{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:51:52Z","timestamp":1791013912527,"version":"4.1.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,12,31]],"date-time":"2011-12-31T00:00:00Z","timestamp":1325289600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1007\/s00726-011-1208-4","type":"journal-article","created":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T11:49:24Z","timestamp":1325245764000},"page":"1349-1357","source":"Crossref","is-referenced-by-count":10,"title":["N-Succinimidyl 4-[18F]-fluoromethylbenzoate-labeled dimeric RGD peptide for imaging tumor integrin expression"],"prefix":"10.1007","volume":"43","author":[{"given":"Weihua","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale O.","family":"Kiesewetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baozhong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,12,31]]},"reference":[{"issue":"4","key":"1208_CR1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1089\/cbr.2007.0457","volume":"23","author":"JR Bading","year":"2008","unstructured":"Bading JR, Horling M, Williams LE, Colcher D, Raubitschek A, Strand SE (2008) Quantitative serial imaging of an 124I anti-CEA monoclonal antibody in tumor-bearing mice. Cancer Biother Radiopharm 23(4):399\u2013409","journal-title":"Cancer Biother Radiopharm"},{"key":"1208_CR2","first-page":"1172","volume":"47","author":"W Cai","year":"2006","unstructured":"Cai W, Zhang X, Wu Y, Chen X (2006) A thiol-reactive 18F-labeling agent, N-[2-(4\u201318F-fluorobenzamido)ethyl]maleimide, and synthesis of RGD peptide-based tracer for PET imaging of \u03b1v\u03b23 integrin expression. J Nucl Med 47:1172\u20131180","journal-title":"J Nucl Med"},{"key":"1208_CR3","doi-asserted-by":"crossref","unstructured":"Chin FT, Shen B, Liu S, Berganos RA, Chang E, Mittra E, Chen X, Gambhir SS (2011) First experience with clinical-grade [18F]FPP(RGD)2: an automated multi-step radiosynthesis for clinical PET studies. Mol Imaging Biol. doi: 10.1007\/s11307-011-0477-3","DOI":"10.1007\/s11307-011-0477-3"},{"key":"1208_CR4","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1021\/mp200006f","volume":"8","author":"H Gao","year":"2011","unstructured":"Gao H, Niu G, Yang M, Quan Q, Ma Y, Murage E, Ahn JM, Kiesewetter D, Chen X (2011) PET of insulinoma using 18F-FBEM-EM3106b, a new GLP-1 analog. Mol Pharm. 8:1669\u20131676","journal-title":"Mol Pharm."},{"key":"1208_CR5","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.2174\/156802610791384298","volume":"10","author":"O Jacobson","year":"2010","unstructured":"Jacobson O, Chen X (2010) PET designated flouride-18 production and chemistry. Curr Top Med Chem 10:1048\u20131059","journal-title":"Curr Top Med Chem"},{"key":"1208_CR6","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1021\/bc100437q","volume":"22","author":"O Jacobson","year":"2011","unstructured":"Jacobson O, Zhu L, Ma Y, Weiss ID, Sun X, Niu G, Kiesewetter DO, Chen X (2011) Rapid and simple one-step F-18 labeling of peptides. Bioconjug Chem 22:422\u2013428","journal-title":"Bioconjug Chem"},{"key":"1208_CR7","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.apradiso.2010.09.023","volume":"69","author":"DO Kiesewetter","year":"2011","unstructured":"Kiesewetter DO, Jacobson O, Lang L, Chen X (2011) Automated radiochemical synthesis of [18F]FBEM: A thiol reactive synthon for radiofluorination of peptides and proteins. Appl Radiat Isot 69:410\u2013414","journal-title":"Appl Radiat Isot"},{"key":"1208_CR8","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/0969-8043(94)90031-0","volume":"45","author":"L Lang","year":"1994","unstructured":"Lang L, Eckelman WC (1994) One-step synthesis of 18F-labeled [18F]-N-succinimidyl 4-(fluoromethyl)benzoate for protein labeling. Appl Radiat Isot 45:1155\u20131163","journal-title":"Appl Radiat Isot"},{"key":"1208_CR9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0969-8043(96)00151-0","volume":"48","author":"L Lang","year":"1997","unstructured":"Lang L, Eckelman WC (1997) Labeling proteins at high specific activity using N-succinimidyl 4-[18F](fluoromethyl)benzoate. Appl Radiat Isot 48:169\u2013173","journal-title":"Appl Radiat Isot"},{"issue":"3","key":"1208_CR10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2967\/jnumed.107.048009","volume":"49","author":"ZB Li","year":"2008","unstructured":"Li ZB, Wu Z, Chen K, Ryu EK, Chen X (2008) 18F-labeled BBN-RGD heterodimer for prostate cancer imaging. J Nucl Med 49(3):453\u2013461","journal-title":"J Nucl Med"},{"key":"1208_CR11","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s11307-009-0284-2","volume":"12","author":"S Liu","year":"2010","unstructured":"Liu S, Liu Z, Chen K, Yan Y, Watzlowik P, Wester HJ, Chin FT, Chen X (2010) 18F-labeled galacto and pegylated RGD dimers for PET imaging of \u03b1v\u03b23 integrin expression. Mol Imaging Biol 12:530\u2013538","journal-title":"Mol Imaging Biol"},{"key":"1208_CR12","doi-asserted-by":"crossref","first-page":"991","DOI":"10.2967\/jnumed.108.060418","volume":"50","author":"WJ McBride","year":"2009","unstructured":"McBride WJ, Sharkey RM, Karacay H, D\u2019Souza CA, Rossi EA, Laverman P, Chang CH, Boerman OC, Goldenberg DM (2009) A novel method of 18F radiolabeling for PET. J Nucl Med 50:991\u2013998","journal-title":"J Nucl Med"},{"issue":"7","key":"1208_CR13","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1021\/bc100137x","volume":"21","author":"WJ McBride","year":"2010","unstructured":"McBride WJ, D\u2019Souza CA, Sharkey RM, Karacay H, Rossi EA, Chang CH, Goldenberg DM (2010) Improved 18F labeling of peptides with a fluoride-aluminum-chelate complex. Bioconjug Chem 21(7):1331\u20131340","journal-title":"Bioconjug Chem"},{"key":"1208_CR14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1148\/radiol.11101139","volume":"260","author":"ES Mittra","year":"2011","unstructured":"Mittra ES, Goris ML, Iagaru AH, Kardan A, Burton L, Berganos R, Chang E, Liu S, Shen B, Chin FT, Chen X, Gambhir SS (2011) Pilot pharmacokinetic and dosimetric studies of 18F-FPPRGD2: a PET radiopharmaceutical agent for imaging \u03b1v\u03b23 integrin levels. Radiology. 260:182\u2013191","journal-title":"Radiology."},{"key":"1208_CR15","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1007\/s00259-007-0427-0","volume":"34","author":"Z Wu","year":"2007","unstructured":"Wu Z, Li ZB, Cai W, He L, Chin FT, Li F, Chen X (2007) 18F-labeled mini-peg spacered RGD dimer (18F-FPRGD2): Synthesis and microPET imaging of \u03b1v\u03b23 integrin expression. Eur J Nucl Med Mol Imaging 34:1823\u20131831","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"7","key":"1208_CR16","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00259-011-1742-z","volume":"38","author":"M Yang","year":"2011","unstructured":"Yang M, Gao H, Yan Y, Sun X, Chen K, Quan Q, Lang L, Kiesewetter D, Niu G, Chen X (2011a) PET imaging of early response to the tyrosine kinase inhibitor ZD4190. Eur J Nucl Med Mol Imag 38(7):1237\u20131247","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"1208_CR17","doi-asserted-by":"crossref","first-page":"220","DOI":"10.7150\/thno\/v01p0220","volume":"1","author":"M Yang","year":"2011","unstructured":"Yang M, Gao H, Zhou Y, Ma Y, Quan Q, Lang L, Chen K, Niu G, Yan Y, Chen X (2011b) 18F-labeled GRPR agonists and antagonists: a comparative study in prostate cancer imaging. Theranostics 1:220\u2013229","journal-title":"Theranostics"},{"key":"1208_CR18","first-page":"113","volume":"47","author":"X Zhang","year":"2006","unstructured":"Zhang X, Xiong Z, Wu Y, Cai W, Tseng JR, Gambhir SS, Chen X (2006) Quantitative PET imaging of tumor integrin \u03b1v\u03b23 expression with 18F-FRGD2. J Nucl Med 47:113\u2013121","journal-title":"J Nucl Med"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-011-1208-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-011-1208-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-011-1208-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T05:43:21Z","timestamp":1559108601000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-011-1208-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,31]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["1208"],"URL":"https:\/\/doi.org\/10.1007\/s00726-011-1208-4","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,31]]}}}