{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:11:55Z","timestamp":1777421515496,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T00:00:00Z","timestamp":1336089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s00726-012-1305-z","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T10:05:39Z","timestamp":1336039539000},"page":"2279-2283","source":"Crossref","is-referenced-by-count":39,"title":["Chemical synthesis and biological evaluation of an antimicrobial peptide gonococcal growth inhibitor"],"prefix":"10.1007","volume":"43","author":[{"given":"John D.","family":"Wade","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Akhter","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond M.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,4]]},"reference":[{"key":"1305_CR1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00726-006-0387-x","volume":"33","author":"S Abel Rahman","year":"2007","unstructured":"Abel Rahman S, El-Kafrawy A, Hattaba A, Anwer MF (2007) Optimization of solid-phase synthesis of difficult peptide sequences via comparison between different improved approaches. Amino Acids 33:531\u2013536","journal-title":"Amino Acids"},{"key":"1305_CR2","doi-asserted-by":"crossref","unstructured":"Bathgate RAD, Lin F, Hanson NF, Otvos Jr L, Guidolin A, Giannakis C, Bastiras S, Layfield S, Ferraro T, Ma S, Zhao C, Gundlach AL, Samuel CS, Tregear GW, Wade JD (2006) Relaxin-3: improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo. Biochemistry 45:1043\u20131053","DOI":"10.1021\/bi052233e"},{"key":"1305_CR3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1128\/AAC.22.2.277","volume":"22","author":"R Beaudet","year":"1982","unstructured":"Beaudet R, Bisaillon JG, Saheb SA, Sylvestre M (1982) Production, purification, and preliminary characterization of a gonococcal growth inhibitor produced by a coagulase-negative staphylococcus isolated from the urogenital flora. Antimicrob Agents Chemother 22:277\u2013283","journal-title":"Antimicrob Agents Chemother"},{"key":"1305_CR4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/10408410802143808","volume":"34","author":"RM Dawson","year":"2008","unstructured":"Dawson RM, Liu CQ (2008) Properties and applications of antimicrobial peptides in biodefense against biological warfare threat agents. Crit Rev Microbiol 34:89\u2013107","journal-title":"Crit Rev Microbiol"},{"key":"1305_CR5","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.ijantimicag.2010.08.011","volume":"36","author":"RM Dawson","year":"2010","unstructured":"Dawson RM, Liu CQ (2010) Disulphide bonds of the peptide protegrin-1 are not essential for antimicrobial activity and haemolytic activity. Int J Antimicrob Agents 36:579\u2013580","journal-title":"Int J Antimicrob Agents"},{"key":"1305_CR6","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ijantimicag.2011.01.007","volume":"37","author":"RM Dawson","year":"2011","unstructured":"Dawson RM, Liu CQ (2011) Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. Int J Antimicrob Agents 37:432\u2013437","journal-title":"Int J Antimicrob Agents"},{"key":"1305_CR7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ijantimicag.2010.06.038","volume":"36","author":"RM Dawson","year":"2010","unstructured":"Dawson RM, McAllister J, Liu CQ (2010) Characterisation and evaluation of synthetic antimicrobial peptides against Bacillus globigii, Bacillus anthracis and Burkholderia thailandensis. Int J Antimicrob Agents 36:359\u2013363","journal-title":"Int J Antimicrob Agents"},{"key":"1305_CR8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ijantimicag.2011.05.006","volume":"38","author":"RM Dawson","year":"2011","unstructured":"Dawson RM, Fox MA, Atkins HS, Liu CQ (2011) Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. Int J Antimicrob Agents 38:237\u2013242","journal-title":"Int J Antimicrob Agents"},{"key":"1305_CR9","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1002\/cbic.200800113","volume":"9","author":"MA Hossain","year":"2008","unstructured":"Hossain MA, Bathgate RA, Kong C, Shabanpoor F, Zhang S, Haugaard-J\u00f6nsson LM, Rosengren KJ, Tregear GW, Wade JD (2008) Synthesis, conformation and receptor binding activity of human insulin-like peptide 5 (INSL5). ChemBioChem 9:1816\u20131822","journal-title":"ChemBioChem"},{"key":"1305_CR10","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00726-009-0454-1","volume":"39","author":"MA Hossain","year":"2010","unstructured":"Hossain MA, Samuel CS, Binder C, Hewitson TD, Tregear GW, Wade JD, Bathgate RA (2010) The chemically synthesized human relaxin-2 analog, B-R13\/17K H2, is an RXFP1 antagonist. Amino Acids 39:409\u2013416","journal-title":"Amino Acids"},{"key":"1305_CR11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00726-010-0632-1","volume":"40","author":"J-Y Kim","year":"2011","unstructured":"Kim J-Y, Park S-C, Hahm K-S, Park Y (2011) C-terminal amidation of PMAP-23: translocation to the inner membrane of Gram-negative bacteria. Amino Acids 40:183\u2013195","journal-title":"Amino Acids"},{"key":"1305_CR12","unstructured":"Lebl M, Krchnak V, Lebl G (1995) Peptide Companion, San Diego, CA. http:\/\/www.5z.com\/psp\/software.shtml"},{"key":"1305_CR13","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.peptides.2011.01.025","volume":"32","author":"A Marchand","year":"2011","unstructured":"Marchand A, Verdon J, Lacombe C, Crapart S, H\u00e9chard Y, Berjeaud JM (2011) Anti-Legionella activity of staphylococcal hemolytic peptides. Peptides 32:845\u2013851","journal-title":"Peptides"},{"key":"1305_CR14","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.1021\/ja00172a020","volume":"112","author":"RC Milton","year":"1990","unstructured":"Milton RC, Milton SCF, Adams PA (1990) Prediction of difficult sequences in solid-phase peptide synthesis. J Am Chem Soc 112:6039\u20136046","journal-title":"J Am Chem Soc"},{"key":"1305_CR15","first-page":"145","volume":"8","author":"M Mutter","year":"1995","unstructured":"Mutter M, Nefzi A, Sato T, Sun X, Wahl F, W\u00f6hr T (1995) Pseudo-prolines (psi Pro) for accessing \u201cinaccessible\u201d peptides. Pept Res 8:145\u2013153","journal-title":"Pept Res"},{"key":"1305_CR16","unstructured":"Tickler AK, Wade JD (2007) Solid phase synthesis of \u201cdifficult\u201d peptide sequences. In: Coligan JE, Dunn BM, Speicher DW, Wingfield PT (eds) Current protocols in protein science, vol. 50. John Wiley & Sons, New York. Unit 18.8, pp 1\u20136"},{"key":"1305_CR17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2174\/0929866043406986","volume":"11","author":"AK Tickler","year":"2004","unstructured":"Tickler AK, Clippingdale AB, Wade JD (2004) Amyloid-\u03b2 as a \u201cdifficult sequence\u201d in solid phase peptide synthesis. Protein Pept Lett 11:377\u2013384","journal-title":"Protein Pept Lett"},{"key":"1305_CR18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1042\/bj2520087","volume":"252","author":"DC Watson","year":"1988","unstructured":"Watson DC, Yaguchi M, Bisaillon JG, Beaudet R, Morosoli R (1988) The amino acid sequence of a gonococcal growth inhibitor from Staphylococcus haemolyticus. Biochem J 252:87\u201393","journal-title":"Biochem J"},{"key":"1305_CR19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/psc.484","volume":"10","author":"P White","year":"2004","unstructured":"White P, Keyte JW, Bailey K, Bloomberg G (2004) Expediting the Fmoc solid phase synthesis of long peptides through the application of dimethyloxazolidine dipeptides. J Pept Sci 10:18\u201326","journal-title":"J Pept Sci"},{"key":"1305_CR20","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.abb.2004.11.006","volume":"434","author":"I Zelezetsky","year":"2005","unstructured":"Zelezetsky I, Pag U, Antcheva N, Sahl H-G, Tossi A (2005) Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. Arch Biochem Biophys 434:358\u2013364","journal-title":"Arch Biochem Biophys"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-012-1305-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-012-1305-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-012-1305-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T05:43:24Z","timestamp":1559108604000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-012-1305-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,4]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["1305"],"URL":"https:\/\/doi.org\/10.1007\/s00726-012-1305-z","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,4]]}}}