{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:26:35Z","timestamp":1792657595795,"version":"4.5.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T00:00:00Z","timestamp":1319155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1007\/s00726-011-1123-8","type":"journal-article","created":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T12:20:52Z","timestamp":1319113252000},"page":"725-734","source":"Crossref","is-referenced-by-count":105,"title":["Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT"],"prefix":"10.1007","volume":"43","author":[{"given":"Ying","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,10,21]]},"reference":[{"issue":"35","key":"1123_CR1","doi-asserted-by":"crossref","first-page":"36553","DOI":"10.1074\/jbc.M404559200","volume":"279","author":"TG Anthony","year":"2004","unstructured":"Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC (2004) Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem 279(35):36553\u201336561","journal-title":"J Biol Chem"},{"issue":"3","key":"1123_CR2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cbpb.2010.07.004","volume":"157","author":"JL Beaudry","year":"2010","unstructured":"Beaudry JL, McClelland GB (2010) Thermogenesis in CD-1 mice after combined chronic hypoxia and cold acclimation. Comp Biochem Physiol 157(3):301\u2013309","journal-title":"Comp Biochem Physiol"},{"issue":"Suppl 1","key":"1123_CR3","doi-asserted-by":"crossref","first-page":"S526","DOI":"10.1177\/089686089601601S108","volume":"16","author":"A Canepa","year":"1996","unstructured":"Canepa A, Perfumo F, Carrea A, Menoni S, Trivelli A, Delucchi P, Gusmano R (1996) Nutritional status in children receiving chronic peritoneal dialysis. Perit Dial Int 16(Suppl 1):S526\u2013S531","journal-title":"Perit Dial Int"},{"issue":"2","key":"1123_CR4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0031-9384(95)00001-Y","volume":"58","author":"E Challet","year":"1995","unstructured":"Challet E, Le Maho Y, Malan A (1995) Locomotor activity and utilization of energy reserves during fasting after ventromedial hypothalamic lesions. Physiol Behav 58(2):257\u2013264","journal-title":"Physiol Behav"},{"issue":"1","key":"1123_CR5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2337\/db09-0929","volume":"59","author":"Y Cheng","year":"2010","unstructured":"Cheng Y, Meng Q, Wang C, Li H, Huang Z, Chen S, Xiao F, Guo F (2010) Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue. Diabetes 59(1):17\u201325","journal-title":"Diabetes"},{"issue":"3","key":"1123_CR6","first-page":"225","volume":"123","author":"N Cochet","year":"1999","unstructured":"Cochet N, Meister R, Florant GL, Barre H (1999) Regional variation of white adipocyte lipolysis during the annual cycle of the alpine marmot. Comp Biochem Physiol 123(3):225\u2013232","journal-title":"Comp Biochem Physiol"},{"issue":"5775","key":"1123_CR7","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1126\/science.1124147","volume":"312","author":"D Cota","year":"2006","unstructured":"Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ (2006) Hypothalamic mTOR signaling regulates food intake. Science 312(5775):927\u2013930","journal-title":"Science"},{"issue":"9","key":"1123_CR8","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1093\/jn\/135.9.2103","volume":"135","author":"M Doi","year":"2005","unstructured":"Doi M, Yamaoka I, Nakayama M, Mochizuki S, Sugahara K, Yoshizawa F (2005) Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity. J Nutr 135(9):2103\u20132108","journal-title":"J Nutr"},{"issue":"6","key":"1123_CR9","first-page":"E1683","volume":"292","author":"M Doi","year":"2007","unstructured":"Doi M, Yamaoka I, Nakayama M, Sugahara K, Yoshizawa F (2007) Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis. Am J Physiol 292(6):E1683\u2013E1693","journal-title":"Am J Physiol"},{"issue":"49","key":"1123_CR10","doi-asserted-by":"crossref","first-page":"29323","DOI":"10.1074\/jbc.270.49.29323","volume":"270","author":"SM Dudek","year":"1995","unstructured":"Dudek SM, Semenkovich CF (1995) Essential amino acids regulate fatty acid synthase expression through an uncharged transfer RNA-dependent mechanism. J Biol Chem 270(49):29323\u201329329","journal-title":"J Biol Chem"},{"issue":"6628","key":"1123_CR11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/387090a0","volume":"387","author":"S Enerback","year":"1997","unstructured":"Enerback S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper ME, Kozak LP (1997) Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387(6628):90\u201394","journal-title":"Nature"},{"issue":"2","key":"1123_CR12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cmet.2008.12.014","volume":"9","author":"HM Feldmann","year":"2009","unstructured":"Feldmann HM, Golozoubova V, Cannon B, Nedergaard J (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9(2):203\u2013209","journal-title":"Cell Metab"},{"issue":"Suppl 1","key":"1123_CR13","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.2337\/diabetes.53.2007.S43","volume":"53","author":"P Ferre","year":"2004","unstructured":"Ferre P (2004) The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 53(Suppl 1):S43\u2013S50","journal-title":"Diabetes"},{"issue":"1","key":"1123_CR14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0026-0495(87)90063-1","volume":"36","author":"S Fujioka","year":"1987","unstructured":"Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S (1987) Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metab Clin Exp 36(1):54\u201359","journal-title":"Metab Clin Exp"},{"issue":"3","key":"1123_CR15","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0031-9384(89)90028-0","volume":"46","author":"DW Gietzen","year":"1989","unstructured":"Gietzen DW, Leung PM, Rogers QR (1989) Dietary amino acid imbalance and neurochemical changes in three hypothalamic areas. Physiol Behav 46(3):503\u2013511","journal-title":"Physiol Behav"},{"issue":"48","key":"1123_CR16","doi-asserted-by":"crossref","first-page":"45456","DOI":"10.1074\/jbc.M104436200","volume":"276","author":"AS Greenberg","year":"2001","unstructured":"Greenberg AS, Shen WJ, Muliro K, Patel S, Souza SC, Roth RA, Kraemer FB (2001) Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway. J Biol Chem 276(48):45456\u201345461","journal-title":"J Biol Chem"},{"issue":"5","key":"1123_CR17","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0031-9384(74)90241-8","volume":"13","author":"MR Greenwood","year":"1974","unstructured":"Greenwood MR, Quartermain D, Johnson PR, Cruce JA, Hirsch J (1974) Food motivated behavior in genetically obese and hypothalamic-hyperphagic rats and mice. Physiol Behav 13(5):687\u2013692","journal-title":"Physiol Behav"},{"issue":"2","key":"1123_CR18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cmet.2007.01.001","volume":"5","author":"F Guo","year":"2007","unstructured":"Guo F, Cavener DR (2007) The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab 5(2):103\u2013114","journal-title":"Cell Metab"},{"issue":"7","key":"1123_CR19","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1210\/er.2006-0037","volume":"27","author":"C Handschin","year":"2006","unstructured":"Handschin C, Spiegelman BM (2006) Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev 27(7):728\u2013735","journal-title":"Endocr Rev"},{"issue":"6","key":"1123_CR20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1006\/scel.1994.1049","volume":"5","author":"AG Hinnebusch","year":"1994","unstructured":"Hinnebusch AG (1994) The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress. Semin Cell Biol 5(6):417\u2013426","journal-title":"Semin Cell Biol"},{"issue":"3","key":"1123_CR21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1248\/bpb.31.469","volume":"31","author":"O Ikehara","year":"2008","unstructured":"Ikehara O, Kawasaki N, Maezono K, Komatsu M, Konishi A (2008) Acute and chronic treatment of l-isoleucine ameliorates glucose metabolism in glucose-intolerant and diabetic mice. Biol Pharm Bull 31(3):469\u2013472","journal-title":"Biol Pharm Bull"},{"issue":"2","key":"1123_CR22","doi-asserted-by":"crossref","first-page":"322","DOI":"10.2337\/diabetes.54.2.322","volume":"54","author":"Y Ishigaki","year":"2005","unstructured":"Ishigaki Y, Katagiri H, Yamada T, Ogihara T, Imai J, Uno K, Hasegawa Y, Gao J, Ishihara H, Shimosegawa T, Sakoda H, Asano T, Oka Y (2005) Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. Diabetes 54(2):322\u2013332","journal-title":"Diabetes"},{"issue":"2","key":"1123_CR23","first-page":"619","volume":"44","author":"R Jakesz","year":"1984","unstructured":"Jakesz R, Smith CA, Aitken S, Huff K, Schuette W, Shackney S, Lippman M (1984) Influence of cell proliferation and cell cycle phase on expression of estrogen receptor in MCF-7 breast cancer cells. Cancer Res 44(2):619\u2013625","journal-title":"Cancer Res"},{"issue":"1 Suppl","key":"1123_CR24","doi-asserted-by":"crossref","first-page":"227S","DOI":"10.1093\/jn\/136.1.227S","volume":"136","author":"SR Kimball","year":"2006","unstructured":"Kimball SR, Jefferson LS (2006) Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr 136(1 Suppl):227S\u2013231S","journal-title":"J Nutr"},{"issue":"3","key":"1123_CR25","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1083\/jcb.200412022","volume":"169","author":"M Komatsu","year":"2005","unstructured":"Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T (2005) Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425\u2013434","journal-title":"J Cell Biol"},{"issue":"1 Suppl","key":"1123_CR26","doi-asserted-by":"crossref","first-page":"319S","DOI":"10.1093\/jn\/136.1.319S","volume":"136","author":"DK Layman","year":"2006","unstructured":"Layman DK, Walker DA (2006) Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr 136(1 Suppl):319S\u2013323S","journal-title":"J Nutr"},{"key":"1123_CR27","unstructured":"Lee Y, Yu X, Gonzales F, Mangelsdorf DJ, Wang MY, Richardson C, Witters LA, Unger RH (2002) PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue. In: Proceedings of the National Academy of Sciences of the United States of America 99, vol 18, pp 11848\u201311853"},{"issue":"10","key":"1123_CR28","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/80450","volume":"6","author":"B Li","year":"2000","unstructured":"Li B, Nolte LA, Ju JS, Han DH, Coleman T, Holloszy JO, Semenkovich CF (2000) Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat Med 6(10):1115\u20131120","journal-title":"Nat Med"},{"issue":"1","key":"1123_CR29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0021-9258(18)65778-3","volume":"219","author":"RB Loftfield","year":"1956","unstructured":"Loftfield RB, Harris A (1956) Participation of free amino acids in protein synthesis. J Biol Chem 219(1):151\u2013159","journal-title":"J Biol Chem"},{"issue":"7","key":"1123_CR30","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.peptides.2010.03.028","volume":"31","author":"N Lopez","year":"2010","unstructured":"Lopez N, Sanchez J, Pico C, Palou A, Serra F (2010) Dietary l-leucine supplementation of lactating rats results in a tendency to increase lean\/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus. Peptides 31(7):1361\u20131367","journal-title":"Peptides"},{"issue":"6778","key":"1123_CR31","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/35007527","volume":"404","author":"BB Lowell","year":"2000","unstructured":"Lowell BB, Spiegelman BM (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404(6778):652\u2013660","journal-title":"Nature"},{"issue":"2","key":"1123_CR32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/j.jrn.2007.11.011","volume":"18","author":"S Malgorzewicz","year":"2008","unstructured":"Malgorzewicz S, Debska-Slizien A, Rutkowski B, Lysiak-Szydlowska W (2008) Serum concentration of amino acids versus nutritional status in hemodialysis patients. J Ren Nutr 18(2):239\u2013247","journal-title":"J Ren Nutr"},{"issue":"5","key":"1123_CR33","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/S0021-9258(19)69758-9","volume":"256","author":"WA Maltese","year":"1981","unstructured":"Maltese WA, Reitz BA, Volpe JJ (1981) Effects of isoleucine deprivation on synthesis of sterols and fatty acids in LM-cells. J Biol Chem 256(5):2185\u20132193","journal-title":"J Biol Chem"},{"issue":"8","key":"1123_CR34","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.2337\/diabetes.50.8.1844","volume":"50","author":"G Marchesini","year":"2001","unstructured":"Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, McCullough AJ, Natale S, Forlani G, Melchionda N (2001) Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 50(8):1844\u20131850","journal-title":"Diabetes"},{"issue":"33","key":"1123_CR35","doi-asserted-by":"crossref","first-page":"25073","DOI":"10.1074\/jbc.M000547200","volume":"275","author":"A Matthias","year":"2000","unstructured":"Matthias A, Ohlson KB, Fredriksson JM, Jacobsson A, Nedergaard J, Cannon B (2000) Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis. J Biol Chem 275(33):25073\u201325081","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"1123_CR36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.physbeh.2007.05.021","volume":"92","author":"B Meister","year":"2007","unstructured":"Meister B (2007) Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight. Physiol Behav 92(1\u20132):263\u2013271","journal-title":"Physiol Behav"},{"issue":"38","key":"1123_CR37","doi-asserted-by":"crossref","first-page":"29900","DOI":"10.1074\/jbc.M003633200","volume":"275","author":"S Mordier","year":"2000","unstructured":"Mordier S, Deval C, Bechet D, Tassa A, Ferrara M (2000) Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway. J Biol Chem 275(38):29900\u201329906","journal-title":"J Biol Chem"},{"issue":"4","key":"1123_CR38","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3945\/jn.108.100081","volume":"139","author":"A Nairizi","year":"2009","unstructured":"Nairizi A, She P, Vary TC, Lynch CJ (2009) Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice. J Nutr 139(4):715\u2013719","journal-title":"J Nutr"},{"issue":"3","key":"1123_CR39","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3945\/jn.109.108977","volume":"140","author":"J Nishimura","year":"2010","unstructured":"Nishimura J, Masaki T, Arakawa M, Seike M, Yoshimatsu H (2010) Isoleucine prevents the accumulation of tissue triglycerides and upregulates the expression of PPARalpha and uncoupling protein in diet-induced obese mice. J Nutr 140(3):496\u2013500","journal-title":"J Nutr"},{"issue":"3","key":"1123_CR40","first-page":"99","volume":"53","author":"N Nishino","year":"2007","unstructured":"Nishino N, Tamori Y, Kasuga M (2007) Insulin efficiently stores triglycerides in adipocytes by inhibiting lipolysis and repressing PGC-1alpha induction. Kobe J Med Sci 53(3):99\u2013106","journal-title":"Kobe J Med Sci"},{"issue":"7","key":"1123_CR41","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.febslet.2010.01.018","volume":"584","author":"NN Noda","year":"2010","unstructured":"Noda NN, Ohsumi Y, Inagaki F (2010) Atg8-family interacting motif crucial for selective autophagy. FEBS Lett 584(7):1379\u20131385","journal-title":"FEBS Lett"},{"issue":"8","key":"1123_CR42","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.metabol.2005.03.007","volume":"54","author":"A Nogalska","year":"2005","unstructured":"Nogalska A, Sucajtys-Szulc E, Swierczynski J (2005) Leptin decreases lipogenic enzyme gene expression through modification of SREBP-1c gene expression in white adipose tissue of aging rats. Metab Clin Exp 54(8):1041\u20131047","journal-title":"Metab Clin Exp"},{"issue":"3","key":"1123_CR43","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1046\/j.1523-1755.1998.00812.x","volume":"53","author":"AR Qureshi","year":"1998","unstructured":"Qureshi AR, Alvestrand A, Danielsson A, Divino-Filho JC, Gutierrez A, Lindholm B, Bergstrom J (1998) Factors predicting malnutrition in hemodialysis patients: a cross-sectional study. Kidney Int 53(3):773\u2013782","journal-title":"Kidney Int"},{"issue":"7","key":"1123_CR44","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/sj.emboj.7601623","volume":"26","author":"R Scherz-Shouval","year":"2007","unstructured":"Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z (2007) Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26(7):1749\u20131760","journal-title":"EMBO J"},{"issue":"5","key":"1123_CR45","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.2337\/db05-1498","volume":"55","author":"V Schoenborn","year":"2006","unstructured":"Schoenborn V, Heid IM, Vollmert C, Lingenhel A, Adams TD, Hopkins PN, Illig T, Zimmermann R, Zechner R, Hunt SC, Kronenberg F (2006) The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. Diabetes 55(5):1270\u20131275","journal-title":"Diabetes"},{"issue":"9","key":"1123_CR46","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0026-0495(79)90095-7","volume":"28","author":"DE Schteingart","year":"1979","unstructured":"Schteingart DE, McKenzie AK, Victoria RS, Tsao HS (1979) Suppression of insulin secretion by protein deprivation in obesity. Metab Clin Exp 28(9):943\u2013949","journal-title":"Metab Clin Exp"},{"issue":"6","key":"1123_CR47","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/jn\/136.6.1466","volume":"136","author":"J Talvas","year":"2006","unstructured":"Talvas J, Obled A, Fafournoux P, Mordier S (2006) Regulation of protein synthesis by leucine starvation involves distinct mechanisms in mouse C2C12 myoblasts and myotubes. J Nutr 136(6):1466\u20131471","journal-title":"J Nutr"},{"issue":"5","key":"1123_CR48","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1037\/h0048419","volume":"50","author":"P Teitelbaum","year":"1957","unstructured":"Teitelbaum P (1957) Random and food-directed activity in hyperphagic and normal rats. J Comp Physiol Psychol 50(5):486\u2013490","journal-title":"J Comp Physiol Psychol"},{"issue":"8","key":"1123_CR49","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/153537020222700806","volume":"227","author":"JC Tou","year":"2002","unstructured":"Tou JC, Wade CE (2002) Determinants affecting physical activity levels in animal models. Exp Biol Med 227(8):587\u2013600","journal-title":"Exp Biol Med"},{"issue":"3","key":"1123_CR50","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00582901","volume":"380","author":"P Trayhurn","year":"1979","unstructured":"Trayhurn P (1979) Thermoregulation in the diabetic-obese (db\/db) mouse. The role of non-shivering thermogenesis in energy balance. Pflugers Arch 380(3):227\u2013232","journal-title":"Pflugers Arch"},{"issue":"5","key":"1123_CR51","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1248\/bpb.31.775","volume":"31","author":"M Watanabe","year":"2008","unstructured":"Watanabe M, Yamamoto T, Mori C, Okada N, Yamazaki N, Kajimoto K, Kataoka M, Shinohara Y (2008) Cold-induced changes in gene expression in brown adipose tissue: implications for the activation of thermogenesis. Biol Pharm Bull 31(5):775\u2013784","journal-title":"Biol Pharm Bull"},{"issue":"3","key":"1123_CR52","first-page":"E500","volume":"290","author":"MJ Watt","year":"2006","unstructured":"Watt MJ, Holmes AG, Pinnamaneni SK, Garnham AP, Steinberg GR, Kemp BE, Febbraio MA (2006) Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. Am J Physiol 290(3):E500\u2013E508","journal-title":"Am J Physiol"},{"issue":"1","key":"1123_CR53","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.physbeh.2010.04.012","volume":"101","author":"PY Wielinga","year":"2010","unstructured":"Wielinga PY, Lowenstein C, Muff S, Munz M, Woods SC, Lutz TA (2010) Central amylin acts as an adiposity signal to control body weight and energy expenditure. Physiol Behav 101(1):45\u201352","journal-title":"Physiol Behav"},{"issue":"2","key":"1123_CR54","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0014-4827(85)90476-8","volume":"158","author":"D Wynford-Thomas","year":"1985","unstructured":"Wynford-Thomas D, LaMontagne A, Marin G, Prescott DM (1985) Location of the isoleucine arrest point in CHO and 3T3 cells. Exp Cell Res 158(2):525\u2013532","journal-title":"Exp Cell Res"},{"issue":"10","key":"1123_CR55","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/ncb1482","volume":"8","author":"S Yousefi","year":"2006","unstructured":"Yousefi S, Perozzo R, Schmid I, Ziemiecki A, Schaffner T, Scapozza L, Brunner T, Simon HU (2006) Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol 8(10):1124\u20131132","journal-title":"Nat Cell Biol"},{"issue":"6","key":"1123_CR56","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2337\/db07-0123","volume":"56","author":"Y Zhang","year":"2007","unstructured":"Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH (2007) Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 56(6):1647\u20131654","journal-title":"Diabetes"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-011-1123-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-011-1123-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-011-1123-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T23:57:58Z","timestamp":1639267078000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-011-1123-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,21]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["1123"],"URL":"https:\/\/doi.org\/10.1007\/s00726-011-1123-8","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,21]]}}}