{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:58:48Z","timestamp":1764997128850,"version":"3.37.3"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T00:00:00Z","timestamp":1492646400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002997","name":"Dutch Kidney Foundation","doi-asserted-by":"crossref","award":["NSN C08-2254, P13-114"],"award-info":[{"award-number":["NSN C08-2254, P13-114"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s00726-017-2420-7","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T04:07:38Z","timestamp":1492661258000},"page":"1193-1202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients"],"prefix":"10.1007","volume":"49","author":[{"given":"Arslan Arinc","family":"Kayacelebi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidor","family":"Minovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Hanff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Roos S.","family":"Frenay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin H.","family":"de Borst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Feelisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"van Goor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan J. L.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Tsikas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"2420_CR1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/cvr\/cvw062","volume":"110","author":"I Alesutan","year":"2016","unstructured":"Alesutan I, Feger M, Tuffaha R, Castor T, Musculus K, Buehling SS et al (2016) Augmentation of phosphate-induced osteo-\/chondrogenic transformation of vascular smooth muscle cells by homoarginine. Cardiovasc Res 110:408\u2013418","journal-title":"Cardiovasc Res"},{"key":"2420_CR2","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1016\/j.ijcard.2013.07.099","volume":"168","author":"D Atzler","year":"2013","unstructured":"Atzler D, Rosenberg M, Anderssohn M et al (2013) Homoarginine\u2014an independent marker of mortality in heart failure. Int J Cardiol 168:4907\u20134909","journal-title":"Int J Cardiol"},{"key":"2420_CR3","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1161\/ATVBAHA.114.304398","volume":"34","author":"D Atzler","year":"2014","unstructured":"Atzler D, Gore MO, Ayers CR et al (2014) Homoarginine and cardiovascular outcome in the population-based Dallas Heart Study. Arterioscler Thromb Vasc Biol 34:2501\u20132507","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2420_CR4","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13068","author":"D Atzler","year":"2016","unstructured":"Atzler D, Sch\u00f6nhoff M, Cordts K, Ortland I, Hoppe J, Hummel FC, Gerloff C, Jaehde U, Jagodzinski A, B\u00f6ger RH, Choe CU, Schwedhelm E (2016) Oral supplementation with l-homoarginine in young volunteers. Br J Clin Pharmacol. doi: 10.1111\/bcp.13068","journal-title":"Br J Clin Pharmacol"},{"key":"2420_CR100","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s00726-015-1960-y","volume":"47","author":"HG Bernstein","year":"2015","unstructured":"Bernstein HG, J\u00e4ger K, Dobrowolny H, Steiner J, Keilhoff G, Bogerts B, Laube G (2015) Possible sources and functions of L-homoarginine in the brain: review of the literature and own findings. Amino Acids 47:1729\u20131740","journal-title":"Amino Acids"},{"key":"2420_CR5","doi-asserted-by":"crossref","first-page":"46789","DOI":"10.1074\/jbc.M306787200","volume":"278","author":"LE Bretscher","year":"2003","unstructured":"Bretscher LE, Li H, Poulos TL, Griffith OW (2003) Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines. J Biol Chem 278:46789\u201346797","journal-title":"J Biol Chem"},{"key":"2420_CR6","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1093\/eurjhf\/hfr056","volume":"13","author":"C Drechsler","year":"2011","unstructured":"Drechsler C, Meinitzer A, Pilz S et al (2011) Homoarginine, heart failure, and sudden cardiac death in haemodialysis patients. Eur J Heart Fail 13:852\u2013859","journal-title":"Eur J Heart Fail"},{"key":"2420_CR7","doi-asserted-by":"crossref","first-page":"e63560","DOI":"10.1371\/journal.pone.0063560","volume":"8","author":"C Drechsler","year":"2013","unstructured":"Drechsler C, Kollerits B, Meinitzer A et al (2013) Homoarginine and progression of chronic kidney disease: results from the Mild to Moderate Kidney Disease Study. PLoS One 8:e63560","journal-title":"PLoS One"},{"key":"2420_CR8","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1097\/TP.0000000000000568","volume":"99","author":"C Drechsler","year":"2015","unstructured":"Drechsler C, Pihlstr\u00f8m H, Meinitzer A, Pilz S, Tomaschitz A, Abedini S, Fellstrom B, Jardine AG, Wanner C, M\u00e4rz W, Holdaas H (2015) Homoarginine and clinical outcomes in renal transplant recipients: results from the assessment of lescol in renal transplantation study. Transplantation 99:1470\u20131476","journal-title":"Transplantation"},{"key":"2420_CR9","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1007\/s00726-015-2023-0","volume":"47","author":"AR Frenay","year":"2015","unstructured":"Frenay AR, van den Berg E, de Borst MH, Beckmann B, Tsikas D, Feelisch M, Navis G, Bakker SJL, van Goor H (2015a) Plasma ADMA associates with all-cause mortality in renal transplant recipients. Amino Acids 47:1941\u20131949","journal-title":"Amino Acids"},{"key":"2420_CR10","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1007\/s00726-015-2038-6","volume":"47","author":"AR Frenay","year":"2015","unstructured":"Frenay AR, Kayacelebi AA, Beckmann B, Soedamah SS, de Borst MH, van den Berg E, van Goor H, Bakker SJL, Tsikas D (2015b) High urinary homoarginine excretion is associated with low rates of all-cause mortality in renal transplant recipients. Amino Acids 47:1827\u20131836","journal-title":"Amino Acids"},{"key":"2420_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-017-2409-2","author":"A Haghikia","year":"2017","unstructured":"Haghikia A, Yanchev GR, Kayacelebi AA, Hanff E, Bledau N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Bauersachs J, Bavendiek U, Tsikas D (2017) The role of l-arginine\/l-homoarginine\/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients. Amino Acids. doi: 10.1007\/s00726-017-2409-2","journal-title":"Amino Acids"},{"key":"2420_CR12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ijcard.2016.08.211","volume":"223","author":"E Hanff","year":"2016","unstructured":"Hanff E, Kayacelebi AA, Herrmann C, Obermann M, Das AM, Tsikas D (2016) Unaltered l-arginine\/NO pathway in a MELAS patient: is mitochondrial NO synthase involved in the MELAS syndrome? Int J Cardiol 223:479\u2013481","journal-title":"Int J Cardiol"},{"key":"2420_CR13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0014-5793(91)81434-A","volume":"294","author":"M Hecker","year":"1991","unstructured":"Hecker M, Walsh DT, Vane JR (1991) On the substrate specificity of nitric oxide synthase. FEBS Lett 294:221\u2013224","journal-title":"FEBS Lett"},{"key":"2420_CR14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.yjmcc.2005.09.011","volume":"40","author":"SP Jones","year":"2006","unstructured":"Jones SP, Bolli R (2006) The ubiquitous role of nitric oxide in cardioprotection. J Mol Cell Cardiol 40:16\u201323","journal-title":"J Mol Cell Cardiol"},{"key":"2420_CR16","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.ijcard.2014.03.080","volume":"173","author":"AA Kayacelebi","year":"2014","unstructured":"Kayacelebi AA, Nguyen TH, Neil C et al (2014a) Homoarginine and 3-nitrotyrosine in patients with takotsubo cardiomyopathy. Int J Cardiol 173:546\u2013547","journal-title":"Int J Cardiol"},{"key":"2420_CR17","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s00726-014-1774-3","volume":"46","author":"AA Kayacelebi","year":"2014","unstructured":"Kayacelebi AA, Beckmann B, Gutzki FM, Jordan J, Tsikas D (2014b) GC-MS and GC-MS\/MS measurement of the cardiovascular risk factor homoarginine in biological samples. Amino Acids 46:2205\u20132217","journal-title":"Amino Acids"},{"key":"2420_CR18","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/CIRCGENETICS.113.000108","volume":"6","author":"ME Kleber","year":"2013","unstructured":"Kleber ME, Seppala I, Pilz S, Hoffmann MM, Tomaschitz A, Oksala N, Raitoharju E, Lyytikainen LP, Makela KM, Laaksonen R, Kahonen M, Raitakari OT, Huang J, Kienreich K, Fahrleitner-Pammer A, Drechsler C, Krane V, Boehm BO, Koenig W, Wanner C, Lehtimaki T, Marz W, Meinitzer A (2013) Genome-wide association study identifies 3 genomic loci significantly associated with serum levels of homoarginine: the AtheroRemo Consortium. Circ Cardiovasc Genet 6:505\u2013513","journal-title":"Circ Cardiovasc Genet"},{"key":"2420_CR19","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1046\/j.1523-1755.2000.00014.x","volume":"57","author":"JD Kopple","year":"2000","unstructured":"Kopple JD, Greene T, Chumlea WC et al (2000) Relationship between nutritional status and the glomerular filtration rate: results from the MDRD study. Kidney Int 57:1688\u20131703","journal-title":"Kidney Int"},{"key":"2420_CR20","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604\u2013612","journal-title":"Ann Intern Med"},{"key":"2420_CR21","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S0026-0495(97)90273-0","volume":"46","author":"B Marescau","year":"1997","unstructured":"Marescau B, Nagels G, Possemiers I, De Broe ME, Becaus I, Billiouw JM, Lornoy W, De Deyn PP (1997) Guanidino compounds in serum and urine of nondialyzed patients with chronic renal insufficiency. Metabolism 46:1024\u20131031","journal-title":"Metabolism"},{"key":"2420_CR22","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/CIRCULATIONAHA.109.908988","volume":"122","author":"W M\u00e4rz","year":"2010","unstructured":"M\u00e4rz W, Meinitzer A, Drechsler C et al (2010) Homoarginine, cardiovascular risk, and mortality. Circulation 122:967\u2013975","journal-title":"Circulation"},{"key":"2420_CR23","doi-asserted-by":"crossref","first-page":"10453","DOI":"10.1021\/bi980742t","volume":"37","author":"C Moali","year":"1998","unstructured":"Moali C, Boucher JL, Sari MA et al (1998) Substrate specificity of NO synthases: detailed comparison of l-arginine, homo-l-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-l-arginine. Biochemistry 37:10453\u201310460","journal-title":"Biochemistry"},{"key":"2420_CR24","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/j.1600-6143.2011.03480.x","volume":"11","author":"MZ Molnar","year":"2011","unstructured":"Molnar MZ, Kovesdy CP, Bunnapradist S et al (2011) Associations of pretransplant serum albumin with post-transplant outcomes in kidney transplant recipients. Am J Transplant 11:1006\u20131015","journal-title":"Am J Transplant"},{"key":"2420_CR25","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","volume":"329","author":"S Moncada","year":"1993","unstructured":"Moncada S, Higgs A (1993) The l-arginine-nitric oxide pathway. N Engl J Med 329:2002\u20132012","journal-title":"N Engl J Med"},{"key":"2420_CR26","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s11906-010-0094-6","volume":"12","author":"PM O\u2019Connor","year":"2010","unstructured":"O\u2019Connor PM, Cowley AW Jr (2010) Modulation of pressure-natriuresis by renal medullary reactive oxygen species and nitric oxide. Curr Hypertens Rep 12:86\u201392","journal-title":"Curr Hypertens Rep"},{"key":"2420_CR27","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1111\/j.1523-1755.2005.00259.x","volume":"67","author":"J Passauer","year":"2005","unstructured":"Passauer J, Pistrosch F, Bussemaker E (2005) Nitric oxide in chronic renal failure. Kidney Int 67:1665\u20131667","journal-title":"Kidney Int"},{"key":"2420_CR28","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1136\/hrt.2010.220731","volume":"97","author":"S Pilz","year":"2011","unstructured":"Pilz S, Meinitzer A, Tomaschitz A et al (2011a) Low homoarginine concentration is a novel risk factor for heart disease. Heart 97:1222\u20131227","journal-title":"Heart"},{"key":"2420_CR29","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1161\/STROKEAHA.110.603035","volume":"42","author":"S Pilz","year":"2011","unstructured":"Pilz S, Tomaschitz A, Meinitzer A et al (2011b) Low serum homoarginine is a novel risk factor for fatal strokes in patients undergoing coronary angiography. Stroke 42:1132\u20131134","journal-title":"Stroke"},{"key":"2420_CR30","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.cardfail.2014.09.004","volume":"20","author":"S Pilz","year":"2014","unstructured":"Pilz S, Edelmann F, Meinitzer A et al (2014) Associations of methylarginines and homoarginine with diastolic dysfunction and cardiovascular risk factors in patients with preserved left ventricular ejection fraction. J Card Fail 20:923\u2013930","journal-title":"J Card Fail"},{"key":"2420_CR31","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00726-015-1993-2","volume":"47","author":"S Pilz","year":"2015","unstructured":"Pilz S, Meinitzer A, Gaksch M, Gr\u00fcbler M, Verheyen N, Drechsler C, Hartaigh B\u00d3, Lang F, Alesutan I, Voelkl J, M\u00e4rz W, Tomaschitz A (2015) Homoarginine in the renal and cardiovascular systems. Amino Acids 47:1703\u20131713","journal-title":"Amino Acids"},{"key":"2420_CR32","doi-asserted-by":"crossref","first-page":"e72694","DOI":"10.1371\/journal.pone.0072694","volume":"8","author":"P Ravani","year":"2013","unstructured":"Ravani P, Maas R, Malberti F et al (2013) Homoarginine and mortality in pre-dialysis chronic kidney disease (CKD) patients. PLoS One 8:e72694","journal-title":"PLoS One"},{"key":"2420_CR33","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.transproceed.2006.11.031","volume":"39","author":"O Rettkowski","year":"2007","unstructured":"Rettkowski O, Wienke A, Hamza A et al (2007) Low body mass index in kidney transplant recipients: risk or advantage for long-term graft function? Transplant Proc 39:1416\u20131420","journal-title":"Transplant Proc"},{"key":"2420_CR34","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1007\/s00726-015-1973-6","volume":"47","author":"S Sasso","year":"2015","unstructured":"Sasso S, Dalmedico L, Magro DD, Pereira EM, Wyse AT, de Lima DD (2015) Differential in vitro effects of homoarginine on oxidative stress in plasma, erythrocytes, kidney and liver of rats in the absence and in the presence alpha-tocopherol, ascorbic acid or L-NAME. Amino Acids 47:1931\u20131939","journal-title":"Amino Acids"},{"key":"2420_CR35","doi-asserted-by":"crossref","first-page":"590541","DOI":"10.1155\/2014\/590541","volume":"2014","author":"T Takahashi","year":"2014","unstructured":"Takahashi T, Harris RC (2014) Role of endothelial nitric oxide synthase in diabetic nephropathy: lessons from diabetic eNOS knockout mice. J Diabetes Res 2014:590541","journal-title":"J Diabetes Res"},{"key":"2420_CR36","unstructured":"The Hague: Dutch food composition table (NEVO 2006) NEVO table\u00a02006 (dutch nutrient databank: NEVO table\u00a02006)"},{"key":"2420_CR37","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/ndt\/gft512","volume":"29","author":"A Tomaschitz","year":"2014","unstructured":"Tomaschitz A, Meinitzer A, Pilz S et al (2014) Homoarginine, kidney function and cardiovascular mortality risk. Nephrol Dial Transplant 29:663\u2013671","journal-title":"Nephrol Dial Transplant"},{"key":"2420_CR38","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/MAJ.0000000000000419","volume":"349","author":"A Tomaschitz","year":"2015","unstructured":"Tomaschitz A, Verheyen N, Gaksch M, Meinitzer A, Pieske B, Kraigher-Krainer E, Colantonio C, M\u00e4rz W, Schmidt A, Belyavskiy E, Rus-Machan J, van Ballegooijen AJ, Stiegler C, Amrein K, Ritz E, Fahrleitner-Pammer A, Pilz S (2015) Homoarginine in patients with primary hyperparathyroidism. Am J Med Sci 349:306\u2013311","journal-title":"Am J Med Sci"},{"key":"2420_CR39","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00726-015-2055-5","volume":"47","author":"D Tsikas","year":"2015","unstructured":"Tsikas D, Wu G (2015) Homoarginine, arginine, and relatives: analysis, metabolism, transport, physiology, and pathology. Amino Acids 47:1697\u20131702","journal-title":"Amino Acids"},{"key":"2420_CR102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(00)01686-0","volume":"478","author":"D Tsikas","year":"2000","unstructured":"Tsikas D, B\u00f6ger RH, Sandmann J, Bode-B\u00f6ger SM, Fr\u00f6lich JC (2000) Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox. FEBS Lett 478:1\u20133","journal-title":"FEBS Lett"},{"key":"2420_CR41","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.2215\/CJN.04590512","volume":"7","author":"E Berg van den","year":"2012","unstructured":"van den Berg E, Engberink MF, Brink EJ et al (2012a) Dietary acid load and metabolic acidosis in renal transplant recipients. Clin J Am Soc Nephrol 7:1811\u20131818","journal-title":"Clin J Am Soc Nephrol"},{"key":"2420_CR42","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1093\/ndt\/gfs069","volume":"27","author":"E Berg van den","year":"2012","unstructured":"van den Berg E, Geleijnse JM, Brink EJ et al (2012b) Sodium intake and blood pressure in renal transplant recipients. Nephrol Dial Transplant 27:3352\u20133359","journal-title":"Nephrol Dial Transplant"},{"key":"2420_CR43","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1017\/S0007114512003455","volume":"109","author":"E Berg van den","year":"2013","unstructured":"van den Berg E, Engberink MF, Brink EJ et al (2013) Dietary protein, blood pressure and renal function in renal transplant recipients. Br J Nutr 109:1463\u20131470","journal-title":"Br J Nutr"},{"key":"2420_CR44","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1681\/ASN.2013050497","volume":"25","author":"E Berg van den","year":"2014","unstructured":"van den Berg E, Pasch A, Westendorp WH et al (2014) Urinary sulfur metabolites associate with a favorable cardiovascular risk profile and survival benefit in renal transplant recipients. J Am Soc Nephrol 25:1303\u20131312","journal-title":"J Am Soc Nephrol"},{"key":"2420_CR45","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00726-008-0210-y","volume":"37","author":"G Wu","year":"2009","unstructured":"Wu G, Bazer FW, Davis TA et al (2009) Arginine metabolism and nutrition in growth, health and disease. Amino Acids 37:153\u2013168","journal-title":"Amino Acids"},{"key":"2420_CR46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0006-8993(01)03197-3","volume":"923","author":"AT Wyse","year":"2001","unstructured":"Wyse AT, Bavaresco CS, Hagen ME, Delwing D, Wannmacher CM, Severo Dutra-Filho C et al (2001) In vitro stimulation of oxidative stress in cerebral cortex of rats by the guanidino compounds accumulating in hyperargininemia. Brain Res 923:50\u201357","journal-title":"Brain Res"},{"key":"2420_CR47","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1152\/physrev.2000.80.3.1107","volume":"80","author":"M Wyss","year":"2000","unstructured":"Wyss M, Kaddurah-Daouk R (2000) Creatine and creatinine metabolism. Physiol Rev 80:1107\u20131213","journal-title":"Physiol Rev"},{"key":"2420_CR48","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.2174\/138161211796391047","volume":"17","author":"Z Xia","year":"2011","unstructured":"Xia Z, Vanhoutte PM (2011) Nitric oxide and protection against cardiac ischemia. Curr Pharm Des 17:1774\u20131782","journal-title":"Curr Pharm Des"},{"key":"2420_CR49","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11906-006-0041-8","volume":"8","author":"Z Yang","year":"2006","unstructured":"Yang Z, Ming XF (2006) Endothelial arginase: a new target in atherosclerosis. Curr Hypertens Rep 8:54\u201359","journal-title":"Curr Hypertens Rep"},{"key":"2420_CR50","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.ki.5000417","volume":"70","author":"C Zoccali","year":"2006","unstructured":"Zoccali C (2006) Traditional and emerging cardiovascular and renal risk factors: an epidemiologic perspective. Kidney Int 70:26\u201333","journal-title":"Kidney Int"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-017-2420-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-017-2420-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-017-2420-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T06:32:20Z","timestamp":1569047540000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-017-2420-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,20]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["2420"],"URL":"https:\/\/doi.org\/10.1007\/s00726-017-2420-7","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"type":"print","value":"0939-4451"},{"type":"electronic","value":"1438-2199"}],"subject":[],"published":{"date-parts":[[2017,4,20]]}}}