{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:47:06Z","timestamp":1792784826457,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia","award":["[Grant No: KFU265343"],"award-info":[{"award-number":["[Grant No: KFU265343"]}],"id":[{"id":"https:\/\/ror.org\/00dn43547","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Protoplasma"],"DOI":"10.1007\/s00709-026-02274-y","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:48:47Z","timestamp":1792723727000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histological and ultrastructural examination of immune cells in the gill epithelium of the silver carp (Hypophtalmichthys molitrix)"],"prefix":"10.1007","author":[{"given":"Hanan H.","family":"Abd-Elhafeez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa Sayed","family":"Abou-Elhamd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma Mohamed","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherief M.","family":"Abdel-Raheem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed I.","family":"El Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alhosein","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faleh A.","family":"Ameen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha A.","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"2274_CR1","doi-asserted-by":"publisher","first-page":"20241884","DOI":"10.1098\/rspb.2024.1884","volume":"291","author":"ML Aaskov","year":"2024","unstructured":"Aaskov ML, Ishimatsu A, Nyengaard JR, Malte H, Lauridsen H, Ha NTK, Huong DTT, Bayley M (2024) Modulation of gill surface area does not correlate with oxygen loss in Chitala ornata. Proc R Soc B Biol Sci 291:20241884. https:\/\/doi.org\/10.1098\/rspb.2024.1884","journal-title":"Proc R Soc B Biol Sci"},{"key":"2274_CR2","first-page":"435","volume":"7","author":"H Abd-Elhafeez","year":"2016","unstructured":"Abd-Elhafeez H, Soliman S (2016) Origin of rodlet cells and mapping their distribution in ruby-red-fin shark (rainbow shark) Epalzeorhynchos frenatum (Teleostei: Cyprinidae): light, immunohistochemistry and ultrastructure study. J Cytol Histol 7:435","journal-title":"J Cytol Histol"},{"key":"2274_CR3","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1002\/jemt.24374","volume":"86","author":"HH Abd-Elhafeez","year":"2023","unstructured":"Abd-Elhafeez HH, Rutland CS, Soliman SA (2023) Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus). Microsc Res Tech 86:1108\u20131121. https:\/\/doi.org\/10.1002\/jemt.24374","journal-title":"Microsc Res Tech"},{"key":"2274_CR4","doi-asserted-by":"publisher","first-page":"104036","DOI":"10.1016\/j.micron.2026.104036","volume":"205","author":"R Abdel-Hameed","year":"2026","unstructured":"Abdel-Hameed R, Abdel-Hafeez HH, Bakry M, Abdel-Raheem SM, El Sheikh AI, Ismail H, Ameen F, Soliman SA (2026) Histological, histochemical, and immunohistochemical characterization of the gill skeleton in the silver carp (Hypophthalmichthys molitrix). Micron 205:104036. https:\/\/doi.org\/10.1016\/j.micron.2026.104036","journal-title":"Micron"},{"key":"2274_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40850-025-00223-5","volume":"10","author":"MA Alsafy","year":"2025","unstructured":"Alsafy MA, Abd-Elhafeez HH, Rashwan AM, Erasha A, Ali S, El-Gendy SA (2025) Anatomy, histology, and morphology of fish gills in relation to feeding habits: a comparative review of marine and freshwater species. BMC Zool 10:3. https:\/\/doi.org\/10.1186\/s40850-025-00223-5","journal-title":"BMC Zool"},{"key":"2274_CR6","doi-asserted-by":"publisher","first-page":"945","DOI":"10.2478\/aoas-2024-0109","volume":"25","author":"S Bagheri","year":"2025","unstructured":"Bagheri S, Gholamhosseini A, Yaghoobpour T, Adel M (2025) Uses of eugenol in aquaculture: benefits and applications-a review. Ann Anim Sci 25:945\u2013953. https:\/\/doi.org\/10.2478\/aoas-2024-0109","journal-title":"Ann Anim Sci"},{"key":"2274_CR7","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1095-8649.1979.tb03519.x","volume":"14","author":"DL Barber","year":"1979","unstructured":"Barber DL, Westermann JEM, Jensen DN (1979) New observations on the rodlet cell (Rhabdospora thelohani) in the white sucker Catostomus commersoni (Lac\u00e9p\u00e8de): LM and EM studies. J Fish Biol 14:277\u2013284. https:\/\/doi.org\/10.1111\/j.1095-8649.1979.tb03519.x","journal-title":"J Fish Biol"},{"key":"2274_CR8","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/jfd.12751","volume":"41","author":"G Bosi","year":"2018","unstructured":"Bosi G, DePasquale J, Manera M, Castaldelli G, Giari L, Sayyaf Dezfuli B (2018) Histochemical and immunohistochemical characterization of rodlet cells in the intestine of two teleosts, Anguilla anguilla and Cyprinus carpio. J Fish Dis 41:475\u2013485. https:\/\/doi.org\/10.1111\/jfd.12751","journal-title":"J Fish Dis"},{"key":"2274_CR9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/JLB.3MR0120-390R","volume":"108","author":"ME Coden","year":"2020","unstructured":"Coden ME, Berdnikovs S (2020) Eosinophils in wound healing and epithelial remodeling: is coagulation a missing link? J Leukoc Biol 108:93\u2013103. https:\/\/doi.org\/10.1002\/JLB.3MR0120-390R","journal-title":"J Leukoc Biol"},{"key":"2274_CR10","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/jfb.14409","volume":"97","author":"KE Cohen","year":"2020","unstructured":"Cohen KE, George AE, Chapman DC, Chick JH, Hernandez LP (2020) Developmental ecomorphology of the epibranchial organ of the silver carp, Hypophthalmichthys molitrix. J Fish Biol 97:527\u2013536. https:\/\/doi.org\/10.1111\/jfb.14409","journal-title":"J Fish Biol"},{"key":"2274_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/978-3-030-85420-1_2","volume-title":"Principles of fish immunology: from cells and molecules to host protection","author":"RA Dalmo","year":"2022","unstructured":"Dalmo RA, B\u00f8gwald J (2022) Innate immunity. In: Buchmann K, Secombes CJ (eds) Principles of fish immunology: from cells and molecules to host protection. Springer, Cham, pp 31\u2013103. https:\/\/doi.org\/10.1007\/978-3-030-85420-1_2"},{"key":"2274_CR12","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3354\/dao043061","volume":"43","author":"BS Dezfuli","year":"2000","unstructured":"Dezfuli BS, Simoni E, Rossi R, Manera M (2000) Rodlet cells and other inflammatory cells of Phoxinus phoxinus infected with Raphidascaris acus (Nematoda). Dis Aquat Organ 43:61\u201369. https:\/\/doi.org\/10.3354\/dao043061","journal-title":"Dis Aquat Organ"},{"key":"2274_CR13","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.fsi.2021.09.045","volume":"121","author":"BS Dezfuli","year":"2022","unstructured":"Dezfuli BS, Pironi F, Maynard B, Simoni E, Bosi G (2022) Rodlet cells, fish immune cells and a sentinel of parasitic harm in teleost organs. Fish Shellfish Immunol 121:516\u2013534. https:\/\/doi.org\/10.1016\/j.fsi.2021.09.045","journal-title":"Fish Shellfish Immunol"},{"key":"2274_CR14","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1111\/j.1095-8649.1986.tb05187.x","volume":"28","author":"CF Ellsaesser","year":"1986","unstructured":"Ellsaesser CF, Clem LW (1986) Haematological and immunological changes in channel catfish stressed by handling and transport. J Fish Biol 28:511\u2013521. https:\/\/doi.org\/10.1111\/j.1095-8649.1986.tb05187.x","journal-title":"J Fish Biol"},{"key":"2274_CR15","volume-title":"The state of world fisheries and aquaculture 2022: towards blue transformation","author":"FAO","year":"2022","unstructured":"FAO (2022) The state of world fisheries and aquaculture 2022: towards blue transformation. Food and Agriculture Organization of the United Nations, Rome"},{"key":"2274_CR16","first-page":"29","volume":"1","author":"M Ghasemi","year":"2017","unstructured":"Ghasemi M, Haghighikarsidani S, Omidvar S, Ramezani Agheleh B, Faeed M (2017) The most important infectious diseases of silver carp, Hypophthalmichthys molitrix, and their control and prevention. Adv Aquac Sci J 1:29\u201342","journal-title":"Adv Aquac Sci J"},{"key":"2274_CR17","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/j.1095-8649.2006.01130.x","volume":"69","author":"L Giari","year":"2006","unstructured":"Giari L, Manera M, Simoni E, Dezfuli BS (2006) Changes to chloride and rodlet cells in gills, kidney and intestine of Dicentrarchus labrax (L.) exposed to reduced salinities. J Fish Biol 69:590\u2013600. https:\/\/doi.org\/10.1111\/j.1095-8649.2006.01130.x","journal-title":"J Fish Biol"},{"key":"2274_CR18","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1016\/j.fsi.2013.09.032","volume":"35","author":"D G\u00f3mez Atria","year":"2013","unstructured":"G\u00f3mez Atria D, Sunyer JO, Salinas I (2013) The mucosal immune system of fish: the evolution of tolerating commensals while fighting pathogens. Fish Shellfish Immunol 35:1729\u20131739. https:\/\/doi.org\/10.1016\/j.fsi.2013.09.032","journal-title":"Fish Shellfish Immunol"},{"key":"2274_CR19","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1577\/1548-8667(2002)014<0161:FROSVO>2.0.CO;2","volume":"14","author":"A Goodwin","year":"2002","unstructured":"Goodwin A (2002) First report of spring viremia of carp virus (SVCV) in North America. J Aquat Anim Health 14:161\u2013164","journal-title":"J Aquat Anim Health"},{"key":"2274_CR20","doi-asserted-by":"publisher","first-page":"3735","DOI":"10.1242\/dev.126.17.3735","volume":"126","author":"P Herbomel","year":"1999","unstructured":"Herbomel P, Thisse B, Thisse C (1999) Ontogeny and behaviour of early macrophages in the zebrafish embryo. Development 126:3735\u20133745","journal-title":"Development"},{"key":"2274_CR21","doi-asserted-by":"publisher","first-page":"110889","DOI":"10.1016\/j.fsi.2025.110889","volume":"167","author":"CC Lazado","year":"2025","unstructured":"Lazado CC, Ara-D\u00edaz JB, Stiller KT (2025) Mucosal defences of salmonids in complex RAS environments. Fish Shellfish Immunol 167:110889. https:\/\/doi.org\/10.1016\/j.fsi.2025.110889","journal-title":"Fish Shellfish Immunol"},{"key":"2274_CR22","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF00222812","volume":"155","author":"RL Leino","year":"1974","unstructured":"Leino RL (1974) Ultrastructure of immature, developing, and secretory rodlet cells in fish. Cell Tissue Res 155:367\u2013381. https:\/\/doi.org\/10.1007\/BF00222812","journal-title":"Cell Tissue Res"},{"key":"2274_CR23","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s00244-013-9910-8","volume":"65","author":"H Li","year":"2013","unstructured":"Li H, Cai Y, Xie P, Li G, Hao L, Xiong Q (2013) Identification and expression profiles of IL-8 in bighead carp (Aristichthys nobilis) in response to microcystin-LR. Arch Environ Contam Toxicol 65:537\u2013545. https:\/\/doi.org\/10.1007\/s00244-013-9910-8","journal-title":"Arch Environ Contam Toxicol"},{"key":"2274_CR24","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/j.1550-7408.1979.tb02757.x","volume":"26","author":"LF Mayberry","year":"1979","unstructured":"Mayberry LF, Marchiondo AA, Ubelaker JE, Kazi\u0107 D (1979) Rhabdospora thelohani Laguess\u00e9, 1895 (Apicomplexa): new host and geographic records with taxonomic considerations. J Protozool 26:168\u2013178. https:\/\/doi.org\/10.1111\/j.1550-7408.1979.tb02757.x","journal-title":"J Protozool"},{"key":"2274_CR25","doi-asserted-by":"publisher","first-page":"R224","DOI":"10.1152\/ajpregu.00189.2009","volume":"297","author":"D Mitrovic","year":"2009","unstructured":"Mitrovic D, Dymowska A, Nilsson GE, Perry SF (2009) Physiological consequences of gill remodeling in goldfish (Carassius auratus) during exposure to long-term hypoxia. Am J Physiol Regul Integr Comp Physiol 297:R224\u2013R234. https:\/\/doi.org\/10.1152\/ajpregu.00189.2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2274_CR26","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/j.1095-8649.2007.01452.x","volume":"70","author":"H Murray","year":"2007","unstructured":"Murray H, Leggiadro C, Douglas S (2007) Immunocytochemical localization of pleurocidin to the cytoplasmic granules of eosinophilic granular cells from the winter flounder gill. J Fish Biol 70:336\u2013345","journal-title":"J Fish Biol"},{"key":"2274_CR27","unstructured":"Nico L, Fuller P, Li J (2023) Hypophthalmichthys molitrix (Valenciennes in Cuvier and Valenciennes, 1844). USGS Nonindigenous Aquatic Species Database, Gainesville. Accessed 19 Sept 2026https:\/\/nas.er.usgs.gov\/queries\/factsheet.aspx?SpeciesID=549"},{"key":"2274_CR28","doi-asserted-by":"publisher","first-page":"494","DOI":"10.4049\/jimmunol.1801139","volume":"202","author":"NV Ogryzko","year":"2019","unstructured":"Ogryzko NV, Lewis A, Wilson HL, Meijer AH, Renshaw SA, Elks PM (2019) Hif-1\u03b1-induced expression of Il-1\u03b2 protects against mycobacterial infection in zebrafish. J Immunol 202:494\u2013502. https:\/\/doi.org\/10.4049\/jimmunol.1801139","journal-title":"J Immunol"},{"key":"2274_CR29","doi-asserted-by":"publisher","first-page":"1900470","DOI":"10.1183\/13993003.00470-2019","volume":"54","author":"C Persson","year":"2019","unstructured":"Persson C (2019) In vivo observations provide insight into roles of eosinophils and epithelial cells in asthma. Eur Respir J 54:1900470. https:\/\/doi.org\/10.1183\/13993003.00470-2019","journal-title":"Eur Respir J"},{"key":"2274_CR30","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1006\/fsim.1998.0162","volume":"8","author":"OB Reite","year":"1998","unstructured":"Reite OB (1998) Mast cells\/eosinophilic granule cells of teleostean fish: a review focusing on staining properties and functional responses. Fish Shellfish Immunol 8:489\u2013513","journal-title":"Fish Shellfish Immunol"},{"key":"2274_CR31","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1083\/jcb.17.1.208","volume":"17","author":"ES Reynolds","year":"1963","unstructured":"Reynolds ES (1963) The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol 17:208\u2013212","journal-title":"J Cell Biol"},{"key":"2274_CR32","unstructured":"Ribeiro RCP (2023) Efeito da metionina e do triptofano nas respostas de estresse, sistema imune inato e antioxidante em juvenis de pacu (Piaractus mesopotamicus) Holmberg, 1887. Dissertation, Universidade Estadual Paulista (UNESP), Centro de Aquicultura, Jaboticabal"},{"key":"2274_CR33","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.fsi.2014.08.020","volume":"40","author":"JH Rombout","year":"2014","unstructured":"Rombout JH, Yang G, Kiron V (2014) Adaptive immune responses at mucosal surfaces of teleost fish. Fish Shellfish Immunol 40:634\u2013643","journal-title":"Fish Shellfish Immunol"},{"key":"2274_CR34","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3390\/biology4030525","volume":"4","author":"I Salinas","year":"2015","unstructured":"Salinas I (2015) The mucosal immune system of teleost fish. Biology 4:525\u2013539","journal-title":"Biology"},{"key":"2274_CR35","doi-asserted-by":"publisher","first-page":"104079","DOI":"10.1016\/j.dci.2021.104079","volume":"121","author":"I Salinas","year":"2021","unstructured":"Salinas I, Fern\u00e1ndez-Montero \u00c1, Ding Y, Sunyer JO (2021) Mucosal immunoglobulins of teleost fish: a decade of advances. Dev Comp Immunol 121:104079. https:\/\/doi.org\/10.1016\/j.dci.2021.104079","journal-title":"Dev Comp Immunol"},{"key":"2274_CR36","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1186\/s12864-025-11719-2","volume":"26","author":"L Shi","year":"2025","unstructured":"Shi L, Ng JK-W, Xiong Q, Ao KF-K, Shin S-K, Law CT-Y, Mu W, Liu G-M, Rao S, Tsui SK-W (2025) Comparative genomic analysis of immune-related genes and chemosensory receptors provides insights into the evolution and adaptation of four major domesticated Asian carps. BMC Genomics 26:529","journal-title":"BMC Genomics"},{"key":"2274_CR37","doi-asserted-by":"publisher","first-page":"12034","DOI":"10.1038\/s41598-024-62103-1","volume":"14","author":"SA Soliman","year":"2024","unstructured":"Soliman SA (2024) Immunohistochemical properties of embryonic telocytes in a myogenic microenvironment. Sci Rep 14:12034. https:\/\/doi.org\/10.1038\/s41598-024-62103-1","journal-title":"Sci Rep"},{"key":"2274_CR38","doi-asserted-by":"publisher","first-page":"5593","DOI":"10.3390\/su17125593","volume":"17","author":"Y Song","year":"2025","unstructured":"Song Y, Zhang W (2025) Balancing growth and sustainability in China\u2019s carp aquaculture: practices, policies, and sustainability pathways. Sustainability 17:5593","journal-title":"Sustainability"},{"key":"2274_CR39","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.it.2013.02.008","volume":"34","author":"CJ Thomas","year":"2013","unstructured":"Thomas CJ, Schroder K (2013) Pattern recognition receptor function in neutrophils. Trends Immunol 34:317\u2013328. https:\/\/doi.org\/10.1016\/j.it.2013.02.008","journal-title":"Trends Immunol"},{"key":"2274_CR40","doi-asserted-by":"publisher","first-page":"110878","DOI":"10.1016\/j.fsi.2025.110878","volume":"167","author":"EA Valdebenito","year":"2025","unstructured":"Valdebenito EA, Az\u00faa M, Silva-Sarmiento D, Ojeda N, Mercado L, Valenzuela CA (2025) Immune-like response and autophagy modulation in gill epithelial cells of rainbow trout challenged with Piscirickettsia salmonis. Fish Shellfish Immunol 167:110878. https:\/\/doi.org\/10.1016\/j.fsi.2025.110878","journal-title":"Fish Shellfish Immunol"},{"key":"2274_CR41","doi-asserted-by":"publisher","first-page":"e12295","DOI":"10.1111\/jfs.12295","volume":"37","author":"F Valipour Kootenaie","year":"2017","unstructured":"Valipour Kootenaie F, Ariaii P, Khademi Shurmasti D, Nemati M (2017) Effect of chitosan edible coating enriched with eucalyptus essential oil and \u03b1-tocopherol on silver carp fillets quality during refrigerated storage. J Food Saf 37:e12295","journal-title":"J Food Saf"},{"key":"2274_CR42","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/2211-5463.13388","volume":"12","author":"C Watts","year":"2022","unstructured":"Watts C (2022) Lysosomes and lysosome-related organelles in immune responses. FEBS Open Bio 12:678\u2013693","journal-title":"FEBS Open Bio"},{"key":"2274_CR43","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/978-3-030-85420-1_6","volume-title":"Principles of fish immunology: from cells and molecules to host protection","author":"GF Wiegertjes","year":"2022","unstructured":"Wiegertjes GF, Elks PM (2022) Fish macrophages. In: Buchmann K, Secombes CJ (eds) Principles of fish immunology: from cells and molecules to host protection. Springer, Cham, pp 203\u2013227. https:\/\/doi.org\/10.1007\/978-3-030-85420-1_6"},{"key":"2274_CR44","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1577\/T04-106.1","volume":"134","author":"CJ Williamson","year":"2005","unstructured":"Williamson CJ, Garvey JE (2005) Growth, fecundity, and diets of newly established silver carp in the middle Mississippi River. Trans Am Fish Soc 134:1423\u20131430","journal-title":"Trans Am Fish Soc"},{"key":"2274_CR45","doi-asserted-by":"publisher","first-page":"10728","DOI":"10.1038\/ncomms10728","volume":"7","author":"Z Xu","year":"2016","unstructured":"Xu Z, Takizawa F, Parra D, G\u00f3mez D, von Gersdorff J\u00f8rgensen L, LaPatra SE, Sunyer JO (2016) Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods. Nat Commun 7:10728","journal-title":"Nat Commun"},{"key":"2274_CR46","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/oxfordjournals.bmb.a011627","volume":"53","author":"LS Young","year":"1997","unstructured":"Young LS, Dawson CW, Eliopoulos AG (1997) Viruses and apoptosis. Br Med Bull 53:509\u2013521","journal-title":"Br Med Bull"},{"key":"2274_CR47","doi-asserted-by":"publisher","first-page":"567941","DOI":"10.3389\/fimmu.2020.567941","volume":"11","author":"Y Yu","year":"2020","unstructured":"Yu Y, Wang Q, Huang Z, Ding L, Xu Z (2020) Immunoglobulins, mucosal immunity and vaccination in teleost fish. Front Immunol 11:567941","journal-title":"Front Immunol"},{"key":"2274_CR48","first-page":"876543","volume":"13","author":"Y Yu","year":"2022","unstructured":"Yu Y, Huang W, Liu Y, Hu W, Wang Q, Liu Z (2022) The mucosal immune system of fish: a comprehensive review. Front Immunol 13:876543","journal-title":"Front Immunol"}],"container-title":["Protoplasma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00709-026-02274-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00709-026-02274-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00709-026-02274-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:02:04Z","timestamp":1792782124000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00709-026-02274-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":48,"alternative-id":["2274"],"URL":"https:\/\/doi.org\/10.1007\/s00709-026-02274-y","relation":{},"ISSN":["0033-183X","1615-6102"],"issn-type":[{"value":"0033-183X","type":"print"},{"value":"1615-6102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"assertion":[{"value":"28 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}