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Epidemiological data suggests that individuals with DM are more susceptible to certain cancers. This study examined the bioactive properties of <jats:italic>Hypericum scabrum<\/jats:italic> extracts, including methanol, hexane, and others, focusing on their inhibitory effects on key enzymes associated with DM and neurodegenerative diseases, such as acetylcholinesterase, butyrylcholinesterase, <jats:italic>\u03b1<\/jats:italic>-amylase, and <jats:italic>\u03b1<\/jats:italic>-glucosidase. Additionally, the impact of these extracts on human fibroblast (HDFa) and glioblastoma (U87MG) cancer cells was evaluated. The methanol extract was analyzed for elemental composition using ICP-MS, secondary metabolites, and amino acids via LC\u2013MS\/MS and underwent morphological and anatomical characterization. The methanol extract demonstrated notable inhibitory activity, with an IC<jats:sub>50<\/jats:sub> value of\u2009&lt;\u20091\u00a0\u00b5g\/mL against <jats:italic>\u03b1<\/jats:italic>-glucosidase, surpassing acarbose in efficacy. The flower essential oil exhibited the highest inhibition (79.95%) of butyrylcholinesterase and the strongest acetylcholinesterase inhibition (21.62%). Elemental analysis revealed high concentrations of Na and K, while quinic acid and proline were identified as major metabolites, with proline concentrations reaching 494.0482\u00a0nmol\/mL in the aerial part extract. The anticancer assays revealed higher cytotoxicity in U87MG glioblastoma cells compared to HDFa fibroblasts, suggesting potential applications for cancer therapy. The plant grows 20\u201350\u00a0cm tall, with yellow flowers and ovoid-ribbed capsules containing brown, reniform seeds. Its leaves are amphistomatic and ornamented, while stems feature striate cuticles and paracytic stomata. The pollen grains are microreticulate with syncolporate apertures. These results underscore the promising therapeutic potential of <jats:italic>H. scabrum<\/jats:italic> in managing DM, cancer, and neurodegenerative diseases, with its ability to inhibit key enzymes and show selective cytotoxicity against cancer cells.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s00709-025-02037-1","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:37:47Z","timestamp":1738283867000},"page":"857-879","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Morphological, anatomical, and bioactive properties of Hypericum scabrum L.: effects on diabetes mellitus, Alzheimer\u2019s disease, and HDFa fibroblasts and U87-MG cancer cells"],"prefix":"10.1007","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-8561","authenticated-orcid":false,"given":"Sena","family":"\u00d6ner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9250-9397","authenticated-orcid":false,"given":"Abdulrahim","family":"Kad\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1226-7218","authenticated-orcid":false,"given":"Enes","family":"Tekman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2058-9798","authenticated-orcid":false,"given":"Ay\u015fe Cemre","family":"Kararenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7484-1126","authenticated-orcid":false,"given":"Elif Beyza","family":"\u00d6zer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8286-8254","authenticated-orcid":false,"given":"K\u00fcbra Nalk\u0131ran","family":"Ergin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0857-4776","authenticated-orcid":false,"given":"Hafize","family":"Yuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-2305","authenticated-orcid":false,"given":"Mehmet Enes","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1447-5985","authenticated-orcid":false,"given":"Resul","family":"Duman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5350-5534","authenticated-orcid":false,"given":"Aydan Acar","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-795X","authenticated-orcid":false,"given":"Nur M\u00fcnevver","family":"Pinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-809X","authenticated-orcid":false,"given":"Alptu\u011f","family":"Atila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6869-8703","authenticated-orcid":false,"given":"G\u00fclnur Ek\u015fi","family":"Bona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3268-721X","authenticated-orcid":false,"given":"Song\u00fcl","family":"Karakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"issue":"7","key":"2037_CR1","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1002\/fsn3.749","volume":"6","author":"BO Ajiboye","year":"2018","unstructured":"Ajiboye BO, Ojo OA, Okesola MA, Akinyemi AJ, Talabi JY, Idowu OT, Anraku de Campos MM (2018) In vitro antioxidant activities and inhibitory effects of phenolic extract of Senecio biafrae (Oliv and Hiern) against key enzymes linked with type II diabetes mellitus and Alzheimer\u2019s disease. 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