{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T01:49:09Z","timestamp":1768528149205,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T00:00:00Z","timestamp":1292284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1007\/s00726-010-0822-x","type":"journal-article","created":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T11:22:17Z","timestamp":1292412137000},"page":"809-820","source":"Crossref","is-referenced-by-count":32,"title":["Expression, purification and fluorine-18 radiolabeling of recombinant S100A4: a potential probe for molecular imaging of receptor for advanced glycation endproducts in vivo?"],"prefix":"10.1007","volume":"41","author":[{"given":"Susann","family":"Wolf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathleen","family":"Haase-Kohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Lenk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Hoppmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Steinbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Pietzsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,12,14]]},"reference":[{"key":"822_CR1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1046\/j.0022-202X.2004.22218.x","volume":"122","author":"R Abe","year":"2004","unstructured":"Abe R, Shimizu T, Sugawara H, Watanabe H, Nakamura H, Choei H, Sasaki N, Yamagishi S, Takeuchi M, Shimizu H (2004) Regulation of human melanoma growth and metastasis by AGE-AGE receptor interactions. J Invest Dermatol 122:461\u2013467","journal-title":"J Invest Dermatol"},{"key":"822_CR2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.plipres.2006.03.002","volume":"45","author":"H Adachi","year":"2006","unstructured":"Adachi H, Tsujimoto M (2006) Endothelial scavenger receptors. Prog Lipid Res 45:379\u2013404","journal-title":"Prog Lipid Res"},{"key":"822_CR3","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1074\/jbc.M310124200","volume":"279","author":"T Arumugam","year":"2004","unstructured":"Arumugam T, Simeone DM, Schmidt AM, Logsdon CD (2004) S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE). J Biol Chem 279:5059\u20135065","journal-title":"J Biol Chem"},{"key":"822_CR4","doi-asserted-by":"crossref","unstructured":"Berge G, Maelandsmo GM (2010) Evaluation of potential interactions between the metastasis-associated protein S100A4 and the tumor suppressor protein p53. Amino Acids (in press)","DOI":"10.1007\/s00726-010-0497-3"},{"key":"822_CR5","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1161\/CIRCRESAHA.107.167544","volume":"102","author":"JH Boyd","year":"2008","unstructured":"Boyd JH, Kan B, Roberts H, Wang Y, Walley KR (2008) S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. Circ Res 102:1239\u20131246","journal-title":"Circ Res"},{"key":"822_CR6","doi-asserted-by":"crossref","first-page":"528","DOI":"10.2353\/ajpath.2010.090526","volume":"176","author":"K Boye","year":"2010","unstructured":"Boye K, Maelandsmo GM (2010) S100A4 and metastasis: a small actor playing many roles. Am J Pathol 176:528\u2013535","journal-title":"Am J Pathol"},{"key":"822_CR7","doi-asserted-by":"crossref","first-page":"G457","DOI":"10.1152\/ajpgi.00351.2009","volume":"299","author":"MF Cunningham","year":"2010","unstructured":"Cunningham MF, Docherty NG, Burke JP, O\u2019Connell PR (2010) S100A4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn\u2019s disease and promotes intestinal fibroblast migration. Am J Physiol Gastrointest Liver Physiol 299:G457\u2013G466","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"822_CR8","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1021\/bi7003735","volume":"46","author":"BM Dattilo","year":"2007","unstructured":"Dattilo BM, Fritz G, Leclerc E, Kooi CW, Heizmann CW, Chazin WJ (2007) The extracellular region of the receptor for advanced glycation end products is composed of two independent structural units. Biochemistry 46:6957\u20136970","journal-title":"Biochemistry"},{"key":"822_CR9","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2174\/156652407783220688","volume":"7","author":"R Donato","year":"2007","unstructured":"Donato R (2007) RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteins. Curr Mol Med 7:711\u2013724","journal-title":"Curr Mol Med"},{"key":"822_CR10","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1073\/pnas.0501459102","volume":"102","author":"MR Fernandez-Fernandez","year":"2005","unstructured":"Fernandez-Fernandez MR, Veprintsev DB, Fersht AR (2005) Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor. Proc Natl Acad Sci USA 102:4735\u20134740","journal-title":"Proc Natl Acad Sci USA"},{"key":"822_CR11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1074\/jbc.R500017200","volume":"281","author":"SC Garrett","year":"2006","unstructured":"Garrett SC, Varney KM, Weber DJ, Bresnick AR (2006) S100A4, a mediator of metastasis. J Biol Chem 281:677\u2013680","journal-title":"J Biol Chem"},{"key":"822_CR12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.20070679","volume":"205","author":"C Gebhardt","year":"2008","unstructured":"Gebhardt C et al (2008) RAGE signaling sustains inflammation and promotes tumor development. J Exp Med 205:275\u2013285","journal-title":"J Exp Med"},{"key":"822_CR13","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1189\/jlb.0607397","volume":"83","author":"S Ghavami","year":"2008","unstructured":"Ghavami S, Rashedi I, Dattilo BM, Eshraghi M, Chazin WJ, Hashemi M, Wesselborg S, Kerkhoff C, Los M (2008) S100A8\/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway. J Leukoc Biol 83:1484\u20131492","journal-title":"J Leukoc Biol"},{"key":"822_CR14","doi-asserted-by":"crossref","first-page":"22699","DOI":"10.1074\/jbc.M010231200","volume":"276","author":"M Grigorian","year":"2001","unstructured":"Grigorian M et al (2001) Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1\/S100A4 protein: functional consequences of their interaction. J Biol Chem 276:22699\u201322708","journal-title":"J Biol Chem"},{"key":"822_CR15","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1038\/sj.bjc.6602613","volume":"92","author":"DM Helfman","year":"2005","unstructured":"Helfman DM, Kim EJ, Lukanidin E, Grigorian M (2005) The metastasis associated protein S100A4: role in tumour progression and metastasis. Br J Cancer 92:1955\u20131958","journal-title":"Br J Cancer"},{"key":"822_CR16","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0092-8674(00)80801-6","volume":"97","author":"MA Hofmann","year":"1999","unstructured":"Hofmann MA et al (1999) RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100\/calgranulin polypeptides. Cell 97:889\u2013901","journal-title":"Cell"},{"key":"822_CR17","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.biocel.2009.12.010","volume":"42","author":"S Hoppmann","year":"2010","unstructured":"Hoppmann S, Steinbach J, Pietzsch J (2010) Scavenger receptors are associated with cellular interactions of S100A12 in vitro and in vivo. Int J Biochem Cell Biol 42:651\u2013661","journal-title":"Int J Biochem Cell Biol"},{"key":"822_CR18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pep.2007.10.009","volume":"57","author":"S Hoppmann","year":"2008","unstructured":"Hoppmann S, Haase C, Richter S, Pietzsch J (2008a) Expression, purification and fluorine-18 radiolabeling of recombinant S100 proteins\u2014potential probes for molecular imaging of receptor for advanced glycation endproducts (RAGE) in vivo. Protein Expr Purif 57:143\u2013152","journal-title":"Protein Expr Purif"},{"key":"822_CR19","first-page":"329","volume-title":"Recent advances of bioconjugation chemistry in molecular imaging","author":"S Hoppmann","year":"2008","unstructured":"Hoppmann S, Haase C, Richter S, Strobel K, Steinbach J, Pietzsch J (2008b) Fluorine-18 radiolabeling of S100\/calgranulins: potential probes for molecular imaging of receptor for advanced glycation endproducts (RAGE) in vivo. In: Chen X (ed) Recent advances of bioconjugation chemistry in molecular imaging. Research Signpost, Trivandrum, pp 329\u2013351"},{"key":"822_CR20","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.bbrc.2004.02.135","volume":"316","author":"HL Hsieh","year":"2004","unstructured":"Hsieh HL, Schafer BW, Weigle B, Heizmann CW (2004) S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells. Biochem Biophys Res Commun 316:949\u2013959","journal-title":"Biochem Biophys Res Commun"},{"key":"822_CR21","doi-asserted-by":"crossref","first-page":"40096","DOI":"10.1074\/jbc.M006993200","volume":"275","author":"HJ Huttunen","year":"2000","unstructured":"Huttunen HJ, Kuja-Panula J, Sorci G, Agneletti AL, Donato R, Rauvala H (2000) Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation. J Biol Chem 275:40096\u201340105","journal-title":"J Biol Chem"},{"key":"822_CR22","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1128\/MCB.26.9.3625-3638.2006","volume":"26","author":"D Kiryushko","year":"2006","unstructured":"Kiryushko D, Novitskaya V, Soroka V, Klingelhofer J, Lukanidin E, Berezin V, Bock E (2006) Molecular mechanisms of Ca(2+) signaling in neurons induced by the S100A4 protein. Mol Cell Biol 26:3625\u20133638","journal-title":"Mol Cell Biol"},{"key":"822_CR25","doi-asserted-by":"crossref","first-page":"31317","DOI":"10.1074\/jbc.M703951200","volume":"282","author":"E Leclerc","year":"2007","unstructured":"Leclerc E, Fritz G, Weibel M, Heizmann CW, Galichet A (2007) S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains. J Biol Chem 282:31317\u201331331","journal-title":"J Biol Chem"},{"key":"822_CR23","unstructured":"Leclerc E, Heizmann CW, Vetter SW (2009a) RAGE and S100 protein transcription levels are highly variable in human melanoma tumors and cells. Gen Physiol Biophys 28(Spec No Focus):F65\u2013F75"},{"key":"822_CR24","doi-asserted-by":"crossref","unstructured":"Leclerc E, Fritz G, Vetter SW, Heizmann CW (2009b) Binding of S100 proteins to RAGE: an update. Biochim Biophys Acta 1793(6):993\u20131007","DOI":"10.1016\/j.bbamcr.2008.11.016"},{"key":"822_CR26","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1091\/mbc.E09-07-0609","volume":"21","author":"ZH Li","year":"2010","unstructured":"Li ZH, Dulyaninova NG, House RP, Almo SC, Bresnick AR (2010) S100A4 regulates macrophage chemotaxis. Mol Biol Cell 21:2598\u20132610","journal-title":"Mol Biol Cell"},{"key":"822_CR27","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2174\/156652407783220697","volume":"7","author":"CD Logsdon","year":"2007","unstructured":"Logsdon CD, Fuentes MK, Huang EH, Arumugam T (2007) RAGE and RAGE ligands in cancer. Curr Mol Med 7:777\u2013789","journal-title":"Curr Mol Med"},{"issue":"41","key":"822_CR28","doi-asserted-by":"crossref","first-page":"31517","DOI":"10.1074\/jbc.M110.125898","volume":"285","author":"KJ Miranda","year":"2010","unstructured":"Miranda KJ, Loeser RF, Yammani RR (2010) Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13. J Biol Chem 285(41):31517\u201331524","journal-title":"J Biol Chem"},{"key":"822_CR29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00726-005-0203-z","volume":"29","author":"J Pietzsch","year":"2005","unstructured":"Pietzsch J, Bergmann R, Wuest F, Pawelke B, Hultsch C, van den Hoff J (2005) Catabolism of native and oxidized low density lipoproteins: in vivo insights from small animal positron emission tomography studies. Amino Acids 29:389\u2013404","journal-title":"Amino Acids"},{"key":"822_CR30","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1074\/jbc.M102950200","volume":"277","author":"MJ Robinson","year":"2002","unstructured":"Robinson MJ, Tessier P, Poulsom R, Hogg N (2002) The S100 family heterodimer, MRP-8\/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells. J Biol Chem 277:3658\u20133665","journal-title":"J Biol Chem"},{"issue":"4","key":"822_CR31","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ejso.2007.04.009","volume":"34","author":"I Salama","year":"2008","unstructured":"Salama I, Malone PS, Mihaimeed F, Jones JL (2008) A review of the S100 proteins in cancer. Eur J Surg Oncol 34(4):357\u2013364","journal-title":"Eur J Surg Oncol"},{"key":"822_CR32","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/01.RES.84.5.489","volume":"84","author":"AM Schmidt","year":"1999","unstructured":"Schmidt AM, Yan SD, Wautier JL, Stern D (1999) Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ Res 84:489\u2013497","journal-title":"Circ Res"},{"key":"822_CR33","doi-asserted-by":"crossref","first-page":"20833","DOI":"10.1074\/jbc.M412653200","volume":"280","author":"A Semov","year":"2005","unstructured":"Semov A, Moreno MJ, Onichtchenko A, Abulrob A, Ball M, Ekiel I, Pietrzynski G, Stanimirovic D, Alakhov V (2005) Metastasis-associated protein S100A4 induces angiogenesis through interaction with Annexin II and accelerated plasmin formation. J Biol Chem 280:20833\u201320841","journal-title":"J Biol Chem"},{"key":"822_CR34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.canlet.2008.10.037","volume":"280","author":"GV Sherbet","year":"2009","unstructured":"Sherbet GV (2009) Metastasis promoter S100A4 is a potentially valuable molecular target for cancer therapy. Cancer Lett 280:15\u201330","journal-title":"Cancer Lett"},{"key":"822_CR35","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/S0169-409X(02)00160-6","volume":"54","author":"D Stern","year":"2002","unstructured":"Stern D, Yan SD, Yan SF, Schmidt AM (2002) Receptor for advanced glycation endproducts: a multiligand receptor magnifying cell stress in diverse pathologic settings. Adv Drug Deliv Rev 54:1615\u20131625","journal-title":"Adv Drug Deliv Rev"},{"key":"822_CR36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/156800907780618329","volume":"7","author":"S Tarabykina","year":"2007","unstructured":"Tarabykina S, Griffiths TR, Tulchinsky E, Mellon JK, Bronstein IB, Kriajevska M (2007) Metastasis-associated protein S100A4: spotlight on its role in cell migration. Curr Cancer Drug Targets 7:217\u2013228","journal-title":"Curr Cancer Drug Targets"},{"key":"822_CR37","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.181.2.1499","volume":"181","author":"R Wolf","year":"2008","unstructured":"Wolf R et al (2008) Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. J Immunol 181:1499\u20131506","journal-title":"J Immunol"},{"key":"822_CR38","volume-title":"Radioactive and stable isotope tracers in biomedicine: principles and practice of kinetic analysis","author":"RR Wolfe","year":"1992","unstructured":"Wolfe RR (1992) Radioactive and stable isotope tracers in biomedicine: principles and practice of kinetic analysis. Wiley Liss, New York"},{"key":"822_CR39","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1002\/art.22042","volume":"54","author":"RR Yammani","year":"2006","unstructured":"Yammani RR, Carlson CS, Bresnick AR, Loeser RF (2006) Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: role of the receptor for advanced glycation end products. Arthritis Rheum 54:2901\u20132911","journal-title":"Arthritis Rheum"},{"key":"822_CR40","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jemt.10297","volume":"60","author":"DB Zimmer","year":"2003","unstructured":"Zimmer DB, Wright Sadosky P, Weber DJ (2003) Molecular mechanisms of S100-target protein interactions. Microsc Res Tech 60:552\u2013559","journal-title":"Microsc Res Tech"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-010-0822-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-010-0822-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-010-0822-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T23:17:05Z","timestamp":1559863025000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-010-0822-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,14]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["822"],"URL":"https:\/\/doi.org\/10.1007\/s00726-010-0822-x","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,14]]}}}