{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:27:00Z","timestamp":1786980420289,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T00:00:00Z","timestamp":1268956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1007\/s00726-010-0554-y","type":"journal-article","created":{"date-parts":[[2010,3,18]],"date-time":"2010-03-18T14:57:30Z","timestamp":1268924250000},"page":"1183-1191","source":"Crossref","is-referenced-by-count":72,"title":["Gluten T cell epitope targeting by TG3 and TG6; implications for dermatitis herpetiformis and gluten ataxia"],"prefix":"10.1007","volume":"39","author":[{"given":"Jorunn","family":"Stamnaes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siri","family":"Dorum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Fleckenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Aeschlimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludvig M.","family":"Sollid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,19]]},"reference":[{"issue":"1","key":"554_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/03008200009005638","volume":"41","author":"D Aeschlimann","year":"2000","unstructured":"Aeschlimann D, Thomazy V (2000) Protein crosslinking in assembly and remodelling of extracellular matrices: the role of transglutaminases. Connect Tissue Res 41(1):1\u201327","journal-title":"Connect Tissue Res"},{"issue":"4","key":"554_CR2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1084\/jem.191.4.603","volume":"191","author":"H Arentz-Hansen","year":"2000","unstructured":"Arentz-Hansen H, Korner R et al (2000) The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase. J Exp Med 191(4):603\u2013612","journal-title":"J Exp Med"},{"issue":"3","key":"554_CR3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1053\/gast.2002.35381","volume":"123","author":"H Arentz-Hansen","year":"2002","unstructured":"Arentz-Hansen H, McAdam SN et al (2002) Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues. Gastroenterology 123(3):803\u2013809","journal-title":"Gastroenterology"},{"issue":"4","key":"554_CR4","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/prot.20837","volume":"62","author":"S Boros","year":"2006","unstructured":"Boros S, Ahrman E et al (2006) Site-specific transamidation and deamidation of the small heat-shock protein Hsp20 by tissue transglutaminase. Proteins 62(4):1044\u20131052","journal-title":"Proteins"},{"issue":"3","key":"554_CR5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0304-4165(94)00172-T","volume":"1243","author":"S Buus","year":"1995","unstructured":"Buus S, Stryhn A et al (1995) Receptor-ligand interactions measured by an improved spun column chromatography technique. A high efficiency and high throughput size separation method. Biochim Biophys Acta 1243(3):453\u2013460","journal-title":"Biochim Biophys Acta"},{"issue":"44","key":"554_CR6","doi-asserted-by":"crossref","first-page":"26382","DOI":"10.1074\/jbc.270.44.26382","volume":"270","author":"E Candi","year":"1995","unstructured":"Candi E, Melino G et al (1995) Biochemical, structural, and transglutaminase substrate properties of human loricrin, the major epidermal cornified cell envelope protein. J Biol Chem 270(44):26382\u201326390","journal-title":"J Biol Chem"},{"issue":"1","key":"554_CR7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0016-5085(88)90607-5","volume":"94","author":"G Ritis de","year":"1988","unstructured":"de Ritis G, Auricchio S et al (1988) In vitro (organ culture) studies of the toxicity of specific A-gliadin peptides in celiac disease. Gastroenterology 94(1):41\u201349","journal-title":"Gastroenterology"},{"issue":"7","key":"554_CR8","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nm0797-797","volume":"3","author":"W Dieterich","year":"1997","unstructured":"Dieterich W, Ehnis T et al (1997) Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 3(7):797\u2013801","journal-title":"Nat Med"},{"issue":"6","key":"554_CR9","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0016-5085(98)70007-1","volume":"115","author":"W Dieterich","year":"1998","unstructured":"Dieterich W, Laag E et al (1998) Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology 115(6):1317\u20131321","journal-title":"Gastroenterology"},{"issue":"4","key":"554_CR10","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1136\/gut.2005.069385","volume":"55","author":"W Dieterich","year":"2006","unstructured":"Dieterich W, Esslinger B et al (2006) Cross linking to tissue transglutaminase and collagen favours gliadin toxicity in coeliac disease. Gut 55(4):478\u2013484","journal-title":"Gut"},{"issue":"4","key":"554_CR11","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1021\/pr800960n","volume":"8","author":"S Dorum","year":"2009","unstructured":"Dorum S, Qiao SW et al (2009) A quantitative analysis of transglutaminase 2-mediated deamidation of gluten peptides: implications for the T-cell response in celiac disease. J Proteome Res 8(4):1748\u20131755","journal-title":"J Proteome Res"},{"issue":"3","key":"554_CR12","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1053\/gast.2001.22123","volume":"120","author":"A Fasano","year":"2001","unstructured":"Fasano A, Catassi C (2001) Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology 120(3):636\u2013651","journal-title":"Gastroenterology"},{"issue":"37","key":"554_CR13","doi-asserted-by":"crossref","first-page":"34109","DOI":"10.1074\/jbc.M204521200","volume":"277","author":"B Fleckenstein","year":"2002","unstructured":"Fleckenstein B, Molberg O et al (2002) Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process. J Biol Chem 277(37):34109\u201334116","journal-title":"J Biol Chem"},{"issue":"17","key":"554_CR14","doi-asserted-by":"crossref","first-page":"17607","DOI":"10.1074\/jbc.M310198200","volume":"279","author":"B Fleckenstein","year":"2004","unstructured":"Fleckenstein B, Qiao SW et al (2004) Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides. J Biol Chem 279(17):17607\u201317616","journal-title":"J Biol Chem"},{"key":"554_CR15","first-page":"1","volume":"54","author":"JE Folk","year":"1983","unstructured":"Folk JE (1983) Mechanism and basis for specificity of transglutaminase-catalyzed epsilon-(gamma-glutamyl) lysine bond formation. Adv Enzymol Relat Areas Mol Biol 54:1\u201356","journal-title":"Adv Enzymol Relat Areas Mol Biol"},{"issue":"2","key":"554_CR16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0950-3528(95)90036-5","volume":"9","author":"L Fry","year":"1995","unstructured":"Fry L (1995) Dermatitis herpetiformis. Baillieres Clin Gastroenterol 9(2):371\u2013393","journal-title":"Baillieres Clin Gastroenterol"},{"key":"554_CR17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1042\/bj0890114","volume":"89","author":"FC Greenwood","year":"1963","unstructured":"Greenwood FC, Hunter WM et al (1963) The preparation of I-131-labelled human growth hormone of high specific radioactivity. Biochem J 89:114\u2013123","journal-title":"Biochem J"},{"issue":"35","key":"554_CR18","doi-asserted-by":"crossref","first-page":"33066","DOI":"10.1074\/jbc.M102553200","volume":"276","author":"P Grenard","year":"2001","unstructured":"Grenard P, Bates MK et al (2001) Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. J Biol Chem 276(35):33066\u201333078","journal-title":"J Biol Chem"},{"issue":"9140","key":"554_CR19","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(98)05342-2","volume":"352","author":"M Hadjivassiliou","year":"1998","unstructured":"Hadjivassiliou M, Grunewald RA et al (1998) Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia. Lancet 352(9140):1582\u20131585","journal-title":"Lancet"},{"issue":"3","key":"554_CR20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1212\/01.wnl.0000196480.55601.3a","volume":"66","author":"M Hadjivassiliou","year":"2006","unstructured":"Hadjivassiliou M, Maki M et al (2006) Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia. Neurology 66(3):373\u2013377","journal-title":"Neurology"},{"issue":"3","key":"554_CR21","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/ana.21450","volume":"64","author":"M Hadjivassiliou","year":"2008","unstructured":"Hadjivassiliou M, Aeschlimann P et al (2008) Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase. Ann Neurol 64(3):332\u2013343","journal-title":"Ann Neurol"},{"issue":"3","key":"554_CR22","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1474-4422(09)70290-X","volume":"9","author":"M Hadjivassiliou","year":"2010","unstructured":"Hadjivassiliou M, Sanders DS et al (2010) Gluten sensitivity: from gut to brain. Lancet Neurol 9(3):318\u2013330","journal-title":"Lancet Neurol"},{"issue":"5","key":"554_CR23","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1357-2725(01)00033-4","volume":"33","author":"K Hitomi","year":"2001","unstructured":"Hitomi K, Horio Y et al (2001) Analysis of epidermal-type transglutaminase (TGase 3) expression in mouse tissues and cell lines. Int J Biochem Cell Biol 33(5):491\u2013498","journal-title":"Int J Biochem Cell Biol"},{"issue":"5","key":"554_CR24","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1046\/j.1471-4159.2001.00673.x","volume":"79","author":"TM Jeitner","year":"2001","unstructured":"Jeitner TM, Bogdanov MB et al (2001) N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington\u2019s disease. J Neurochem 79(5):1109\u20131112","journal-title":"J Neurochem"},{"issue":"11","key":"554_CR25","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1110\/ps.051818406","volume":"15","author":"Z Keresztessy","year":"2006","unstructured":"Keresztessy Z, Csosz E et al (2006) Phage display selection of efficient glutamine-donor substrate peptides for transglutaminase 2. Protein Sci 15(11):2466\u20132480","journal-title":"Protein Sci"},{"issue":"2","key":"554_CR26","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrm1014","volume":"4","author":"L Lorand","year":"2003","unstructured":"Lorand L, Graham RM (2003) Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol 4(2):140\u2013156","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"554_CR27","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nm0698-713","volume":"4","author":"O Molberg","year":"1998","unstructured":"Molberg O, McAdam SN et al (1998) Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 4(6):713\u2013717","journal-title":"Nat Med"},{"issue":"3","key":"554_CR28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0197-4580(01)00224-X","volume":"22","author":"Z Nemes","year":"2001","unstructured":"Nemes Z, Fesus L et al (2001) N(epsilon)(gamma-glutamyl)lysine in cerebrospinal fluid marks Alzheimer type and vascular dementia. Neurobiol Aging 22(3):403\u2013406","journal-title":"Neurobiol Aging"},{"issue":"1","key":"554_CR29","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1021\/bi011715x","volume":"41","author":"JL Piper","year":"2002","unstructured":"Piper JL, Gray GM et al (2002) High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue. Biochemistry 41(1):386\u2013393","journal-title":"Biochemistry"},{"issue":"1","key":"554_CR30","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4049\/jimmunol.175.1.254","volume":"175","author":"SW Qiao","year":"2005","unstructured":"Qiao SW, Bergseng E et al (2005) Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation. J Immunol 175(1):254\u2013261","journal-title":"J Immunol"},{"issue":"6","key":"554_CR31","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1084\/jem.20011299","volume":"195","author":"M Sardy","year":"2002","unstructured":"Sardy M, Karpati S et al (2002) Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis. J Exp Med 195(6):747\u2013757","journal-title":"J Exp Med"},{"issue":"5590","key":"554_CR32","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1126\/science.1074129","volume":"297","author":"L Shan","year":"2002","unstructured":"Shan L, Molberg O et al (2002) Structural basis for gluten intolerance in celiac sprue. Science 297(5590):2275\u20132279","journal-title":"Science"},{"issue":"5","key":"554_CR33","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1021\/pr050173t","volume":"4","author":"L Shan","year":"2005","unstructured":"Shan L, Qiao SW et al (2005) Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue. J Proteome Res 4(5):1732\u20131741","journal-title":"J Proteome Res"},{"issue":"9","key":"554_CR34","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nri885","volume":"2","author":"LM Sollid","year":"2002","unstructured":"Sollid LM (2002) Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2(9):647\u2013655","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"554_CR35","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/gut.41.6.851","volume":"41","author":"LM Sollid","year":"1997","unstructured":"Sollid LM, Molberg O et al (1997) Autoantibodies in coeliac disease: tissue transglutaminase\u2014guilt by association? Gut 41(6):851\u2013852","journal-title":"Gut"},{"issue":"11","key":"554_CR36","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.bbapap.2008.08.011","volume":"1784","author":"J Stamnaes","year":"2008","unstructured":"Stamnaes J, Fleckenstein B et al (2008) The propensity for deamidation and transamidation of peptides by transglutaminase 2 is dependent on substrate affinity and reaction conditions. Biochim Biophys Acta 1784(11):1804\u20131811","journal-title":"Biochim Biophys Acta"},{"issue":"26","key":"554_CR37","doi-asserted-by":"crossref","first-page":"17699","DOI":"10.1074\/jbc.M513538200","volume":"281","author":"Y Sugimura","year":"2006","unstructured":"Sugimura Y, Hosono M et al (2006) Screening for the preferred substrate sequence of transglutaminase using a phage-displayed peptide library: identification of peptide substrates for TGASE 2 and Factor XIIIA. J Biol Chem 281(26):17699\u201317706","journal-title":"J Biol Chem"},{"issue":"6","key":"554_CR38","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/S0016-5085(98)70008-3","volume":"115","author":"S Sulkanen","year":"1998","unstructured":"Sulkanen S, Halttunen T et al (1998) Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology 115(6):1322\u20131328","journal-title":"Gastroenterology"},{"issue":"13","key":"554_CR39","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1073\/pnas.0832466100","volume":"100","author":"Z Szondy","year":"2003","unstructured":"Szondy Z, Sarang Z et al (2003) Transglutaminase 2\u2212\/\u2212 mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells. Proc Natl Acad Sci USA 100(13):7812\u20137817","journal-title":"Proc Natl Acad Sci USA"},{"key":"554_CR40","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.bi.57.070188.000441","volume":"57","author":"DA Towler","year":"1988","unstructured":"Towler DA, Gordon JI et al (1988) The biology and enzymology of eukaryotic protein acylation. Annu Rev Biochem 57:69\u201399","journal-title":"Annu Rev Biochem"},{"issue":"5","key":"554_CR41","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1084\/jem.20012028","volume":"195","author":"LW Vader","year":"2002","unstructured":"Vader LW, de Ru A et al (2002a) Specificity of tissue transglutaminase explains cereal toxicity in celiac disease. J Exp Med 195(5):643\u2013649","journal-title":"J Exp Med"},{"issue":"7","key":"554_CR42","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1053\/gast.2002.33606","volume":"122","author":"W Vader","year":"2002","unstructured":"Vader W, Kooy Y et al (2002b) The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides. Gastroenterology 122(7):1729\u20131737","journal-title":"Gastroenterology"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-010-0554-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-010-0554-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-010-0554-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T01:40:50Z","timestamp":1559094050000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-010-0554-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,19]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["554"],"URL":"https:\/\/doi.org\/10.1007\/s00726-010-0554-y","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,19]]}}}