{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:44:16Z","timestamp":1788777856918,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:00:00Z","timestamp":1524787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Evaluation- orientation de la COop\u00e9ration Scientifique","award":["C12S01"],"award-info":[{"award-number":["C12S01"]}]},{"name":"Fondecyt","award":["1120290"],"award-info":[{"award-number":["1120290"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s00726-018-2558-y","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T01:59:51Z","timestamp":1524794391000},"page":"755-763","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Proanthocyanidin-containing polyphenol extracts from fruits prevent the inhibitory effect of hydrogen sulfide on human colonocyte oxygen consumption"],"prefix":"10.1007","volume":"50","author":[{"given":"Mireille","family":"Andriamihaja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u00efg","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Beaumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Grauso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gotteland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Pastene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jose","family":"Cires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Carrasco-Pozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tom\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Blachier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,27]]},"reference":[{"key":"2558_CR1","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1021\/jf803059z","volume":"57","author":"MM Appeldoorn","year":"2009","unstructured":"Appeldoorn MM, Vincken JP, Aura AM, Hollman PC, Gruppen H (2009) Procyanidin dimers are metabolized by human microbiota with 2-(3,4-dihydroxyphenyl)acetic acid and 5-(3,4-dihydroxyphenyl)-gamma-valerolactone as the major metabolites. J Agric Food Chem 57:1084\u20131092","journal-title":"J Agric Food Chem"},{"key":"2558_CR2","doi-asserted-by":"publisher","first-page":"E70","DOI":"10.1097\/MIB.0b013e31827e790e","volume":"19","author":"I Arijs","year":"2013","unstructured":"Arijs I, Vanhove W, Rutgeerts P, Schuit F, Verbeke K, De Preter V (2013) Decreased mucosal sulfide detoxification capacity in patients with Crohn\u2019s disease. Inflamm Bowel Dis 19:E70\u2013E72","journal-title":"Inflamm Bowel Dis"},{"key":"2558_CR3","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.freeradbiomed.2016.01.028","volume":"93","author":"M Beaumont","year":"2016","unstructured":"Beaumont M, Andriamihaja M, Lan A, Khodorova N, Audebert M, Blouin JM, Grauso M, Lancha L, Benetti PH, Benamouzig R, Tome D, Bouillaud F, Davila AM, Blachier F (2016) Detrimental effects for colonocytes of an increased exposure to luminal hydrogen sulfide: the adaptive response. Free Radic Biol Med 93:155\u2013164","journal-title":"Free Radic Biol Med"},{"key":"2558_CR4","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s00726-006-0477-9","volume":"33","author":"F Blachier","year":"2007","unstructured":"Blachier F, Mariotti F, Huneau JF, Tome D (2007) Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences. Amino Acids 33:547\u2013562","journal-title":"Amino Acids"},{"key":"2558_CR5","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00726-009-0445-2","volume":"39","author":"F Blachier","year":"2010","unstructured":"Blachier F, Davila AM, Mimoun S, Benetti PH, Atanasiu C, Andriamihaja M, Benamouzig R, Bouillaud F, Tome D (2010) Luminal sulfide and large intestine mucosa: friend or foe? Amino Acids 39:335\u2013347","journal-title":"Amino Acids"},{"key":"2558_CR6","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.ajpath.2016.11.015","volume":"187","author":"F Blachier","year":"2017","unstructured":"Blachier F, Beaumont M, Andriamihaja M, Davila AM, Lan A, Grauso M, Armand L, Benamouzig R, Tome D (2017) Changes in the luminal environment of the colonic epithelial cells and physiopathological consequences. Am J Pathol 187:476\u2013486","journal-title":"Am J Pathol"},{"key":"2558_CR7","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1089\/ars.2010.3678","volume":"15","author":"F Bouillaud","year":"2011","unstructured":"Bouillaud F, Blachier F (2011) Mitochondria and sulfide: a very old story of poisoning, feeding, and signaling? Antioxid Redox Signal 15:379\u2013391","journal-title":"Antioxid Redox Signal"},{"key":"2558_CR8","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nrgastro.2012.85","volume":"9","author":"F Carbonero","year":"2012","unstructured":"Carbonero F, Benefiel AC, Gaskins HR (2012) Contributions of the microbial hydrogen economy to colonic homeostasis. Nat Rev Gastroenterol Hepatol 9:504\u2013518","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2558_CR9","first-page":"57","volume":"3","author":"MJ Cires","year":"2016","unstructured":"Cires MJ, Wong X, Carrasco-Pozo C, Gotteland M (2016) The gastrointestinal tract as a key target organ for the health-promoting effects of dietary proanthocyanidins. Front Nutr 3:57","journal-title":"Front Nutr"},{"key":"2558_CR10","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s10863-008-9166-6","volume":"40","author":"CE Cooper","year":"2008","unstructured":"Cooper CE, Brown GC (2008) The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance. J Bioenerg Biomembr 40:533\u2013539","journal-title":"J Bioenerg Biomembr"},{"key":"2558_CR11","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1002\/ibd.22949","volume":"18","author":"V Preter De","year":"2012","unstructured":"De Preter V, Arijs I, Windey K, Vanhove W, Vermeire S, Schuit F, Rutgeerts P, Verbeke K (2012) Decreased mucosal sulfide detoxification is related to an impaired butyrate oxidation in ulcerative colitis. Inflamm Bowel Dis 18:2371\u20132380","journal-title":"Inflamm Bowel Dis"},{"key":"2558_CR12","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1096\/fj.06-7407com","volume":"21","author":"M Goubern","year":"2007","unstructured":"Goubern M, Andriamihaja M, Nubel T, Blachier F, Bouillaud F (2007) Sulfide, the first inorganic substrate for human cells. FASEB J 21:1699\u20131706","journal-title":"FASEB J"},{"key":"2558_CR13","doi-asserted-by":"publisher","first-page":"C260","DOI":"10.1152\/ajpcell.1984.247.3.C260","volume":"247","author":"E Grasset","year":"1984","unstructured":"Grasset E, Pinto M, Dussaulx E, Zweibaum A, Desjeux JF (1984) Epithelial properties of human colonic carcinoma cell line Caco-2: electrical parameters. Am J Physiol 247:C260\u2013C267","journal-title":"Am J Physiol"},{"key":"2558_CR14","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1093\/jn\/134.3.613","volume":"134","author":"L Gu","year":"2004","unstructured":"Gu L, Kelm MA, Hammerstone JF, Beecher G, Holden J, Haytowitz D, Gebhardt S, Prior RL (2004) Concentrations of proanthocyanidins in common foods and estimations of normal consumption. J Nutr 134:613\u2013617","journal-title":"J Nutr"},{"key":"2558_CR15","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/S0016-5085(89)80072-1","volume":"96","author":"IJ Hidalgo","year":"1989","unstructured":"Hidalgo IJ, Raub TJ, Borchardt RT (1989) Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96:736\u2013749","journal-title":"Gastroenterology"},{"key":"2558_CR16","doi-asserted-by":"publisher","first-page":"6804","DOI":"10.1021\/bi300778t","volume":"51","author":"MR Jackson","year":"2012","unstructured":"Jackson MR, Melideo SL, Jorns MS (2012) Human sulfide: quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite. Biochemistry 51:6804\u20136815","journal-title":"Biochemistry"},{"key":"2558_CR17","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.freeradbiomed.2004.11.020","volume":"38","author":"AM Jenner","year":"2005","unstructured":"Jenner AM, Rafter J, Halliwell B (2005) Human fecal water content of phenolics: the extent of colonic exposure to aromatic compounds. Free Radic Biol Med 38:763\u2013772","journal-title":"Free Radic Biol Med"},{"key":"2558_CR18","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1016\/j.bbabio.2010.04.004","volume":"1797","author":"E Lagoutte","year":"2010","unstructured":"Lagoutte E, Mimoun S, Andriamihaja M, Chaumontet C, Blachier F, Bouillaud F (2010) Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes. Biochim Biophys Acta 1797:1500\u20131511","journal-title":"Biochim Biophys Acta"},{"key":"2558_CR19","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1023\/A:1015515821390","volume":"18","author":"X Leschelle","year":"2002","unstructured":"Leschelle X, Robert V, Delpal S, Mouille B, Mayeur C, Martel P, Blachier F (2002) Isolation of pig colonic crypts for cytotoxic assay of luminal compounds: effects of hydrogen sulfide, ammonia, and deoxycholic acid. Cell Biol Toxicol 18:193\u2013203","journal-title":"Cell Biol Toxicol"},{"key":"2558_CR20","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.bbagen.2005.06.002","volume":"1725","author":"X Leschelle","year":"2005","unstructured":"Leschelle X, Goubern M, Andriamihaja M, Blottiere HM, Couplan E, Gonzalez-Barroso MD, Petit C, Pagniez A, Chaumontet C, Mignotte B, Bouillaud F, Blachier F (2005) Adaptative metabolic response of human colonic epithelial cells to the adverse effects of the luminal compound sulfide. Biochim Biophys Acta 1725:201\u2013212","journal-title":"Biochim Biophys Acta"},{"key":"2558_CR21","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s00726-009-0264-5","volume":"37","author":"X Li","year":"2009","unstructured":"Li X, Bazer FW, Gao H, Jobgen W, Johnson GA, Li P, McKnight JR, Satterfield MC, Spencer TE, Wu G (2009) Amino acids and gaseous signaling. Amino Acids 37:65\u201378","journal-title":"Amino Acids"},{"key":"2558_CR22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3177\/jnsv.54.89","volume":"54","author":"P Lodhia","year":"2008","unstructured":"Lodhia P, Yaegaki K, Khakbaznejad A, Imai T, Sato T, Tanaka T, Murata T, Kamoda T (2008) Effect of green tea on volatile sulfur compounds in mouth air. J Nutr Sci Vitaminol (Tokyo) 54:89\u201394","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"2558_CR23","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/mnfr.201100672","volume":"56","author":"ML Mateos-Martin","year":"2012","unstructured":"Mateos-Martin ML, Perez-Jimenez J, Fuguet E, Torres JL (2012) Profile of urinary and fecal proanthocyanidin metabolites from common cinnamon (Cinnamomum zeylanicum L.) in rats. Mol Nutr Food Res 56:671\u2013675","journal-title":"Mol Nutr Food Res"},{"key":"2558_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/ars.2011.4186","volume":"17","author":"S Mimoun","year":"2012","unstructured":"Mimoun S, Andriamihaja M, Chaumontet C, Atanasiu C, Benamouzig R, Blouin JM, Tome D, Bouillaud F, Blachier F (2012) Detoxification of H2S by differentiated colonic epithelial cells: implication of the sulfide oxidizing unit and of the cell respiratory capacity. Antioxid Redox Signal 17:1\u201310","journal-title":"Antioxid Redox Signal"},{"key":"2558_CR25","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.3945\/ajcn.110.007096","volume":"93","author":"J Perez-Jimenez","year":"2011","unstructured":"Perez-Jimenez J, Fezeu L, Touvier M, Arnault N, Manach C, Hercberg S, Galan P, Scalbert A (2011) Dietary intake of 337 polyphenols in French adults. Am J Clin Nutr 93:1220\u20131228","journal-title":"Am J Clin Nutr"},{"key":"2558_CR26","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.tifs.2016.08.011","volume":"57","author":"KJ Portune","year":"2016","unstructured":"Portune KJ, Beaumont M, Davila AM, Tome D, Blachier F, Sanz Y (2016) Gut microbiota role in dietary protein metabolism and health-related outcomes: the two sides of the coin. Trends Food Sci Technol 57:213\u2013232","journal-title":"Trends Food Sci Technol"},{"key":"2558_CR27","doi-asserted-by":"publisher","first-page":"304","DOI":"10.2174\/138920101504140825113815","volume":"15","author":"R Rodrigo","year":"2014","unstructured":"Rodrigo R, Libuy M, Feliu F, Hasson D (2014) Polyphenols in disease: from diet to supplements. Curr Pharm Biotechnol 15:304\u2013317","journal-title":"Curr Pharm Biotechnol"},{"key":"2558_CR28","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/biof.5520130119","volume":"13","author":"A Scalbert","year":"2000","unstructured":"Scalbert A, Deprez S, Mila I, Albrecht AM, Huneau JF, Rabot S (2000) Proanthocyanidins and human health: systemic effects and local effects in the gut. BioFactors 13:115\u2013120","journal-title":"BioFactors"},{"key":"2558_CR29","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.1021\/acs.jafc.6b00656","volume":"64","author":"X Wong","year":"2016","unstructured":"Wong X, Carrasco-Pozo C, Escobar E, Navarrete P, Blachier F, Andriamihaja M, Lan A, Tome D, Cires MJ, Pastene E, Gotteland M (2016a) Deleterious effect of p-cresol on human colonic epithelial cells prevented by proanthocyanidin-containing polyphenol extracts from fruits and proanthocyanidin bacterial metabolites. J Agric Food Chem 64:3574\u20133583","journal-title":"J Agric Food Chem"},{"key":"2558_CR30","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.jff.2016.08.011","volume":"26","author":"X Wong","year":"2016","unstructured":"Wong X, Madrid AM, Tralma K, Castillo R, Carrasco-Pozo C, Navarrete P, Beltran C, Pastene E, Gotteland M (2016b) Polyphenol extracts interfere with bacterial lipopolysaccharide in vitro and decrease endotoxemia in human volunteers. Funct Foods 26:406\u2013416","journal-title":"Funct Foods"},{"key":"2558_CR31","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/j.intimp.2008.08.021","volume":"8","author":"Y Yoshioka","year":"2008","unstructured":"Yoshioka Y, Akiyama H, Nakano M, Shoji T, Kanda T, Ohtake Y, Takita T, Matsuda R, Maitani T (2008) Orally administered apple procyanidins protect against experimental inflammatory bowel disease in mice. Int Immunopharmacol 8:1802\u20131807","journal-title":"Int Immunopharmacol"},{"key":"2558_CR32","doi-asserted-by":"publisher","first-page":"036005","DOI":"10.1088\/1752-7155\/4\/3\/036005","volume":"4","author":"QC Zeng","year":"2010","unstructured":"Zeng QC, Wu AZ, Pika J (2010) The effect of green tea extract on the removal of sulfur-containing oral malodor volatiles in vitro and its potential application in chewing gum. J Breath Res 4:036005","journal-title":"J Breath Res"},{"key":"2558_CR33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/jcp.1041220105","volume":"122","author":"A Zweibaum","year":"1985","unstructured":"Zweibaum A, Pinto M, Chevalier G, Dussaulx E, Triadou N, Lacroix B, Haffen K, Brun JL, Rousset M (1985) Enterocytic differentiation of a subpopulation of the human colon tumor cell line HT-29 selected for growth in sugar-free medium and its inhibition by glucose. J Cell Physiol 122:21\u201329","journal-title":"J Cell Physiol"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-018-2558-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-018-2558-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-018-2558-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T07:07:07Z","timestamp":1556348827000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-018-2558-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,27]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["2558"],"URL":"https:\/\/doi.org\/10.1007\/s00726-018-2558-y","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,27]]},"assertion":[{"value":"16 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}