{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:00:13Z","timestamp":1790748013398,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T00:00:00Z","timestamp":1267660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1007\/s00726-010-0523-5","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T11:31:19Z","timestamp":1267615879000},"page":"785-794","source":"Crossref","is-referenced-by-count":30,"title":["Protective effect of isoflavones against homocysteine-mediated neuronal degeneration in SH-SY5Y cells"],"prefix":"10.1007","volume":"39","author":[{"given":"Youn-Jin","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hye","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,4]]},"reference":[{"key":"523_CR1","doi-asserted-by":"crossref","first-page":"6923","DOI":"10.1073\/pnas.121119298","volume":"98","author":"ADC Alonso","year":"2001","unstructured":"Alonso ADC, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K (2001) Hyperphosphorylation induces self-assembly of \u03c4 into tangles of paired helical filaments\/straight filaments. Proc Natl Acad Sci USA 98:6923\u20136928","journal-title":"Proc Natl Acad Sci USA"},{"key":"523_CR2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0169-328X(00)00208-4","volume":"84","author":"S Althausen","year":"2000","unstructured":"Althausen S, Paschen W (2000) Homocysteine-induced changes in mRNA levels of genes coding for cytoplasmic- and endoplasmic reticulum-resident stress proteins in neuronal cell cultures. Brain Res Mol Brain Res 84:32\u201340","journal-title":"Brain Res Mol Brain Res"},{"key":"523_CR3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1079\/BJN19980068","volume":"79","author":"S Bingham","year":"1998","unstructured":"Bingham S, Atkinson C, Liggins J, Bluck L, Coward A (1998) Phyto-oestrogens: where are we now? Br J Nutr 79:393\u2013406","journal-title":"Br J Nutr"},{"key":"523_CR4","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1073\/pnas.94.7.3290","volume":"94","author":"BC Blount","year":"1997","unstructured":"Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB, Ames BN (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 94:3290\u20133295","journal-title":"Proc Natl Acad Sci USA"},{"key":"523_CR5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/bmc.1130040606","volume":"4","author":"T Bottiglieri","year":"1990","unstructured":"Bottiglieri T (1990) Isocratic high-performance liquid chromatographic analysis of S-adenosylmethionine and S-adenosylhomocysteine in animal tissues: the effect of exposure to nitrous oxide. Biomed Chromatogr 4:239\u2013241","journal-title":"Biomed Chromatogr"},{"key":"523_CR6","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/sj.cdd.4401817","volume":"13","author":"M Boyce","year":"2006","unstructured":"Boyce M, Yuan J (2006) Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ 13:363\u2013373","journal-title":"Cell Death Differ"},{"key":"523_CR7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/415092a","volume":"415","author":"M Calfon","year":"2002","unstructured":"Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D (2002) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415:92\u201396","journal-title":"Nature"},{"key":"523_CR8","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.mcn.2003.10.008","volume":"25","author":"P Cardona-Gomez","year":"2004","unstructured":"Cardona-Gomez P, Perez M, Avila J, Garcia-Segura LM, Wandosell F (2004) Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus. Mol Cell Neurosci 25:363\u2013373","journal-title":"Mol Cell Neurosci"},{"key":"523_CR9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1096\/fasebj.10.4.8647346","volume":"10","author":"PK Chiang","year":"1996","unstructured":"Chiang PK, Gordon RK, Tal J, Zeng GC, Doctor BP, Pardhasaradhi K, McCann PP (1996) S-Adenosylmethionine and methylation. FASEB J 10:471\u2013480","journal-title":"FASEB J"},{"key":"523_CR10","doi-asserted-by":"crossref","first-page":"2419S","DOI":"10.1093\/jn\/132.8.2419S","volume":"132","author":"JK Day","year":"2002","unstructured":"Day JK, Bauer AM, desBordes C, Zhuang Y, Kim B-E, Newton LG, Nehra V, Forsee KM, MacDonald RS, Besch-Williford C, Huang TH-M, Lubahn DB (2002) Genistein alters methylation patterns in mice. J Nutr 132:2419S\u20132423S","journal-title":"J Nutr"},{"key":"523_CR11","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1289\/ehp.8700","volume":"114","author":"D Dolinoy","year":"2006","unstructured":"Dolinoy D, Weidman J, Waterland R, Jirtle R (2006) Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect 114:567\u2013572","journal-title":"Environ Health Perspect"},{"key":"523_CR12","doi-asserted-by":"crossref","first-page":"13056","DOI":"10.1073\/pnas.0703739104","volume":"104","author":"DC Dolinoy","year":"2007","unstructured":"Dolinoy DC, Huang D, Jirtle RL (2007) Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc Natl Acad Sci USA 104:13056\u201313061","journal-title":"Proc Natl Acad Sci USA"},{"key":"523_CR13","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.pharmtox.45.120403.095832","volume":"45","author":"M Esteller","year":"2005","unstructured":"Esteller M (2005) Aberrant DNA methylation as a cancer-inducing mechanism. Annu Rev Pharmacol Toxicol 45:629\u2013656","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"523_CR14","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1002\/pmic.200401174","volume":"5","author":"D Fuchs","year":"2005","unstructured":"Fuchs D, Erhard P, Rimbach G, Daniel H, Wenzel U (2005) Genistein blocks homocysteine-induced alterations in the proteome of human endothelial cells. Proteomics 5:2808\u20132818","journal-title":"Proteomics"},{"key":"523_CR15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3233\/JAD-2007-11303","volume":"11","author":"A Fuso","year":"2007","unstructured":"Fuso A, Cavallaro RA, Zampelli A, D\u2019Anselmi F, Piscopo P, Confaloni A, Scarpa S (2007) \u03b3-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells. J Alzheimers Dis 11:275\u2013290","journal-title":"J Alzheimers Dis"},{"key":"523_CR16","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.neuroscience.2004.12.029","volume":"132","author":"S Goodenough","year":"2005","unstructured":"Goodenough S, Schleusner D, Pietrzik C, Skutella T, Behl C (2005) Glycogen synthase kinase 3beta links neuroprotection by 17beta-estradiol to key Alzheimer processes. Neuroscience 132:581\u2013589","journal-title":"Neuroscience"},{"key":"523_CR17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1472-6793-8-17","volume":"8","author":"C Guerrero-Bosagna","year":"2008","unstructured":"Guerrero-Bosagna C, Sabat P, Valdovinos F, Valladares L, Clark S (2008) Epigenetic and phenotypic changes result from a continuous pre and post natal dietary exposure to phytoestrogens in an experimental population of mice. BMC Physiol 8:17","journal-title":"BMC Physiol"},{"key":"523_CR18","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1016\/S0002-9343(97)00261-1","volume":"103","author":"VW Henderson","year":"1997","unstructured":"Henderson VW (1997) Estrogen, cognition, and a woman\u2019s risk of Alzheimer\u2019s disease. Am J Med 103:11S\u201318S","journal-title":"Am J Med"},{"key":"523_CR19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1023\/A:1024142004575","volume":"247","author":"KP Ho","year":"2003","unstructured":"Ho KP, Li L, Zhao L, Qian ZM (2003) Genistein protects primary cortical neurons from iron-induced lipid peroxidation. Mol Cell Biochem 247:219\u2013222","journal-title":"Mol Cell Biochem"},{"key":"523_CR20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.bbrc.2004.03.041","volume":"317","author":"T Hong","year":"2004","unstructured":"Hong T, Nakagawa T, Pan W, Kim MY, Lee Kraus W, Ikehara T, Yasui K, Aihara H, Takebe M, Muramatsu M, Ito T (2004) Isoflavones stimulate estrogen receptor-mediated core histone acetylation. Biochem Biophys Res Commun 317:259\u2013264","journal-title":"Biochem Biophys Res Commun"},{"key":"523_CR21","doi-asserted-by":"crossref","first-page":"2361S","DOI":"10.1093\/jn\/132.8.2361S","volume":"132","author":"SJ James","year":"2002","unstructured":"James SJ, Melnyk S, Pogribna M, Pogribny IP, Caudill MA (2002) Elevation in S-Adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 132:2361S\u20132366S","journal-title":"J Nutr"},{"key":"523_CR22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jchemneu.2003.12.004","volume":"28","author":"T Katayama","year":"2004","unstructured":"Katayama T, Imaizumi K, Manabe T, Hitomi J, Kudo T, Tohyama M (2004) Induction of neuronal death by ER stress in Alzheimer\u2019s disease. J Chem Neuroanat 28:67\u201378","journal-title":"J Chem Neuroanat"},{"key":"523_CR23","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI0216886","volume":"110","author":"R Kaufman","year":"2002","unstructured":"Kaufman R (2002) Orchestrating the unfolded protein response in health and disease. J Clin Invest 110:1389\u20131398","journal-title":"J Clin Invest"},{"key":"523_CR24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00702-003-0096-5","volume":"111","author":"BP Kennedy","year":"2004","unstructured":"Kennedy BP, Bottiglieri T, Arning E, Ziegler MG, Hansen LA, Masliah E (2004) Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive function. J Neural Transm 111:547\u2013567","journal-title":"J Neural Transm"},{"key":"523_CR25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/biof.5520120137","volume":"12","author":"H Kim","year":"2000","unstructured":"Kim H, Xia H, Li L, Gewin J (2000) Attenuation of neurodegeneration-relevant modifications of brain proteins by dietary soy. BioFactors 12:243\u2013250","journal-title":"BioFactors"},{"key":"523_CR26","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jnutbio.2007.09.009","volume":"19","author":"H-J Kim","year":"2008","unstructured":"Kim H-J, Cho H-K, Kwon YH (2008) Synergistic induction of ER stress by homocysteine and \u03b2-amyloid in SH-SY5Y cells. J Nutr Biochem 19:754\u2013761","journal-title":"J Nutr Biochem"},{"key":"523_CR27","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1523\/JNEUROSCI.20-18-06920.2000","volume":"20","author":"II Kruman","year":"2000","unstructured":"Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix L, Mattson MP (2000) Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci 20:6920\u20136926","journal-title":"J Neurosci"},{"key":"523_CR28","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1523\/JNEUROSCI.22-05-01752.2002","volume":"22","author":"II Kruman","year":"2002","unstructured":"Kruman II, Kumaravel TS, Lohani A, Pedersen WA, Cutler RG, Kruman Y, Haughey N, Lee J, Evans M, Mattson MP (2002) Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer\u2019s disease. J Neurosci 22:1752\u20131762","journal-title":"J Neurosci"},{"key":"523_CR29","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jnutbio.2005.06.010","volume":"16","author":"Y Lee","year":"2005","unstructured":"Lee Y, Lee H, Sohn H (2005) Soy isoflavones and cognitive function. J Nutr Biochem 16:641\u2013649","journal-title":"J Nutr Biochem"},{"key":"523_CR30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1017\/S0007114508998457","volume":"101","author":"H Leung","year":"2009","unstructured":"Leung H, Yung L, Poon C, Shi G, Lu A, Leung L (2009) Genistein protects against polycyclic aromatic hydrocarbon-induced oxidative DNA damage in non-cancerous breast cells MCF-10A. Br J Nutr 101:257\u2013262","journal-title":"Br J Nutr"},{"key":"523_CR31","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0039-128X(02)00062-4","volume":"67","author":"N Linford","year":"2002","unstructured":"Linford N, Dorsa D (2002) 17\u03b2-Estradiol and the phytoestrogen genistein attenuate neuronal apoptosis induced by the endoplasmic reticulum calcium-ATPase inhibitor thapsigargin. Steroids 67:1029\u20131040","journal-title":"Steroids"},{"key":"523_CR32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-5793(02)03487-7","volume":"530","author":"F Liu","year":"2002","unstructured":"Liu F, Iqbal K, Grundke-Iqbal I, Gong C-X (2002) Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3\u03b2. FEBS Lett 530:209\u2013214","journal-title":"FEBS Lett"},{"key":"523_CR33","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S1474-4422(04)00878-6","volume":"3","author":"J Luchsinger","year":"2004","unstructured":"Luchsinger J, Mayeux R (2004) Dietary factors and Alzheimer\u2019s disease. Lancet Neurol 3:579\u2013587","journal-title":"Lancet Neurol"},{"key":"523_CR34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","volume":"430","author":"MP Mattson","year":"2004","unstructured":"Mattson MP (2004) Pathways towards and away from Alzheimer\u2019s disease. Nature 430:631\u2013639","journal-title":"Nature"},{"key":"523_CR35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1385\/JMN:17:2:205","volume":"17","author":"MP Mattson","year":"2001","unstructured":"Mattson MP, Chan SL (2001) Dysregulation of cellular calcium homeostasis in Alzheimer\u2019s disease: bad genes and bad habits. J Mol Neurosci 17:205\u2013224","journal-title":"J Mol Neurosci"},{"key":"523_CR36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0166-2236(03)00032-8","volume":"26","author":"M Mattson","year":"2003","unstructured":"Mattson M, Shea T (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 26:137\u2013146","journal-title":"Trends Neurosci"},{"key":"523_CR37","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1016\/j.febslet.2006.04.088","volume":"580","author":"R Obeid","year":"2006","unstructured":"Obeid R, Herrmann W (2006) Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia. FEBS Lett 580:2994\u20133005","journal-title":"FEBS Lett"},{"key":"523_CR38","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/bj3320213","volume":"332","author":"PA Outinen","year":"1998","unstructured":"Outinen PA, Sood SK, Liaw PC, Sarge KD, Maeda N, Hirsh J, Ribau J, Podor TJ, Weitz JI, Austin RC (1998) Characterization of the stress-inducing effects of homocysteine. Biochem J 332:213\u2013221","journal-title":"Biochem J"},{"key":"523_CR39","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1089\/jmf.2008.1069","volume":"12","author":"Y-J Park","year":"2009","unstructured":"Park Y-J, Jang Y-m, Kwon YH (2009) Isoflavones prevent endoplasmic reticulum stress-mediated neuronal degeneration by inhibiting tau hyperphosphorylaltion in SH-SY5Y cells. J Med Food 12:528\u2013535","journal-title":"J Med Food"},{"key":"523_CR40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10522-006-9040-z","volume":"8","author":"I Picerno","year":"2007","unstructured":"Picerno I, Chirico C, Condello S, Visalli G, Ferlazzo N, Gorgone G, Caccamo D, Ientile R (2007) Homocysteine induces DNA damage and alterations in proliferative capacity of T-lymphocytes: a model for immunosenescence? Biogerontology 8:111\u2013119","journal-title":"Biogerontology"},{"key":"523_CR41","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1093\/carcin\/bgl082","volume":"27","author":"M Raschke","year":"2006","unstructured":"Raschke M, Rowland IR, Magee PJ, Pool-Zobel BL (2006) Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stress. Carcinogenesis 27:2322\u20132330","journal-title":"Carcinogenesis"},{"key":"523_CR42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-5793(03)00277-1","volume":"541","author":"S Scarpa","year":"2003","unstructured":"Scarpa S, Fuso A, D\u2019Anselmi F, Cavallaro RA (2003) Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease? FEBS Lett 541:145\u2013148","journal-title":"FEBS Lett"},{"key":"523_CR43","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1523\/JNEUROSCI.3316-06.2007","volume":"27","author":"E Sontag","year":"2007","unstructured":"Sontag E, Nunbhakdi-Craig V, Sontag J-M, Diaz-Arrastia R, Ogris E, Dayal S, Lentz SR, Arning E, Bottiglieri T (2007) Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. J Neurosci 27:2751\u20132759","journal-title":"J Neurosci"},{"key":"523_CR44","doi-asserted-by":"crossref","first-page":"22570","DOI":"10.1016\/S0021-9258(18)41710-3","volume":"267","author":"R Vulliet","year":"1992","unstructured":"Vulliet R, Halloran SM, Braun RK, Smith AJ, Lee G (1992) Proline-directed phosphorylation of human Tau protein. J Biol Chem 267:22570\u201322574","journal-title":"J Biol Chem"},{"key":"523_CR45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0166-2236(99)01479-4","volume":"23","author":"KKW Wang","year":"2000","unstructured":"Wang KKW (2000) Calpain and caspase: can you tell the difference? Trends Neurosci 23:20\u201326","journal-title":"Trends Neurosci"},{"key":"523_CR46","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1172\/JCI11596","volume":"107","author":"GH Werstuck","year":"2001","unstructured":"Werstuck GH, Lentz SR, Dayal S, Hossain GS, Sood SK, Shi YY, Zhou J, Maeda N, Krisans SK, Malinow MR, Austin RC (2001) Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J Clin Invest 107:1263\u20131273","journal-title":"J Clin Invest"},{"key":"523_CR47","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1172\/JCI26373","volume":"115","author":"C Xu","year":"2005","unstructured":"Xu C, Bailly-Maitre B, Reed JC (2005) Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115:2656\u20132664","journal-title":"J Clin Invest"},{"key":"523_CR48","doi-asserted-by":"crossref","first-page":"29318","DOI":"10.1074\/jbc.M002725200","volume":"275","author":"P Yi","year":"2000","unstructured":"Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ (2000) Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 275:29318\u201329323","journal-title":"J Biol Chem"},{"key":"523_CR49","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.bbrc.2007.09.060","volume":"363","author":"SY Yoon","year":"2007","unstructured":"Yoon SY, Choi HI, Choi JE, Sul CA, Choi JM, Kim DH (2007) Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron. Biochem Biophys Res Commun 363:811\u2013816","journal-title":"Biochem Biophys Res Commun"},{"key":"523_CR50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2202-7-49","volume":"7","author":"Y Zhang","year":"2006","unstructured":"Zhang Y, Bhavnani B (2006) Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens. BMC Neurosci 7:49","journal-title":"BMC Neurosci"},{"key":"523_CR51","doi-asserted-by":"crossref","first-page":"35867","DOI":"10.1074\/jbc.M100747200","volume":"276","author":"C Zhang","year":"2001","unstructured":"Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, Kitajima S (2001) Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. J Biol Chem 276:35867\u201335874","journal-title":"J Biol Chem"},{"key":"523_CR52","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.neurobiolaging.2007.04.015","volume":"29","author":"C-E Zhang","year":"2008","unstructured":"Zhang C-E, Tian Q, Wei W, Peng J-H, Liu G-P, Zhou X-W, Wang Q, Wang D-W, Wang J-Z (2008) Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 29:1654\u20131665","journal-title":"Neurobiol Aging"},{"key":"523_CR53","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/153537020222700716","volume":"227","author":"L Zhao","year":"2002","unstructured":"Zhao L, Chen Q, Brinton RD (2002) Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons. Exp Biol Med (Maywood) 227:509\u2013519","journal-title":"Exp Biol Med (Maywood)"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-010-0523-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-010-0523-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-010-0523-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T08:13:30Z","timestamp":1635063210000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-010-0523-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,4]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["523"],"URL":"https:\/\/doi.org\/10.1007\/s00726-010-0523-5","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,4]]}}}