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This study aimed to identify the prevalence and characterize HPgV-1 genomes obtained from acute febrile patients (n\u2009=\u200992 from 2019) and from blood donors (n\u2009=\u2009633 from 2022) sampled in Mato Grosso, Brazil. The serum samples were tested by RT-qPCR for a conserved 5\u2019 UTR region of HPgV-1. Nucleic acid of 28 positive samples was converted to ds-cDNA, purified and sequenced with an Illumina NextSeq platform. The prevalence of HPgV-1 among acute febrile patients was 4.35% (4\/92), who were mostly female (3\/4; 75.00%) mean 28.86 (12\u201367) years-old; whereas among blood donors it was 3.79% (24\/633), which were predominantly male (16\/24; 66.67%), aged 30\u201345 years-old (13\/24; 54.17%). Eight HPgV-1 genomic sequences (7,708-9,248) were recovered; two belong to subgenotype 2a and clustered with strains from United States, Brazil, France and Japan, while the remaining six genomes from subgenotype 2b grouped with strains from Par\u00e1, Brazil and abroad. HPgV-1 detection in acute febrile patients and in healthy blood donors highlights the necessity to investigate the epidemiological aspects of this infection, as well as the possible impact to public health in Midwestern Brazil.\n                  <\/jats:p>","DOI":"10.1007\/s00705-026-06720-3","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:30:46Z","timestamp":1787909446000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human pegivirus 1 in healthy blood donors and in acute febrile patients from Mato Grosso, Midwestern Brazil"],"prefix":"10.1007","volume":"171","author":[{"given":"Eduarda","family":"Pavan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Millena Moreira","family":"Carrasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janeth Aracely Ramirez","family":"Pav\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Roberto Teixeira","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Adriano Mendes","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Dezengrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"6720_CR1","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nm0695-564","volume":"1","author":"JN Simons","year":"1995","unstructured":"Simons JN, Leary TP, DawsonGJ, Pilot-Matias TJ, Muerhoff AS, Schlauder GG, Desai SM, Mushahwar IK (1995) Isolation of novel virus-like sequences associated with human hepatitis. 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