{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:12:04Z","timestamp":1792066324054,"version":"4.4.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST)","award":["2012R1A2A2A01046132"],"award-info":[{"award-number":["2012R1A2A2A01046132"]}]},{"name":"Hallym University Specialization Fund","award":["HRF-S-52"],"award-info":[{"award-number":["HRF-S-52"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s00726-016-2221-4","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:54:46Z","timestamp":1459731286000},"page":"1619-1629","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Decreased cysteine uptake by EAAC1 gene deletion exacerbates neuronal oxidative stress and neuronal death after traumatic brain injury"],"prefix":"10.1007","volume":"48","author":[{"given":"Bo Young","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Yeol","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Ra","family":"Kho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jae","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Ki","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,4]]},"reference":[{"issue":"1","key":"2221_CR1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nn1609","volume":"9","author":"K Aoyama","year":"2006","unstructured":"Aoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, Swanson RA (2006) Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat Neurosci 9(1):119\u2013126. doi: 10.1038\/nn1609","journal-title":"Nat Neurosci"},{"key":"2221_CR2","doi-asserted-by":"crossref","unstructured":"Aoyama K, Watabe M, Nakaki T (2008) Regulation of neuronal glutathione synthesis. J Pharmacol Sci 108(3):227\u2013238. pii:\u00a0JST.JSTAGE\/jphs\/08R01CR","DOI":"10.1254\/jphs.08R01CR"},{"key":"2221_CR3","unstructured":"Bains JS, Shaw CA (1997) Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. Brain Res Brain Res Rev 25(3):335\u2013358. pii:\u00a0S0165017397000453"},{"key":"2221_CR4","unstructured":"Banbury-Conference (1997) Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice. Neuron 19(4):755\u2013759. pii:\u00a0S0896-6273(00)80958-7"},{"key":"2221_CR5","first-page":"49","volume":"55","author":"R Bullock","year":"1992","unstructured":"Bullock R, Kuroda Y, Teasdale GM, McCulloch J (1992) Prevention of post-traumatic excitotoxic brain damage with NMDA antagonist drugs: a new strategy for the nineties. Acta Neurochir Suppl (Wien) 55:49\u201355","journal-title":"Acta Neurochir Suppl (Wien)"},{"key":"2221_CR6","doi-asserted-by":"crossref","unstructured":"Chen Y, Swanson RA (2003) The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures. J Neurochem 84(6):1332\u20131339. pii:\u00a01630","DOI":"10.1046\/j.1471-4159.2003.01630.x"},{"key":"2221_CR7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.brainres.2012.08.032","volume":"1481","author":"BY Choi","year":"2012","unstructured":"Choi BY, Jang BG, Kim JH, Lee BE, Sohn M, Song HK, Suh SW (2012) Prevention of traumatic brain injury-induced neuronal death by inhibition of NADPH oxidase activation. Brain Res 1481:49\u201358. doi: 10.1016\/j.brainres.2012.08.032","journal-title":"Brain Res"},{"issue":"11","key":"2221_CR8","doi-asserted-by":"crossref","first-page":"19444","DOI":"10.3390\/ijms151119444","volume":"15","author":"BY Choi","year":"2014","unstructured":"Choi BY, Kim JH, Kim HJ, Lee BE, Kim IY, Sohn M, Suh SW (2014) EAAC1 gene deletion increases neuronal death and blood brain barrier disruption after transient cerebral ischemia in female mice. Int J Mol Sci 15(11):19444\u201319457. doi: 10.3390\/ijms151119444","journal-title":"Int J Mol Sci"},{"issue":"5","key":"2221_CR9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1089\/neu.1994.11.499","volume":"11","author":"RS Clark","year":"1994","unstructured":"Clark RS, Schiding JK, Kaczorowski SL, Marion DW, Kochanek PM (1994) Neutrophil accumulation after traumatic brain injury in rats: comparison of weight drop and controlled cortical impact models. J Neurotrauma 11(5):499\u2013506","journal-title":"J Neurotrauma"},{"key":"2221_CR10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1742-2094-9-31","volume":"9","author":"JC d\u2019Avila","year":"2012","unstructured":"d\u2019Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa S, Liu J, Swanson RA (2012) Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor. J Neuroinflamm 9:31. doi: 10.1186\/1742-2094-9-31","journal-title":"J Neuroinflamm"},{"key":"2221_CR11","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/jcb.240531040","volume":"17F","author":"N Vries De","year":"1993","unstructured":"De Vries N, De Flora S (1993) N-acetyl-l-cysteine. J Cell Biochem Suppl 17F:270\u2013277","journal-title":"J Cell Biochem Suppl"},{"key":"2221_CR12","doi-asserted-by":"crossref","unstructured":"Dringen R (2000) Metabolism and functions of glutathione in brain. Prog Neurobiol 62(6):649\u2013671. pii:\u00a0S030100829900060X","DOI":"10.1016\/S0301-0082(99)00060-X"},{"issue":"4906","key":"2221_CR13","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1126\/science.2567056","volume":"244","author":"AI Faden","year":"1989","unstructured":"Faden AI, Demediuk P, Panter SS, Vink R (1989) The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 244(4906):798\u2013800","journal-title":"Science"},{"issue":"2","key":"2221_CR14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0165-0270(87)90042-2","volume":"20","author":"CJ Frederickson","year":"1987","unstructured":"Frederickson CJ, Kasarskis EJ, Ringo D, Frederickson RE (1987) A quinoline fluorescence method for visualizing and assaying the histochemically reactive zinc (bouton zinc) in the brain. J Neurosci Methods 20(2):91\u2013103","journal-title":"J Neurosci Methods"},{"issue":"12","key":"2221_CR15","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s00702-003-0049-z","volume":"110","author":"T Himi","year":"2003","unstructured":"Himi T, Ikeda M, Yasuhara T, Nishida M, Morita I (2003) Role of neuronal glutamate transporter in the cysteine uptake and intracellular glutathione levels in cultured cortical neurons. J Neural Transm 110(12):1337\u20131348. doi: 10.1007\/s00702-003-0049-z","journal-title":"J Neural Transm"},{"issue":"2\u20133","key":"2221_CR16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jtemb.2012.04.010","volume":"26","author":"BG Jang","year":"2012","unstructured":"Jang BG, Won SJ, Kim JH, Choi BY, Lee MW, Sohn M, Song HK, Suh SW (2012) EAAC1 gene deletion alters zinc homeostasis and enhances cortical neuronal injury after transient cerebral ischemia in mice. J Trace Elem Med Biol 26(2\u20133):85\u201388. doi: 10.1016\/j.jtemb.2012.04.010","journal-title":"J Trace Elem Med Biol"},{"issue":"6403","key":"2221_CR17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/360467a0","volume":"360","author":"Y Kanai","year":"1992","unstructured":"Kanai Y, Hediger MA (1992) Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 360(6403):467\u2013471. doi: 10.1038\/360467a0","journal-title":"Nature"},{"issue":"6","key":"2221_CR18","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3171\/jns.1990.73.6.0889","volume":"73","author":"Y Katayama","year":"1990","unstructured":"Katayama Y, Becker DP, Tamura T, Hovda DA (1990) Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J Neurosurg 73(6):889\u2013900. doi: 10.3171\/jns.1990.73.6.0889","journal-title":"J Neurosurg"},{"key":"2221_CR19","unstructured":"Kauppinen TM, Swanson RA (2005) Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death. J Immunol 174(4):2288\u20132296. pii:\u00a0174\/4\/2288"},{"issue":"22","key":"2221_CR20","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1523\/JNEUROSCI.1236-08.2008","volume":"28","author":"TM Kauppinen","year":"2008","unstructured":"Kauppinen TM, Higashi Y, Suh SW, Escartin C, Nagasawa K, Swanson RA (2008) Zinc triggers microglial activation. J Neurosci 28(22):5827\u20135835. doi: 10.1523\/JNEUROSCI.1236-08.2008","journal-title":"J Neurosci"},{"issue":"6","key":"2221_CR21","doi-asserted-by":"crossref","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"C Kilkenny","year":"2012","unstructured":"Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG (2012) Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol 8(6):e1000412. doi: 10.1371\/journal.pbio.1000412","journal-title":"PLoS Biol"},{"key":"2221_CR22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neuint.2013.11.013","volume":"73","author":"MC Lane","year":"2014","unstructured":"Lane MC, Jackson JG, Krizman EN, Rothstein JD, Porter BE, Robinson MB (2014) Genetic deletion of the neuronal glutamate transporter, EAAC1, results in decreased neuronal death after pilocarpine-induced status epilepticus. Neurochem Int 73:152\u2013158. doi: 10.1016\/j.neuint.2013.11.013","journal-title":"Neurochem Int"},{"issue":"5","key":"2221_CR23","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1213\/ANE.0b013e3181b6709a","volume":"109","author":"SA Lee","year":"2009","unstructured":"Lee SA, Choi JG, Zuo Z (2009) Volatile anesthetics attenuate oxidative stress-reduced activity of glutamate transporter type 3. Anesth Analg 109(5):1506\u20131510. doi: 10.1213\/ANE.0b013e3181b6709a","journal-title":"Anesth Analg"},{"issue":"5","key":"2221_CR24","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/jcbfm.2010.222","volume":"31","author":"L Li","year":"2011","unstructured":"Li L, Zuo Z (2011) Glutamate transporter type 3 knockout reduces brain tolerance to focal brain ischemia in mice. J Cereb Blood Flow Metab 31(5):1283\u20131292. doi: 10.1038\/jcbfm.2010.222","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"2221_CR25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-0609.1996.tb01370.x","volume":"57","author":"D Mazor","year":"1996","unstructured":"Mazor D, Golan E, Philip V, Katz M, Jafe A, Ben-Zvi Z, Meyerstein N (1996) Red blood cell permeability to thiol compounds following oxidative stress. Eur J Haematol 57(3):241\u2013246","journal-title":"Eur J Haematol"},{"issue":"1","key":"2221_CR26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1523\/JNEUROSCI.18-01-00205.1998","volume":"18","author":"K Murakami","year":"1998","unstructured":"Murakami K, Kondo T, Kawase M, Li Y, Sato S, Chen SF, Chan PH (1998) Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci 18(1):205\u2013213","journal-title":"J Neurosci"},{"issue":"13","key":"2221_CR27","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1093\/emboj\/16.13.3822","volume":"16","author":"P Peghini","year":"1997","unstructured":"Peghini P, Janzen J, Stoffel W (1997) Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO J 16(13):3822\u20133832. doi: 10.1093\/emboj\/16.13.3822","journal-title":"EMBO J"},{"issue":"3","key":"2221_CR28","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ana.22455","volume":"70","author":"AF Ramlackhansingh","year":"2011","unstructured":"Ramlackhansingh AF, Brooks DJ, Greenwood RJ, Bose SK, Turkheimer FE, Kinnunen KM, Gentleman S, Heckemann RA, Gunanayagam K, Gelosa G, Sharp DJ (2011) Inflammation after trauma: microglial activation and traumatic brain injury. Ann Neurol 70(3):374\u2013383. doi: 10.1002\/ana.22455","journal-title":"Ann Neurol"},{"key":"2221_CR29","doi-asserted-by":"crossref","unstructured":"Rao VL, Dogan A, Todd KG, Bowen KK, Kim BT, Rothstein JD, Dempsey RJ (2001) Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain. J Neurosci 21(6):1876\u20131883. pii:\u00a021\/6\/1876","DOI":"10.1523\/JNEUROSCI.21-06-01876.2001"},{"issue":"3","key":"2221_CR30","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0896-6273(00)80086-0","volume":"16","author":"JD Rothstein","year":"1996","unstructured":"Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger MA, Wang Y, Schielke JP, Welty DF (1996) Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16(3):675\u2013686","journal-title":"Neuron"},{"key":"2221_CR31","unstructured":"Schmued LC, Hopkins KJ (2000) Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 874(2):123\u2013130. pii:\u00a0S0006-8993(00)02513-0"},{"key":"2221_CR32","doi-asserted-by":"crossref","unstructured":"Schulz JB, Lindenau J, Seyfried J, Dichgans J (2000) Glutathione, oxidative stress and neurodegeneration. Eur J Biochem 267(16):4904\u20134911. pii:\u00a0ejb1595","DOI":"10.1046\/j.1432-1327.2000.01595.x"},{"issue":"2","key":"2221_CR33","first-page":"215","volume":"51","author":"P Singh","year":"2003","unstructured":"Singh P (2003) Missile injuries of the brain: results of less aggressive surgery. Neurol India 51(2):215\u2013219","journal-title":"Neurol India"},{"issue":"3","key":"2221_CR34","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/1098-1136(200103)33:3<256::AID-GLIA1024>3.0.CO;2-J","volume":"33","author":"N Stence","year":"2001","unstructured":"Stence N, Waite M, Dailey ME (2001) Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33(3):256\u2013266. doi: 10.1002\/1098-1136(200103)33:3<256:AID-GLIA1024>3.0.CO;2-J","journal-title":"Glia"},{"key":"2221_CR35","doi-asserted-by":"crossref","unstructured":"Suh SW, Chen JW, Motamedi M, Bell B, Listiak K, Pons NF, Danscher G, Frederickson CJ (2000) Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury. Brain Res 852(2):268\u2013273. pii:\u00a0S0006899399020958","DOI":"10.1016\/S0006-8993(99)02095-8"},{"issue":"2","key":"2221_CR36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/sj.jcbfm.9600176","volume":"26","author":"SW Suh","year":"2006","unstructured":"Suh SW, Frederickson CJ, Danscher G (2006) Neurotoxic zinc translocation into hippocampal neurons is inhibited by hypothermia and is aggravated by hyperthermia after traumatic brain injury in rats. J Cereb Blood Flow Metab 26(2):161\u2013169. doi: 10.1038\/sj.jcbfm.9600176","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"2221_CR37","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1172\/JCI30077","volume":"117","author":"SW Suh","year":"2007","unstructured":"Suh SW, Gum ET, Hamby AM, Chan PH, Swanson RA (2007) Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase. J Clin Invest 117(4):910\u2013918. doi: 10.1172\/JCI30077","journal-title":"J Clin Invest"},{"issue":"10","key":"2221_CR38","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1038\/jcbfm.2008.61","volume":"28","author":"SW Suh","year":"2008","unstructured":"Suh SW, Hamby AM, Gum ET, Shin BS, Won SJ, Sheline CT, Chan PH, Swanson RA (2008) Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death. J Cereb Blood Flow Metab 28(10):1697\u20131706. doi: 10.1038\/jcbfm.2008.61","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5319","key":"2221_CR39","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1126\/science.276.5319.1699","volume":"276","author":"K Tanaka","year":"1997","unstructured":"Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276(5319):1699\u20131702","journal-title":"Science"},{"issue":"4","key":"2221_CR40","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0163-7827(03)00014-6","volume":"42","author":"K Uchida","year":"2003","unstructured":"Uchida K (2003) 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res 42(4):318\u2013343","journal-title":"Prog Lipid Res"},{"issue":"3","key":"2221_CR41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/glia.1082","volume":"35","author":"FK Landeghem van","year":"2001","unstructured":"van Landeghem FK, Stover JF, Bechmann I, Bruck W, Unterberg A, Buhrer C, von Deimling A (2001) Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia 35(3):167\u2013179","journal-title":"Glia"},{"issue":"38","key":"2221_CR42","doi-asserted-by":"crossref","first-page":"9404","DOI":"10.1523\/JNEUROSCI.3351-08.2008","volume":"28","author":"M Watabe","year":"2008","unstructured":"Watabe M, Aoyama K, Nakaki T (2008) A dominant role of GTRAP3-18 in neuronal glutathione synthesis. J Neurosci 28(38):9404\u20139413. doi: 10.1523\/JNEUROSCI.3351-08.2008","journal-title":"J Neurosci"},{"issue":"3","key":"2221_CR43","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1046\/j.1460-9568.1998.00108.x","volume":"10","author":"K Watase","year":"1998","unstructured":"Watase K, Hashimoto K, Kano M, Yamada K, Watanabe M, Inoue Y, Okuyama S, Sakagawa T, Ogawa S, Kawashima N, Hori S, Takimoto M, Wada K, Tanaka K (1998) Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur J Neurosci 10(3):976\u2013988","journal-title":"Eur J Neurosci"},{"issue":"46","key":"2221_CR44","doi-asserted-by":"crossref","first-page":"15409","DOI":"10.1523\/JNEUROSCI.2084-10.2010","volume":"30","author":"SJ Won","year":"2010","unstructured":"Won SJ, Yoo BH, Brennan AM, Shin BS, Kauppinen TM, Berman AE, Swanson RA, Suh SW (2010) EAAC1 gene deletion alters zinc homeostasis and exacerbates neuronal injury after transient cerebral ischemia. J Neurosci 30(46):15409\u201315418. doi: 10.1523\/JNEUROSCI.2084-10.2010","journal-title":"J Neurosci"},{"issue":"Pt 2","key":"2221_CR45","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1113\/jphysiol.1996.sp021393","volume":"493","author":"N Zerangue","year":"1996","unstructured":"Zerangue N, Kavanaugh MP (1996) Interaction of l-cysteine with a human excitatory amino acid transporter. J Physiol 493(Pt 2):419\u2013423","journal-title":"J Physiol"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-016-2221-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-016-2221-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-016-2221-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T02:48:25Z","timestamp":1567738105000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-016-2221-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,4]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["2221"],"URL":"https:\/\/doi.org\/10.1007\/s00726-016-2221-4","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,4]]}}}