{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T21:53:01Z","timestamp":1764193981950,"version":"3.40.4"},"reference-count":112,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,1,28]],"date-time":"2012-01-28T00:00:00Z","timestamp":1327708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2012,1,28]],"date-time":"2012-01-28T00:00:00Z","timestamp":1327708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s00726-012-1224-z","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T09:09:23Z","timestamp":1327655363000},"page":"111-126","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Transforming dietary peptides in promising lead compounds: the case of bioavailable carnosine analogs"],"prefix":"10.1007","volume":"43","author":[{"given":"Giulio","family":"Vistoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Carini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Aldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,1,28]]},"reference":[{"key":"1224_CR1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0006-291X(02)02545-7","volume":"298","author":"G Aldini","year":"2002","unstructured":"Aldini G, Carini M, Beretta G, Bradamante S, Facino RM (2002) Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction? Biochem Biophys Res Commun 298:699\u2013706","journal-title":"Biochem Biophys Res Commun"},{"key":"1224_CR2","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/jms.696","volume":"39","author":"G Aldini","year":"2004","unstructured":"Aldini G, Orioli M, Carini M, Maffei Facino R (2004) Profiling histidine-containing dipeptides in rat tissues by liquid chromatography\/electrospray ionization tandem mass spectrometry. J Mass Spectrom 39:1417\u20131428","journal-title":"J Mass Spectrom"},{"key":"1224_CR3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/biof.5520240109","volume":"24","author":"G Aldini","year":"2005","unstructured":"Aldini G, Facino RM, Beretta G, Carini M (2005) Carnosine and related dipeptides as quenchers of reactive carbonyl species: from structural studies to therapeutic perspectives. Biofactors 24:77\u201387","journal-title":"Biofactors"},{"issue":"10","key":"1224_CR4","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/cmdc.200600075","volume":"1","author":"G Aldini","year":"2006","unstructured":"Aldini G, Dalle-Donne I, Colombo R, Maffei Facino R, Milzani A, Carini M (2006) Lipoxidation-derived reactive carbonyl species as potential drug targets in preventing protein carbonylation and related cellular dysfunction. ChemMedChem 1(10):1045\u20131058","journal-title":"ChemMedChem"},{"issue":"6","key":"1224_CR5","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/med.20073","volume":"27","author":"G Aldini","year":"2007","unstructured":"Aldini G, Dalle-Donne I, Facino RM, Milzani A, Carini M (2007) Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls. Med Res Rev 27(6):817\u2013868","journal-title":"Med Res Rev"},{"key":"1224_CR6","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/j.1582-4934.2010.01101.x","volume":"15","author":"G Aldini","year":"2011","unstructured":"Aldini G, Orioli M, Rossoni G, Savi F, Braidotti P, Vistoli G, Yeum KJ, Negrisoli G, Carini M (2011) The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats. J Cell Mol Med 15:1339\u20131354","journal-title":"J Cell Mol Med"},{"issue":"1","key":"1224_CR7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1177\/089686080702700118","volume":"27","author":"MS Alhamdani","year":"2007","unstructured":"Alhamdani MS, Al-Azzawie HF, Abbas FK (2007a) Decreased formation of advanced glycation end-products in peritoneal fluid by carnosine and related peptides. Perit Dial Int 27(1):86\u201389","journal-title":"Perit Dial Int"},{"issue":"1","key":"1224_CR8","doi-asserted-by":"crossref","first-page":"c26","DOI":"10.1159\/000106509","volume":"107","author":"MS Alhamdani","year":"2007","unstructured":"Alhamdani MS, Al-Kassir AH, Abbas FK, Jaleel NA, Al-Taee MF (2007b) Antiglycation and antioxidant effect of carnosine against glucose degradation products in peritoneal mesothelial cells. Nephron Clin Pract 107(1):c26\u2013c34","journal-title":"Nephron Clin Pract"},{"key":"1224_CR9","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.ejmech.2006.12.036","volume":"42","author":"AM Amorini","year":"2007","unstructured":"Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G (2007) Synthesis and antioxidant activity of new homocarnosine beta-cyclodextrin conjugates. Eur J Med Chem 42:910\u2013920","journal-title":"Eur J Med Chem"},{"issue":"21","key":"1224_CR10","doi-asserted-by":"crossref","first-page":"8240","DOI":"10.1021\/ja200820m","volume":"133","author":"R Appel","year":"2011","unstructured":"Appel R, Mayr H (2011) Quantification of the electrophilic reactivities of aldehydes, imines, and enones. J Am Chem Soc 133(21):8240\u20138251","journal-title":"J Am Chem Soc"},{"key":"1224_CR11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2174\/187221110793237547","volume":"4","author":"MA Babizhayev","year":"2010","unstructured":"Babizhayev MA, Yegorov YE (2010) Advanced drug delivery of N-acetylcarnosine (N-acetyl-beta-alanyl-l-histidine), carcinine (beta-alanylhistamine) and l-carnosine (beta-alanyl-l-histidine) in targeting peptide compounds as pharmacological chaperones for use in tissue engineering, human disease management and therapy: from in vitro to the clinic. Recent Pat Drug Deliv Formul 4:198\u2013230","journal-title":"Recent Pat Drug Deliv Formul"},{"key":"1224_CR12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/MJT.0b013e318195e327","volume":"16","author":"MA Babizhayev","year":"2009","unstructured":"Babizhayev MA, Micans P, Guiotto A, Kasus-Jacobi A (2009) N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of l-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patients. Am J Ther 16:517\u2013533","journal-title":"Am J Ther"},{"issue":"2","key":"1224_CR13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/CS20100501","volume":"121","author":"DP Barlovic","year":"2011","unstructured":"Barlovic DP, Soro-Paavonen A, Jandeleit-Dahm KA (2011) RAGE biology, atherosclerosis and diabetes. Clin Sci (Lond) 121(2):43\u201355","journal-title":"Clin Sci (Lond)"},{"issue":"3","key":"1224_CR14","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/jn\/137.3.589","volume":"137","author":"C Bauchart","year":"2007","unstructured":"Bauchart C, Savary-Auzeloux I, Patureau Mirand P, Thomas E, Morzel M, R\u00e9mond D (2007) Carnosine concentration of ingested meat affects carnosine net release into the portal vein of minipigs. J Nutr 137(3):589\u2013593","journal-title":"J Nutr"},{"issue":"9","key":"1224_CR15","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1515\/CCLM.2003.179","volume":"41","author":"JW Baynes","year":"2003","unstructured":"Baynes JW (2003) Chemical modification of proteins by lipids in diabetes. Clin Chem Lab Med 41(9):1159\u20131165. Review. PubMed PMID: 14598865","journal-title":"Clin Chem Lab Med"},{"issue":"12","key":"1224_CR16","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/S0891-5849(00)00228-8","volume":"28","author":"JW Baynes","year":"2000","unstructured":"Baynes JW, Thorpe SR (2000) Glycoxidation and lipoxidation in atherogenesis. Free Radic Biol Med 28(12):1708\u20131716 Review","journal-title":"Free Radic Biol Med"},{"key":"1224_CR17","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1021\/tx700185s","volume":"20","author":"G Beretta","year":"2007","unstructured":"Beretta G, Artali R, Regazzoni L, Panigati M (2007) Glycyl-histidyl-lysine (GHK) is a quencher of alpha, beta-4-hydroxy-trans-2-nonenal: a comparison with carnosine. Insights into the mechanism of reaction by electrospray ionization mass spectrometry, 1H NMR, and computational techniques. Chem Res Toxicol 20:1309\u20131314","journal-title":"Chem Res Toxicol"},{"key":"1224_CR18","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1021\/jm101394n","volume":"54","author":"M Bertinaria","year":"2011","unstructured":"Bertinaria M, Rolando B, Giorgis M, Montanaro G, Guglielmo S, Buonsanti MF, Carabelli V, Gavello D, Daniele PG, Fruttero R, Gasco A (2011) Synthesis, physicochemical characterization, and biological activities of new carnosine derivatives stable in human serum as potential neuroprotective agents. J Med Chem 54:611\u2013621","journal-title":"J Med Chem"},{"key":"1224_CR19","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ejps.2005.09.014","volume":"27","author":"RK Bhardwaj","year":"2006","unstructured":"Bhardwaj RK, Herrera-Ruiz D, Eltoukhy N, Saad M, Knipp GT (2006) The functional evaluation of human peptide\/histidine transporter 1 (hPHT1) in transiently transfected COS-7 cells. Eur J Pharm Sci 27:533\u2013542","journal-title":"Eur J Pharm Sci"},{"key":"1224_CR20","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1021\/jm048982w","volume":"48","author":"A Biegel","year":"2005","unstructured":"Biegel A, Gebauer S, Brandsch M, Neubert K (2005) Thondorf I Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+\/peptide cotransporter PEPT1. J Med Chem 48:4410\u20134419","journal-title":"J Med Chem"},{"key":"1224_CR21","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.1021\/jm0601811","volume":"49","author":"A Biegel","year":"2006","unstructured":"Biegel A, Gebauer S, Brandsch M, Neubert K, Thondorf I (2006) Structural requirements for the substrates of the H+\/peptide cotransporter PEPT2 determined by three-dimensional quantitative structure-activity relationship analysis. J Med Chem 49:4286\u20134296","journal-title":"J Med Chem"},{"key":"1224_CR22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00726-004-0142-0","volume":"28","author":"I Cacciatore","year":"2005","unstructured":"Cacciatore I, Cocco A, Costa M, Fontana M, Lucente G, Pecci L, Pinnen F (2005) Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation. Amino Acids 28:77\u201383","journal-title":"Amino Acids"},{"key":"1224_CR23","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0014-827X(99)00079-8","volume":"54","author":"A Calcagni","year":"1999","unstructured":"Calcagni A, Ciattini PG, Di Stefano A, Dupr\u00e8 S, Luisi G, Pinnen F, Rossi D, Spirito A (1999) psi(SO2NH) transition state isosteres of peptides. Synthesis and bioactivity of sulfonamido pseudopeptides related to carnosine. Farmaco 54:673\u2013677","journal-title":"Farmaco"},{"key":"1224_CR24","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/jms.517","volume":"38","author":"M Carini","year":"2003","unstructured":"Carini M, Aldini G, Beretta G, Arlandini E, Facino RM (2003) Acrolein-sequestering ability of endogenous dipeptides: characterization of carnosine and homocarnosine\/acrolein adducts by electrospray ionization tandem mass spectrometry. J Mass Spectrom 38:996\u20131006","journal-title":"J Mass Spectrom"},{"key":"1224_CR25","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1021\/la104495g","volume":"27","author":"V Castelletto","year":"2011","unstructured":"Castelletto V, Cheng G, Greenland BW, Hamley IW, Harris PJ (2011) Tuning the self-assembly of the bioactive dipeptide l-carnosine by incorporation of a bulky aromatic substituent. Langmuir 27:2980\u20132988","journal-title":"Langmuir"},{"key":"1224_CR26","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/sj.bjp.0705978","volume":"143","author":"Z Chen","year":"2004","unstructured":"Chen Z, Sakurai E, Hu W, Jin C, Kiso Y, Kato M, Watanabe T, Wei E, Yanai K (2004) Pharmacological effects of carcinine on histaminergic neurons in the brain. Br J Pharmacol 143:573\u2013580","journal-title":"Br J Pharmacol"},{"issue":"5","key":"1224_CR27","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1111\/j.1471-4159.2006.04181.x","volume":"99","author":"K Chen","year":"2006","unstructured":"Chen K, Maley J, Yu PH (2006) Potential inplications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis. J Neurochem 99(5):1413\u20131424","journal-title":"J Neurochem"},{"issue":"1","key":"1224_CR28","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejphar.2010.09.033","volume":"650","author":"J Cheng","year":"2011","unstructured":"Cheng J, Wang F, Yu DF, Wu PF, Chen JG (2011) The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking\/mitochondrial dysfunction\/reactive oxygen species\/MAPK pathway in neurons. Eur J Pharmacol 650(1):184\u2013194 Epub 2010 Sep 21","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"1224_CR29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/187152911798347025","volume":"11","author":"MM Ciulla","year":"2011","unstructured":"Ciulla MM, Paliotti R, Carini M, Magrini F, Aldini G (2011) Fibrosis, enzymatic and non-enzymatic cross-links in hypertensive heart disease. Cardiovasc Hematol Disord Drug Targets 11(2):61\u201373","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"key":"1224_CR30","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.tetasy.2009.05.040","volume":"20","author":"P D\u2019Arrigo","year":"2009","unstructured":"D\u2019Arrigo P, Kanerva LT, Li XG, Saraceno C, Servi S, Tessaro D (2009) Enzymatic synthesis of carnosine derivatives catalysed by Burkholderia cepacia lipase. Tetrahedron Asymmetry 20:1641\u20131645","journal-title":"Tetrahedron Asymmetry"},{"issue":"9","key":"1224_CR31","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.bcp.2008.08.011","volume":"76","author":"KC David","year":"2008","unstructured":"David KC, Scott RH, Nixon GF (2008) Advanced glycation endproducts induce a proliferative response in vascular smooth muscle cells via altered calcium signaling. Biochem Pharmacol 76(9):1110\u20131120","journal-title":"Biochem Pharmacol"},{"key":"1224_CR32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2165\/11530310-000000000-00000","volume":"40","author":"W Derave","year":"2010","unstructured":"Derave W, Everaert I, Beeckman S, Baguet A (2010) Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training. Sports Med 40:247\u2013263","journal-title":"Sports Med"},{"issue":"10","key":"1224_CR33","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s11064-005-8799-7","volume":"30","author":"D Dobrota","year":"2005","unstructured":"Dobrota D, Fedorova T, Stvolinsky S, Babusikova E, Likavcanova K, Drgova A, Strapkova A, Boldyrev A (2005) Carnosine protects the brain of rats and Mongolian gerbils against ischemic injury: after-stroke-effect. Neurochem Res 30(10):1283\u20131288","journal-title":"Neurochem Res"},{"issue":"6","key":"1224_CR34","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/ard.61.6.488","volume":"61","author":"S Drinda","year":"2002","unstructured":"Drinda S, Franke S, Canet CC, Petrow P, Br\u00e4uer R, H\u00fcttich C, Stein G, Hein G (2002) Identification of the advanced glycation end products N(epsilon)-carboxymethyllysine in the synovial tissue of patients with rheumatoid arthritis. Ann Rheum Dis 61(6):488\u2013492","journal-title":"Ann Rheum Dis"},{"key":"1224_CR35","doi-asserted-by":"crossref","first-page":"9346","DOI":"10.1074\/jbc.M109.095505","volume":"285","author":"J Drozak","year":"2010","unstructured":"Drozak J, Veiga-da-Cunha M, Vertommen D, Stroobant V, Van Schaftingen E (2010) Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1). J Biol Chem 285:9346\u20139356","journal-title":"J Biol Chem"},{"issue":"5","key":"1224_CR36","doi-asserted-by":"crossref","first-page":"R201","DOI":"10.1186\/ar3173","volume":"12","author":"R El-Bikai","year":"2010","unstructured":"El-Bikai R, Welman M, Margaron Y, C\u00f4t\u00e9 JF, Macqueen L, Buschmann MD, Fahmi H, Shi Q, Maghni K, Fernandes JC, Benderdour M (2010) Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis. Arthr Res Ther 12(5):R201","journal-title":"Arthr Res Ther"},{"issue":"2","key":"1224_CR37","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3233\/JAD-2010-100960","volume":"22","author":"G Ellis","year":"2010","unstructured":"Ellis G, Fang E, Maheshwari M, Roltsch E, Holcomb L, Zimmer D, Martinez D, Murray IV (2010) Lipid oxidation and modification of amyloid-\u03b2 (A\u03b2) in vitro and in vivo. J Alzheimers Dis 22(2):593\u2013607","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"1224_CR38","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000322087","volume":"57","author":"TH Fleming","year":"2011","unstructured":"Fleming TH, Humpert PM, Nawroth PP, Bierhaus A (2011) Reactive metabolites and AGE\/RAGE-mediated cellular dysfunction affect the aging process\u2014a mini-review. Gerontology 57(5):435\u2013443","journal-title":"Gerontology"},{"key":"1224_CR39","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.freeradbiomed.2008.08.026","volume":"45","author":"S Galvani","year":"2008","unstructured":"Galvani S, Coatrieux C, Elbaz M, Grazide MH, Thiers JC, Parini A, Uchida K, Kamar N, Rostaing L, Baltas M, Salvayre R, N\u00e8gre-Salvayre A (2008) Carbonyl scavenger and antiatherogenic effects of hydrazine derivatives. Free Radic Biol Med 45:1457\u20131467","journal-title":"Free Radic Biol Med"},{"key":"1224_CR40","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1113\/jphysiol.1991.sp018673","volume":"439","author":"ML Gardner","year":"1991","unstructured":"Gardner ML, Illingworth KM, Kelleher J, Wood D (1991) Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose. J Physiol 439:411\u2013422","journal-title":"J Physiol"},{"key":"1224_CR41","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1742-4658.2009.07528.x","volume":"277","author":"S Geissler","year":"2010","unstructured":"Geissler S, Zwarg M, Kn\u00fctter I, Markwardt F, Brandsch M (2010) The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters. FEBS J 277:790\u2013795","journal-title":"FEBS J"},{"key":"1224_CR42","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.febslet.2008.11.052","volume":"583","author":"M Gorlero","year":"2009","unstructured":"Gorlero M, Wieczorek R, Adamala K, Giorgi A, Schinin\u00e0 ME, Stano P, Luisi PL (2009) Ser-His catalyses the formation of peptides and PNAs. FEBS Lett 583:153\u2013156","journal-title":"FEBS Lett"},{"issue":"10","key":"1224_CR43","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3109\/10715762.2010.498477","volume":"44","author":"F Gu\u00e9raud","year":"2010","unstructured":"Gu\u00e9raud F, Atalay M, Bresgen N, Cipak A, Eckl PM, Huc L, Jouanin I, Siems W, Uchida K (2010) Chemistry and biochemistry of lipid peroxidation products. Free Radic Res 44(10):1098\u20131124 Review","journal-title":"Free Radic Res"},{"key":"1224_CR44","doi-asserted-by":"crossref","first-page":"6156","DOI":"10.1021\/jm050507q","volume":"48","author":"A Guiotto","year":"2005","unstructured":"Guiotto A, Calderan A, Ruzza P, Osler A, Rubini C, Jo DG, Mattson MP, Borin G (2005) Synthesis and evaluation of neuroprotective alpha, beta-unsaturated aldehyde scavenger histidyl-containing analogues of carnosine. J Med Chem 48:6156\u20136161","journal-title":"J Med Chem"},{"key":"1224_CR45","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.1016\/j.bmc.2007.06.029","volume":"15","author":"A Guiotto","year":"2007","unstructured":"Guiotto A, Ruzza P, Babizhayev MA, Calderan A (2007) Malondialdehyde scavenging and aldose-derived Schiff bases\u2019 transglycation properties of synthetic histidyl-hydrazide carnosine analogs. Bioorg Med Chem 15:6158\u20136163","journal-title":"Bioorg Med Chem"},{"key":"1224_CR46","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1002\/cber.19000330275","volume":"33","author":"W Gulewitsch","year":"1900","unstructured":"Gulewitsch W, Amiradzibi S (1900) Uber das carnosine, eine neue organische Base des Fleischextraktes. Ber Dtsch Chem Ges 33:1902\u20131903","journal-title":"Ber Dtsch Chem Ges"},{"key":"1224_CR47","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1021\/jp9810825","volume":"102","author":"NE Hall","year":"1998","unstructured":"Hall NE, Smith BJ (1998) High-level ab initio molecular orbital calculations of imine formation. J Phys Chem A 102:4930\u20134938","journal-title":"J Phys Chem A"},{"key":"1224_CR48","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2165\/00063030-200519030-00003","volume":"19","author":"JH Hamman","year":"2005","unstructured":"Hamman JH, Enslin GM, Kotz\u00e9 AF (2005) Oral delivery of peptide drugs: barriers and developments. BioDrugs 19:165\u2013177","journal-title":"BioDrugs"},{"key":"1224_CR49","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1043-4526(09)57003-9","volume":"57","author":"AR Hipkiss","year":"2009","unstructured":"Hipkiss AR (2009) Carnosine and its possible roles in nutrition and health. Adv Food Nutr Res 57:87\u2013154 Review. PubMed PMID: 19595386","journal-title":"Adv Food Nutr Res"},{"issue":"3","key":"1224_CR50","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/A:1010057412184","volume":"1","author":"AR Hipkiss","year":"2000","unstructured":"Hipkiss AR, Brownson C (2000) Carnosine reacts with protein carbonyl groups: nother possible role for the anti-ageing peptide? Biogerontology 1(3):217\u2013223","journal-title":"Biogerontology"},{"issue":"854","key":"1224_CR51","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1749-6632.1998.tb09890.x","volume":"20","author":"AR Hipkiss","year":"1998","unstructured":"Hipkiss AR, Preston JE, Himsworth DT, Worthington VC, Keown M, Michaelis J, Lawrence J, Mateen A, Allende L, Eagles PA, Abbott NJ (1998) Pluripotent protective effects of carnosine, a naturally occurring dipeptide. Ann NY Acad Sci 20(854):37\u201353","journal-title":"Ann NY Acad Sci"},{"issue":"13","key":"1224_CR52","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0047-6374(01)00272-X","volume":"122","author":"AR Hipkiss","year":"2001","unstructured":"Hipkiss AR, Brownson C, Carrier MJ (2001) Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups. Mech Ageing Dev 122(13):1431\u20131445","journal-title":"Mech Ageing Dev"},{"key":"1224_CR53","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0009-8981(91)90073-L","volume":"196","author":"MC Jackson","year":"1991","unstructured":"Jackson MC, Kucera CM, Lenney JF (1991) Purification and properties of human serum carnosinase. Clin Chim Acta 196:193\u2013205","journal-title":"Clin Chim Acta"},{"key":"1224_CR54","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/poc.1251","volume":"20","author":"P Jaramillo","year":"2007","unstructured":"Jaramillo P, Perez P, Fuentealba P (2007) Relationship between basicity and nucleophilicity. J Phys Org Chem 20:1050\u20131057","journal-title":"J Phys Org Chem"},{"key":"1224_CR55","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2133\/dmpk.23.236","volume":"23","author":"MA Kamal","year":"2008","unstructured":"Kamal MA, Keep RF, Smith DE (2008) Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity. Drug Metab Pharmacokinet 23:236\u2013242","journal-title":"Drug Metab Pharmacokinet"},{"key":"1224_CR56","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1152\/ajpregu.90744.2008","volume":"296","author":"MA Kamal","year":"2009","unstructured":"Kamal MA, Jiang H, Hu Y, Keep RF, Smith DE (2009) Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice. Am J Physiol Regul Integr Comp Physiol 296:986\u2013991","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"1224_CR57","first-page":"89","volume":"12","author":"GI Klebanov","year":"1998","unstructured":"Klebanov GI, Teselkin YO, Babenkova IV, Lyubitsky OB, Rebrova OY, Boldyrev AA, Vladimirov YA (1998) Effect of carnosine and its components on free-radical reactions. Membr Cell Biol 12(1):89\u201399","journal-title":"Membr Cell Biol"},{"issue":"2","key":"1224_CR58","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1124\/jpet.106.110122","volume":"319","author":"H Kurata","year":"2006","unstructured":"Kurata H, Fujii T, Tsutsui H, Katayama T, Ohkita M, Takaoka M, Tsuruoka N, Kiso Y, Ohno Y, Fujisawa Y, Shokoji T, Nishiyama A, Abe Y, Matsumura Y (2006) Renoprotective effects of l-carnosine on ischemia\/reperfusion-induced renal injury in rats. J Pharmacol Exp Ther 319(2):640\u2013647","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"1224_CR59","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0026-0495(97)90240-7","volume":"46","author":"S Lal","year":"1997","unstructured":"Lal S, Randall WC, Taylor AH, Kappler F, Walker M, Brown TR, Szwergold BS (1997) Fructose-3-phosphate production and polyol pathway metabolism in diabetic rat hearts. Metabolism 46(11):1333\u20131338","journal-title":"Metabolism"},{"key":"1224_CR60","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jinorgbio.2010.10.014","volume":"105","author":"V Lanza","year":"2011","unstructured":"Lanza V, Bellia F, D\u2019Agata R, Grasso G, Rizzarelli E, Vecchio G (2011) New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes. J Inorg Biochem 105:181\u2013188","journal-title":"J Inorg Biochem"},{"issue":"1","key":"1224_CR61","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/jmcc.1998.0850","volume":"31","author":"JW Lee","year":"1999","unstructured":"Lee JW, Miyawaki H, Bobst EV, Hester JD, Ashraf M, Bobst AM (1999) Improved functional recovery of ischemic rat hearts due to singlet oxygen scavengers histidine and carnosine. J Mol Cell Cardiol 31(1):113\u2013121","journal-title":"J Mol Cell Cardiol"},{"issue":"1\u20132","key":"1224_CR62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ejphar.2005.02.010","volume":"513","author":"YT Lee","year":"2005","unstructured":"Lee YT, Hsu CC, Lin MH, Liu KS, Yin MC (2005) Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation. Eur J Pharmacol 513(1\u20132):145\u2013150","journal-title":"Eur J Pharmacol"},{"key":"1224_CR63","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0009-8981(82)90166-8","volume":"123","author":"JF Lenney","year":"1982","unstructured":"Lenney JF, George RP, Weiss AM, Kucera CM, Chan PW, Rinzler GS (1982) Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium. Clin Chim Acta 123:221\u2013231","journal-title":"Clin Chim Acta"},{"key":"1224_CR64","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1042\/bj2280653","volume":"228","author":"JF Lenney","year":"1985","unstructured":"Lenney JF, Peppers SC, Kucera-Orallo CM, George RP (1985) Characterization of human tissue carnosinase. Biochem J 228:653\u2013660","journal-title":"Biochem J"},{"issue":"12","key":"1224_CR65","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1021\/tx034160a","volume":"16","author":"Y Liu","year":"2003","unstructured":"Liu Y, Xu G, Sayre LM (2003) Carnosine inhibits (E)-4-hydroxy-2-nonenal-induced protein cross-linking: structural characterization of carnosine-HNE adducts. Chem Res Toxicol 16(12):1589\u20131597","journal-title":"Chem Res Toxicol"},{"key":"1224_CR66","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1021\/tx900147g","volume":"22","author":"RM LoPachin","year":"2009","unstructured":"LoPachin RM, Gavin T, Petersen DR, Barber DS (2009) Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation. Chem Res Toxicol 22:1499\u20131508","journal-title":"Chem Res Toxicol"},{"key":"1224_CR67","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00726-007-0597-x","volume":"35","author":"Y Ma","year":"2008","unstructured":"Ma Y, Chen X, Sun M, Wan R, Zhu C, Li Y, Zhao Y (2008) DNA cleavage function of seryl-histidine dipeptide and its application. Amino Acids 35:251\u2013256","journal-title":"Amino Acids"},{"key":"1224_CR68","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1351\/pac200577111807","volume":"77","author":"H Mayr","year":"2005","unstructured":"Mayr H, Ofial AR (2005) Kinetics of electrophile-nucleophile combinations: a general approach to polar organic reactivity. Pure Appl Chem 77:1807\u20131821","journal-title":"Pure Appl Chem"},{"key":"1224_CR69","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1098\/rstb.2008.0139","volume":"364","author":"D Meredith","year":"2009","unstructured":"Meredith D (2009) Review: the mammalian proton-coupled peptide cotransporter PepT1: sitting on the transporter-channel fence? Phil Trans R Soc Lond B Biol Sci 364:203\u2013207","journal-title":"Phil Trans R Soc Lond B Biol Sci"},{"key":"1224_CR70","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/clpt.2010.355","volume":"89","author":"IG Metushi","year":"2011","unstructured":"Metushi IG, Cai P, Zhu X, Nakagawa T, Uetrecht JP (2011) A fresh look at the mechanism of isoniazid-induced hepatotoxicity. Clin Pharmacol Ther 89:911\u2013914","journal-title":"Clin Pharmacol Ther"},{"key":"1224_CR71","doi-asserted-by":"crossref","first-page":"14450","DOI":"10.1021\/jp101592m","volume":"114","author":"GF Moore","year":"2010","unstructured":"Moore GF, Hambourger M, Kodis G, Michl W, Gust D, Moore TA, Moore AL (2010) Effects of protonation state on a tyrosine-histidine bioinspired redox mediator. J Phys Chem B 114:14450\u201314457","journal-title":"J Phys Chem B"},{"issue":"3","key":"1224_CR72","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.freeradbiomed.2010.11.027","volume":"50","author":"T N\u00e4sstr\u00f6m","year":"2011","unstructured":"N\u00e4sstr\u00f6m T, Fagerqvist T, Barbu M, Karlsson M, Nikolajeff F, Kasrayan A, Ekberg M, Lannfelt L, Ingelsson M, Bergstr\u00f6m J (2011) The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of \u03b1-synuclein oligomers with distinct biochemical, morphological, and functional properties. Free Radic Biol Med 50(3):428\u2013437","journal-title":"Free Radic Biol Med"},{"key":"1224_CR73","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1042\/BST0391353","volume":"39","author":"S Newstead","year":"2011","unstructured":"Newstead S (2011) Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) family. Biochem Soc Trans 39:1353\u20131358","journal-title":"Biochem Soc Trans"},{"issue":"28","key":"1224_CR74","doi-asserted-by":"crossref","first-page":"21177","DOI":"10.1074\/jbc.M003263200","volume":"275","author":"JM Onorato","year":"2000","unstructured":"Onorato JM, Jenkins AJ, Thorpe SR, Baynes JW (2000) Pyridoxamine, an inhibitor of advanced glycation reactions, also inhibits advanced lipoxidation reactions. Mechanism of action of pyridoxamine. J Biol Chem 275(28):21177\u201321184","journal-title":"J Biol Chem"},{"key":"1224_CR75","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jchromb.2005.04.025","volume":"827","author":"M Orioli","year":"2005","unstructured":"Orioli M, Aldini G, Beretta G, Facino RM, Carini M (2005) LC-ESI-MS\/MS determination of 4-hydroxy-trans-2-nonenal Michael adducts with cysteine and histidine-containing peptides as early markers of oxidative stress in excitable tissues. J Chromatogr B Anal Technol Biomed Life Sci 827:109\u2013118","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"issue":"23","key":"1224_CR76","doi-asserted-by":"crossref","first-page":"9174","DOI":"10.1021\/ac7016184","volume":"79","author":"M Orioli","year":"2007","unstructured":"Orioli M, Aldini G, Benfatto MC, Facino RM, Carini M (2007) HNE Michael adducts to histidine and histidine-containing peptides as biomarkers of lipid-derived carbonyl stress in urines: LC-MS\/MS profiling in Zucker obese rats. Anal Chem 79(23):9174\u20139184","journal-title":"Anal Chem"},{"key":"1224_CR77","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/cmdc.201100042","volume":"6","author":"M Orioli","year":"2011","unstructured":"Orioli M, Vistoli G, Regazzoni L, Pedretti A, Lapolla A, Rossoni G, Canevotti R, Gamberoni L, Previtali M, Carini M, Aldini G (2011) Design, synthesis, ADME properties, and pharmacological activities of \u03b2-alanyl-d-histidine (d-carnosine) prodrugs with improved bioavailability. ChemMedChem 6:1269\u20131282","journal-title":"ChemMedChem"},{"key":"1224_CR78","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jinorgbio.2003.09.009","volume":"98","author":"K Osz","year":"2004","unstructured":"Osz K, V\u00e1rnagy K, S\u00fcli-Vargha H, Cs\u00e1mpay A, Sanna D, Micera G, S\u00f3v\u00e1g\u00f3 I (2004) Acid-base properties and copper(II) complexes of dipeptides containing histidine and additional chelating bis(imidazol-2-yl) residues. J Inorg Biochem 98:24\u201332","journal-title":"J Inorg Biochem"},{"issue":"1\u20132","key":"1224_CR79","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cbi.2011.01.007","volume":"192","author":"R Pamplona","year":"2011","unstructured":"Pamplona R (2011) Advanced lipoxidation end-products. Chem Biol Interact 192(1\u20132):14\u201320","journal-title":"Chem Biol Interact"},{"issue":"12","key":"1224_CR80","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1021\/jf047934h","volume":"53","author":"YJ Park","year":"2005","unstructured":"Park YJ, Volpe SL, Decker EA (2005) Quantitation of carnosine in humans plasma after dietary consumption of beef. J Agric Food Chem 53(12):4736\u20134739","journal-title":"J Agric Food Chem"},{"key":"1224_CR81","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/cmdc.200800184","volume":"3","author":"A Pedretti","year":"2008","unstructured":"Pedretti A, De Luca L, Marconi C, Negrisoli G, Aldini G, Vistoli G (2008) Modeling of the intestinal peptide transporter hPepT1 and analysis of its transport capacities by docking and pharmacophore mapping. ChemMedChem 3:1913\u20131921","journal-title":"ChemMedChem"},{"key":"1224_CR82","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1016\/j.bmc.2011.06.027","volume":"19","author":"A Pedretti","year":"2011","unstructured":"Pedretti A, De Luca L, Marconi C, Regazzoni L, Aldini G, Vistoli G (2011) Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping. Bioorg Med Chem 19:4544\u20134551","journal-title":"Bioorg Med Chem"},{"key":"1224_CR83","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0305-0491(00)00279-0","volume":"127","author":"A Pegova","year":"2000","unstructured":"Pegova A, Abe H, Boldyrev A (2000) Hydrolysis of carnosine and related compounds by mammalian carnosinases. Comp Biochem Physiol B Biochem Mol Biol 127:443\u2013446","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"issue":"2","key":"1224_CR84","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1556\/ABiol.60.2009.2.1","volume":"60","author":"C Pekcetin","year":"2009","unstructured":"Pekcetin C, Kiray M, Ergur BU, Tugyan K, Bagriyanik HA, Erbil G, Baykara B, Camsari UM (2009) Carnosine attenuates oxidative stress and apoptosis in transient cerebral ischemia in rats. Acta Biol Hung 60(2):137\u2013148","journal-title":"Acta Biol Hung"},{"issue":"24","key":"1224_CR85","doi-asserted-by":"crossref","first-page":"7925","DOI":"10.1128\/AEM.01369-10","volume":"76","author":"ED Pepper","year":"2010","unstructured":"Pepper ED, Farrell MJ, Nord G, Finkel SE (2010) Antiglycation effects of carnosine and other compounds on the long-term survival of Escherichia coli. Appl Environ Microbiol 76(24):7925\u20137930 [Epub 15 Oct 2010]","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"1224_CR86","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000331721","volume":"28","author":"F Pfister","year":"2011","unstructured":"Pfister F, Riedl E, Wang Q, vom Hagen F, Deinzer M, Harmsen MC, Molema G, Yard B, Feng Y, Hammes HP (2011) Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy. Cell Physiol Biochem 28(1):125\u2013136","journal-title":"Cell Physiol Biochem"},{"issue":"3","key":"1224_CR87","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10930-011-9307-3","volume":"30","author":"J Pietkiewicz","year":"2011","unstructured":"Pietkiewicz J, Bronowicka-Szyde\u0142ko A, Dzierzba K, Danielewicz R, Gamian A (2011) Glycation of the muscle-specific enolase by reactive carbonyls: effect of temperature and the protection role of carnosine, pyridoxamine and phosphatidylserine. Protein J 30(3):149\u2013158","journal-title":"Protein J"},{"issue":"5","key":"1224_CR88","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.febslet.2007.01.082","volume":"581","author":"I Rashid","year":"2007","unstructured":"Rashid I, van Reyk DM, Davies MJ (2007) Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro. FEBS Lett 581(5):1067\u20131070","journal-title":"FEBS Lett"},{"key":"1224_CR89","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1007\/s00216-011-4668-1","volume":"399","author":"A Reis","year":"2011","unstructured":"Reis A, Fonseca C, Maciel E, Domingues P, Domingues MR (2011) Influence of amino acid relative position on the oxidative modification of histidine and glycine peptides. Anal Bioanal Chem 399:2779\u20132794","journal-title":"Anal Bioanal Chem"},{"issue":"2","key":"1224_CR90","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000331740","volume":"28","author":"E Riedl","year":"2011","unstructured":"Riedl E, Pfister F, Braunagel M, Brinkk\u00f6tter P, Sternik P, Deinzer M, Bakker SJ, Henning RH, van den Born J, Kr\u00e4mer BK, Navis G, Hammes HP, Yard B, Koeppel H (2011) Carnosine prevents apoptosis of glomerular cells and podocyte loss in STZ diabetic rats. Cell Physiol Biochem 28(2):279\u2013288","journal-title":"Cell Physiol Biochem"},{"key":"1224_CR91","doi-asserted-by":"crossref","first-page":"8906","DOI":"10.1039\/c0dt00163e","volume":"39","author":"U Rychlewska","year":"2010","unstructured":"Rychlewska U, Warzajtis B, Glisi\u0107 BD, Zivkovi\u0107 MD, Rajkovi\u0107 S, Djuran MI (2010) Monocationic gold(III) Gly-l-His and l-Ala-l-His dipeptide complexes: crystal structures arising from solvent free and solvent-containing crystal formation and structural modifications tuned by counter-anions. Dalton Trans 39:8906\u20138913","journal-title":"Dalton Trans"},{"key":"1224_CR92","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/j.bmc.2009.02.018","volume":"17","author":"NA Sasaki","year":"2009","unstructured":"Sasaki NA, Garcia-Alvarez MC, Wang Q, Ermolenko L, Franck G, Nhiri N, Martin MT, Audic N, Potier P (2009) N-terminal 2,3-diaminopropionic acid (Dap) peptides as efficient methylglyoxal scavengers to inhibit advanced glycation endproduct (AGE) formation. Bioorg Med Chem 17:2310\u20132320","journal-title":"Bioorg Med Chem"},{"issue":"6","key":"1224_CR93","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1021\/bi061853s","volume":"46","author":"SJ Siegel","year":"2007","unstructured":"Siegel SJ, Bieschke J, Powers ET, Kelly JW (2007) The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation. Biochemistry 46(6):1503\u20131510","journal-title":"Biochemistry"},{"issue":"10","key":"1224_CR94","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1167\/iovs.10-5881","volume":"51","author":"AW Stitt","year":"2010","unstructured":"Stitt AW (2010) AGEs and diabetic retinopathy. Invest Ophthalmol Vis Sci 51(10):4867\u20134874","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1224_CR95","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10571-009-9462-7","volume":"30","author":"SL Stvolinsky","year":"2010","unstructured":"Stvolinsky SL, Bulygina ER, Fedorova TN, Meguro K, Sato T, Tyulina OV, Abe H, Boldyrev AA (2010) Biological activity of novel synthetic derivatives of carnosine. Cell Mol Neurobiol 30:395\u2013404","journal-title":"Cell Mol Neurobiol"},{"issue":"4","key":"1224_CR96","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1039\/b006901i","volume":"2","author":"DC Tahmassebi","year":"2001","unstructured":"Tahmassebi DC (2001) Substituent effects on the stability of carbodiimides. J Chem Soc Perkin Trans 2(4):613\u2013617","journal-title":"J Chem Soc Perkin Trans"},{"issue":"11","key":"1224_CR97","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.2174\/1389450111009011468","volume":"11","author":"M Takeuchi","year":"2010","unstructured":"Takeuchi M, Takino J, Yamagishi S (2010) Involvement of the toxic AGEs (TAGE)-RAGE system in the pathogenesis of diabetic vascular complications: a novel therapeutic strategy. Curr Drug Targets 11(11):1468\u20131482","journal-title":"Curr Drug Targets"},{"issue":"4","key":"1224_CR98","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0306-3623(95)02054-3","volume":"27","author":"PJ Thornalley","year":"1996","unstructured":"Thornalley PJ (1996) Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification\u2014a role in pathogenesis and antiproliferative chemotherapy. Gen Pharmacol 27(4):565\u2013573","journal-title":"Gen Pharmacol"},{"key":"1224_CR99","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1021\/jf803376d","volume":"57","author":"S Toelstede","year":"2009","unstructured":"Toelstede S, Dunkel A, Hofmann T (2009) A series of kokumi peptides impart the long-lasting mouthfulness of matured Gouda cheese. J Agric Food Chem 57:1440\u20131448","journal-title":"J Agric Food Chem"},{"key":"1224_CR100","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1124\/jpet.301.3.812","volume":"301","author":"H Toyobuku","year":"2002","unstructured":"Toyobuku H, Sai Y, Tamai I, Tsuji A (2002) Enhanced delivery of drugs to the liver by adenovirus-mediated heterologous expression of the human oligopeptide transporter PEPT1. J Pharmacol Exp Ther 301:812\u2013819","journal-title":"J Pharmacol Exp Ther"},{"issue":"1\u20132","key":"1224_CR101","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0009-8981(00)00389-2","volume":"303","author":"Z Turk","year":"2001","unstructured":"Turk Z, Ljubic S, Turk N, Benko B (2001) Detection of autoantibodies against advanced glycation endproducts and AGE-immune complexes in serum of patients with diabetes mellitus. Clin Chim Acta 303(1\u20132):105\u2013115","journal-title":"Clin Chim Acta"},{"key":"1224_CR102","doi-asserted-by":"crossref","first-page":"27289","DOI":"10.1074\/jbc.M801657200","volume":"283","author":"H Unno","year":"2008","unstructured":"Unno H, Yamashita T, Ujita S, Okumura N, Otani H, Okumura A, Nagai K, Kusunoki M (2008) Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2. J Biol Chem 283:27289\u201327299","journal-title":"J Biol Chem"},{"issue":"3","key":"1224_CR103","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1194\/jlr.M200370-JLR200","volume":"44","author":"G Virella","year":"2003","unstructured":"Virella G, Thorpe SR, Alderson NL, Stephan EM, Atchley D, Wagner F, DCCT\/EDIC Research Group (2003) Autoimmune response to advanced glycosylation end-products of human LDL. J Lipid Res 44(3):487\u2013493","journal-title":"J Lipid Res"},{"key":"1224_CR104","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1021\/jm0602099","volume":"49","author":"G Vistoli","year":"2006","unstructured":"Vistoli G, Pedretti A, Cattaneo M, Aldini G, Testa B (2006) Homology modeling of human serum carnosinase, a potential medicinal target, and MD simulations of its allosteric activation by citrate. J Med Chem 49:3269\u20133277","journal-title":"J Med Chem"},{"key":"1224_CR105","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/cmdc.200800433","volume":"4","author":"G Vistoli","year":"2009","unstructured":"Vistoli G, Orioli M, Pedretti A, Regazzoni L, Canevotti R, Negrisoli G, Carini M, Aldini G (2009) Design, synthesis, and evaluation of carnosine derivatives as selective and efficient sequestering agents of cytotoxic reactive carbonyl species. ChemMedChem 4:967\u2013975","journal-title":"ChemMedChem"},{"key":"1224_CR106","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s10822-010-9373-1","volume":"24","author":"G Vistoli","year":"2010","unstructured":"Vistoli G, Pedretti A, Mazzolari A, Testa B (2010a) Homology modeling and metabolism prediction of human carboxylesterase-2 (hCES2) using docking analyses by GriDock\u2014a parallelized tool based on AutoDock 4.0. J Comp Aided Mol Des 24:771\u2013787","journal-title":"J Comp Aided Mol Des"},{"key":"1224_CR107","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.bmc.2009.10.052","volume":"18","author":"G Vistoli","year":"2010","unstructured":"Vistoli G, Pedretti A, Mazzolari A, Testa B (2010b) In silico prediction of human carboxylesterase-1 (hCES1) metabolism combining docking analyses and MD simulations. Bioorg Med Chem 18:320\u2013329","journal-title":"Bioorg Med Chem"},{"key":"1224_CR108","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/j.peptides.2010.07.013","volume":"31","author":"Z Wang","year":"2010","unstructured":"Wang Z, Watanabe S, Kobayashi Y, Tanaka M, Matsui T (2010) Trp-His, a vasorelaxant di-peptide, can inhibit extracellular Ca2+ entry to rat vascular smooth muscle cells through blockade of dihydropyridine-like L-type Ca2+ channels. Peptides 31:2060\u20132066","journal-title":"Peptides"},{"issue":"6","key":"1224_CR109","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1159\/000108104","volume":"27","author":"ME Williams","year":"2007","unstructured":"Williams ME, Bolton WK, Khalifah RG, Degenhardt TP, Schotzinger RJ, McGill JB (2007) Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy. Am J Nephrol 27(6):605\u2013614","journal-title":"Am J Nephrol"},{"issue":"4","key":"1224_CR110","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.exger.2010.11.007","volume":"46","author":"S Yamagishi","year":"2011","unstructured":"Yamagishi S (2011) Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes. Exp Gerontol 46(4):217\u2013224","journal-title":"Exp Gerontol"},{"issue":"3","key":"1224_CR111","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00726-009-0291-2","volume":"38","author":"KJ Yeum","year":"2010","unstructured":"Yeum KJ, Orioli M, Regazzoni L, Carini M, Rasmussen H, Russell RM, Aldini G (2010) Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans. Amino Acids 38(3):847\u2013858. Epub 19 Apr 2009. PubMed PMID: 19381778","journal-title":"Amino Acids"},{"issue":"1","key":"1224_CR112","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1021\/jf980780j","volume":"47","author":"S Zhou","year":"1999","unstructured":"Zhou S, Decker EA (1999) Ability of carnosine and other skeletal muscle components to quench unsaturated aldehydic lipid oxidation products. J Agric Food Chem 47(1):51\u201355","journal-title":"J Agric Food Chem"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-012-1224-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00726-012-1224-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-012-1224-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-012-1224-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T03:41:40Z","timestamp":1744170100000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00726-012-1224-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,28]]},"references-count":112,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["1224"],"URL":"https:\/\/doi.org\/10.1007\/s00726-012-1224-z","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"type":"print","value":"0939-4451"},{"type":"electronic","value":"1438-2199"}],"subject":[],"published":{"date-parts":[[2012,1,28]]},"assertion":[{"value":"17 October 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}