{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:07:15Z","timestamp":1783397235952,"version":"3.54.6"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["133202\/2018-6"],"award-info":[{"award-number":["133202\/2018-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304450\/2019-7"],"award-info":[{"award-number":["304450\/2019-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["420695\/2018-4"],"award-info":[{"award-number":["420695\/2018-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["17\/2551-0000977-0"],"award-info":[{"award-number":["17\/2551-0000977-0"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00726-021-03019-2","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T04:53:37Z","timestamp":1624337617000},"page":"1153-1167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Paternal exposure to excessive methionine altered behavior and neurochemical activities in zebrafish offspring"],"prefix":"10.1007","volume":"53","author":[{"given":"Rodrigo","family":"Zanandrea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Talita","family":"Wiprich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefani","family":"Altenhofen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Rubensam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Marcon","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela T. S.","family":"Wyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-6244","authenticated-orcid":false,"given":"Carla Denise","family":"Bonan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"3019_CR1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Oxygen radicals in biological systems. Methods Enzymol 105:121\u2013126. https:\/\/doi.org\/10.1016\/S0076-6879(84)05016-3","journal-title":"Methods Enzymol"},{"key":"3019_CR2","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.chemosphere.2017.04.029","volume":"180","author":"S Altenhofen","year":"2017","unstructured":"Altenhofen S, Nabinger DD, Wiprich MT et al (2017a) Tebuconazole alters morphological, behavioral and neurochemical parameters in larvae and adult zebrafish (Danio rerio). Chemosphere 180:483\u2013490. https:\/\/doi.org\/10.1016\/j.chemosphere.2017.04.029","journal-title":"Chemosphere"},{"key":"3019_CR3","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.aquatox.2016.11.013","volume":"182","author":"S Altenhofen","year":"2017","unstructured":"Altenhofen S, Wiprich MT, Nery LR et al (2017b) Manganese(II) chloride alters behavioral and neurochemical parameters in larvae and adult zebrafish. Aquat Toxicol 182:172\u2013183. https:\/\/doi.org\/10.1016\/j.aquatox.2016.11.013","journal-title":"Aquat Toxicol"},{"key":"3019_CR4","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1101\/gr.144700","volume":"10","author":"WB Barbazuk","year":"2000","unstructured":"Barbazuk WB, Korf I, Kadavi C et al (2000) The syntenic relationship of the zebrafish and human genomes. Genome Res 10:1351\u20131358. https:\/\/doi.org\/10.1101\/gr.144700","journal-title":"Genome Res"},{"key":"3019_CR5","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s10646-019-02146-7","volume":"29","author":"F Bevilaqua","year":"2020","unstructured":"Bevilaqua F, Sachett A, Chitolina R et al (2020) A mixture of fipronil and fungicides induces alterations on behavioral and oxidative stress parameters in zebrafish. Ecotoxicology 29:140\u2013147. https:\/\/doi.org\/10.1007\/s10646-019-02146-7","journal-title":"Ecotoxicology"},{"key":"3019_CR6","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.nlm.2009.07.001","volume":"92","author":"M Blank","year":"2009","unstructured":"Blank M, Guerim LD, Cordeiro RF, Vianna MRM (2009) A one-trial inhibitory avoidance task to zebrafish: rapid acquisition of an NMDA-dependent long-term memory. Neurobiol Learn Mem 92:529\u2013534. https:\/\/doi.org\/10.1016\/j.nlm.2009.07.001","journal-title":"Neurobiol Learn Mem"},{"key":"3019_CR7","doi-asserted-by":"publisher","first-page":"993","DOI":"10.3945\/ajcn.114.096511","volume":"100","author":"ML Blumfield","year":"2014","unstructured":"Blumfield ML, Collins CE (2014) High-protein diets during pregnancy: healthful or harmful for offspring? Am J Clin Nutr 100:993\u2013995. https:\/\/doi.org\/10.3945\/ajcn.114.096511","journal-title":"Am J Clin Nutr"},{"key":"3019_CR8","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. https:\/\/doi.org\/10.1016\/0003-2697(76)90527-3","journal-title":"Anal Biochem"},{"key":"3019_CR9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3389\/fpsyt.2014.00047","volume":"5","author":"R Brisch","year":"2014","unstructured":"Brisch R, Saniotis A, Wolf R et al (2014) The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue. Front Psychiatry 5:47. https:\/\/doi.org\/10.3389\/fpsyt.2014.00047","journal-title":"Front Psychiatry"},{"key":"3019_CR10","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1042\/BCJ20160822","volume":"474","author":"S Br\u00f6er","year":"2017","unstructured":"Br\u00f6er S, Br\u00f6er A (2017) Amino acid homeostasis and signalling in mammalian cells and organisms. Biochem J 474:1935\u20131963. https:\/\/doi.org\/10.1042\/BCJ20160822","journal-title":"Biochem J"},{"key":"3019_CR11","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1146\/annurev.nutr.012809.104751","volume":"30","author":"GC Burdge","year":"2010","unstructured":"Burdge GC, Lillycrop KA (2010) Nutrition, epigenetics, and developmental plasticity: implications for understanding human disease. Annu Rev Nutr 30:315\u2013339. https:\/\/doi.org\/10.1146\/annurev.nutr.012809.104751","journal-title":"Annu Rev Nutr"},{"key":"3019_CR12","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.ntt.2011.08.010","volume":"33","author":"KM Capiotti","year":"2011","unstructured":"Capiotti KM, Menezes FP, Nazario LR et al (2011) Early exposure to caffeine affects gene expression of adenosine receptors, DARPP-32 and BDNF without affecting sensibility and morphology of developing zebrafish (Danio rerio). Neurotoxicol Teratol 33:680\u2013685. https:\/\/doi.org\/10.1016\/j.ntt.2011.08.010","journal-title":"Neurotoxicol Teratol"},{"key":"3019_CR13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ijdevneu.2012.09.002","volume":"31","author":"KM Capiotti","year":"2013","unstructured":"Capiotti KM, Fazenda L, Nazario LR et al (2013) Arginine exposure alters ectonucleotidase activities and morphology of zebrafish larvae (Danio rerio). Int J Dev Neurosci 31:75\u201381. https:\/\/doi.org\/10.1016\/j.ijdevneu.2012.09.002","journal-title":"Int J Dev Neurosci"},{"key":"3019_CR14","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/S0015-0282(16)42563-X","volume":"28","author":"V Chandrashekar","year":"1977","unstructured":"Chandrashekar V, Leathem JH (1977) Effect of excess dietary methionine on rat pregnancy: influence on ovarian \u03945 3\u03b2 hydroxysteroid dehydrogenase activity. Fertil Steril 28:590\u2013593. https:\/\/doi.org\/10.1016\/S0015-0282(16)42563-X","journal-title":"Fertil Steril"},{"key":"3019_CR15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/jmd2.12064","volume":"49","author":"CA Chang","year":"2019","unstructured":"Chang CA, Wei X-C, Martin SR et al (2019) Transiently elevated plasma methionine, S-adenosylmethionine and S-adenosylhomocysteine: Unreported laboratory findings in a patient with NGLY1 deficiency, a congenital disorder of deglycosylation. JIMD Rep 49:21\u201329. https:\/\/doi.org\/10.1002\/jmd2.12064","journal-title":"JIMD Rep"},{"key":"3019_CR16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1515\/RNS.2011.008","volume":"22","author":"RM Colwill","year":"2011","unstructured":"Colwill RM, Creton R (2011) Imaging escape and avoidance behavior in zebrafish larvae. Rev Neurosci 22:63\u201373. https:\/\/doi.org\/10.1515\/RNS.2011.008","journal-title":"Rev Neurosci"},{"key":"3019_CR17","doi-asserted-by":"publisher","first-page":"e113","DOI":"10.1016\/j.biopsych.2011.03.028","volume":"69","author":"R Cools","year":"2011","unstructured":"Cools R, D\u2019Esposito M (2011) Inverted-U\u2013shaped dopamine actions on human working memory and cognitive control. Biol Psychiatry 69:e113\u2013e125. https:\/\/doi.org\/10.1016\/j.biopsych.2011.03.028","journal-title":"Biol Psychiatry"},{"key":"3019_CR18","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00726-016-2365-2","volume":"49","author":"DSC de Lima","year":"2017","unstructured":"de Lima DSC, Francisco ES, Lima CB, Guedes RCA (2017) Neonatal l-glutamine modulates anxiety-like behavior, cortical spreading depression, and microglial immunoreactivity: analysis in developing rats suckled on normal size- and large size litters. Amino Acids 49:337\u2013346. https:\/\/doi.org\/10.1007\/s00726-016-2365-2","journal-title":"Amino Acids"},{"key":"3019_CR19","doi-asserted-by":"publisher","first-page":"839S","DOI":"10.3945\/an.115.011817","volume":"7","author":"R Elango","year":"2016","unstructured":"Elango R, Ball RO (2016) Protein and amino acid requirements during pregnancy. Adv Nutr 7:839S-844S. https:\/\/doi.org\/10.3945\/an.115.011817","journal-title":"Adv Nutr"},{"key":"3019_CR20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.cbi.2018.07.021","volume":"293","author":"AN Gaiday","year":"2018","unstructured":"Gaiday AN, Tussupkaliyev AB, Bermagambetova SK et al (2018) Effect of homocysteine on pregnancy: a systematic review. Chem Biol Interact 293:70\u201376. https:\/\/doi.org\/10.1016\/j.cbi.2018.07.021","journal-title":"Chem Biol Interact"},{"key":"3019_CR21","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/S0091-3057(00)00422-6","volume":"67","author":"R Gerlai","year":"2000","unstructured":"Gerlai R, Lahav M, Guo S, Rosenthal A (2000) Drinks like a fish: Zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects. Pharmacol Biochem Behav 67:773\u2013782. https:\/\/doi.org\/10.1016\/S0091-3057(00)00422-6","journal-title":"Pharmacol Biochem Behav"},{"key":"3019_CR22","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-x","volume":"126","author":"LC Green","year":"1982","unstructured":"Green LC, Wagner DA, Glogowski J et al (1982) Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 126:131\u2013138. https:\/\/doi.org\/10.1016\/0003-2697(82)90118-x","journal-title":"Anal Biochem"},{"key":"3019_CR23","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/13651501.2016.1144771","volume":"20","author":"M Gulsun","year":"2016","unstructured":"Gulsun M, Oznur T, Aydemir E et al (2016) Possible relationship between amino acids, aggression and psychopathy. Int J Psychiatry Clin Pract 20:91\u2013100. https:\/\/doi.org\/10.3109\/13651501.2016.1144771","journal-title":"Int J Psychiatry Clin Pract"},{"key":"3019_CR24","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.rasd.2012.12.005","volume":"7","author":"TH Hassan","year":"2013","unstructured":"Hassan TH, Abdelrahman HM, Abdel Fattah NR et al (2013) Blood and brain glutamate levels in children with autistic disorder. Res Autism Spectr Disord 7:541\u2013548. https:\/\/doi.org\/10.1016\/j.rasd.2012.12.005","journal-title":"Res Autism Spectr Disord"},{"key":"3019_CR25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/toxsci\/kfy044","volume":"163","author":"KA Horzmann","year":"2018","unstructured":"Horzmann KA, Freeman JL (2018) Making waves: new developments in toxicology with the zebrafish. Toxicol Sci 163:5\u201312. https:\/\/doi.org\/10.1093\/toxsci\/kfy044","journal-title":"Toxicol Sci"},{"key":"3019_CR26","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1139\/cjpp-2015-0581","volume":"94","author":"D Hrncic","year":"2016","unstructured":"Hrncic D, Miki\u0107 J, Rasic-Markovic A et al (2016) Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: Role of the brain oxidative stress. Can J Physiol Pharmacol 94:1074\u20131082. https:\/\/doi.org\/10.1139\/cjpp-2015-0581","journal-title":"Can J Physiol Pharmacol"},{"key":"3019_CR27","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1007\/s00726-010-0752-7","volume":"41","author":"N Le Floc\u2019h","year":"2011","unstructured":"Le Floc\u2019h N, Otten W, Merlot E (2011) Tryptophan metabolism, from nutrition to potential therapeutic applications. Amino Acids 41:1195\u20131205. https:\/\/doi.org\/10.1007\/s00726-010-0752-7","journal-title":"Amino Acids"},{"key":"3019_CR28","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0041-008X(90)90278-3","volume":"104","author":"CP LeBel","year":"1990","unstructured":"LeBel CP, Ali SF, McKee M, Bondy SC (1990) Organometal-induced increases in oxygen reactive species: The potential of 2\u2032,7\u2032-dichlorofluorescin diacetate as an index of neurotoxic damage. Toxicol Appl Pharmacol 104:17\u201324. https:\/\/doi.org\/10.1016\/0041-008X(90)90278-3","journal-title":"Toxicol Appl Pharmacol"},{"key":"3019_CR29","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.tins.2010.06.004","volume":"33","author":"US Lee","year":"2010","unstructured":"Lee US, Cui J (2010) BK channel activation: structural and functional insights. Trends Neurosci 33:415\u2013423. https:\/\/doi.org\/10.1016\/j.tins.2010.06.004","journal-title":"Trends Neurosci"},{"key":"3019_CR30","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/s41386-018-0236-0","volume":"44","author":"CS Legind","year":"2019","unstructured":"Legind CS, Broberg BV, Mandl RCW et al (2019) Heritability of cerebral glutamate levels and their association with schizophrenia spectrum disorders: a 1[H]-spectroscopy twin study. Neuropsychopharmacology 44:581\u2013589. https:\/\/doi.org\/10.1038\/s41386-018-0236-0","journal-title":"Neuropsychopharmacology"},{"key":"3019_CR31","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/0304-3894(92)87011-4","volume":"217","author":"OH Lowry","year":"1994","unstructured":"Lowry OH, Rosebrough A, Farr L, Randall RJ (1994) Protein measurement with the folin phenol reagent. Anal Biochem 217:220\u2013230. https:\/\/doi.org\/10.1016\/0304-3894(92)87011-4","journal-title":"Anal Biochem"},{"key":"3019_CR32","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.reprotox.2015.04.001","volume":"53","author":"AH Lutte","year":"2015","unstructured":"Lutte AH, Capiotti KM, da Silva NLG et al (2015) Contributions from extracellular sources of adenosine to the ethanol toxicity in zebrafish larvae. Reprod Toxicol 53:82\u201391. https:\/\/doi.org\/10.1016\/j.reprotox.2015.04.001","journal-title":"Reprod Toxicol"},{"key":"3019_CR33","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.ejmech.2018.06.005","volume":"155","author":"FS Macchi","year":"2018","unstructured":"Macchi FS, Pissinate K, Villela AD et al (2018) 1H-Benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones: design, synthesis and antitubercular activity. Eur J Med Chem 155:153\u2013164. https:\/\/doi.org\/10.1016\/j.ejmech.2018.06.005","journal-title":"Eur J Med Chem"},{"key":"3019_CR34","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1080\/14767058.2018.1489795","volume":"33","author":"PD Manta-Vogli","year":"2020","unstructured":"Manta-Vogli PD, Schulpis KH, Dotsikas Y, Loukas YL (2020) The significant role of amino acids during pregnancy: nutritional support. J Matern Neonatal Med 33:334\u2013340. https:\/\/doi.org\/10.1080\/14767058.2018.1489795","journal-title":"J Matern Neonatal Med"},{"key":"3019_CR35","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469\u2013474. https:\/\/doi.org\/10.1111\/j.1432-1033.1974.tb03714.x","journal-title":"Eur J Biochem"},{"key":"3019_CR36","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1007\/s00726-017-2494-2","volume":"49","author":"Y Mart\u00ednez","year":"2017","unstructured":"Mart\u00ednez Y, Li X, Liu G et al (2017) The role of methionine on metabolism, oxidative stress, and diseases. Amino Acids 49:2091\u20132098. https:\/\/doi.org\/10.1007\/s00726-017-2494-2","journal-title":"Amino Acids"},{"key":"3019_CR37","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.freeradbiomed.2009.05.018","volume":"47","author":"L Miao","year":"2009","unstructured":"Miao L, St Clair DK (2009) Regulation of superoxide dismutase genes: implications in disease. Free Radic Biol Med 47:344\u2013356. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2009.05.018","journal-title":"Free Radic Biol Med"},{"key":"3019_CR38","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.pnpbp.2019.03.014","volume":"93","author":"R Mocelin","year":"2019","unstructured":"Mocelin R, Marcon M, da Rosa Araujo AS et al (2019) Withdrawal effects following repeated ethanol exposure are prevented by N-acetylcysteine in zebrafish. Prog Neuro Psychopharmacol Biol Psychiatry 93:161\u2013170. https:\/\/doi.org\/10.1016\/j.pnpbp.2019.03.014","journal-title":"Prog Neuro Psychopharmacol Biol Psychiatry"},{"key":"3019_CR39","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jns.2011.06.056","volume":"310","author":"TS Moriyama","year":"2011","unstructured":"Moriyama TS, Felicio AC, Chagas MHN et al (2011) Increased dopamine transporter density in Parkinson\u2019s disease patients with social anxiety disorder. J Neurol Sci 310:53\u201357. https:\/\/doi.org\/10.1016\/j.jns.2011.06.056","journal-title":"J Neurol Sci"},{"key":"3019_CR40","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/ajmg.c.30293","volume":"157","author":"SH Mudd","year":"2011","unstructured":"Mudd SH (2011) Hypermethioninemias of genetic and non-genetic origin: a review. Am J Med Genet Part C Semin Med Genet 157:3\u201332. https:\/\/doi.org\/10.1002\/ajmg.c.30293","journal-title":"Am J Med Genet Part C Semin Med Genet"},{"key":"3019_CR41","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/j.scitotenv.2017.10.057","volume":"624","author":"DD Nabinger","year":"2018","unstructured":"Nabinger DD, Altenhofen S, Bitencourt PER et al (2018) Nickel exposure alters behavioral parameters in larval and adult zebrafish. Sci Total Environ 624:1623\u20131633. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.10.057","journal-title":"Sci Total Environ"},{"key":"3019_CR42","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10815-012-9709-y","volume":"29","author":"P Ocal","year":"2012","unstructured":"Ocal P, Ersoylu B, Cepni I et al (2012) The association between homocysteine in the follicular fluid with embryo quality and pregnancy rate in assisted reproductive techniques. J Assist Reprod Genet 29:299\u2013304. https:\/\/doi.org\/10.1007\/s10815-012-9709-y","journal-title":"J Assist Reprod Genet"},{"key":"3019_CR43","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"key":"3019_CR44","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3389\/fncel.2018.00158","volume":"12","author":"C Penas","year":"2018","unstructured":"Penas C, Navarro X (2018) Epigenetic modifications associated to neuroinflammation and neuropathic pain after neural trauma. Front Cell Neurosci 12:158","journal-title":"Front Cell Neurosci"},{"key":"3019_CR45","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3945\/ajcn.110.009456","volume":"95","author":"BW Prick","year":"2011","unstructured":"Prick BW, Hop WCJ, Duvekot JJ (2011) Maternal phenylketonuria and hyperphenylalaninemia in pregnancy: pregnancy complications and neonatal sequelae in untreated and treated pregnancies. Am J Clin Nutr 95:374\u2013382. https:\/\/doi.org\/10.3945\/ajcn.110.009456","journal-title":"Am J Clin Nutr"},{"key":"3019_CR46","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1093\/hmg\/ddx157","volume":"26","author":"AM Quintana","year":"2017","unstructured":"Quintana AM, Yu HC, Brebner A et al (2017) Mutations in THAP11 cause an inborn error of cobalamin metabolism and developmental abnormalities. Hum Mol Genet 26:2838\u20132849. https:\/\/doi.org\/10.1093\/hmg\/ddx157","journal-title":"Hum Mol Genet"},{"key":"3019_CR47","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1113\/jphysiol.2004.062661","volume":"557","author":"G Raffaelli","year":"2004","unstructured":"Raffaelli G, Saviane C, Mohajerani MH et al (2004) BK potassium channels control transmitter release at CA3\u2013CA3 synapses in the rat hippocampus. J Physiol 557:147\u2013157. https:\/\/doi.org\/10.1113\/jphysiol.2004.062661","journal-title":"J Physiol"},{"key":"3019_CR48","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1523\/JNEUROSCI.23-07-02627.2003","volume":"23","author":"SD Rao","year":"2003","unstructured":"Rao SD, Yin HZ, Weiss JH (2003) Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons. J Neurosci 23:2627\u20132633. https:\/\/doi.org\/10.1523\/JNEUROSCI.23-07-02627.2003","journal-title":"J Neurosci"},{"key":"3019_CR49","doi-asserted-by":"publisher","first-page":"1701S","DOI":"10.1093\/jn\/136.6.1701S","volume":"136","author":"WD Rees","year":"2006","unstructured":"Rees WD, Wilson FA, Maloney CA (2006) Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet. J Nutr 136:1701S-1705S. https:\/\/doi.org\/10.1093\/jn\/136.6.1701S","journal-title":"J Nutr"},{"key":"3019_CR50","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1038\/mp.2017.53","volume":"23","author":"DP Ryan","year":"2018","unstructured":"Ryan DP, Henzel KS, Pearson BL et al (2018) A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice. Mol Psychiatry 23:1345\u20131355. https:\/\/doi.org\/10.1038\/mp.2017.53","journal-title":"Mol Psychiatry"},{"key":"3019_CR51","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/sj.npp.1301285","volume":"32","author":"M Sarter","year":"2007","unstructured":"Sarter M, Bruno JP, Parikh V (2007) Abnormal neurotransmitter release underlying behavioral and cognitive disorders: toward concepts of dynamic and function-specific dysregulation. Neuropsychopharmacology 32:1452\u20131461. https:\/\/doi.org\/10.1038\/sj.npp.1301285","journal-title":"Neuropsychopharmacology"},{"key":"3019_CR52","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.neuroscience.2013.07.004","volume":"250","author":"LEB Savio","year":"2013","unstructured":"Savio LEB, Vuaden FC, Kist LW et al (2013) Proline-induced changes in acetylcholinesterase activity and gene expression in zebrafish brain: reversal by antipsychotic drugs. Neuroscience 250:121\u2013128. https:\/\/doi.org\/10.1016\/j.neuroscience.2013.07.004","journal-title":"Neuroscience"},{"key":"3019_CR53","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1007\/s00726-016-2302-4","volume":"48","author":"BM Schweinberger","year":"2016","unstructured":"Schweinberger BM, Wyse ATS (2016) Mechanistic basis of hypermethioninemia. Amino Acids 48:2479\u20132489. https:\/\/doi.org\/10.1007\/s00726-016-2302-4","journal-title":"Amino Acids"},{"key":"3019_CR54","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s11011-013-9451-x","volume":"29","author":"BM Schweinberger","year":"2014","unstructured":"Schweinberger BM, Schwieder L, Scherer E et al (2014) Development of an animal model for gestational hypermethioninemia in rat and its effect on brain Na+, K+-ATPase\/Mg2+-ATPase activity and oxidative status of the offspring. Metab Brain Dis 29:153\u2013160. https:\/\/doi.org\/10.1007\/s11011-013-9451-x","journal-title":"Metab Brain Dis"},{"key":"3019_CR55","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1007\/s12035-017-0383-z","volume":"55","author":"BM Schweinberger","year":"2017","unstructured":"Schweinberger BM, Rodrigues AF, Turcatel E et al (2017) Maternal hypermethioninemia affects neurons number, neurotrophins levels, energy metabolism, and Na+, K+-ATPase expression\/content in brain of rat offspring. Mol Neurobiol 55:980\u2013988. https:\/\/doi.org\/10.1007\/s12035-017-0383-z","journal-title":"Mol Neurobiol"},{"key":"3019_CR56","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s12640-017-9830-x","volume":"33","author":"BM Schweinberger","year":"2018","unstructured":"Schweinberger BM, Rodrigues AF, dos Santos TM et al (2018) Methionine administration in pregnant rats causes memory deficit in the offspring and alters ultrastructure in brain tissue. Neurotox Res 33:239\u2013246. https:\/\/doi.org\/10.1007\/s12640-017-9830-x","journal-title":"Neurotox Res"},{"key":"3019_CR57","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.pnpbp.2004.01.013","volume":"28","author":"K Shioda","year":"2004","unstructured":"Shioda K, Nisijima K, Yoshino T, Kato S (2004) Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine. Prog Neuro Psychopharmacol Biol Psychiatry 28:633\u2013640. https:\/\/doi.org\/10.1016\/j.pnpbp.2004.01.013","journal-title":"Prog Neuro Psychopharmacol Biol Psychiatry"},{"key":"3019_CR58","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1007\/s11011-017-0054-9","volume":"32","author":"MSP Soares","year":"2017","unstructured":"Soares MSP, Viau CM, Saffi J et al (2017) Acute administration of methionine and\/or methionine sulfoxide impairs redox status and induces apoptosis in rat cerebral cortex. Metab Brain Dis 32:1693\u20131703. https:\/\/doi.org\/10.1007\/s11011-017-0054-9","journal-title":"Metab Brain Dis"},{"key":"3019_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jneumeth.2006.07.029","volume":"160","author":"FM Stefanello","year":"2007","unstructured":"Stefanello FM, Matt\u00e9 C, Scherer EB et al (2007a) Chemically induced model of hypermethioninemia in rats. J Neurosci Methods 160:1\u20134. https:\/\/doi.org\/10.1016\/j.jneumeth.2006.07.029","journal-title":"J Neurosci Methods"},{"key":"3019_CR60","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s11011-007-9052-7","volume":"22","author":"FM Stefanello","year":"2007","unstructured":"Stefanello FM, Scherer EB, Kurek AG et al (2007b) Effect of hypermethioninemia on some parameters of oxidative stress and on Na(+), K (+)-ATPase activity in hippocampus of rats. Metab Brain Dis 22:172\u2013182. https:\/\/doi.org\/10.1007\/s11011-007-9052-7","journal-title":"Metab Brain Dis"},{"key":"3019_CR61","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.brainres.2012.09.036","volume":"1511","author":"EE Steinberg","year":"2013","unstructured":"Steinberg EE, Janak PH (2013) Establishing causality for dopamine in neural function and behavior with optogenetics. Brain Res 1511:46\u201364. https:\/\/doi.org\/10.1016\/j.brainres.2012.09.036","journal-title":"Brain Res"},{"key":"3019_CR62","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201796708","author":"S Tang","year":"2017","unstructured":"Tang S, Fang Y, Huang G et al (2017) Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. EMBO J. https:\/\/doi.org\/10.15252\/embj.201796708","journal-title":"EMBO J"},{"key":"3019_CR63","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1620\/tjem.138.281","volume":"138","author":"A Tsuchiyama","year":"1982","unstructured":"Tsuchiyama A, Oyanagi K, Nakata F et al (1982) A new type of hypermethioninemia in neonates. Tohoku J Exp Med 138:281\u2013288. https:\/\/doi.org\/10.1620\/tjem.138.281","journal-title":"Tohoku J Exp Med"},{"key":"3019_CR64","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1007\/s11064-012-0749-6","volume":"37","author":"FC Vuaden","year":"2012","unstructured":"Vuaden FC, Savio LEB, Piato AL et al (2012) Long-term methionine exposure induces memory impairment on inhibitory avoidance and alters acetylcholinesterase activity and expression in Zebrafish (Danio rerio). Neurochem Res 37:1545\u20131553. https:\/\/doi.org\/10.1007\/s11064-012-0749-6","journal-title":"Neurochem Res"},{"key":"3019_CR65","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1007\/s12035-014-8983-3","volume":"53","author":"FC Vuaden","year":"2016","unstructured":"Vuaden FC, Savio LEB, Rico EP et al (2016) Methionine exposure alters glutamate uptake and adenine nucleotide hydrolysis in the zebrafish brain. Mol Neurobiol 53:200\u2013209. https:\/\/doi.org\/10.1007\/s12035-014-8983-3","journal-title":"Mol Neurobiol"},{"key":"3019_CR66","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s10545-014-9696-5","volume":"37","author":"K Wager","year":"2014","unstructured":"Wager K, Mahmood F, Russell C (2014) Modelling inborn errors of metabolism in zebrafish. J Inherit Metab Dis 37:483\u2013495. https:\/\/doi.org\/10.1007\/s10545-014-9696-5","journal-title":"J Inherit Metab Dis"},{"key":"3019_CR67","volume-title":"The Zebrafish Book, A guide for the laboratory use of zebrafish (Danio rerio)","author":"M Westerfield","year":"2007","unstructured":"Westerfield M (2007) The Zebrafish Book, A guide for the laboratory use of zebrafish (Danio rerio), 5th edn. University of Oregon Press, Eugene","edition":"5"},{"key":"3019_CR68","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3389\/fncel.2018.00360","volume":"12","author":"M Yu","year":"2018","unstructured":"Yu M, Guo L, Li N et al (2018) Overexpression of Kcnmb2 in dorsal CA1 of offspring mice rescues hippocampal dysfunction caused by a methyl donor-rich paternal diet. Front Cell Neurosci 12:360","journal-title":"Front Cell Neurosci"},{"key":"3019_CR69","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neulet.2017.11.010","volume":"664","author":"R Zanandrea","year":"2018","unstructured":"Zanandrea R, Abreu MSMS, Piato A et al (2018) Lithium prevents scopolamine-induced memory impairment in zebrafish. Neurosci Lett 664:34\u201337. https:\/\/doi.org\/10.1016\/j.neulet.2017.11.010","journal-title":"Neurosci Lett"},{"key":"3019_CR70","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-01970-x","author":"R Zanandrea","year":"2020","unstructured":"Zanandrea R, Wiprich MT, Altenhofen S et al (2020) Withdrawal effects following methionine exposure in adult zebrafish. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-020-01970-x","journal-title":"Mol Neurobiol"},{"key":"3019_CR71","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.aninu.2017.08.009","volume":"4","author":"N Zhang","year":"2018","unstructured":"Zhang N (2018) Role of methionine on epigenetic modification of DNA methylation and gene expression in animals. Anim Nutr 4:11\u201316. https:\/\/doi.org\/10.1016\/j.aninu.2017.08.009","journal-title":"Anim Nutr"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-021-03019-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00726-021-03019-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-021-03019-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T18:26:15Z","timestamp":1624991175000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00726-021-03019-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":71,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["3019"],"URL":"https:\/\/doi.org\/10.1007\/s00726-021-03019-2","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,22]]},"assertion":[{"value":"27 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Comiss\u00e3o de \u00c9tica no Uso de Animais of Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (3758-CEUA-PUCRS) and was registered in the Sistema Nacional de Gest\u00e3o do Patrim\u00f4nio Gen\u00e9tico e Conhecimento Tradicional Associado\u2014SISGEN (Protocol No. A3B073D).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}