10.1097\/INF.0000000000002774","journal-title":"Pediatr Infect Dis J"},{"key":"6247_CR23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1742-6405-6-23","volume":"6","author":"Y Jiang","year":"2009","unstructured":"Jiang Y, Tian B, Saifuddin M, Agy MB, Emau P, Cairns JS, Tsai C (2009) RT-SHIV, an infectious CCR5-tropic chimeric virus suitable for evaluating HIV reverse transcriptase inhibitors in macaque models. AIDS RES THER 6:23. https:\/\/doi.org\/10.1186\/1742-6405-6-23","journal-title":"AIDS RES THER"},{"issue":"7","key":"6247_CR24","doi-asserted-by":"publisher","first-page":"e148","DOI":"10.1371\/journal.pmed.0050148","volume":"5","author":"O Keiser","year":"2008","unstructured":"Keiser O, Orrell C, Egger M, Wood R, Brinkhof MWG, Furrer H, van Cutsem G, Ledergerber B, Boulle A, Iedea-Sa SHCS (2008) Public-health and individual approaches to antiretroviral therapy: Township South Africa and Switzerland compared. PLOS MED 5(7):e148. https:\/\/doi.org\/10.1371\/journal.pmed.0050148","journal-title":"PLOS MED"},{"issue":"1","key":"6247_CR25","doi-asserted-by":"publisher","first-page":"18037","DOI":"10.7448\/IAS.16.1.18037","volume":"16","author":"R Lazarus","year":"2013","unstructured":"Lazarus R, Struthers H, Violari A (2013) Promoting safe infant feeding practices - the importance of structural, social and contextual factors in Southern Africa. J INT AIDS SOC 16(1):18037. https:\/\/doi.org\/10.7448\/IAS.16.1.18037","journal-title":"J INT AIDS SOC"},{"issue":"1","key":"6247_CR26","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.molcel.2008.11.024","volume":"33","author":"J Henao-Mejia","year":"2009","unstructured":"Henao-Mejia J, Liu Y, Park I, Zhang J, Sanford J, He JJ (2009) Suppression of HIV-1 Nef translation by Sam68 mutant-induced stress granules and nef mRNA sequestration. MOL CELL 33(1):87\u201396. https:\/\/doi.org\/10.1016\/j.molcel.2008.11.024","journal-title":"MOL CELL"},{"issue":"1","key":"6247_CR27","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12977-016-0322-5","volume":"13","author":"K Post","year":"2016","unstructured":"Post K, Olson ED, Naufer MN, Gorelick RJ, Rouzina I, Williams MC, Musier-Forsyth K, Levin JG (2016) Mechanistic differences between HIV-1 and SIV nucleocapsid proteins and cross-species HIV-1 genomic RNA recognition. RETROVIROLOGY 13(1):89. https:\/\/doi.org\/10.1186\/s12977-016-0322-5","journal-title":"RETROVIROLOGY"},{"key":"6247_CR28","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.3389\/fimmu.2018.02719","volume":"9","author":"RT Trifonova","year":"2018","unstructured":"Trifonova RT, Bollman B, Barteneva NS, Lieberman J (2018) Myeloid cells in intact human cervical explants capture HIV and can transmit it to CD4 t cells. FRONT IMMUNOL 9:2719. https:\/\/doi.org\/10.3389\/fimmu.2018.02719","journal-title":"FRONT IMMUNOL"},{"issue":"1","key":"6247_CR29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1365-2796.2008.02045.x","volume":"265","author":"G Alter","year":"2009","unstructured":"Alter G, Altfeld M (2009) NK cells in HIV-1 infection: Evidence for their role in the control of HIV-1 infection. J INTERN MED 265(1):29\u201342. https:\/\/doi.org\/10.1111\/j.1365-2796.2008.02045.x","journal-title":"J INTERN MED"},{"key":"6247_CR30","doi-asserted-by":"publisher","first-page":"878743","DOI":"10.3389\/fimmu.2022.878743","volume":"13","author":"M Pace","year":"2022","unstructured":"Pace M, Ogbe A, Hurst J, Robinson N, Meyerowitz J, Olejniczak N, Thornhill JP, Jones M, Waters A, Lwanga J, Kuldanek K, Hall R, Zacharopoulou P, Martin GE, Brown H, Nwokolo N, Peppa D, Fox J, Fidler S, Frater J (2022) Impact of antiretroviral therapy in primary HIV infection on natural killer cell function and the association with viral rebound and HIV DNA following treatment interruption. FRONT IMMUNOL 13:878743. https:\/\/doi.org\/10.3389\/fimmu.2022.878743","journal-title":"FRONT IMMUNOL"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-025-06247-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00705-025-06247-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-025-06247-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T08:33:48Z","timestamp":1741336428000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00705-025-06247-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["6247"],"URL":"https:\/\/doi.org\/10.1007\/s00705-025-06247-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3372433\/v1","asserted-by":"object"}]},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]},"assertion":[{"value":"20 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal experiments in this study were carried out in strict accordance with the Chinese Guidelines for Animal Care, complying with the internationally accepted uses of experimental animals. The protocols were approved by the Animal Experiment Ethics of Guangzhou University of Chinese Medicine.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"56"}}