{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T02:17:03Z","timestamp":1679365023377},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,7,6]],"date-time":"2008-07-06T00:00:00Z","timestamp":1215302400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1007\/s00726-008-0141-7","type":"journal-article","created":{"date-parts":[[2008,7,5]],"date-time":"2008-07-05T05:39:37Z","timestamp":1215236377000},"page":"257-262","source":"Crossref","is-referenced-by-count":4,"title":["Skp2 inversely correlates with p27 and tuberin in transformed cells"],"prefix":"10.1007","volume":"37","author":[{"given":"M.","family":"Rosner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hanneder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Valli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hengstschl\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,7,6]]},"reference":[{"key":"141_CR1","doi-asserted-by":"crossref","first-page":"7475","DOI":"10.1038\/sj.onc.1209090","volume":"24","author":"A Astrinidis","year":"2005","unstructured":"Astrinidis A, Henske EP (2005) Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene 24:7475\u20137481","journal-title":"Oncogene"},{"key":"141_CR2","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1101\/gad.1185504","volume":"18","author":"A Besson","year":"2004","unstructured":"Besson A, Gurian-West M, Schmidt A, Hall A, Roberts JM (2004) p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 18:862\u2013876","journal-title":"Genes Dev"},{"key":"141_CR3","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1101\/gad.1556607","volume":"21","author":"A Besson","year":"2007","unstructured":"Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, Clurman BE, Dyer MA, Roberts JM (2007) Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev 21:1731\u20131746","journal-title":"Genes Dev"},{"key":"141_CR4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1535-6108(03)00026-6","volume":"3","author":"SW Blain","year":"2003","unstructured":"Blain SW, Scher HI, Cordon-Cardo C, Koff A (2003) p27 as a target for cancer therapeutics. Cancer Cell 3:111\u2013115","journal-title":"Cancer Cell"},{"key":"141_CR5","unstructured":"Burgstaller S, Rosner M, Lindengr\u00fcn C, Hanneder M, Siegel N, Valli A, Fuchs C, Hengstschl\u00e4ger M (2008) Tuberin, p27 and mTOR in different cells. Amino Acids doi 10.1007\/s00726-008-0066-1"},{"key":"141_CR6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/12013","volume":"1","author":"AC Carrano","year":"1999","unstructured":"Carrano AC, Etan E, Hershko A, Pagano M (1999) Skp2 is required fir ubiquitin-mediated degradation of the cdk inhibitor p27. Nat Cell Biol 1:193\u2013199","journal-title":"Nat Cell Biol"},{"key":"141_CR7","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.1038\/sj.onc.1209885","volume":"25","author":"MN Corradetti","year":"2006","unstructured":"Corradetti MN, Guan K-L (2006) Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene 25:6347\u20136360","journal-title":"Oncogene"},{"key":"141_CR8","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1056\/NEJMra055323","volume":"355","author":"PB Crino","year":"2006","unstructured":"Crino PB, Nathanson KL, Henske EP (2006) The tuberous sclerosis complex. New Engl J Med 355:1345\u20131356","journal-title":"New Engl J Med"},{"key":"141_CR9","doi-asserted-by":"crossref","first-page":"9238","DOI":"10.1158\/0008-5472.CAN-07-1375","volume":"67","author":"C Denicourt","year":"2007","unstructured":"Denicourt C, Saenz CC, Datnow B, Cui XS, Dowdy SF (2007) Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma. Cancer Res 67:9238\u20139243","journal-title":"Cancer Res"},{"key":"141_CR10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00726-006-0359-1","volume":"30","author":"A Freilinger","year":"2006","unstructured":"Freilinger A, Rosner M, Hengstschl\u00e4ger m (2006a) Tuberin negatively affects BCL-2\u2032s cell survival function. Amino Acids 30:391\u2013396","journal-title":"Amino Acids"},{"key":"141_CR11","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.1038\/sj.onc.1209660","volume":"25","author":"A Freilinger","year":"2006","unstructured":"Freilinger A, Rosner M, Krupitza G, Nishino M, Lubec G, Korsmeyer SJ, Hengstschl\u00e4ger M (2006b) Tuberin activates the proapoptotic molecule BAD. Oncogene 25:6467\u20136479","journal-title":"Oncogene"},{"issue":"14","key":"141_CR12","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1038\/sj.onc.1210844","volume":"27","author":"A Freilinger","year":"2008","unstructured":"Freilinger A, Rosner M, Hanneder M, Hengstschl\u00e4ger M (2008) Ras mediates cell survival by regulating tuberin. Oncogene 27(14):2072\u20132083. doi: 10.1038\/sj.onc.1210844","journal-title":"Oncogene"},{"key":"141_CR13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2007.05.008","volume":"12","author":"DA Guertin","year":"2007","unstructured":"Guertin DA, Sabatini DM (2007) Defining the role of mTOR in cancer. Cancer Cell 12:9\u201322","journal-title":"Cancer Cell"},{"key":"141_CR14","doi-asserted-by":"crossref","first-page":"20535","DOI":"10.1074\/jbc.273.32.20535","volume":"273","author":"KW Henry","year":"1998","unstructured":"Henry KW, Yuan X, Koszewski NJ, Onda H, Kwiatkowski DJ, Noonan DJ (1998) Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members. J Biol Chem 273:20535\u201320539","journal-title":"J Biol Chem"},{"key":"141_CR15","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0092-8674(03)00929-2","volume":"115","author":"K Inoki","year":"2003","unstructured":"Inoki K, Zhu T, Guan K-L (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115:577\u2013590","journal-title":"Cell"},{"key":"141_CR16","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/ncb1194","volume":"6","author":"T Kamura","year":"2004","unstructured":"Kamura T, Hara T, Matsumoto M, Ishida N, Okumura F, Hatakeyama S, Yoshida M, Nakayama K, Nakayama KI (2004) Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase. Nat Cell Biol 6:1229\u20131235","journal-title":"Nat Cell Biol"},{"key":"141_CR17","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1093\/hmg\/9.12.1721","volume":"9","author":"A Miloloza","year":"2000","unstructured":"Miloloza A, Rosner M, Nellist M, Halley D, Bernaschek G, Hengstschl\u00e4ger M (2000) The TSC1 gene product, hamartin, negatively regulates cell proliferation. Hum Mol Genet 9:1721\u20131727","journal-title":"Hum Mol Genet"},{"key":"141_CR18","first-page":"249","volume":"5","author":"RS Nho","year":"2003","unstructured":"Nho RS, Sheaff RJ (2003) p27kip1 contributes to cancer. Progr Cell Cycle Res 5:249\u2013259","journal-title":"Progr Cell Cycle Res"},{"key":"141_CR19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.tcb.2003.12.006","volume":"14","author":"D Pan","year":"2004","unstructured":"Pan D, Dong J, Zhang Y, Gao X (2004) Tuberous sclerosis complex: from Drosophila to human disease. Trends Cell Biol 14:78\u201385","journal-title":"Trends Cell Biol"},{"key":"141_CR20","doi-asserted-by":"crossref","first-page":"48707","DOI":"10.1074\/jbc.M405528200","volume":"279","author":"M Rosner","year":"2004","unstructured":"Rosner M, Hengstschl\u00e4ger M (2004) Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2. J Biol Chem 279:48707\u201348715","journal-title":"J Biol Chem"},{"key":"141_CR21","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00726-007-0541-0","volume":"33","author":"M Rosner","year":"2007","unstructured":"Rosner M, Hengstschl\u00e4ger M (2007) Cytoplasmic\/nuclear localization of tuberin in different cell lines. Amino Acids 33:575\u2013579","journal-title":"Amino Acids"},{"key":"141_CR22","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1038\/sj.onc.1206776","volume":"22","author":"M Rosner","year":"2003","unstructured":"Rosner M, Hofer K, Kubista M, Hengstschl\u00e4ger M (2003) Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38. Oncogene 22:4786\u20134798","journal-title":"Oncogene"},{"key":"141_CR23","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/hmg\/ddm103","volume":"16","author":"M Rosner","year":"2007","unstructured":"Rosner M, Freilinger A, Hanneder M, Fujita N, Lubec G, Tsuruo T, Hengstschl\u00e4ger M (2007a) p27 localization depends on the tumor suppressor protein tuberin. Hum Mol Genet 16:1541\u20131556","journal-title":"Hum Mol Genet"},{"key":"141_CR24","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/sj.onc.1209812","volume":"26","author":"M Rosner","year":"2007","unstructured":"Rosner M, Freilinger A, Hengstschl\u00e4ger M (2007b) Akt regulates nuclear\/cytoplasmic localization of tuberin. Oncogene 26:521\u2013531","journal-title":"Oncogene"},{"issue":"3","key":"141_CR25","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.mrrev.2008.01.001","volume":"658","author":"M Rosner","year":"2008","unstructured":"Rosner M, Hanneder M, Siegel N, Valli A, Hengstschl\u00e4ger M (2008) The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners. Mutat Res Rev Mutat Res 658(3):234\u2013246. doi: 10.1016\/j.mmrev.2008.01.001","journal-title":"Mutat Res Rev Mutat Res"},{"key":"141_CR26","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.cub.2004.08.026","volume":"14","author":"OJ Shah","year":"2004","unstructured":"Shah OJ, Wang Z, Hunter T (2004) Inappropriate activation of the TSC\/Rheb\/mTOR\/S6K cassette induces IRS1\/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 14:1650\u20131656","journal-title":"Curr Biol"},{"key":"141_CR27","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1101\/gad.1583207","volume":"21","author":"P Sicinski","year":"2007","unstructured":"Sicinski P, Zacharek S, Kim C (2007) Duality of p27Kip1 function in tumorigenesis. Genes Dev 21:1703\u20131706","journal-title":"Genes Dev"},{"key":"141_CR28","doi-asserted-by":"crossref","first-page":"29301","DOI":"10.1074\/jbc.272.46.29301","volume":"272","author":"T Soucek","year":"1997","unstructured":"Soucek T, Pusch O, Wienecke R, DeClue JE, Hengstschl\u00e4ger M (1997) Role of the tuberous sclerosis gene-2 product in cell cycle control. J Biol Chem 272:29301\u201329308","journal-title":"J Biol Chem"},{"key":"141_CR29","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1038\/sj.onc.1201743","volume":"16","author":"T Soucek","year":"1998","unstructured":"Soucek T, H\u00f6lzl G, Bernaschek G, Hengstschl\u00e4ger M (1998a) A role of the tuberous sclerosis gene-2 product during neuronal differentiation. Oncogene 16:2197\u20132204","journal-title":"Oncogene"},{"key":"141_CR30","doi-asserted-by":"crossref","first-page":"15653","DOI":"10.1073\/pnas.95.26.15653","volume":"95","author":"T Soucek","year":"1998","unstructured":"Soucek T, Yeung RS, Hengstschl\u00e4ger M (1998b) Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. Proc Natl Acad Sci USA 95:15653\u201315658","journal-title":"Proc Natl Acad Sci USA"},{"key":"141_CR31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/12027","volume":"1","author":"H Sutterl\u00fcty","year":"1999","unstructured":"Sutterl\u00fcty H, Chatelain E, Marti A, Wirbelbauer C, Senften M, M\u00fcller U, Krek W (1999) p45Skp2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nat Cell Biol 1:207\u2013214","journal-title":"Nat Cell Biol"},{"key":"141_CR32","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/0092-8674(93)90618-Z","volume":"75","author":"The European Chromosome 16 Tuberous Sclerosis Consortium","year":"1993","unstructured":"The European Chromosome 16 Tuberous Sclerosis Consortium (1993) Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75:1305\u20131315","journal-title":"Cell"},{"key":"141_CR33","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.277.5327.805","volume":"277","author":"The TSC1 Consortium","year":"1997","unstructured":"The TSC1 Consortium (1997) Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277:805\u2013808","journal-title":"Science"},{"key":"141_CR34","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","volume":"124","author":"S Wullschleger","year":"2006","unstructured":"Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471\u2013484","journal-title":"Cell"},{"key":"141_CR35","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1074\/jbc.272.10.6097","volume":"272","author":"G-H Xiao","year":"1997","unstructured":"Xiao G-H, Shoarinejad F, Jin F, Golemis EA, Yeung RS (1997) The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis. J Biol Chem 272:6097\u20136100","journal-title":"J Biol Chem"},{"key":"141_CR36","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrm1331","volume":"5","author":"L Xu","year":"2004","unstructured":"Xu L, Massague J (2004) Nucleocytoplasmic shuttling of signal tranducers. Nat Rev Mol Cell Biol 5:209\u2013219","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-008-0141-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-008-0141-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-008-0141-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T01:40:36Z","timestamp":1559094036000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-008-0141-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,6]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["141"],"URL":"https:\/\/doi.org\/10.1007\/s00726-008-0141-7","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,6]]}}}