{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:34:01Z","timestamp":1789853641861,"version":"4.0.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National key research and development program of China","doi-asserted-by":"crossref","award":["2016YFD0500504"],"award-info":[{"award-number":["2016YFD0500504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"International Partnership Program of Chinese Academy of Sciences","award":["161343KYSB20160008"],"award-info":[{"award-number":["161343KYSB20160008"]}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["13JJ2034, 2013FJ3011, 2014NK3048, 2014NK4134 and 2014WK2032"],"award-info":[{"award-number":["13JJ2034, 2013FJ3011, 2014NK3048, 2014NK4134 and 2014WK2032"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31330075, 31110103909, 31572416, 31402092, 31501965 and 31372326"],"award-info":[{"award-number":["31330075, 31110103909, 31572416, 31402092, 31501965 and 31372326"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Academy of Sciences visiting professorship for senior international scientists","award":["2016VBB007"],"award-info":[{"award-number":["2016VBB007"]}]},{"name":"King Saud University, through Vice Deanship of Research Chairs"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s00726-017-2410-9","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T03:43:59Z","timestamp":1489549439000},"page":"1945-1954","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["l-Glutamine and l-arginine protect against enterotoxigenic Escherichia coli infection via intestinal innate immunity in mice"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9475-5134","authenticated-orcid":false,"given":"Gang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkai","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-An Andy","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiping","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naif Abdullah","family":"Al-Dhabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veeramuthu","family":"Duraipandiyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"issue":"4","key":"2410_CR1","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","volume":"124","author":"S Akira","year":"2006","unstructured":"Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124(4):783\u2013801. doi: 10.1016\/j.cell.2006.02.015","journal-title":"Cell"},{"issue":"5","key":"2410_CR2","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nrmicro2546","volume":"9","author":"CL Bevins","year":"2011","unstructured":"Bevins CL, Salzman NH (2011) Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 9(5):356\u2013368. doi: 10.1038\/nrmicro2546","journal-title":"Nat Rev Microbiol"},{"issue":"2","key":"2410_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.micinf.2009.10.002","volume":"12","author":"JM Fleckenstein","year":"2010","unstructured":"Fleckenstein JM, Hardwidge PR, Munson GP, Rasko DA, Sommerfelt H, Steinsland H (2010) Molecular mechanisms of enterotoxigenic Escherichia coli infection. Microbes Infect\/Inst Pasteur 12(2):89\u201398. doi: 10.1016\/j.micinf.2009.10.002","journal-title":"Microbes Infect\/Inst Pasteur"},{"issue":"12","key":"2410_CR4","doi-asserted-by":"publisher","first-page":"e1000708","DOI":"10.1371\/journal.ppat.1000708","volume":"5","author":"X Gao","year":"2009","unstructured":"Gao X, Wan F, Mateo K, Callegari E, Wang D, Deng W, Puente J, Li F, Chaussee MS, Finlay BB, Lenardo MJ, Hardwidge PR (2009) Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function. PLoS Pathog 5(12):e1000708. doi: 10.1371\/journal.ppat.1000708","journal-title":"PLoS Pathog"},{"issue":"1","key":"2410_CR5","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.chom.2012.11.010","volume":"13","author":"X Gao","year":"2013","unstructured":"Gao X, Wang X, Pham TH, Feuerbacher LA, Lubos ML, Huang M, Olsen R, Mushegian A, Slawson C, Hardwidge PR (2013) NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-kappaB activation. Cell Host Microbe 13(1):87\u201399. doi: 10.1016\/j.chom.2012.11.010","journal-title":"Cell Host Microbe"},{"issue":"12","key":"2410_CR6","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1017\/S0007114514003171","volume":"112","author":"G Heim","year":"2014","unstructured":"Heim G, Sweeney T, O\u2019Shea CJ, Doyle DN, O\u2019Doherty JV (2014) Effect of maternal supplementation with seaweed extracts on growth performance and aspects of gastrointestinal health of newly weaned piglets after challenge with enterotoxigenic Escherichia coli K88. Br J Nutr 112(12):1955\u20131965. doi: 10.1017\/S0007114514003171","journal-title":"Br J Nutr"},{"issue":"3","key":"2410_CR7","doi-asserted-by":"publisher","first-page":"451","DOI":"10.4269\/ajtmh.2011.10-0445","volume":"84","author":"RB Kreisberg","year":"2011","unstructured":"Kreisberg RB, Harper J, Strauman MC, Marohn M, Clements JD, Nataro JP (2011) Induction of increased permeability of polarized enterocyte monolayers by enterotoxigenic Escherichia coli heat-labile enterotoxin. Am J Trop Med Hyg 84(3):451\u2013455. doi: 10.4269\/ajtmh.2011.10-0445","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"2410_CR8","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1080\/01635581.2015.1004730","volume":"67","author":"PC Leocadio","year":"2015","unstructured":"Leocadio PC, Antunes MM, Teixeira LG, Leonel AJ, Alvarez-Leite JI, Machado DC, Generoso SV, Cardoso VN, Correia MI (2015) l-Arginine pretreatment reduces intestinal mucositis as induced by 5-FU in mice. Nutr Cancer 67(3):486\u2013493. doi: 10.1080\/01635581.2015.1004730","journal-title":"Nutr Cancer"},{"issue":"4","key":"2410_CR9","doi-asserted-by":"publisher","first-page":"710","DOI":"10.3945\/jn.108.101485","volume":"139","author":"N Li","year":"2009","unstructured":"Li N, Neu J (2009) Glutamine deprivation alters intestinal tight junctions via a PI3-K\/Akt mediated pathway in Caco-2 cells. J Nutr 139(4):710\u2013714. doi: 10.3945\/jn.108.101485","journal-title":"J Nutr"},{"issue":"7","key":"2410_CR10","doi-asserted-by":"publisher","first-page":"e41041","DOI":"10.1371\/journal.pone.0041041","volume":"7","author":"M Loos","year":"2012","unstructured":"Loos M, Geens M, Schauvliege S, Gasthuys F, van der Meulen J, Dubreuil JD, Goddeeris BM, Niewold T, Cox E (2012) Role of heat-stable enterotoxins in the induction of early immune responses in piglets after infection with enterotoxigenic Escherichia coli. PLoS One 7(7):e41041. doi: 10.1371\/journal.pone.0041041","journal-title":"PLoS One"},{"issue":"1\u20132","key":"2410_CR11","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.vetimm.2012.09.026","volume":"152","author":"R Nakashima","year":"2013","unstructured":"Nakashima R, Kamata Y, Nishikawa Y (2013) Effects of Escherichia coli heat-stable enterotoxin and guanylin on the barrier integrity of intestinal epithelial T84 cells. Vet Immunol Immunopathol 152(1\u20132):78\u201381. doi: 10.1016\/j.vetimm.2012.09.026","journal-title":"Vet Immunol Immunopathol"},{"issue":"11","key":"2410_CR12","doi-asserted-by":"publisher","first-page":"e113273","DOI":"10.1371\/journal.pone.0113273","volume":"9","author":"H Nassour","year":"2014","unstructured":"Nassour H, Dubreuil JD (2014) Escherichia coli STb enterotoxin dislodges claudin-1 from epithelial tight junctions. PLoS One 9(11):e113273. doi: 10.1371\/journal.pone.0113273","journal-title":"PLoS One"},{"issue":"8","key":"2410_CR13","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.1128\/IAI.00455-13","volume":"81","author":"C Ngendahayo Mukiza","year":"2013","unstructured":"Ngendahayo Mukiza C, Dubreuil JD (2013) Escherichia coli heat-stable toxin b impairs intestinal epithelial barrier function by altering tight junction proteins. Infect Immun 81(8):2819\u20132827. doi: 10.1128\/IAI.00455-13","journal-title":"Infect Immun"},{"issue":"6","key":"2410_CR14","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1007\/s00726-011-0942-y","volume":"42","author":"W Ren","year":"2012","unstructured":"Ren W, Yin Y, Liu G, Yu X, Li Y, Yang G, Li T, Wu G (2012) Effect of dietary arginine supplementation on reproductive performance of mice with porcine circovirus type 2 infection. Amino Acids 42(6):2089\u20132094. doi: 10.1007\/s00726-011-0942-y","journal-title":"Amino Acids"},{"issue":"6","key":"2410_CR15","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1017\/S0007114512006101","volume":"110","author":"W Ren","year":"2013","unstructured":"Ren W, Li Y, Yu X, Luo W, Liu G, Shao H, Yin Y (2013a) Glutamine modifies immune responses of mice infected with porcine circovirus type 2. Br J Nutr 110(6):1053\u20131060. doi: 10.1017\/S0007114512006101","journal-title":"Br J Nutr"},{"issue":"4","key":"2410_CR16","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s00726-013-1551-8","volume":"45","author":"W Ren","year":"2013","unstructured":"Ren W, Liu S, Chen S, Zhang F, Li N, Yin J, Peng Y, Wu L, Liu G, Yin Y, Wu G (2013b) Dietary l-glutamine supplementation increases Pasteurella multocida burden and the expression of its major virulence factors in mice. Amino Acids 45(4):947\u2013955. doi: 10.1007\/s00726-013-1551-8","journal-title":"Amino Acids"},{"issue":"3","key":"2410_CR17","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s00726-011-1134-5","volume":"45","author":"W Ren","year":"2013","unstructured":"Ren W, Luo W, Wu M, Liu G, Yu X, Fang J, Li T, Yin Y, Wu G (2013c) Dietary l-glutamine supplementation improves pregnancy outcome in mice infected with type-2 porcine circovirus. Amino Acids 45(3):479\u2013488. doi: 10.1007\/s00726-011-1134-5","journal-title":"Amino Acids"},{"issue":"5","key":"2410_CR18","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1017\/S0007114512002681","volume":"109","author":"W Ren","year":"2013","unstructured":"Ren W, Zou L, Li N, Wang Y, Liu G, Peng Y, Ding J, Cai L, Yin Y, Wu G (2013d) Dietary arginine supplementation enhances immune responses to inactivated Pasteurella multocida vaccination in mice. Br J Nutr 109(5):867\u2013872. doi: 10.1017\/S0007114512002681","journal-title":"Br J Nutr"},{"issue":"6","key":"2410_CR19","doi-asserted-by":"publisher","first-page":"988","DOI":"10.3945\/jn.114.192120","volume":"144","author":"W Ren","year":"2014","unstructured":"Ren W, Chen S, Yin J, Duan J, Li T, Liu G, Feng Z, Tan B, Yin Y, Wu G (2014a) Dietary arginine supplementation of mice alters the microbial population and activates intestinal innate immunity. J Nutr 144(6):988\u2013995. doi: 10.3945\/jn.114.192120","journal-title":"J Nutr"},{"issue":"10","key":"2410_CR20","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1007\/s00726-014-1793-0","volume":"46","author":"W Ren","year":"2014","unstructured":"Ren W, Duan J, Yin J, Liu G, Cao Z, Xiong X, Chen S, Li T, Yin Y, Hou Y, Wu G (2014b) Dietary l-glutamine supplementation modulates microbial community and activates innate immunity in the mouse intestine. Amino Acids 46(10):2403\u20132413. doi: 10.1007\/s00726-014-1793-0","journal-title":"Amino Acids"},{"issue":"11","key":"2410_CR21","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.micinf.2014.09.005","volume":"16","author":"W Ren","year":"2014","unstructured":"Ren W, Yin J, Duan J, Liu G, Zhu X, Chen S, Li T, Wang S, Tang Y, Hardwidge PR (2014c) Mouse intestinal innate immune responses altered by enterotoxigenic Escherichia coli (ETEC) infection. Microbes Infect\/Inst Pasteur 16(11):954\u2013961. doi: 10.1016\/j.micinf.2014.09.005","journal-title":"Microbes Infect\/Inst Pasteur"},{"issue":"2","key":"2410_CR22","doi-asserted-by":"publisher","first-page":"e88335","DOI":"10.1371\/journal.pone.0088335","volume":"9","author":"W Ren","year":"2014","unstructured":"Ren W, Yin J, Wu M, Liu G, Yang G, Xion Y, Su D, Wu L, Li T, Chen S, Duan J, Yin Y, Wu G (2014d) Serum amino acids profile and the beneficial effects of l-arginine or l-glutamine supplementation in dextran sulfate sodium colitis. PLoS One 9(2):e88335. doi: 10.1371\/journal.pone.0088335","journal-title":"PLoS One"},{"issue":"73","key":"2410_CR23","doi-asserted-by":"publisher","first-page":"59550","DOI":"10.1039\/c5ra09513a","volume":"5","author":"WK Ren","year":"2015","unstructured":"Ren WK, Yin J, Gao W, Chen S, Duan JL, Liu G, Li TJ, Li NZ, Peng YY, Yin YL (2015) Metabolomics study of metabolic variations in enterotoxigenic Escherichia coli-infected piglets. Rsc Adv 5(73):59550\u201359555. doi: 10.1039\/c5ra09513a","journal-title":"Rsc Adv"},{"key":"2410_CR24","doi-asserted-by":"publisher","first-page":"25640","DOI":"10.1038\/srep25640","volume":"6","author":"W Ren","year":"2016","unstructured":"Ren W, Yin J, Chen S, Duan J, Liu G, Li T, Li N, Peng Y, Tan B, Yin Y (2016a) Proteome analysis for the global proteins in the jejunum tissues of enterotoxigenic Escherichia coli-infected piglets. Sci Rep 6:25640. doi: 10.1038\/srep25640","journal-title":"Sci Rep"},{"key":"2410_CR25","doi-asserted-by":"publisher","first-page":"503","DOI":"10.3389\/fimmu.2016.00503","volume":"7","author":"W Ren","year":"2016","unstructured":"Ren W, Wang K, Yin J, Chen S, Liu G, Tan B, Wu G, Bazer FW, Peng Y, Yin Y (2016b) Glutamine-induced secretion of intestinal secretory immunoglobulin A: a mechanistic perspective. Front Immunol 7:503. doi: 10.3389\/fimmu.2016.00503","journal-title":"Front Immunol"},{"issue":"2","key":"2410_CR43","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/eji.201545886","volume":"46","author":"W Ren","year":"2016","unstructured":"Ren W, Yin J, Duan J, Liu G, Tan B, Yang G, Wu G, Bazer FW, Peng Y, Yin Y (2016c) mTORC1 signaling and IL-17 expression: Defining pathways and possible therapeutic targets. Eur J Immunol 46(2):291\u2013299","journal-title":"Eur J Immunol"},{"key":"2410_CR46","doi-asserted-by":"crossref","unstructured":"Ren W, Yin J, Xiao H, Chen S, Liu G, Tan B, Li N, Peng Y, Li T, Zeng B, Li W, Wei H, Yin Z, Wu G, Hardwidge PR, Yin Y (2017a) Intestinal microbiota-derived GABA mediates interleukin-17 expression during enterotoxigenic Escherichia coli infection. Front Immunol 7","DOI":"10.3389\/fimmu.2016.00685"},{"issue":"3","key":"2410_CR44","doi-asserted-by":"crossref","first-page":"e2655","DOI":"10.1038\/cddis.2016.222","volume":"8","author":"W Ren","year":"2017","unstructured":"Ren W, Liu G, Yin J, Tan B, Wu G, Bazer FW, Peng Y, Yin Y (2017b) Amino-acid transporters in T-cell activation and differentiation. Cell Death Dis 8(3):e2655","journal-title":"Cell Death Dis"},{"issue":"7636","key":"2410_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0140-6736(70)90520-9","volume":"1","author":"B Rowe","year":"1970","unstructured":"Rowe B, Taylor J, Bettelheim KA (1970) An investigation of traveller\u2019s diarrhoea. Lancet 1(7636):1\u20135","journal-title":"Lancet"},{"issue":"6","key":"2410_CR27","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","volume":"140","author":"K Schroder","year":"2010","unstructured":"Schroder K, Tschopp J (2010) The inflammasomes. Cell 140(6):821\u2013832. doi: 10.1016\/j.cell.2010.01.040","journal-title":"Cell"},{"issue":"1","key":"2410_CR28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/MMBR.60.1.167-215.1996","volume":"60","author":"CL Sears","year":"1996","unstructured":"Sears CL, Kaper JB (1996) Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion. Microbiol Rev 60(1):167\u2013215","journal-title":"Microbiol Rev"},{"issue":"6","key":"2410_CR29","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","volume":"140","author":"O Takeuchi","year":"2010","unstructured":"Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140(6):805\u2013820. doi: 10.1016\/j.cell.2010.01.022","journal-title":"Cell"},{"key":"2410_CR30","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2741\/4352","volume":"20","author":"B Tan","year":"2015","unstructured":"Tan B, Xiao H, Xiong X, Wang J, Li G, Yin Y, Huang B, Hou Y, Wu G (2015) l-Arginine improves DNA synthesis in LPS-challenged enterocytes. Frontiers Biosci 20:989\u20131003","journal-title":"Frontiers Biosci"},{"issue":"1\u20132","key":"2410_CR31","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.vetmic.2014.03.025","volume":"171","author":"Y Tang","year":"2014","unstructured":"Tang Y, Li F, Tan B, Liu G, Kong X, Hardwidge PR, Yin Y (2014) Enterotoxigenic Escherichia coli infection induces intestinal epithelial cell autophagy. Vet Microbiol 171(1\u20132):160\u2013164. doi: 10.1016\/j.vetmic.2014.03.025","journal-title":"Vet Microbiol"},{"issue":"10","key":"2410_CR32","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.molmed.2011.05.011","volume":"17","author":"L Vereecke","year":"2011","unstructured":"Vereecke L, Beyaert R, van Loo G (2011) Enterocyte death and intestinal barrier maintenance in homeostasis and disease. Trends Mol Med 17(10):584\u2013593. doi: 10.1016\/j.molmed.2011.05.011","journal-title":"Trends Mol Med"},{"issue":"4","key":"2410_CR33","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/ni.2007","volume":"12","author":"F Wan","year":"2011","unstructured":"Wan F, Weaver A, Gao X, Bern M, Hardwidge PR, Lenardo MJ (2011) IKKbeta phosphorylation regulates RPS3 nuclear translocation and NF-kappaB function during infection with Escherichia coli strain O157:H7. Nat Immunol 12(4):335\u2013343. doi: 10.1038\/ni.2007","journal-title":"Nat Immunol"},{"issue":"12","key":"2410_CR34","doi-asserted-by":"publisher","first-page":"4417","DOI":"10.1128\/IAI.00809-12","volume":"80","author":"X Wang","year":"2012","unstructured":"Wang X, Hardwidge PR (2012) Enterotoxigenic Escherichia coli prevents host NF-kappaB activation by targeting IkappaBalpha polyubiquitination. Infect Immun 80(12):4417\u20134425. doi: 10.1128\/IAI.00809-12","journal-title":"Infect Immun"},{"issue":"8","key":"2410_CR35","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1111\/j.1462-5822.2012.01793.x","volume":"14","author":"X Wang","year":"2012","unstructured":"Wang X, Gao X, Hardwidge PR (2012) Heat-labile enterotoxin-induced activation of NF-kappaB and MAPK pathways in intestinal epithelial cells impacts enterotoxigenic Escherichia coli (ETEC) adherence. Cell Microbiol 14(8):1231\u20131241. doi: 10.1111\/j.1462-5822.2012.01793.x","journal-title":"Cell Microbiol"},{"issue":"3","key":"2410_CR36","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3945\/jn.115.224857","volume":"146","author":"B Wang","year":"2016","unstructured":"Wang B, Wu Z, Ji Y, Sun K, Dai Z, Wu G (2016) l-Glutamine enhances tight junction integrity by activating CaMK kinase 2-AMP-activated protein kinase signaling in intestinal porcine epithelial cells. J Nutr 146(3):501\u2013508. doi: 10.3945\/jn.115.224857","journal-title":"J Nutr"},{"issue":"4","key":"2410_CR37","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.3390\/toxins7041341","volume":"7","author":"L Wu","year":"2015","unstructured":"Wu L, Liao P, He L, Feng Z, Ren W, Yin J, Duan J, Li T, Yin Y (2015) Dietary l-arginine supplementation protects weanling pigs from deoxynivalenol-induced toxicity. Toxins 7(4):1341\u20131354. doi: 10.3390\/toxins7041341","journal-title":"Toxins"},{"issue":"7","key":"2410_CR38","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1002\/mnfr.201600026","volume":"60","author":"M Wu","year":"2016","unstructured":"Wu M, Xiao H, Liu G, Chen S, Tan B, Ren W, Bazer FW, Wu G, Yin Y (2016) Glutamine promotes intestinal SIgA secretion through intestinal microbiota and IL-13. Mol Nutr Food Res 60(7):1637\u20131648. doi: 10.1002\/mnfr.201600026","journal-title":"Mol Nutr Food Res"},{"issue":"8","key":"2410_CR39","doi-asserted-by":"publisher","first-page":"e104192","DOI":"10.1371\/journal.pone.0104192","volume":"9","author":"D Xiao","year":"2014","unstructured":"Xiao D, Wang Y, Liu G, He J, Qiu W, Hu X, Feng Z, Ran M, Nyachoti CM, Kim SW, Tang Z, Yin Y (2014) Effects of chitosan on intestinal inflammation in weaned pigs challenged by enterotoxigenic Escherichia coli. PLoS One 9(8):e104192. doi: 10.1371\/journal.pone.0104192","journal-title":"PLoS One"},{"key":"2410_CR40","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jff.2016.01.009","volume":"22","author":"DF Xiao","year":"2016","unstructured":"Xiao DF, Ren WK, Bin P, Chen S, Yin J, Gao W, Liu G, Nan Z, Hu XG, He JH (2016) Chitosan lowers body weight through intestinal microbiota and reduces IL-17 expression via mTOR signalling. J Funct Foods 22:166\u2013176. doi: 10.1016\/j.jff.2016.01.009","journal-title":"J Funct Foods"},{"key":"2410_CR41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40104-016-0061-4","volume":"7","author":"L Zhang","year":"2016","unstructured":"Zhang L, Zhang L, Zhan X, Zeng X, Zhou L, Cao G, Chen A, Yang C (2016) Effects of dietary supplementation of probiotic, Clostridium butyricum, on growth performance, immune response, intestinal barrier function, and digestive enzyme activity in broiler chickens challenged with Escherichia coli K88. J Anim Sci Biotechnol 7:3. doi: 10.1186\/s40104-016-0061-4","journal-title":"J Anim Sci Biotechnol"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-017-2410-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-017-2410-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-017-2410-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T17:59:28Z","timestamp":1601747968000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-017-2410-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,15]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2410"],"URL":"https:\/\/doi.org\/10.1007\/s00726-017-2410-9","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,15]]}}}