{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:47:58Z","timestamp":1769356078365,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:00:00Z","timestamp":1424217600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1007\/s00726-015-1938-9","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T14:14:04Z","timestamp":1424182444000},"page":"1053-1063","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Differential regional and cellular distribution of TFF3 peptide in the human brain"],"prefix":"10.1007","volume":"47","author":[{"given":"Hans-Gert","family":"Bernstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Dobrowolny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Tr\u00fcbner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Bogerts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,2,18]]},"reference":[{"key":"1938_CR1","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1021\/pr100020c","volume":"9","author":"TK Albert","year":"2010","unstructured":"Albert TK, Laubinger W, M\u00fcller S, Hanisch FG, Kalinski T, Meyer F, Hoffmann W (2010) Human intestinal TFF3 forms disulfide-linked heteromers with the mucus-associated FCGBP protein and is released by hydrogen sulfide. J Proteome Res 9:3108\u20133117","journal-title":"J Proteome Res"},{"key":"1938_CR2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0736-5748(87)90034-7","volume":"5","author":"HG Bernstein","year":"1987","unstructured":"Bernstein HG, Sch\u00f6n E, Ansorge S, R\u00f6se I, Dorn A (1987) Immunolocalization of dipeptidyl aminopeptidase (DAP IV) in the developing human brain. Int J Dev Neurosci 5:237\u2013242","journal-title":"Int J Dev Neurosci"},{"key":"1938_CR3","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1023\/A:1007056731551","volume":"28","author":"HG Bernstein","year":"1999","unstructured":"Bernstein HG, Baumann B, Danos P, Diekmann S, Bogerts B, Gundelfinger ED, Braunewell KH (1999) Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain. J Neurocytol 28:655\u2013662","journal-title":"J Neurocytol"},{"key":"1938_CR4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.2174\/187152710793361496","volume":"9","author":"JL Cadet","year":"2010","unstructured":"Cadet JL, Jayanthi S, McCoy MT, Beauvais G, Cai NS (2010) Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration. CNS Neurol Disord Drug Targ 9:526\u2013528","journal-title":"CNS Neurol Disord Drug Targ"},{"key":"1938_CR5","unstructured":"Chissoe St, Ehm MG, Jean P St (2008) Genes associated with schizophrenia, US Patent Application Publication US 2008\/0176239 A1, pp 1\u201349"},{"key":"1938_CR6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1152\/physiolgenomics.00109.2005","volume":"24","author":"D Cui","year":"2006","unstructured":"Cui D, Dougherty KJ, Machacek DW, Sawchuk M, Hochman S, Baro DJ (2006) Divergence between motoneurons: gene expression profiling provides a molecular characterization of functionally discrete somatic and autonomic motoneurons. Physiol Genomics 24:276\u2013289","journal-title":"Physiol Genomics"},{"key":"1938_CR7","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.peptides.2003.11.020","volume":"25","author":"A Derbyshire","year":"2004","unstructured":"Derbyshire A, Ludwig M (2004) TFF3 induced Fos protein expression in the magnocellular oxytocin neurons of the hypothalamus. Peptides 25:833\u2013838","journal-title":"Peptides"},{"key":"1938_CR9","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1159\/000366389","volume":"34","author":"T Fu","year":"2014","unstructured":"Fu T, Stellmacher A, Znalesniak EB, Dieterich DC, Kalbacher H, Hoffmann W (2014) Tff3 is expressed in neurons and microglial cells. Cell Physiol Biochem 34:1912\u20131919","journal-title":"Cell Physiol Biochem"},{"key":"1938_CR10","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jpsychires.2012.11.007","volume":"47","author":"EJ Gardiner","year":"2013","unstructured":"Gardiner EJ, Cairns MJ, Liu B, Beveridge NJ, Carr V, Kelly B, Scott RJ, Tooney PA (2013) Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells. J Psychiatr Res 47:425\u2013437","journal-title":"J Psychiatr Res"},{"key":"1938_CR11","first-page":"111","volume":"3","author":"T Griepentrog","year":"1999","unstructured":"Griepentrog T, Bauer M, Hornstein C, Sauer H, Jirikowski GF (1999) Tanycytes in the human median eminence contain intestinal trefoil factor (hITF). Eur J Anat 3:111\u2013114","journal-title":"Eur J Anat"},{"key":"1938_CR12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1055\/s-2007-978604","volume":"32","author":"T Griepentrog","year":"2000","unstructured":"Griepentrog T, Bauer M, Hornstein C, Sauer H, Jirikowski GF (2000) Coexistence of intestinal trefoil factor (hITF) and oxytocin in magnocellular neurons in the human hypothalamus. Horm Metab Res 32:121\u2013124","journal-title":"Horm Metab Res"},{"key":"1938_CR13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuroscience.2010.11.006","volume":"173","author":"JG Hashimoto","year":"2011","unstructured":"Hashimoto JG, Forquer MR, Tanchuck MA, Finn DA, Wiren KM (2011) Importance of genetic background for risk of relapse shown in altered prefrontal cortex gene expression during abstinence following chronic alcohol intoxication. Neuroscience 173:57\u201375","journal-title":"Neuroscience"},{"key":"1938_CR14","doi-asserted-by":"crossref","first-page":"6961","DOI":"10.1073\/pnas.90.15.6961","volume":"90","author":"F Hauser","year":"1993","unstructured":"Hauser F, Poulsom R, Chinery R, Rogers LA, Hanby AW, Wright NA, Hoffmann W (1993) hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus. Proc Natl Acad Sci USA 90:6961\u20136965","journal-title":"Proc Natl Acad Sci USA"},{"key":"1938_CR15","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.peptides.2004.01.020","volume":"25","author":"M Hinz","year":"2004","unstructured":"Hinz M, Schwegler H, Chwieralski CE, Laube G, Linke R, Pohle W, Hoffmann W (2004) Trefoil factor family (TFF) expression in the mouse brain and pituitary: changes in the developing cerebellum. Peptides 25:827\u2013832","journal-title":"Peptides"},{"key":"1938_CR16","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/B978-0-12-385095-9.00182-2","volume-title":"Handbook of biologically active peptides","author":"W Hoffmann","year":"2013","unstructured":"Hoffmann W (2013) TFF peptides. In: Kastin AJ (ed) Handbook of biologically active peptides, 2nd edn. Elsevier, San Diego, pp 1338\u20131345","edition":"2"},{"key":"1938_CR17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0074-7696(02)13014-2","volume":"213","author":"W Hoffmann","year":"2002","unstructured":"Hoffmann W, Jagla W (2002) Cell type specific expression of secretory TFF peptides: colocalization with mucins and synthesis in the brain. Int Rev Cytol 213:147\u2013181","journal-title":"Int Rev Cytol"},{"key":"1938_CR18","first-page":"319","volume":"16","author":"W Hoffmann","year":"2001","unstructured":"Hoffmann W, Jagla W, Wiede A (2001) Molecular medicine of TFF-peptides: from gut to brain. Histol Histopathol 16:319\u2013334","journal-title":"Histol Histopathol"},{"key":"1938_CR19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s004419900087","volume":"298","author":"W Jagla","year":"1999","unstructured":"Jagla W, Wiede A, Hinz M, Dietzmann K, G\u00fclicher D, Gerlach KL, Hoffmann W (1999) Secretion of TFF-peptides by human salivary glands. Cell Tissue Res 298:161\u2013166","journal-title":"Cell Tissue Res"},{"key":"1938_CR20","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1096\/fasebj.14.9.1126","volume":"14","author":"W Jagla","year":"2000","unstructured":"Jagla W, Wiede A, Dietzmann K, Rutkowski K, Hoffmann W (2000) Co-localization of TFF3 peptide and oxytocin in the human hypothalamus. FASEB J 14:1126\u20131131","journal-title":"FASEB J"},{"key":"1938_CR21","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1007\/s00018-008-8646-5","volume":"66","author":"S Kjellev","year":"2009","unstructured":"Kjellev S (2009) The trefoil factor family\u2014small peptides with multiple functionalities. Cell Mol Life Sci 66:1350\u20131369","journal-title":"Cell Mol Life Sci"},{"key":"1938_CR22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00441-004-0854-1","volume":"316","author":"I Kouznetsova","year":"2004","unstructured":"Kouznetsova I, Peitz U, Vieth M, Meyer F, Vestergaard EM, Malfertheiner P, Roessner A, Lippert H, Hoffmann W (2004) A gradient of TFF3 (trefoil factor family 3) peptide synthesis within the normal human gastric mucosa. Cell Tissue Res 316:155\u2013165","journal-title":"Cell Tissue Res"},{"key":"1938_CR23","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature10648","volume":"480","author":"S Kriks","year":"2011","unstructured":"Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal MF, Surmeier DJ, Kordower JH, Tabar V, Studer L (2011) Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson\u2019s disease. Nature 480:547\u2013551","journal-title":"Nature"},{"key":"1938_CR24","doi-asserted-by":"crossref","first-page":"e77732","DOI":"10.1371\/journal.pone.0077732","volume":"8","author":"SQ Liu","year":"2013","unstructured":"Liu SQ, Roberts D, Zhang B, Ren Y, Zhang LQ, Wu YH (2013) Trefoil factor 3 as an endocrine neuroprotective factor from the liver in experimental cerebral ischemia\/reperfusion injury. PLoS One 8:e77732","journal-title":"PLoS One"},{"key":"1938_CR26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/(SICI)1096-9896(199709)183:1<4::AID-PATH1099>3.0.CO;2-5","volume":"183","author":"FE May","year":"1997","unstructured":"May FE, Westley BR (1997) Trefoil proteins: their role in normal and malignant cells. J Pathol 183:4\u20137","journal-title":"J Pathol"},{"key":"1938_CR27","volume-title":"The embryonic human brain: an atlas of developmental stages","author":"R O\u2019Rahilly","year":"2005","unstructured":"O\u00b4Rahilly R, M\u00fcller F (2005) The embryonic human brain: an atlas of developmental stages, 3rd edn. Wiley, New York","edition":"3"},{"key":"1938_CR28","doi-asserted-by":"crossref","first-page":"e419","DOI":"10.1038\/tp.2014.58","volume":"4","author":"RW Paterson","year":"2014","unstructured":"Paterson RW, Bartlett JW, Blennow K, Fox NC, Shaw LM, Trojanowski JQ, Zetterberg H, Schott JM (2014) Cerebrospinal fluid markers including trefoil factor 3 are associated with neurodegeneration in amyloid-positive individuals. Transl Psychiatry 4:e419","journal-title":"Transl Psychiatry"},{"key":"1938_CR29","first-page":"3359","volume":"43","author":"FP Paulsen","year":"2002","unstructured":"Paulsen FP, Hinz M, Schaudig U, Thale AB, Hoffmann W (2002) TFF peptides in the human efferent tear ducts. Invest Ophthalmol Vis Sci 43:3359\u20133364","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1938_CR30","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1093\/hmg\/ddp438","volume":"18","author":"PL Pereira","year":"2009","unstructured":"Pereira PL, Magnol L, Sah\u00fan I, Brault V, Duchon A, Prandini P, Gruart A, Bizot JC, Chadefaux-Vekemans B, Deutsch S, Trovero F, Delgado-Garc\u00eda JM, Antonarakis SE, Dierssen M, Herault Y (2009) A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of Down syndrome. Hum Mol Genet 18:4756\u20134769","journal-title":"Hum Mol Genet"},{"key":"1938_CR32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0169-328X(95)00137-H","volume":"33","author":"JC Probst","year":"1995","unstructured":"Probst JC, Skutella T, M\u00fcller-Schmid A, Jirikowski GF, Hoffmann W (1995) Molecular and cellular analysis of rP1.B in the rat hypothalamus: in situ hybridization and immunohistochemistry of a new P-domain neuropeptide. Brain Res Mol Brain Res 33:269\u2013276","journal-title":"Brain Res Mol Brain Res"},{"key":"1938_CR33","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1096\/fasebj.10.13.8940297","volume":"10","author":"JC Probst","year":"1996","unstructured":"Probst JC, Zetzsche T, Weber M, Theilemann P, Skutella T, Landgraf R, Jirikowski GF (1996) Human intestinal trefoil factor is expressed in human hypothalamus and pituitary: evidence for a novel neuropeptide. FASEB J 10:1518\u20131523","journal-title":"FASEB J"},{"key":"1938_CR34","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1053\/j.gastro.2008.08.049","volume":"135","author":"EP Reeves","year":"2008","unstructured":"Reeves EP, Ali T, Leonard P, Hearty S, O\u2019Kennedy R, May FE, Westley BR, Josenhans C, Rust M, Suerbaum S, Smith A, Drumm B, Clyne M (2008) Helicibacter pylori lipopolysaccharide interacts with TFF1 in a pH-dependent manner. Gastroenterology 135:2043\u20132054","journal-title":"Gastroenterology"},{"key":"1938_CR35","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nature01178","volume":"420","author":"A Reymond","year":"2002","unstructured":"Reymond A, Marigo V, Yaylaoglu MB, Leoni A, Ucla C, Scamuffa N, Caccioppoli C, Dermitzakis ET, Lyle R, Banfi S, Eichele G, Antonarakis SE, Ballabio A (2002) Human chromosome 21 gene expression atlas in the mouse. Nature 420:582\u2013586","journal-title":"Nature"},{"key":"1938_CR36","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00441-009-0913-8","volume":"339","author":"M Rinnert","year":"2010","unstructured":"Rinnert M, Hinz M, Buhtz P, Reiher F, Lessel W, Hoffmann W (2010) Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine. Cell Tissue Res 339:639\u2013647","journal-title":"Cell Tissue Res"},{"key":"1938_CR37","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/dvdy.21489","volume":"237","author":"AE Rojas-Mayorqu\u00edn","year":"2008","unstructured":"Rojas-Mayorqu\u00edn AE, Torres-Ru\u00edz NM, Ortu\u00f1o-Sahag\u00fan D, Gudi\u00f1o-Cabrera G (2008) Microarray analysis of striatal embryonic stem cells induced to differentiate by ensheathing cell conditioned media. Dev Dyn 237:979\u2013994","journal-title":"Dev Dyn"},{"key":"1938_CR38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3109\/00365513.2013.765962","volume":"73","author":"MH Samson","year":"2013","unstructured":"Samson MH (2013) Quantitative measurements of trefoil factor family peptides: possibilities and pitfalls. Scand J Clin Lab Invest 73:193\u2013202","journal-title":"Scand J Clin Lab Invest"},{"key":"1938_CR39","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1515\/CCLM.2011.123","volume":"49","author":"MH Samson","year":"2011","unstructured":"Samson MH, Chaiyarit P, Nortvig H, Vestergaard EM, Ernst E, Nexo E (2011) Trefoil factor family peptides in human saliva and cyclical cervical mucus. Method evaluation and results on healthy individuals. Clin Chem Lab Med 49:861\u2013868","journal-title":"Clin Chem Lab Med"},{"key":"1938_CR41","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s004410100412","volume":"305","author":"H Schwarz","year":"2001","unstructured":"Schwarz H, Jagla W, Wiede A, Hoffmann W (2001) Ultrastructural co-localization of TFF3-peptide and oxytocin in the neural lobe of the porcine pituitary. Cell Tissue Res 305:411\u2013416","journal-title":"Cell Tissue Res"},{"key":"1938_CR42","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0091-3057(98)00137-3","volume":"62","author":"H Schwarzberg","year":"1999","unstructured":"Schwarzberg H, Kalbacher H, Hoffmann W (1999) Differential behavioral effects of TFF peptides: injections of synthetic TFF3 into the rat amygdala. Pharmacol Biochem Behav 62:173\u2013178","journal-title":"Pharmacol Biochem Behav"},{"key":"1938_CR43","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1038\/npp.2012.131","volume":"37","author":"HS Shi","year":"2012","unstructured":"Shi HS, Zhu WL, Liu JF, Luo YX, Si JJ, Wang SJ, Xue YX, Ding ZB, Shi J, Lu L (2012a) PI3\u00a0K\/Akt signaling pathway in the basolateral amygdala mediates the rapid antidepressant-like effects of trefoil factor 3. Neuropsychopharmacology 37:2671\u20132683","journal-title":"Neuropsychopharmacology"},{"key":"1938_CR44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.bbr.2011.10.051","volume":"227","author":"HS Shi","year":"2012","unstructured":"Shi HS, Yin X, Song L, Guo QJ, Luo XH (2012b) Neuropeptide Trefoil factor 3 improves learning and retention of novel object recognition memory in mice. Behav Brain Res 227:265\u2013269","journal-title":"Behav Brain Res"},{"key":"1938_CR47","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.earlhumdev.2008.04.001","volume":"84","author":"EM Vestergaard","year":"2008","unstructured":"Vestergaard EM, Nexo E, Wendt A, Guthmann F (2008) Trefoil factors in human milk. Early Hum Dev 84:631\u2013635","journal-title":"Early Hum Dev"},{"key":"1938_CR48","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1164\/ajrccm.159.4.9804149","volume":"159","author":"A Wiede","year":"1999","unstructured":"Wiede A, Jagla W, Welte T, K\u00f6hnlein T, Busk H, Hoffmann W (1999) Localization of TFF3, a new mucus-associated peptide of the human respiratory tract. Am J Respir Crit Care Med 159:1330\u20131335","journal-title":"Am J Respir Crit Care Med"},{"key":"1938_CR50","doi-asserted-by":"crossref","unstructured":"Wu P, Shi HS, Luo YX, Zhang RX, Li JL, Shi J, Lu L, Zhu WL (2014) Neuropeptide trefoil factor 3 attenuates naloxone-precipitated withdrawal in morphine-dependent mice. Psychopharmacol 2014. (Epub ahead of print)","DOI":"10.1007\/s00213-014-3615-1"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-015-1938-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-015-1938-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-015-1938-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,6]],"date-time":"2023-08-06T03:28:40Z","timestamp":1691292520000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-015-1938-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,18]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["1938"],"URL":"https:\/\/doi.org\/10.1007\/s00726-015-1938-9","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,18]]}}}