{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:50:16Z","timestamp":1770072616917,"version":"3.49.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s00726-013-1661-3","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T11:14:19Z","timestamp":1390216459000},"page":"1047-1058","source":"Crossref","is-referenced-by-count":27,"title":["A BODIPY-embedding miltefosine analog linked to cell-penetrating Tat(48-60) peptide favors intracellular delivery and visualization of the antiparasitic drug"],"prefix":"10.1007","volume":"46","author":[{"given":"Beatriz G.","family":"de la Torre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valent\u00edn","family":"Hornillos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan R.","family":"Luque-Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Abeng\u00f3zar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Amat-Guerri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ulises Acu\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Andreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,1,21]]},"reference":[{"key":"1661_CR1","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","volume":"7","author":"J Alvar","year":"2012","unstructured":"Alvar J, Velez ID, Bern C, Herrero M, Desjeux P, Cano J, Jannin J, den Boer M (2012) Leishmaniasis worldwide and global estimates of its incidence. PLoS One 7:e35671","journal-title":"PLoS One"},{"key":"1661_CR2","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1007\/s10495-009-0397-8","volume":"14","author":"S Aroui","year":"2009","unstructured":"Aroui S, Brahim S, Hamelin J, De Waard M, Breard J, Kenani A (2009) Conjugation of doxorubicin to cell penetrating peptides sensitizes human breast MDA-MB 231 cancer cells to endogenous TRAIL-induced apoptosis. Apoptosis 14:1352\u20131365","journal-title":"Apoptosis"},{"key":"1661_CR3","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1096\/fj.08-127563","volume":"23","author":"S Aubry","year":"2009","unstructured":"Aubry S, Burlina F, Dupont E, Delaroche D, Joliot A, Lavielle S, Chassaing G, Sagan S (2009) Cell-surface thiols affect cell entry of disulfide-conjugated peptides. FASEB J 23:2956\u20132967","journal-title":"FASEB J"},{"key":"1661_CR4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijpharm.2008.10.036","volume":"369","author":"MP Barnes","year":"2009","unstructured":"Barnes MP, Shen WC (2009) Disulfide and thioether linked cytochrome c-oligoarginine conjugates in HeLa cells. Int J Pharm 369:79\u201384","journal-title":"Int J Pharm"},{"key":"1661_CR5","doi-asserted-by":"crossref","first-page":"10360","DOI":"10.1021\/ja903984s","volume":"131","author":"TT Beaudette","year":"2009","unstructured":"Beaudette TT, Cohen JA, Bachelder EM, Broaders KE, Cohen JL, Engleman EG, Frechet JM (2009) Chemoselective ligation in the functionalization of polysaccharide-based particles. J Am Chem Soc 131:10360\u201310361","journal-title":"J Am Chem Soc"},{"key":"1661_CR6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1399-3011.1986.tb03236.x","volume":"28","author":"MS Bernatowicz","year":"1986","unstructured":"Bernatowicz MS, Matsueda R, Matsueda GR (1986) Preparation of Boc-[S-(3-nitro-2-pyridinesulfenyl)]-cysteine and its use for unsymmetrical disulfide bond formation. Int J Pept Protein Res 28:107\u2013112","journal-title":"Int J Pept Protein Res"},{"key":"1661_CR7","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.2174\/092986712801661004","volume":"19","author":"RJ Boohaker","year":"2012","unstructured":"Boohaker RJ, Lee MW, Vishnubhotla P, Perez JM, Khaled AR (2012) The use of therapeutic peptides to target and to kill cancer cells. Curr Med Chem 19:3794\u20133804","journal-title":"Curr Med Chem"},{"key":"1661_CR8","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrmicro1748","volume":"5","author":"F Chappuis","year":"2007","unstructured":"Chappuis F, Sundar S, Hailu A, Ghalib H, Rijal S, Peeling RW, Alvar J, Boelaert M (2007) Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nat Rev Microbiol 5:873\u2013882","journal-title":"Nat Rev Microbiol"},{"key":"1661_CR9","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.2174\/138920111796117391","volume":"12","author":"YS Choi","year":"2011","unstructured":"Choi YS, Lee JY, Suh JS, Lee SJ, Yang VC, Chung CP, Park YJ (2011) Cell penetrating peptides for tumor targeting. Curr Pharm Biotechnol 12:1166\u20131182","journal-title":"Curr Pharm Biotechnol"},{"key":"1661_CR10","doi-asserted-by":"crossref","unstructured":"Coates AR Halls G (2012) Antibiotics in phase II and III clinical trials. Handb Exp Pharmacol, 167\u2013183","DOI":"10.1007\/978-3-642-28951-4_11"},{"key":"1661_CR11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-1-61779-188-8_4","volume":"764","author":"L Crombez","year":"2011","unstructured":"Crombez L, Morris MC, Heitz F, Divita G (2011) A non-covalent peptide-based strategy for ex vivo and in vivo oligonucleotide delivery. Methods Mol Biol 764:59\u201373","journal-title":"Methods Mol Biol"},{"key":"1661_CR12","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1517\/14728210903153862","volume":"14","author":"ML Boer den","year":"2009","unstructured":"den Boer ML, Alvar J, Davidson RN, Ritmeijer K, Balasegaram M (2009) Developments in the treatment of visceral leishmaniasis. Expert Opin Emerg Drugs 14:395\u2013410","journal-title":"Expert Opin Emerg Drugs"},{"key":"1661_CR13","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1016\/j.bbamem.2010.06.005","volume":"1798","author":"S Deshayes","year":"2010","unstructured":"Deshayes S, Konate K, Aldrian G, Crombez L, Heitz F, Divita G (2010) Structural polymorphism of non-covalent peptide-based delivery systems: highway to cellular uptake. Biochim Biophys Acta 1798:2304\u20132314","journal-title":"Biochim Biophys Acta"},{"key":"1661_CR14","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/jac\/dks275","volume":"67","author":"TP Dorlo","year":"2012","unstructured":"Dorlo TP, Balasegaram M, Beijnen JH, de Vries PJ (2012) Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis. J Antimicrob Chemother 67:2576\u20132597","journal-title":"J Antimicrob Chemother"},{"key":"1661_CR15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12154-009-0031-9","volume":"3","author":"L Dutot","year":"2009","unstructured":"Dutot L, Lecorche P, Burlina F, Marquant R, Point V, Sagan S, Chassaing G, Mallet JM, Lavielle S (2009) Glycosylated cell-penetrating peptides and their conjugates to a proapoptotic peptide: preparation by click chemistry and cell viability studies. J Chem Biol 3:51\u201365","journal-title":"J Chem Biol"},{"key":"1661_CR16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2174\/156652312800840612","volume":"12","author":"SA Andaloussi El","year":"2012","unstructured":"El Andaloussi SA, Hammond SM, Mager I, Wood MJ (2012) Use of cell-penetrating-peptides in oligonucleotide splice switching therapy. Curr Gene Ther 12:161\u2013178","journal-title":"Curr Gene Ther"},{"key":"1661_CR18","doi-asserted-by":"crossref","first-page":"e1974","DOI":"10.1371\/journal.pntd.0001974","volume":"6","author":"R Garcia-Hernandez","year":"2012","unstructured":"Garcia-Hernandez R, Manzano JI, Castanys S, Gamarro F (2012) Leishmania donovani develops resistance to drug combinations. PLoS Negl Trop Dis 6:e1974","journal-title":"PLoS Negl Trop Dis"},{"key":"1661_CR19","doi-asserted-by":"crossref","first-page":"10189","DOI":"10.1021\/bi0502644","volume":"44","author":"ST Henriques","year":"2005","unstructured":"Henriques ST, Costa J, Castanho MA (2005) Translocation of beta-galactosidase mediated by the cell-penetrating peptide pep-1 into lipid vesicles and human HeLa cells is driven by membrane electrostatic potential. Biochemistry 44:10189\u201310198","journal-title":"Biochemistry"},{"key":"1661_CR20","doi-asserted-by":"crossref","first-page":"5190","DOI":"10.1016\/j.bmcl.2006.07.004","volume":"16","author":"V Hornillos","year":"2006","unstructured":"Hornillos V, Saugar JM, de la Torre BG, Andreu D, Rivas L, Acuna AU, Amat-Guerri F (2006) Synthesis of 16-mercaptohexadecylphosphocholine, a miltefosine analog with leishmanicidal activity. Bioorg Med Chem Lett 16:5190\u20135193","journal-title":"Bioorg Med Chem Lett"},{"key":"1661_CR21","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1016\/j.bmcl.2008.10.089","volume":"18","author":"V Hornillos","year":"2008","unstructured":"Hornillos V, Carrillo E, Rivas L, Amat-Guerri F, Acuna AU (2008) Synthesis of BODIPY-labeled alkylphosphocholines with leishmanicidal activity, as fluorescent analogues of miltefosine. Bioorg Med Chem Lett 18:6336\u20136339","journal-title":"Bioorg Med Chem Lett"},{"key":"1661_CR22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jphotochem.2010.09.010","volume":"216","author":"V Hornillos","year":"2010","unstructured":"Hornillos V, Tormo L, Amat-Guerri F, Acu\u00f1a AU (2010) Synthesis and spectral properties of fluorescent linear alkylphosphocholines labeled with all-(E)-1,6-diphenyl-1,3,5-hexatriene. J Photochem Photobiol A 216:79\u201384","journal-title":"J Photochem Photobiol A"},{"key":"1661_CR23","doi-asserted-by":"crossref","unstructured":"Huang Y, Jiang Y, Wang H, Wang J, Shin MC, Byun Y, He H, Liang Y, Yang VC (2013) Curb challenges of the \u201cTrojan Horse\u201d approach: Smart strategies in achieving effective yet safe cell-penetrating peptide-based drug delivery. Adv Drug Deliv Rev 65:1299\u20131315","DOI":"10.1016\/j.addr.2012.11.007"},{"key":"1661_CR24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1021\/ja002154k","volume":"123","author":"H Imahori","year":"2001","unstructured":"Imahori H, Norieda H, Yamada H, Nishimura Y, Yamazaki I, Sakata Y, Fukuzumi S (2001) Light-harvesting and photocurrent generation by gold electrodes modified with mixed self-assembled monolayers of boron-dipyrrin and ferrocene-porphyrin-fullerene triad. J Am Chem Soc 123:100\u2013110","journal-title":"J Am Chem Soc"},{"key":"1661_CR17","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.addr.2011.12.014","volume":"64","author":"S Khafagy el","year":"2012","unstructured":"Khafagy el S, Morishita M (2012) Oral biodrug delivery using cell-penetrating peptide. Adv Drug Deliv Rev 64:531\u2013539","journal-title":"Adv Drug Deliv Rev"},{"key":"1661_CR25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.molmed.2012.04.012","volume":"18","author":"E Koren","year":"2012","unstructured":"Koren E, Torchilin VP (2012) Cell-penetrating peptides: breaking through to the other side. Trends Mol Med 18:385\u2013393","journal-title":"Trends Mol Med"},{"key":"1661_CR26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/138161211795049642","volume":"17","author":"H Li","year":"2011","unstructured":"Li H, Nelson CE, Evans BC, Duvall CL (2011) Delivery of intracellular-acting biologics in pro-apoptotic therapies. Curr Pharm Des 17:293\u2013319","journal-title":"Curr Pharm Des"},{"key":"1661_CR27","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijpharm.2012.11.037","volume":"441","author":"S Lindberg","year":"2013","unstructured":"Lindberg S, Munoz-Alarcon A, Helmfors H, Mosqueira D, Gyllborg D, Tudoran O, Langel U (2013) PepFect15, a novel endosomolytic cell-penetrating peptide for oligonucleotide delivery via scavenger receptors. Int J Pharm 441:242\u2013247","journal-title":"Int J Pharm"},{"key":"1661_CR28","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.bcp.2005.10.048","volume":"71","author":"M Lindgren","year":"2006","unstructured":"Lindgren M, Rosenthal-Aizman K, Saar K, Eiriksdottir E, Jiang Y, Sassian M, Ostlund P, Hallbrink M, Langel U (2006) Overcoming methotrexate resistance in breast cancer tumour cells by the use of a new cell-penetrating peptide. Biochem Pharmacol 71:416\u2013425","journal-title":"Biochem Pharmacol"},{"key":"1661_CR29","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jconrel.2012.05.023","volume":"161","author":"JR Luque-Ortega","year":"2012","unstructured":"Luque-Ortega JR, de la Torre BG, Hornillos V, Bart JM, Rueda C, Navarro M, Amat-Guerri F, Acuna AU, Andreu D, Rivas L (2012) Defeating Leishmania resistance to miltefosine (hexadecylphosphocholine) by peptide-mediated drug smuggling: a proof of mechanism for trypanosomatid chemotherapy. J Control Release 161:835\u2013842","journal-title":"J Control Release"},{"key":"1661_CR30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/wnan.1197","volume":"5","author":"SR MacEwan","year":"2013","unstructured":"MacEwan SR, Chilkoti A (2013) Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents. Wiley Interdiscip Rev Nanomed Nanobiotechnol 5:31\u201348","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"1661_CR31","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1177\/00970002042006005","volume":"42","author":"MN Martinez","year":"2002","unstructured":"Martinez MN, Amidon GL (2002) A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals. J Clin Pharmacol 42:620\u2013643","journal-title":"J Clin Pharmacol"},{"key":"1661_CR32","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1021\/bc990116o","volume":"11","author":"G Mez\u00f6","year":"2000","unstructured":"Mez\u00f6 G, Mihala N, Andreu D, Hudecz F (2000) Conjugation of epitope peptides with SH group to branched chain polymeric polypeptides via Cys(Npys). Bioconjug Chem 11:484\u2013491","journal-title":"Bioconjug Chem"},{"key":"1661_CR33","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1039\/c2ob06819b","volume":"10","author":"M Monso","year":"2012","unstructured":"Monso M, Kowalczyk W, Andreu D, de la Torre BG (2012) Reverse thioether ligation route to multimeric peptide antigens. Org Biomol Chem 10:3116\u20133121","journal-title":"Org Biomol Chem"},{"key":"1661_CR34","doi-asserted-by":"crossref","unstructured":"Nakamura S, Furutani A, Toru T (2002) Highly enantioselective reaction of \u03b1-lithio 2-quinolyl sulfide using chiral bis(oxazoline)s: a new synthesis of enantioenriched thiols. Eur J Org Chem 1690\u20131695","DOI":"10.1002\/1099-0690(200205)2002:10<1690::AID-EJOC1690>3.0.CO;2-9"},{"key":"1661_CR35","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1021\/mp3004034","volume":"10","author":"A Nasrolahi Shirazi","year":"2013","unstructured":"Nasrolahi Shirazi A, Tiwari R, Chhikara BS, Mandal D, Parang K (2013) Design and biological evaluation of cell-penetrating peptide-doxorubicin conjugates as prodrugs. Mol Pharm 10:488\u2013499","journal-title":"Mol Pharm"},{"key":"1661_CR36","doi-asserted-by":"crossref","first-page":"49965","DOI":"10.1074\/jbc.M308352200","volume":"278","author":"FJ Perez-Victoria","year":"2003","unstructured":"Perez-Victoria FJ, Gamarro F, Ouellette M, Castanys S (2003) Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance. J Biol Chem 278:49965\u201349971","journal-title":"J Biol Chem"},{"key":"1661_CR37","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1399-3011.1982.tb02634.x","volume":"19","author":"RJ Ridge","year":"1982","unstructured":"Ridge RJ, Matsueda GR, Haber E, Matsueda R (1982) Sulfur protection with the 3-nitro-2-pyridine sulfenyl group in solid-phase peptide synthesis. Int J Pept Protein Res 19:490\u2013498","journal-title":"Int J Pept Protein Res"},{"key":"1661_CR38","doi-asserted-by":"crossref","unstructured":"Rijal S, Ostyn B, Uranw S, Rai K, Bhattarai NR, Dorlo TP, Beijnen JH, Vanaerschot M, Decuypere S, Dhakal SS, Das ML, Karki P, Singh R, Boelaert M, Dujardin JC (2013) Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance. Clin Infect Dis 56:1530\u20131538","DOI":"10.1093\/cid\/cit102"},{"key":"1661_CR39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1462-5822.2006.00769.x","volume":"9","author":"A Ruhland","year":"2007","unstructured":"Ruhland A, Leal N, Kima PE (2007) Leishmania promastigotes activate PI3K\/Akt signalling to confer host cell resistance to apoptosis. Cell Microbiol 9:84\u201396","journal-title":"Cell Microbiol"},{"key":"1661_CR40","doi-asserted-by":"crossref","first-page":"5994","DOI":"10.1021\/jm070595+","volume":"50","author":"JM Saugar","year":"2007","unstructured":"Saugar JM, Delgado J, Hornillos V, Luque-Ortega JR, Amat-Guerri F, Acuna AU, Rivas L (2007) Synthesis and biological evaluation of fluorescent leishmanicidal analogues of hexadecylphosphocholine (miltefosine) as probes of antiparasite mechanisms. J Med Chem 50:5994\u20136003","journal-title":"J Med Chem"},{"key":"1661_CR41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijantimicag.2007.05.007","volume":"30","author":"K Seifert","year":"2007","unstructured":"Seifert K, Perez-Victoria FJ, Stettler M, Sanchez-Canete MP, Castanys S, Gamarro F, Croft SL (2007) Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo. Int J Antimicrob Agents 30:229\u2013235","journal-title":"Int J Antimicrob Agents"},{"key":"1661_CR42","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1039\/b807843b","volume":"6","author":"V Steven","year":"2008","unstructured":"Steven V, Graham D (2008) Oligonucleotide conjugation to a cell-penetrating (TAT) peptide by Diels-Alder cycloaddition. Org Biomol Chem 6:3781\u20133787","journal-title":"Org Biomol Chem"},{"key":"1661_CR43","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tips.2012.02.002","volume":"33","author":"N Svensen","year":"2012","unstructured":"Svensen N, Walton JG, Bradley M (2012) Peptides for cell-selective drug delivery. Trends Pharmacol Sci 33:186\u2013192","journal-title":"Trends Pharmacol Sci"},{"key":"1661_CR44","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1074\/jbc.M006701200","volume":"276","author":"M Tyagi","year":"2001","unstructured":"Tyagi M, Rusnati M, Presta M, Giacca M (2001) Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans. J Biol Chem 276:3254\u20133261","journal-title":"J Biol Chem"},{"key":"1661_CR45","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbalip.2012.10.008","volume":"1831","author":"WJ Blitterswijk van","year":"2013","unstructured":"van Blitterswijk WJ, Verheij M (2013) Anticancer mechanisms and clinical application of alkyl phospholipids. Biochim Biophys Acta 1831:663\u2013674","journal-title":"Biochim Biophys Acta"},{"key":"1661_CR46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/B978-0-12-396548-6.00006-8","volume":"114","author":"HY Wang","year":"2012","unstructured":"Wang HY, Wang RF (2012) Enhancing cancer immunotherapy by intracellular delivery of cell-penetrating peptides and stimulation of pattern-recognition receptor signaling. Adv Immunol 114:151\u2013176","journal-title":"Adv Immunol"},{"key":"1661_CR47","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1021\/cr050052c","volume":"107","author":"TE Wood","year":"2007","unstructured":"Wood TE, Thompson A (2007) Advances in the chemistry of dipyrrins and their complexes. Chem Rev 107:1831\u20131861","journal-title":"Chem Rev"},{"key":"1661_CR48","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0040-4039(98)02694-X","volume":"40","author":"J Zhang","year":"1999","unstructured":"Zhang J, Matteucci MD (1999) A novel thiol protecting group: a 2-thioquinoline sulfide as a masked sulfhydryl moiety. Tetrahedron Lett 40:1467\u20131470","journal-title":"Tetrahedron Lett"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-013-1661-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-013-1661-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-013-1661-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T20:42:06Z","timestamp":1565124126000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-013-1661-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,21]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["1661"],"URL":"https:\/\/doi.org\/10.1007\/s00726-013-1661-3","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,21]]}}}