{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:11:19Z","timestamp":1788858679224,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Tamil Nadu Innovation and Initiatives","award":["Tamil Nadu Innovation and Initiatives"],"award-info":[{"award-number":["Tamil Nadu Innovation and Initiatives"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s00705-026-06714-1","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:43:11Z","timestamp":1786542191000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uncovering host transcriptional responses to tilapia lake virus (TiLV) through De novo RNA-seq assembly in Nile tilapia, Oreochromis niloticus"],"prefix":"10.1007","volume":"171","author":[{"given":"G.","family":"Rebecca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9429-4075","authenticated-orcid":false,"given":"A.","family":"Uma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. G.","family":"Tirumurugaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gangatharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Shanmugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Kathirvel","family":"Pandian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"6714_CR1","unstructured":"IMARC (2025) India Tilapia Market Size, Share, Trends and Forecast by Farmed vs Wild Capture, Species, Product, Sector, and Region, 2025\u20132033. Report ID: SR112025A30269"},{"key":"6714_CR2","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/j.1365-2761.2009.01037.x","volume":"32","author":"L Bigarre","year":"2009","unstructured":"Bigarre L, Cabon J, Baud M, Heimann M, Body A, Lieffrig F, Castric J (2009) Outbreak of betanodavirus infection in tilapia, Oreochromis niloticus (L.), in fresh water. J Fish Dis 32:667\u2013673. https:\/\/doi.org\/10.1111\/j.1365-2761.2009.01037.x","journal-title":"J Fish Dis"},{"key":"6714_CR3","first-page":"678","volume":"9","author":"S Sathish","year":"2021","unstructured":"Sathish S, Chidambaram P, Uma A, Yuvarajan P (2021) Prevalence of parasites in tilapia farms and their management practices in Tamil Nadu, India. J Entomol Zool Stud 9:678\u2013689","journal-title":"J Entomol Zool Stud"},{"key":"6714_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.62757\/IVA.2024.101.1.11-14","volume":"101","author":"A Uma","year":"2024","unstructured":"Uma A, Rebecca G, Gangatharan S, Palanivel N (2024) Isolation and identification of Brucella melitensis in diseased Nile tilapia, Oreochromis niloticus from a commercial fish farm in Tamil Nadu, India. Indian Vet J 101:11\u201314. https:\/\/doi.org\/10.62757\/IVA.2024.101.1.11-14","journal-title":"Indian Vet J"},{"key":"6714_CR5","doi-asserted-by":"publisher","first-page":"4137","DOI":"10.1128\/JCM.00827-14","volume":"52","author":"M Eyngor","year":"2014","unstructured":"Eyngor M, Zamostiano R, Kembou Tsofack JE, Berkowitz A, Bercovier H, Tinman S, Lev M, Hurvitz A, Galeotti M, Bacharach E, Eldar A (2014) Identification of a novel RNA virus lethal to tilapia. J Clin Microbiol 52:4137\u20134146. https:\/\/doi.org\/10.1128\/JCM.00827-14","journal-title":"J Clin Microbiol"},{"key":"6714_CR6","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/jfd.12142","volume":"37","author":"HW Ferguson","year":"2014","unstructured":"Ferguson HW, Kabuusu R, Beltran S, Reyes E, Lince JA, del Pozo J (2014) Syncytial hepatitis of farmed tilapia, Oreochromis niloticus (L.): a case report. J Fish Dis 37:583\u2013589","journal-title":"J Fish Dis"},{"key":"6714_CR7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.aaf.2021.04.007","volume":"7","author":"N Aich","year":"2022","unstructured":"Aich N, Paul A, Choudhury TG, Saha H (2022) Tilapia Lake Virus (TiLV) disease: current status of understanding. Aquac Fish 7:7\u201317. https:\/\/doi.org\/10.1016\/j.aaf.2021.04.007","journal-title":"Aquac Fish"},{"key":"6714_CR8","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1007\/s00705-017-3358-5","volume":"162","author":"MJ Adams","year":"2017","unstructured":"Adams MJ, Lefkowitz EJ, King AM, Harrach B, Harrison RL, Knowles NJ, Kropinski AM, Krupovic M, Kuhn JH, Mushegian AR, Nibert M (2017) Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2017). Arch Virol 162:2505\u20132538. https:\/\/doi.org\/10.1007\/s00705-017-3358-5","journal-title":"Arch Virol"},{"key":"6714_CR9","doi-asserted-by":"publisher","first-page":"001903","DOI":"10.1099\/jgv.0.001903","volume":"104","author":"EV Koonin","year":"2023","unstructured":"Koonin EV, Krupovic M, Surachetpong W, Wolf YI, Kuhn JH (2023) ICTV virus taxonomy profile: Amnoonviridae 2023. J Gen Virol 104:001903","journal-title":"J Gen Virol"},{"key":"6714_CR10","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.vetmic.2017.06.014","volume":"207","author":"P Tattiyapong","year":"2017","unstructured":"Tattiyapong P, Dachavichitlead W, Surachetpong W (2017) Experimental infection of Tilapia Lake Virus (TiLV) in Nile tilapia (Oreochromis niloticus) and red tilapia (Oreochromis sp). Vet Microbiol 207:170\u2013177. https:\/\/doi.org\/10.1016\/j.vetmic.2017.06.014","journal-title":"Vet Microbiol"},{"key":"6714_CR11","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.aquaculture.2017.11.025","volume":"484","author":"BK Behera","year":"2018","unstructured":"Behera BK, Pradhan PK, Swaminathan TR, Sood N, Paria P, Das A, Verma DK, Kumar R, Yadav MK, Dev AK, Parida PK (2018) Emergence of Tilapia Lake Virus associated with mortalities of farmed Nile tilapia Oreochromis niloticus (Linnaeus 1758) in India. Aquaculture 484:168\u2013174. https:\/\/doi.org\/10.1016\/j.aquaculture.2017.11.025","journal-title":"Aquaculture"},{"key":"6714_CR12","doi-asserted-by":"publisher","unstructured":"Rebecca G, Uma A, Shanmugam SA, Tirumurugaan KG (2025) Massive surveillance of Tilapia Lake Virus (TiLV) in tilapia farms and wild from various districts of Tamil Nadu, India. Indian J Anim Res 1\u20137. https:\/\/doi.org\/10.18805\/IJAR.B-5558","DOI":"10.18805\/IJAR.B-5558"},{"key":"6714_CR13","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3390\/v11100893","volume":"11","author":"KK Mugimba","year":"2019","unstructured":"Mugimba KK, Tal S, Dubey S, Mutoloki S, Dishon A, Evensen O, Munangandu HM (2019) Gray (Oreochromis niloticus \u00d7 O. aureus) and Red (Oreochromis spp.) tilapia show equal susceptibility and proinflammatory cytokine responses to experimental Tilapia Lake Virus infection. Viruses 11:893. https:\/\/doi.org\/10.3390\/v11100893","journal-title":"Viruses"},{"key":"6714_CR14","doi-asserted-by":"publisher","first-page":"8145","DOI":"10.1038\/s41467-023-44044-x","volume":"14","author":"B Arragain","year":"2023","unstructured":"Arragain B, Pelosse M, Thompson A, Cusack S (2023) Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family. Nat Commun 14:8145. https:\/\/doi.org\/10.1038\/s41467-023-44044-x","journal-title":"Nat Commun"},{"key":"6714_CR15","doi-asserted-by":"publisher","first-page":"20364","DOI":"10.1038\/s41598-020-73781-y","volume":"10","author":"KK Mugimba","year":"2020","unstructured":"Mugimba KK, Lamkhannat M, Dubey S, Mutoloki S, Munangandu HM, Evensen O (2020) Tilapia lake virus downplays innate immune responses during early stage of infection in Nile tilapia (Oreochromis niloticus). Sci Rep 10:20364. https:\/\/doi.org\/10.1038\/s41598-020-73781-y","journal-title":"Sci Rep"},{"key":"6714_CR16","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.fsi.2021.02.005","volume":"111","author":"N Sood","year":"2021","unstructured":"Sood N, Verma DK, Paria A, Yadav SC, Yadav MK, Bedekar MK, Kumar S, Swaminathan TR, Mohan CV, Rajendran KV, Pradhan PK (2021) Transcriptome analysis of liver elucidates key immune-related pathways in Nile tilapia Oreochromis niloticus following infection with Tilapia Lake Virus. Fish Shellfish Immunol 111:208\u2013219. https:\/\/doi.org\/10.1016\/j.fsi.2021.02.005","journal-title":"Fish Shellfish Immunol"},{"key":"6714_CR17","doi-asserted-by":"publisher","first-page":"e16190","DOI":"10.7717\/peerj.16190","volume":"11","author":"P Raksaseri","year":"2023","unstructured":"Raksaseri P, Lertwanakarn T, Tattiyapong P, Kijtawornrat A, Klomkleaw W, Surachetpong W (2023) Tilapia lake virus causes mitochondrial damage: a proposed mechanism that leads to extensive death in fish cells. PeerJ 11:e16190. https:\/\/doi.org\/10.7717\/peerj.16190","journal-title":"PeerJ"},{"key":"6714_CR18","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.virol.2010.01.001","volume":"399","author":"M Shlapobersky","year":"2010","unstructured":"Shlapobersky M, Sinyakov MS, Katzenellenbogen M, Sarid R, Don J, Avtalion RR (2010) Viral encephalitis of tilapia larvae: primary characterization of a novel herpeslike virus. Virology 399:239\u2013247. https:\/\/doi.org\/10.1016\/j.virol.2010.01.001","journal-title":"Virology"},{"key":"6714_CR19","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/j.1365-2761.2009.01037","volume":"32","author":"L Bigarre","year":"2009","unstructured":"Bigarre L, Cabon J, Baud M, Heimann M, Body A, Lieffrig F, Castric J (2009) Outbreak of betanodavirus infection in tilapia, Oreochromis niloticus (L.), in freshwater. J Fish Dis 32:667\u2013673. https:\/\/doi.org\/10.1111\/j.1365-2761.2009.01037","journal-title":"J Fish Dis"},{"key":"6714_CR20","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.aquaculture.2017.04.019","volume":"476","author":"HT Dong","year":"2017","unstructured":"Dong HT, Siriroob S, Meemetta W, Santimanawong W, Gangnonngiw W, Pirarat N, Khunrae P, Rattanarojpong T, Vanichviriyakit R, Senapin S (2017) Emergence of Tilapia Lake Virus in Thailand and an alternative semi-nested RT-PCR for detection. Aquaculture 476:111\u2013118. https:\/\/doi.org\/10.1016\/j.aquaculture.2017.04.019","journal-title":"Aquaculture"},{"key":"6714_CR21","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead B, Salzberg SL (2012) Fast gapped-read alignment with Bowtie 2. Nat Methods 9:357\u2013359. https:\/\/doi.org\/10.1038\/nmeth.1923","journal-title":"Nat Methods"},{"key":"6714_CR22","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/1471-2105-12-323","volume":"12","author":"B Li","year":"2011","unstructured":"Li B, Dewey CN (2011) RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics 12:323. https:\/\/doi.org\/10.1186\/1471-2105-12-323","journal-title":"BMC Bioinformatics"},{"key":"6714_CR23","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1038\/nprot.2013.084","volume":"8","author":"BJ Haas","year":"2013","unstructured":"Haas BJ, Papanicolaou A, Yassour M, Grabherr M, Blood PD, Bowden J, Couger MB, Eccles D, Li BO, Lieber M, MacManes MD (2013) De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis. Nat Protoc 8:1494\u20131512. https:\/\/doi.org\/10.1038\/nprot.2013.084","journal-title":"Nat Protoc"},{"key":"6714_CR24","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s12864-019-5548-x","volume":"20","author":"K Choi","year":"2019","unstructured":"Choi K, Ratner N (2019) iGEAK: an interactive gene expression analysis kit for seamless workflow using the R\/shiny platform. BMC Genomics 20:177. https:\/\/doi.org\/10.1186\/s12864-019-5548-x","journal-title":"BMC Genomics"},{"key":"6714_CR25","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1016\/j.molimm.2010.05.282","volume":"47","author":"FF Yu","year":"2010","unstructured":"Yu FF, Zhang YB, Liu TK, Liu Y, Sun F, Jiang J, Gui JF (2010) Fish virus-induced interferon exerts antiviral function through Stat1 pathway. Mol Immunol 47:2330\u20132341. https:\/\/doi.org\/10.1016\/j.molimm.2010.05.282","journal-title":"Mol Immunol"},{"key":"6714_CR26","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.fsi.2017.08.041","volume":"70","author":"CF Ken","year":"2017","unstructured":"Ken CF, Chen CN, Ting CH, Pan CY, Chen JY (2017) Transcriptome analysis of hybrid tilapia (Oreochromis spp.) with Streptococcus agalactiae infection identifies Toll-like receptor pathway-mediated induction of NADPH oxidase complex and piscidins as primary immune-related responses. Fish Shellfish Immunol 70:106\u2013120. https:\/\/doi.org\/10.1016\/j.fsi.2017.08.041","journal-title":"Fish Shellfish Immunol"},{"key":"6714_CR27","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.aquaculture.2019.01.025","volume":"503","author":"Z Mehrabi","year":"2019","unstructured":"Mehrabi Z, Firouzbakhsh F, Rahimi-Mianji G, Paknejad H (2019) Immunostimulatory effect of Aloe vera (Aloe barbadensis) on non-specific immune response, immune gene expression, and experimental challenge with Saprolegnia parasitica in rainbow trout (Oncorhynchus mykiss). Aquaculture 503:330\u2013338. https:\/\/doi.org\/10.1016\/j.aquaculture.2019.01.025","journal-title":"Aquaculture"},{"key":"6714_CR28","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.dci.2009.12.015","volume":"34","author":"A Lopez-Munoz","year":"2010","unstructured":"Lopez-Munoz A, Roca FJ, Sepulcre MP, Meseguer J, Mulero V (2010) Zebrafish larvae are unable to mount a protective antiviral response against waterborne infection by spring viremia of carp virus. Dev Comp Immunol 34:546\u2013552. https:\/\/doi.org\/10.1016\/j.dci.2009.12.015","journal-title":"Dev Comp Immunol"},{"key":"6714_CR29","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.fsi.2005.07.008","volume":"20","author":"HB Huttenhuis","year":"2006","unstructured":"Huttenhuis HB, Grou CP, Taverne-Thiele AJ, Taverne N, Rombout JH (2006) Carp (Cyprinus carpio L.) innate immune factors are present before hatching. Fish Shellfish Immunol 20:586\u2013596. https:\/\/doi.org\/10.1016\/j.fsi.2005.07.008","journal-title":"Fish Shellfish Immunol"},{"key":"6714_CR30","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.fsi.2018.05.060","volume":"80","author":"T Zhi","year":"2018","unstructured":"Zhi T, Xu X, Chen J, Zheng Y, Zhang S, Peng J, Brown C L, Yang T (2018) Expression of immune-related genes of Nile tilapia Oreochromis niloticus after Gyrodactylus cichlidarum and Cichlidogyrus sclerosus infections demonstrating immunosupression in co-infection. Fish shellfish immunol 80:397\u2013404. https:\/\/doi.org\/10.1016\/j.fsi.2018.05.060","journal-title":"Fish shellfish immunol"},{"key":"6714_CR31","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1080\/1547691x.2016.1242673","volume":"13","author":"K Thummabancha","year":"2016","unstructured":"Thummabancha K, Onparn N, Srisapoome P (2016) Analysis of hematologic alterations, immune responses and metallothionein gene expression in Nile tilapia (Oreochromis niloticus) exposed to silver nanoparticles. J Immunotoxicol 13:909\u2013917. https:\/\/doi.org\/10.1080\/1547691x.2016.1242673","journal-title":"J Immunotoxicol"},{"key":"6714_CR32","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2009\u2013 \u2206\u2206CT method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"6714_CR33","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1007\/s12033-019-00217-y","volume":"61","author":"V Acharya","year":"2019","unstructured":"Acharya V, Chakraborty HJ, Rout AK, Balabantaray S, Behera BK, Das BK (2019) Structural characterization of open reading frame-encoded functional genes from Tilapia Lake Virus (TiLV). Mol Biotechnol 61:945\u2013957. https:\/\/doi.org\/10.1007\/s12033-019-00217-y","journal-title":"Mol Biotechnol"},{"issue":"7","key":"6714_CR34","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s00705-025-06355-w","volume":"170","author":"A Ponsrinivasan","year":"2025","unstructured":"Ponsrinivasan A, Uma A, Chidambaram P, Antony C, Sudhagar A, Selvaraj S, Palaniappan S, Ethirajan M (2025) Environmental variability and pathogen synergy influencing tilapia lake virus outbreaks on tilapia farms in Tamil Nadu, India. Arch Virol 170(7):162. https:\/\/doi.org\/10.1007\/s00705-025-06355-w","journal-title":"Arch Virol"},{"key":"6714_CR35","doi-asserted-by":"publisher","first-page":"e13216","DOI":"10.1111\/cmi.13216","volume":"22","author":"Y Huang","year":"2020","unstructured":"Huang Y, Zhang Y, Zheng J, Wang L, Qin Q, Huang X (2020) Metabolic profiles of fish nodavirus infection in vitro: RGNNV induced and exploited cellular fatty acid synthesis for virus infection. Cell Microbiol 22:e13216. https:\/\/doi.org\/10.1111\/cmi.13216","journal-title":"Cell Microbiol"},{"key":"6714_CR36","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.fsi.2017.09.053","volume":"71","author":"CC Liu","year":"2017","unstructured":"Liu CC, Ho LP, Yang CH, Kao TY, Chou HY, Pai TW (2017) Comparison of grouper infection with two different iridoviruses using transcriptome sequencing and multiple reference species selection. Fish Shellfish Immunol 71:264\u2013274. https:\/\/doi.org\/10.1016\/j.fsi.2017.09.053","journal-title":"Fish Shellfish Immunol"},{"key":"6714_CR37","doi-asserted-by":"publisher","first-page":"900","DOI":"10.3390\/v15040900","volume":"15","author":"T Lertwanakarn","year":"2023","unstructured":"Lertwanakarn T, Khemthong M, Tattiyapong P, Surachetpong W (2023) Modulation of immune responses in Tilapinevirus tilapiae-infected fish cells through MAPK\/ERK signaling. Viruses 15:900. https:\/\/doi.org\/10.3390\/v15040900","journal-title":"Viruses"},{"key":"6714_CR38","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1186\/1471-2164-12-556","volume":"12","author":"Y Huang","year":"2011","unstructured":"Huang Y, Huang X, Yan Y, Cai J, Ouyang Z, Cui H, Wang P, Qin Q (2011) Transcriptome analysis of orange-spotted grouper (Epinephelus coioides) spleen in response to Singapore grouper iridovirus. BMC Genomics 12:556. https:\/\/doi.org\/10.1186\/1471-2164-12-556","journal-title":"BMC Genomics"},{"key":"6714_CR39","doi-asserted-by":"publisher","first-page":"44189","DOI":"10.1038\/srep44189","volume":"7","author":"S Arokiasamy","year":"2017","unstructured":"Arokiasamy S, Zakian C, Dilliway J, Wang W, Nourshargh S, Voisin MB (2017) Endogenous TNF\u03b1 orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation. Sci Rep 7:44189. https:\/\/doi.org\/10.1038\/srep44189","journal-title":"Sci Rep"},{"key":"6714_CR40","doi-asserted-by":"publisher","first-page":"20404","DOI":"10.1038\/srep20404","volume":"6","author":"W Liu","year":"2016","unstructured":"Liu W, Dai N, Wang Y, Xu C, Zhao H, Xia P, Gu J, Liu X, Bian J, Yuan Y, Zhu J (2016) Role of autophagy in cadmium-induced apoptosis of primary rat osteoblasts. Sci Rep 6:20404. https:\/\/doi.org\/10.1038\/srep20404","journal-title":"Sci Rep"},{"key":"6714_CR41","doi-asserted-by":"publisher","first-page":"36896","DOI":"10.18632\/oncotarget.9213","volume":"7","author":"LH Wang","year":"2016","unstructured":"Wang LH, Lin CY, Liu SC, Liu GT, Chen YL, Chen JJ, Chan CH, Lin TY, Chen CK, Xu GH, Chen SS (2016) CCL5 promotes VEGF-C production and induces lymphangiogenesis by suppressing miR-507 in human chondrosarcoma cells. Oncotarget 7:36896. https:\/\/doi.org\/10.18632\/oncotarget.9213","journal-title":"Oncotarget"},{"key":"6714_CR42","doi-asserted-by":"publisher","first-page":"859","DOI":"10.3390\/v14050859","volume":"14","author":"J Kim","year":"2022","unstructured":"Kim J, Cho M, Lim J, Choi H, Hong S (2022) Pathogenic mechanism of a highly virulent infectious hematopoietic necrosis virus in head kidney of rainbow trout (Oncorhynchus mykiss) analyzed by RNA-seq transcriptome profiling. Viruses 14:859. https:\/\/doi.org\/10.3390\/v14050859","journal-title":"Viruses"},{"key":"6714_CR43","doi-asserted-by":"publisher","first-page":"827752","DOI":"10.1155\/2020\/8827752","volume":"2020","author":"TK Mohanta","year":"2020","unstructured":"Mohanta TK, Sharma N, Arina P, Defilippi P (2020) Molecular insights into the MAPK cascade during viral infection: potential crosstalk between HCQ and HCQ analogues. Biomed Res Int 2020:827752. https:\/\/doi.org\/10.1155\/2020\/8827752","journal-title":"Biomed Res Int"},{"key":"6714_CR44","doi-asserted-by":"publisher","unstructured":"Saadawy AH, Khalil AM, Sidarous LR, Ibrahim MS, Salem TZ (2023) Voltage-dependent anion channels: key players in viral infection. Rev Med Virol 2453. https:\/\/doi.org\/10.1002\/rmv.2453","DOI":"10.1002\/rmv.2453"},{"key":"6714_CR45","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nature08699","volume":"463","author":"R Konig","year":"2010","unstructured":"Konig R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, Bhattacharyya S, Alamares JG, Tscherne DM, Ortigoza MB, Liang Y, Gao Q (2010) Human host factors required for influenza virus replication. Nature 463:813\u2013817. https:\/\/doi.org\/10.1038\/nature08699","journal-title":"Nature"},{"key":"6714_CR46","doi-asserted-by":"publisher","first-page":"926","DOI":"10.3390\/cancers6020926","volume":"6","author":"A Xiong","year":"2014","unstructured":"Xiong A, Yang Z, Shen Y, Zhou J, Shen Q (2014) Transcription factor STAT3 as a novel molecular target for cancer prevention. Cancers 6:926\u2013957. https:\/\/doi.org\/10.3390\/cancers6020926","journal-title":"Cancers"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-026-06714-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00705-026-06714-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-026-06714-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:48:24Z","timestamp":1788857304000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00705-026-06714-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["6714"],"URL":"https:\/\/doi.org\/10.1007\/s00705-026-06714-1","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"assertion":[{"value":"16 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors assert that there are no conflicts of interest to disclose.","order":1,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We used OpenAI\u2019s ChatGPT [GPT-5] to assist with Editorial and language support. After using this tool\/service, the author[s] reviewed and edited the content as needed and take[s] full responsibility for the content of the published article.","order":2,"name":"Ethics","label":"Declaration of generative AI use","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"253"}}