{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:19:49Z","timestamp":1792232389753,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s00726-020-02935-z","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T18:02:59Z","timestamp":1609783379000},"page":"171-181","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Angiotensin-(1\u20137) attenuates collagen-induced arthritis via inhibiting oxidative stress in rats"],"prefix":"10.1007","volume":"53","author":[{"given":"Juan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyou","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-7854","authenticated-orcid":false,"given":"Yongsheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"issue":"5\u20136","key":"2935_CR1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1159\/000444188","volume":"97","author":"O Acikalin","year":"2016","unstructured":"Acikalin O, Bolukbasi Hatip FF, Tan RF, Hatip-Al-Khatib I (2016) Effect of angiotensin-(1\u20137) on aortic response, TNF-alpha, IL-1beta and receptor for advanced glycation endproduct in rat\u2019s adjuvant-induced arthritis. Pharmacology 97(5\u20136):207\u2013217. https:\/\/doi.org\/10.1159\/000444188","journal-title":"Pharmacology"},{"key":"2935_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143576","author":"TS Agidigbi","year":"2019","unstructured":"Agidigbi TS, Kim C (2019) Reactive oxygen species in osteoclast differentiation and possible pharmaceutical targets of ROS-mediated osteoclast diseases. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20143576","journal-title":"Int J Mol Sci"},{"key":"2935_CR3","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.3389\/fimmu.2017.01596","volume":"8","author":"LC Barroso","year":"2017","unstructured":"Barroso LC, Magalhaes GS, Galvao I, Reis AC, Souza DG, Sousa LP, Santos RAS, Campagnole-Santos MJ, Pinho V, Teixeira MM (2017) Angiotensin-(1\u20137) promotes resolution of neutrophilic inflammation in a model of antigen-induced arthritis in mice. Front Immunol 8:1596. https:\/\/doi.org\/10.3389\/fimmu.2017.01596","journal-title":"Front Immunol"},{"issue":"18","key":"2935_CR4","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1007\/s00018-020-03476-0","volume":"77","author":"I Bellezza","year":"2020","unstructured":"Bellezza I, Riuzzi F, Chiappalupi S, Arcuri C, Giambanco I, Sorci G, Donato R (2020) Reductive stress in striated muscle cells. Cell Mol Life Sci 77(18):3547\u20133565. https:\/\/doi.org\/10.1007\/s00018-020-03476-0","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"2935_CR5","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1172\/JCI31044","volume":"117","author":"BC Berk","year":"2007","unstructured":"Berk BC, Fujiwara K, Lehoux S (2007) ECM remodeling in hypertensive heart disease. J Clin Investig 117(3):568\u2013575. https:\/\/doi.org\/10.1172\/JCI31044","journal-title":"J Clin Investig"},{"issue":"3","key":"2935_CR6","first-page":"347","volume":"37","author":"C Croia","year":"2019","unstructured":"Croia C, Bursi R, Sutera D, Petrelli F, Alunno A, Puxeddu I (2019) One year in review 2019: pathogenesis of rheumatoid arthritis. Clin Exp Rheumatol 37(3):347\u2013357","journal-title":"Clin Exp Rheumatol"},{"issue":"9","key":"2935_CR7","doi-asserted-by":"publisher","first-page":"5569","DOI":"10.4049\/jimmunol.1000314","volume":"185","author":"KD da Silveira","year":"2010","unstructured":"da Silveira KD, Coelho FM, Vieira AT, Sachs D, Barroso LC, Costa VV, Bretas TL, Bader M, de Sousa LP, da Silva TA, dos Santos RA, Simoes e Silva AC, Teixeira MM (2010) Anti-inflammatory effects of the activation of the angiotensin-(1\u20137) receptor, MAS, in experimental models of arthritis. J Immunol 185(9):5569\u20135576. https:\/\/doi.org\/10.4049\/jimmunol.1000314","journal-title":"J Immunol"},{"key":"2935_CR8","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.redox.2015.09.005","volume":"6","author":"J Dan Dunn","year":"2015","unstructured":"Dan Dunn J, Alvarez LA, Zhang X, Soldati T (2015) Reactive oxygen species and mitochondria: a nexus of cellular homeostasis. Redox Biol 6:472\u2013485. https:\/\/doi.org\/10.1016\/j.redox.2015.09.005","journal-title":"Redox Biol"},{"issue":"2","key":"2935_CR9","doi-asserted-by":"publisher","first-page":"rkz035","DOI":"10.1093\/rap\/rkz035","volume":"3","author":"D De Cock","year":"2019","unstructured":"De Cock D, Van der Elst K, Stouten V, Peerboom D, Joly J, Westhovens R, Verschueren P (2019) The perspective of patients with early rheumatoid arthritis on the journey from symptom onset until referral to a rheumatologist. Rheumatol Adv Pract 3(2):rkz035. https:\/\/doi.org\/10.1093\/rap\/rkz035","journal-title":"Rheumatol Adv Pract"},{"issue":"1","key":"2935_CR10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.berh.2017.08.003","volume":"31","author":"KD Deane","year":"2017","unstructured":"Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM (2017) Genetic and environmental risk factors for rheumatoid arthritis. Best Pract Res Clin Rheumatol 31(1):3\u201318. https:\/\/doi.org\/10.1016\/j.berh.2017.08.003","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"11","key":"2935_CR11","doi-asserted-by":"publisher","first-page":"8812","DOI":"10.1002\/jcp.29724","volume":"235","author":"SO Ebrahimi","year":"2020","unstructured":"Ebrahimi SO, Reiisi S, Shareef S (2020) miRNAs, oxidative stress, and cancer: a comprehensive and updated review. J Cell Physiol 235(11):8812\u20138825. https:\/\/doi.org\/10.1002\/jcp.29724","journal-title":"J Cell Physiol"},{"issue":"6","key":"2935_CR12","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1111\/j.1476-5381.2012.01905.x","volume":"166","author":"AZ El-Hashim","year":"2012","unstructured":"El-Hashim AZ, Renno WM, Raghupathy R, Abduo HT, Akhtar S, Benter IF (2012) Angiotensin-(1\u20137) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1\/2- and NF-kappaB-dependent pathways. Br J Pharmacol 166(6):1964\u20131976. https:\/\/doi.org\/10.1111\/j.1476-5381.2012.01905.x","journal-title":"Br J Pharmacol"},{"key":"2935_CR13","doi-asserted-by":"publisher","first-page":"9076042","DOI":"10.1155\/2020\/9076042","volume":"2020","author":"P Feng","year":"2020","unstructured":"Feng P, Wu Z, Liu H, Shen Y, Yao X, Li X, Shen Z (2020) Electroacupuncture improved chronic cerebral hypoperfusion-induced anxiety-like behavior and memory impairments in spontaneously hypertensive rats by downregulating the ACE\/Ang II\/AT1R axis and upregulating the ACE2\/Ang-(1\u20137)\/MasR axis. Neural Plast 2020:9076042. https:\/\/doi.org\/10.1155\/2020\/9076042","journal-title":"Neural Plast"},{"key":"2935_CR14","doi-asserted-by":"publisher","first-page":"106527","DOI":"10.1016\/j.intimp.2020.106527","volume":"84","author":"Q Gao","year":"2020","unstructured":"Gao Q, Qin H, Zhu L, Li D, Hao X (2020) Celastrol attenuates collagen-induced arthritis via inhibiting oxidative stress in rats. Int Immunopharmacol 84:106527. https:\/\/doi.org\/10.1016\/j.intimp.2020.106527","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"2935_CR15","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s10753-010-9269-1","volume":"34","author":"S Hanafy","year":"2011","unstructured":"Hanafy S, Tavasoli M, Jamali F (2011) Inflammation alters angiotensin converting enzymes (ACE and ACE-2) balance in rat heart. Inflammation 34(6):609\u2013613. https:\/\/doi.org\/10.1007\/s10753-010-9269-1","journal-title":"Inflammation"},{"issue":"18","key":"2935_CR16","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1056\/NEJM199005033221805","volume":"322","author":"ED Harris Jr","year":"1990","unstructured":"Harris ED Jr (1990) Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med 322(18):1277\u20131289. https:\/\/doi.org\/10.1056\/NEJM199005033221805","journal-title":"N Engl J Med"},{"key":"2935_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jep.2016.05.027","volume":"189","author":"N Jia","year":"2016","unstructured":"Jia N, Chu W, Li Y, Ding L, Duan J, Cui J, Cao S, Zhao C, Wu Y, Wen A (2016) Iridoid glycosides from the flowers of Gentiana macrophylla Pall. ameliorate collagen-induced arthritis in rats. J Ethnopharmacol 189:1\u20139. https:\/\/doi.org\/10.1016\/j.jep.2016.05.027","journal-title":"J Ethnopharmacol"},{"key":"2935_CR18","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.dci.2018.11.009","volume":"92","author":"M Jiang","year":"2019","unstructured":"Jiang M, Huang W, Wang Z, Ren F, Luo L, Zhou J, Yan R, Xia N, Tang L (2019) Anti-inflammatory effects of Ang-(1\u20137) via TLR4-mediated inhibition of the JNK\/FoxO1 pathway in lipopolysaccharide-stimulated RAW264.7cells. Dev Comp Immunol 92:291\u2013298. https:\/\/doi.org\/10.1016\/j.dci.2018.11.009","journal-title":"Dev Comp Immunol"},{"issue":"8","key":"2935_CR19","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1161\/CIRCRESAHA.113.301077","volume":"112","author":"RQ Lautner","year":"2013","unstructured":"Lautner RQ, Villela DC, Fraga-Silva RA, Silva N, Verano-Braga T, Costa-Fraga F, Jankowski J, Jankowski V, Sousa F, Alzamora A, Soares E, Barbosa C, Kjeldsen F, Oliveira A, Braga J, Savergnini S, Maia G, Peluso AB, Passos-Silva D, Ferreira A, Alves F, Martins A, Raizada M, Paula R, Motta-Santos D, Klempin F, Pimenta A, Alenina N, Sinisterra R, Bader M, Campagnole-Santos MJ, Santos RA (2013) Discovery and characterization of alamandine: a novel component of the renin-angiotensin system. Circ Res 112(8):1104\u20131111. https:\/\/doi.org\/10.1161\/CIRCRESAHA.113.301077","journal-title":"Circ Res"},{"key":"2935_CR20","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.metabol.2019.03.006","volume":"95","author":"DF Lelis","year":"2019","unstructured":"Lelis DF, Freitas DF, Machado AS, Crespo TS, Santos SHS (2019) Angiotensin-(1\u20137), adipokines and inflammation. Metab Clin Exp 95:36\u201345. https:\/\/doi.org\/10.1016\/j.metabol.2019.03.006","journal-title":"Metab Clin Exp"},{"issue":"11","key":"2935_CR21","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1007\/s11655-017-2909-7","volume":"24","author":"XY Li","year":"2018","unstructured":"Li XY, Peng Y, Bu XW, Yao J, Yao L (2018) Balancing effect of Biejiajian oral liquid () on ACE-Ang II-AT1R axis and ACE2-Ang-(1\u20137)-Mas axis in rats with ccl4-induced hepatic fibrosis. Chin J Integr Med 24(11):853\u2013859. https:\/\/doi.org\/10.1007\/s11655-017-2909-7","journal-title":"Chin J Integr Med"},{"issue":"4","key":"2935_CR22","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00592-011-0348-z","volume":"49","author":"C Liu","year":"2012","unstructured":"Liu C, Lv XH, Li HX, Cao X, Zhang F, Wang L, Yu M, Yang JK (2012) Angiotensin-(1\u20137) suppresses oxidative stress and improves glucose uptake via Mas receptor in adipocytes. Acta Diabetol 49(4):291\u2013299. https:\/\/doi.org\/10.1007\/s00592-011-0348-z","journal-title":"Acta Diabetol"},{"issue":"35","key":"2935_CR23","doi-asserted-by":"publisher","first-page":"6716","DOI":"10.1021\/acs.jafc.6b03001","volume":"64","author":"Q Liu","year":"2016","unstructured":"Liu Q, Tian J, Xu Y, Li C, Meng X, Fu F (2016) Protective effect of RA on myocardial infarction-induced cardiac fibrosis via AT1R\/p38 MAPK pathway signaling and modulation of the ACE2\/ACE ratio. J Agric Food Chem 64(35):6716\u20136722. https:\/\/doi.org\/10.1021\/acs.jafc.6b03001","journal-title":"J Agric Food Chem"},{"issue":"23","key":"2935_CR24","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.lfs.2013.04.011","volume":"92","author":"A Mackenzie","year":"2013","unstructured":"Mackenzie A, Dunning L, Ferrell WR, Lockhart JC (2013) Angiotensin II type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis. Life Sci 92(23):1131\u20131137. https:\/\/doi.org\/10.1016\/j.lfs.2013.04.011","journal-title":"Life Sci"},{"issue":"5","key":"2935_CR25","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1210\/en.2011-2031","volume":"153","author":"NM Mordwinkin","year":"2012","unstructured":"Mordwinkin NM, Meeks CJ, Jadhav SS, Espinoza T, Roda N, diZerega GS, Louie SG, Rodgers KE (2012) Angiotensin-(1\u20137) administration reduces oxidative stress in diabetic bone marrow. Endocrinology 153(5):2189\u20132197. https:\/\/doi.org\/10.1210\/en.2011-2031","journal-title":"Endocrinology"},{"issue":"1","key":"2935_CR26","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s13075-019-1909-8","volume":"21","author":"G Mouterde","year":"2019","unstructured":"Mouterde G, Rincheval N, Lukas C, Daien C, Saraux A, Dieude P, Morel J, Combe B (2019) Outcome of patients with early arthritis without rheumatoid factor and ACPA and predictors of rheumatoid arthritis in the ESPOIR cohort. Arthritis Res Ther 21(1):140. https:\/\/doi.org\/10.1186\/s13075-019-1909-8","journal-title":"Arthritis Res Ther"},{"key":"2935_CR27","doi-asserted-by":"publisher","first-page":"6097417","DOI":"10.1155\/2016\/6097417","volume":"2016","author":"CM Quinonez-Flores","year":"2016","unstructured":"Quinonez-Flores CM, Gonzalez-Chavez SA, Del Rio ND, Pacheco-Tena C (2016) Oxidative stress relevance in the pathogenesis of the rheumatoid arthritis: a systematic review. Biomed Res Int 2016:6097417. https:\/\/doi.org\/10.1155\/2016\/6097417","journal-title":"Biomed Res Int"},{"issue":"3","key":"2935_CR28","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1002\/jcp.27205","volume":"234","author":"R Ranjbar","year":"2019","unstructured":"Ranjbar R, Shafiee M, Hesari A, Ferns GA, Ghasemi F, Avan A (2019) The potential therapeutic use of renin-angiotensin system inhibitors in the treatment of inflammatory diseases. J Cell Physiol 234(3):2277\u20132295. https:\/\/doi.org\/10.1002\/jcp.27205","journal-title":"J Cell Physiol"},{"issue":"5","key":"2935_CR29","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1002\/art.27384","volume":"62","author":"T Sakuta","year":"2010","unstructured":"Sakuta T, Morita Y, Satoh M, Fox DA, Kashihara N (2010) Involvement of the renin-angiotensin system in the development of vascular damage in a rat model of arthritis: effect of angiotensin receptor blockers. Arthritis Rheum 62(5):1319\u20131328. https:\/\/doi.org\/10.1002\/art.27384","journal-title":"Arthritis Rheum"},{"issue":"9746","key":"2935_CR30","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/S0140-6736(10)60826-4","volume":"376","author":"DL Scott","year":"2010","unstructured":"Scott DL, Wolfe F, Huizinga TW (2010) Rheumatoid arthritis. Lancet 376(9746):1094\u20131108. https:\/\/doi.org\/10.1016\/S0140-6736(10)60826-4","journal-title":"Lancet"},{"issue":"3","key":"2935_CR31","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/bph.12159","volume":"169","author":"AC Simoes e Silva","year":"2013","unstructured":"Simoes e Silva AC, Silveira KD, Ferreira AJ, Teixeira MM (2013) ACE2, angiotensin-(1\u20137) and Mas receptor axis in inflammation and fibrosis. Br J Pharmacol 169(3):477\u2013492. https:\/\/doi.org\/10.1111\/bph.12159","journal-title":"Br J Pharmacol"},{"issue":"1","key":"2935_CR32","doi-asserted-by":"publisher","first-page":"ITC1","DOI":"10.7326\/AITC201901010","volume":"170","author":"JA Sparks","year":"2019","unstructured":"Sparks JA (2019) Rheumatoid arthritis. Ann Intern Med 170(1):ITC1\u2013ITC16. https:\/\/doi.org\/10.7326\/AITC201901010","journal-title":"Ann Intern Med"},{"key":"2935_CR33","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.intimp.2018.11.001","volume":"65","author":"Y Wang","year":"2018","unstructured":"Wang Y, Kou J, Zhang H, Wang C, Li H, Ren Y, Zhang Y (2018) The renin-angiotensin system in the synovium promotes periarticular osteopenia in a rat model of collagen-induced arthritis. Int Immunopharmacol 65:550\u2013558. https:\/\/doi.org\/10.1016\/j.intimp.2018.11.001","journal-title":"Int Immunopharmacol"},{"key":"2935_CR34","doi-asserted-by":"publisher","first-page":"105796","DOI":"10.1016\/j.intimp.2019.105796","volume":"75","author":"Y Wu","year":"2019","unstructured":"Wu Y, Lu X, Li M, Zeng J, Zeng J, Shen B, Zeng Y (2019) Renin-angiotensin system in osteoarthritis: a new potential therapy. Int Immunopharmacol 75:105796. https:\/\/doi.org\/10.1016\/j.intimp.2019.105796","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2935_CR35","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.amjms.2019.10.014","volume":"359","author":"Y Wu","year":"2020","unstructured":"Wu Y, Li M, Zeng J, Feng Z, Yang J, Shen B, Zeng Y (2020) Differential expression of renin\u2013angiotensin system-related components in patients with rheumatoid arthritis and osteoarthritis. Am J Med Sci 359(1):17\u201326. https:\/\/doi.org\/10.1016\/j.amjms.2019.10.014","journal-title":"Am J Med Sci"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-020-02935-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00726-020-02935-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-020-02935-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T02:02:55Z","timestamp":1614391375000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00726-020-02935-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,4]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["2935"],"URL":"https:\/\/doi.org\/10.1007\/s00726-020-02935-z","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,4]]},"assertion":[{"value":"15 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that no competing financial interests exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures were approved by the Experimental Animal Care and Use Committee of Nanjing Medical University and conducted in accordance with the Guide for the Care and Use of Laboratory Animals. T The ethical\u00a0approval number was 17062846 and the study was approved in June 2017.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}