{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:25:36Z","timestamp":1740108336642,"version":"3.37.3"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6-7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s00726-020-02872-x","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T07:03:32Z","timestamp":1595315012000},"page":"1033-1041","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Structure and function of resistance arteries from BB-creatine kinase and ubiquitous Mt-creatine kinase double knockout mice"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7185-970X","authenticated-orcid":false,"given":"Zhila","family":"Taherzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"van Montfrans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E. E. M.","family":"Van der Zee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Streijger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. N. T. P.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M.","family":"Brewster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"2872_CR2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/01.RES.0000151333.56089.66","volume":"96","author":"EN Bakker","year":"2005","unstructured":"Bakker EN, Buus CL, Spaan JA, Perree J, Ganga A, Rolf TM, Sorop O, Bramsen LH, Mulvany MJ, Vanbavel E (2005) Small artery remodeling depends on tissue-type transglutaminase. Circ Res 96(1):119\u2013126","journal-title":"Circ Res"},{"key":"2872_CR3","doi-asserted-by":"crossref","first-page":"292","DOI":"10.21037\/atm.2018.07.15","volume":"6","author":"LM Brewster","year":"2018","unstructured":"Brewster LM (2018) Creatine kinase, energy reserve, and hypertension: from bench to bedside. Ann Transl Med 6:292","journal-title":"Ann Transl Med"},{"key":"2872_CR4","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1097\/00004872-200018110-00002","volume":"18","author":"LM Brewster","year":"2000","unstructured":"Brewster LM, Clark JF, van Montfrans GA (2000) Is greater tissue activity of creatine kinase the genetic factor increasing hypertension risk in black people of sub-Saharan African descent? J Hypertens 18:1537\u20131544","journal-title":"J Hypertens"},{"key":"2872_CR5","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1161\/CIRCULATIONAHA.105.584490","volume":"114","author":"LM Brewster","year":"2006","unstructured":"Brewster LM, Mairuhu G, Bindraban NR, Koopmans RP, Clark JF, van Montfrans GA (2006) Creatine kinase activity is associated with blood pressure. Circulation 114:2034\u20132039","journal-title":"Circulation"},{"key":"2872_CR6","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ajh.2009.268","volume":"23","author":"LM Brewster","year":"2010","unstructured":"Brewster LM, Van Montfrans GA (2010) Calcium channel blocker therapy in black hypertensive patients. Am J Hypertens 23:218\u2013218","journal-title":"Am J Hypertens"},{"key":"2872_CR7","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1161\/01.HYP.0000137302.06623.fd","volume":"44","author":"LM Brewster","year":"2004","unstructured":"Brewster LM, van Montfrans GA, Luke A, Adeyemo A, Kramer H, Forrester T, Cooper RS (2004) Response: blood pressure, resting energy expenditure, and creatine kinase activity. Hypertension 44:e6\u2013e6","journal-title":"Hypertension"},{"key":"2872_CR8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF01267956","volume":"133","author":"JF Clark","year":"1994","unstructured":"Clark JF (1994) The creatine kinase system in smooth muscle. Mol Cell Biochem 133:221\u2013232","journal-title":"Mol Cell Biochem"},{"key":"2872_CR10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pathophys.2005.02.007","volume":"12","author":"JF Clark","year":"2005","unstructured":"Clark JF, Pyne-Geithman G (2005) Vascular smooth muscle function: the physiology and pathology of vasoconstriction. Pathophysiology 12:35\u201345","journal-title":"Pathophysiology"},{"key":"2872_CR11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0014-5793(01)02879-4","volume":"506","author":"A De Groof","year":"2001","unstructured":"De Groof A, Smeets B, Groot Koerkamp M, Mul A, Janssen E, Tabak H, Wieringa B (2001) Changes in mRNA expression profile underlie phenotypic adaptations in creatine kinase-deficient muscles. FEBS Lett 506:73\u201378","journal-title":"FEBS Lett"},{"key":"2872_CR12","doi-asserted-by":"crossref","unstructured":"Decking UK, Alves C, Wallimann T, Wyss M, Jr S (2001) Functional aspects of creatine kinase isoenzymes in endothelial cells. Am J Physiol 281:C320\u2013C328","DOI":"10.1152\/ajpcell.2001.281.1.C320"},{"key":"2872_CR500","doi-asserted-by":"crossref","unstructured":"Dzeja PP, Terzic A (2003) Phosphotransfer networks and cellular energetics. J Exp Biol 206:2039\u20132047","DOI":"10.1242\/jeb.00426"},{"key":"2872_CR13","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.3390\/ijms10041729","volume":"10","author":"P Dzeja","year":"2009","unstructured":"Dzeja P, Terzic A (2009) Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing. Int J Mol Sci 10:1729\u20131772","journal-title":"Int J Mol Sci"},{"key":"2872_CR14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/B:MCBI.0000009856.23646.38","volume":"256","author":"PP Dzeja","year":"2004","unstructured":"Dzeja PP, Terzic A, Wieringa B (2004) Phosphotransfer dynamics in skeletal muscle from creatine kinase gene-deleted mice. Mol Cell Biochem 256:13\u201327","journal-title":"Mol Cell Biochem"},{"key":"2872_CR15","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1161\/01.RES.84.10.1137","volume":"84","author":"PP Dzeja","year":"1999","unstructured":"Dzeja PP, Vitkevicius KT, Redfield MM, Burnett JC, Terzic A (1999) Adenylate kinase\u2013catalyzed phosphotransfer in the myocardium: increased contribution in heart failure. Circ Res 84:1137\u20131143","journal-title":"Circ Res"},{"key":"2872_CR16","doi-asserted-by":"crossref","first-page":"12847","DOI":"10.1074\/jbc.271.22.12847","volume":"271","author":"PP Dzeja","year":"1996","unstructured":"Dzeja PP, Zeleznikar RJ, Goldberg ND (1996) Suppression of creatine kinase-catalyzed phosphotransfer results in increased phosphoryl transfer by adenylate kinase in intact skeletal muscle. J Biol Chem 271:12847\u201312851","journal-title":"J Biol Chem"},{"key":"2872_CR17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1080\/15216549700201471","volume":"41","author":"S Gagliardi","year":"1997","unstructured":"Gagliardi S, Atlante A, Passarella S (1997) A novel property of adenine nucleotides: Sensitivity to helium-neon laser in mitochondrial reactions. IUBMB Life 41:449\u2013460","journal-title":"IUBMB Life"},{"key":"2872_CR19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0014-5793(91)80548-H","volume":"283","author":"Y Ishida","year":"1991","unstructured":"Ishida Y, Wyss M, Hemmer W, Wallimann T (1991) Identification of creatine kinase isoenzymes in the guinea-pig presence of mitochondrial creatine kinase in smooth muscle. FEBS Lett 283:37\u201343","journal-title":"FEBS Lett"},{"issue":"6","key":"2872_CR20","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1096\/fj.02-0684fje","volume":"17","author":"A Kaasik","year":"2003","unstructured":"Kaasik A, Veksler V, Boehm E, Novotova M, Ventura-Clapier R (2003) From energy store to energy flux: a study in creatine kinase-deficient fast skeletal muscle. FASEB J 17(6):708\u2013710. https:\/\/doi.org\/10.1096\/fj.02-0684fje","journal-title":"FASEB J"},{"key":"2872_CR21","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1161\/HYPERTENSIONAHA.113.01352","volume":"63","author":"FA Karamat","year":"2014","unstructured":"Karamat FA, Oudman I, Ris-Stalpers C, Afink GB, Keijser R, Clark JF, van Montfrans GA, Brewsterl LM (2014) Resistance artery creatine kinase mRNA and blood pressure in humans. Hypertension 63(1):68\u201373","journal-title":"Hypertension"},{"key":"2872_CR22","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1097\/HJH.0000000000001090","volume":"34","author":"FA Karamat","year":"2016","unstructured":"Karamat FA, Oudman I, Haan YC, van Kuilenburg AB, Leen R, Danser JA, Leijten FP, Ris-Stalpers C, van Montfrans GA, Clark JF, Brewsterl LM (2016) Creatine kinase inhibition lowers systemic arterial blood pressure in spontaneously hypertensive rats: a randomized controlled trial. J Hypertens 34(12):2418\u20132426","journal-title":"J Hypertens"},{"key":"2872_CR23","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1111\/bcp.13390","volume":"83","author":"FA Karamat","year":"2017","unstructured":"Karamat FA, Horjus DL, Haan YC, van der Woude L, Schaap MC, Oudman I, van Montfrans GA, Clark JF, Brewster LM (2017) The acute effect of beta-guanidinopropionic acid versus creatine or placebo in healthy men (ABC-Trial): a randomized controlled first-in-human trial. Br J Clin Pharmacol 83(12):2626\u20132635","journal-title":"Br J Clin Pharmacol"},{"key":"2872_CR24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1471-2202-9-73","volume":"9","author":"JW Kuiper","year":"2008","unstructured":"Kuiper JW, Oerlemans FT, Fransen JA, Wieringa B (2008) Creatine kinase B deficient neurons exhibit an increased fraction of motile mitochondria. BMC Neurosci 9(1):73","journal-title":"BMC Neurosci"},{"key":"2872_CR25","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1152\/jappl.1998.84.4.1166","volume":"84","author":"JJ Labella","year":"1998","unstructured":"Labella JJ, Daood MJ, Koretsky A, Roman BB, Sieck GC, Wieringa B, Watchko JF (1998) Absence of myofibrillar creatine kinase and diaphragm isometric function during repetitive activation. J Appl Physiol 84:1166\u20131173","journal-title":"J Appl Physiol"},{"key":"2872_CR501","doi-asserted-by":"crossref","unstructured":"Lenz H, Schmidt M, Welge V, Kueper T, Schlattner U, Wallimann T, Els\u00e4sser HP, Wittern KP, Wenck H, Staeb F, Blatt T (2007). Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT-and HeLaS3-cells affects cell viability and mitochondrial morphology. Mol Cell Biochem 306(1\u20132):153\u2013162","DOI":"10.1007\/s11010-007-9565-8"},{"key":"2872_CR28","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0014-5793(86)80181-8","volume":"195","author":"M Lorusso","year":"1986","unstructured":"Lorusso M, Marzo M, Gatti D, Papa S (1986) Effect of 2,4-dinitrofluorobenzene on theenzymatic properties of the b-c1 complex isolated from beef heart mitochondria. FEBSLett 195:298\u2013302","journal-title":"FEBSLett"},{"key":"2872_CR29","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1136\/heart.89.9.1104","volume":"89","author":"J Mayet","year":"2003","unstructured":"Mayet J, Hughes A (2003) Cardiac and vascular pathophysiology in hypertension. Heart 89:1104\u20131109","journal-title":"Heart"},{"key":"2872_CR30","doi-asserted-by":"publisher","unstructured":"Mulvany MJ (2018) Small artery remodeling and significance in the development of hypertension. Physiology. https:\/\/doi.org\/10.1152\/nips.01366.2001","DOI":"10.1152\/nips.01366.2001"},{"key":"2872_CR31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","volume":"41","author":"MJ Mulvany","year":"1977","unstructured":"Mulvany MJ, Halpern W (1977) Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41:19\u201326","journal-title":"Circ Res"},{"key":"2872_CR33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/A:1022431101158","volume":"244","author":"S Nakayama","year":"2003","unstructured":"Nakayama S, Clark JF (2003) Smooth muscle and NMR review: an overview of smooth muscle metabolism. Mol Cell Biochem 244:17\u201330","journal-title":"Mol Cell Biochem"},{"key":"2872_CR34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/clinchem\/31.2.333","volume":"31","author":"D Nealon","year":"1985","unstructured":"Nealon D (1985) Relative inhibition of human adenylate kinase and creatine kinase isoenzymes by adenosine 5'-monophosphate and diadenosine pentaphosphate. Clin Chem 31:333\u2013334","journal-title":"Clin Chem"},{"key":"2872_CR35","doi-asserted-by":"crossref","first-page":"C1279","DOI":"10.1152\/ajpcell.00114.2006","volume":"291","author":"M Novotov\u00e1","year":"2006","unstructured":"Novotov\u00e1 M, Pavlovicov\u00e1 M, Veksler VI, Ventura-Clapier R, Zahradn\u00edk I (2006) Ultrastructural remodeling of fast skeletal muscle fibers induced by invalidation of creatine kinase. Am J Physiol Cell Physiol 291:C1279\u2013C1285","journal-title":"Am J Physiol Cell Physiol"},{"key":"2872_CR36","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/01.HYP.11.6.635","volume":"11","author":"N Nyborg","year":"1988","unstructured":"Nyborg N, Bevan JA (1988) Increased alpha-adrenergic receptor affinity in resistance vessels from hypertensive rats. Hypertension 11:635\u2013638","journal-title":"Hypertension"},{"key":"2872_CR37","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/sj.bjc.6602986","volume":"94","author":"T Onda","year":"2006","unstructured":"Onda T, Uzawa K, Endo Y, Bukawa H, Yokoe H, Shibahara T, Tanzawa H (2006) Ubiquitous mitochondrial creatine kinase downregulated in oral squamous cell carcinoma. Br J Cancer 94(5):698\u2013709","journal-title":"Br J Cancer"},{"key":"2872_CR38","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1016\/S0021-9258(18)93433-2","volume":"243","author":"W O'Sullivan","year":"1968","unstructured":"O'Sullivan W, Cohn M (1968) Magnetic resonance studies on inactivated forms of creatine kinase. J Biol Chem 243:2737\u20132744","journal-title":"J Biol Chem"},{"key":"2872_CR40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF01267957","volume":"133","author":"RM Payne","year":"1994","unstructured":"Payne RM, Strauss AW (1994) Expression of the mitochondrial creatine kinase genes. Mol Cell Biochem 133:235\u2013243","journal-title":"Mol Cell Biochem"},{"key":"2872_CR43","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbadis.2005.09.004","volume":"1762","author":"U Schlattner","year":"2006","unstructured":"Schlattner U, Tokarska-Schlattner M, Wallimann T (2006) Mitochondrial creatine kinase in human health and disease. Biochim Biophys Acta 1762:164\u2013180","journal-title":"Biochim Biophys Acta"},{"key":"2872_CR44","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1007\/s11064-007-9458-y","volume":"32","author":"B Sperl\u00e1gh","year":"2007","unstructured":"Sperl\u00e1gh B, Vizi ES (2007) Extracellular interconversion of nucleotides reveals an ecto-adenylate kinase activity in the rat hippocampus. Neurochem 32:1978\u20131989","journal-title":"Neurochem"},{"key":"2872_CR45","doi-asserted-by":"crossref","unstructured":"Steeghs K, Oerlemans F, De Haan A, Heerschap A, Verdoodt L, De Bie M, Ruitenbeek W, Benders Ad, Jost C, van Deursen J, Tullson P, Terjung R, Jap P, Jacob W, Pette D, Wieringa B\u00e9 (1998) Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies. Mol Cell Biochem 184(1\u20132):183\u2013194","DOI":"10.1023\/A:1006811717709"},{"key":"2872_CR46","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1089\/dna.1995.14.539","volume":"14","author":"K Steeghs","year":"1995","unstructured":"Steeghs K, Peters W, Bruckwilder M, Croes H, Van Alewijk D, Wieringa B (1995) Mouse ubiquitous mitochondrial creatine kinase: Gene organization and consequences from inactivation in mouse embryonic stem cells. DNA Cell Biol 14:539\u2013553","journal-title":"DNA Cell Biol"},{"key":"2872_CR47","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbr.2004.07.002","volume":"157","author":"F Streijger","year":"2005","unstructured":"Streijger F, Oerlemans F, Ellenbroek BA, Jost CR, Wieringa B, Van der Zee CE (2005) Structural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit. Behav Brain Res 157:219\u2013234","journal-title":"Behav Brain Res"},{"key":"2872_CR48","doi-asserted-by":"crossref","unstructured":"Streijger F, Pluk H, Oerlemans F, Beckers G, Bianco AC, Ribeiro MO, Wieringa B\u00e9, Van der Zee CEEM (2009) Mice lacking brain-type creatine kinase activity show defective thermoregulation. Physiol Behav 97(1):76\u201386","DOI":"10.1016\/j.physbeh.2009.02.003"},{"key":"2872_CR49","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1751-7176.2010.00269.x","volume":"12","author":"Z Taherzadeh","year":"2010","unstructured":"Taherzadeh Z, Brewster LM, Van Montfrans GA, VanBavel E (2010) Function and structure of resistance vessels in black and white people. J Clin Hypertens 12:431\u2013438","journal-title":"J Clin Hypertens"},{"key":"2872_CR50","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/ajh\/hpv078","volume":"29","author":"Z Taherzadeh","year":"2015","unstructured":"Taherzadeh Z, Karamat FA, Ankum WM, Clark JF, van Montfrans GA, van Bavel E, Brewster LM (2015) The effect of creatine kinase inhibition on contractile properties of human resistance arteries. Am J Hypertens 29:170\u2013177","journal-title":"Am J Hypertens"},{"key":"2872_CR51","unstructured":"Takagi Y, Yasuhara T, Gomi K (2001) Creatine kinase and its isozymes. Rinsho Byori. Japan J Clin Pathol, 52\u201361"},{"key":"2872_CR52","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1136\/jcp.35.2.204","volume":"35","author":"SH Tsung","year":"1982","unstructured":"Tsung SH (1982) Total CK activity and isoenzyme patterns in normal and neoplastic tissue of gastrointestinal tract. J Clin Pathol 35:204\u2013206","journal-title":"J Clin Pathol"},{"key":"2872_CR53","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1021\/bi00592a005","volume":"18","author":"P VanDerLijn","year":"1979","unstructured":"VanDerLijn P, Barrio JR, Leonard NJ (1979) Inhibition of adenylate kinase by P1-(lin-benzo-5'-adenosyl)-P4-(5'-adenosyl) tetraphosphate and P1-(lin-benzo-5'-adenosyl)-P5-(5'-adenosyl) pentaphosphate. Biochemistry 18:5557\u20135561","journal-title":"Biochemistry"},{"key":"2872_CR54","doi-asserted-by":"crossref","first-page":"19921","DOI":"10.1074\/jbc.270.34.19921","volume":"270","author":"VI Veksler","year":"1995","unstructured":"Veksler VI, Kuznetsov AV, Anflous K, Mateo P, Van Deursen J, Wieringa B, Ventura-Clapier R (1995) Muscle creatine kinase-deficient mice II. Cardiac and skeletal muscles exhibit tissue-specific adaptation of the mitochondrial function. J Biol Chem 270:19921\u201319929","journal-title":"J Biol Chem"},{"issue":"34","key":"2872_CR55","doi-asserted-by":"crossref","first-page":"19914","DOI":"10.1074\/jbc.270.34.19914","volume":"270","author":"R Ventura-Clapier","year":"1995","unstructured":"Ventura-Clapier R, Kuznetsov AV, d'Albis A, van Deursen J, Wieringa B, Veksler VI (1995) Muscle creatine kinase-deficient mice. I. Alterations in myofibrillar function. J Biol Chem. 270(34):19914\u201319920","journal-title":"J Biol Chem."},{"key":"2872_CR56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1023\/B:MCBI.0000009857.69730.97","volume":"256","author":"R Ventura-Clapier","year":"2004","unstructured":"Ventura-Clapier R, Kaasik A, Veksler V (2004) Structural and functional adaptations of striated muscles to CK deficiency. Mol Cell Biochem 256:29\u201341","journal-title":"Mol Cell Biochem"},{"key":"2872_CR57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/bj2810021","volume":"281","author":"T Wallimann","year":"1992","unstructured":"Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger H (1992) Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the'phosphocreatine circuit'for cellular energy homeostasis. Biochem J 281:21","journal-title":"Biochem J"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-020-02872-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00726-020-02872-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-020-02872-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T23:53:12Z","timestamp":1626825192000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00726-020-02872-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":50,"journal-issue":{"issue":"6-7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["2872"],"URL":"https:\/\/doi.org\/10.1007\/s00726-020-02872-x","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"type":"print","value":"0939-4451"},{"type":"electronic","value":"1438-2199"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"3 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"LMB is an inventor on patent WO\/2012\/138226 (filed). The other authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures involving animals were approved by the Animal Care Committee of the Radboud University Nijmegen Medical Centre (RU-DEC) conform the guidelines of the Dutch Council for Animal Care and the European Communities Council Directive of 24 November 1986 (86\/609\/EEC).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}