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However, in contrast to striated muscle, the arrangement of its contractile filaments, composed of myosin and actin, is not readily apparent by light microscopy and, even electron microscopy fails to reveal an obviously ordered structural organisation. The aim of this review is to bring together classic ultrastructural data with more recent immunofluorescent analyses to develop a model how the protoplasma of a smooth muscle cell might be organised.<\/jats:p>","DOI":"10.1007\/s00709-026-02278-8","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:51:46Z","timestamp":1791982306000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Smooth muscle ultrastructure \u2013 still shrouded in mystery?"],"prefix":"10.1007","author":[{"given":"Elisabeth","family":"Ehler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"2278_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.tcb.2005.07.001","volume":"15","author":"I Agarkova","year":"2005","unstructured":"Agarkova I, Perriard JC (2005) The M-band: an elastic web that crosslinks thick filaments in the center of the sarcomere. 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