{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:33:36Z","timestamp":1785760416773,"version":"3.56.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072689"],"award-info":[{"award-number":["32072689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31301979"],"award-info":[{"award-number":["31301979"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s00726-022-03179-9","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T14:04:55Z","timestamp":1657893895000},"page":"1421-1435","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Tryptophan regulates bile and nitrogen metabolism in two pig gut lactobacilli species in vitro based on metabolomics study"],"prefix":"10.1007","volume":"54","author":[{"given":"Shizhe","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4471-0154","authenticated-orcid":false,"given":"Zhaolai","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"issue":"1","key":"3179_CR1","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1038\/s41598-020-59617-9","volume":"10","author":"R Afshari","year":"2020","unstructured":"Afshari R, Pillidge CJ, Read E, Rochfort S, Dias DA, Osborn AM, Gill H (2020) New insights into cheddar cheese microbiota-metabolome relationships revealed by integrative analysis of multi-omics data. Sci Rep 10(1):3164. https:\/\/doi.org\/10.1038\/s41598-020-59617-9","journal-title":"Sci Rep"},{"issue":"6","key":"3179_CR2","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","volume":"23","author":"A Agus","year":"2018","unstructured":"Agus A, Planchais J, Sokol H (2018) Gut microbiota regulation of tryptophan metabolism in health and disease. Cell Host Microbe 23(6):716\u2013724. https:\/\/doi.org\/10.1016\/j.chom.2018.05.003","journal-title":"Cell Host Microbe"},{"issue":"6","key":"3179_CR3","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1136\/gutjnl-2020-323071","volume":"70","author":"A Agus","year":"2021","unstructured":"Agus A, Cl\u00e9ment K, Sokol H (2021) Gut microbiota-derived metabolites as central regulators in metabolic disorders. Gut 70(6):1174\u20131182. https:\/\/doi.org\/10.1136\/gutjnl-2020-323071","journal-title":"Gut"},{"issue":"1","key":"3179_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2323\/jgam.43.9","volume":"43","author":"MR Amin","year":"1997","unstructured":"Amin MR, Onodera R (1997) Synthesis of phenylalanine and production of other related compounds from phenylpyruvic acid and phenylacetic acid by ruminal bacteria, protozoa, and their mixture in vitro. J Gen Appl Microbiol 43(1):9\u201315. https:\/\/doi.org\/10.2323\/jgam.43.9","journal-title":"J Gen Appl Microbiol"},{"issue":"12","key":"3179_CR5","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.4049\/jimmunol.1701734","volume":"201","author":"R Aoki","year":"2018","unstructured":"Aoki R, Aoki-Yoshida A, Suzuki C, Takayama Y (2018) Indole-3-pyruvic acid, an aryl hydrocarbon receptor activator, suppresses experimental colitis in mice. J Immunol 201(12):3683\u20133693. https:\/\/doi.org\/10.4049\/jimmunol.1701734","journal-title":"J Immunol"},{"issue":"3","key":"3179_CR6","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1128\/AEM.72.3.1729-1738.2006","volume":"72","author":"M Begley","year":"2006","unstructured":"Begley M, Hill C, Gahan C (2006) Bile salt hydrolase activity in probiotics. Appl Environ Microbiol 72(3):1729\u20131738. https:\/\/doi.org\/10.1128\/AEM.72.3.1729-1738.2006","journal-title":"Appl Environ Microbiol"},{"issue":"6353","key":"3179_CR7","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1126\/science.aah5825","volume":"357","author":"L Cervantes-Barragan","year":"2017","unstructured":"Cervantes-Barragan L, Chai J, Tianero M, Di Luccia B, Ahern P, Merriman J, Cortez V, Caparon M, Donia M, Gilfillan S, Cella M, Gordon J, Hsieh C, Colonna M (2017) Lactobacillus reuteri induces gut intraepithelial CD4+CD8 aa+ T cells. Science 357(6353):806\u2013810. https:\/\/doi.org\/10.1126\/science.aah5825","journal-title":"Science"},{"issue":"11","key":"3179_CR8","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1038\/s41592-021-01303-3","volume":"18","author":"L Chen","year":"2021","unstructured":"Chen L, Lu W, Wang L, Xing X, Chen Z, Teng X, Zeng X, Muscarella A, Shen Y, Cowan A, McReynolds M, Kennedy B, Lato A, Campagna S, Singh M, Rabinowitz J (2021) Metabolite discovery through global annotation of untargeted metabolomics data. Nat Methods 18(11):1377\u20131385. https:\/\/doi.org\/10.1038\/s41592-021-01303-3","journal-title":"Nat Methods"},{"issue":"6","key":"3179_CR9","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1016\/j.cell.2015.11.004","volume":"163","author":"C Chevalier","year":"2015","unstructured":"Chevalier C, Stojanovic O, Colin D, Suarez-Zamorano N, Tarallo V, Veyrat-Durebex C, Rigo D, Fabbiano S, Stevanovic A, Hagemann S, Montet X, Seimbille Y, Zamboni N, Hapfelmeier S, Trajkovski M (2015) Gut microbiota orchestrates energy homeostasis during cold. Cell 163(6):1360\u20131374. https:\/\/doi.org\/10.1016\/j.cell.2015.11.004","journal-title":"Cell"},{"key":"3179_CR10","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.2741\/3820","volume":"16","author":"ZL Dai","year":"2011","unstructured":"Dai ZL, Wu G, Zhu WY (2011) Amino acid metabolism in intestinal bacteria: links between gut ecology and host health. Front Biosci (landmark Ed) 16:1768\u20131786. https:\/\/doi.org\/10.2741\/3820","journal-title":"Front Biosci (landmark Ed)"},{"issue":"5","key":"3179_CR11","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1007\/s00726-011-0846-x","volume":"42","author":"ZL Dai","year":"2012","unstructured":"Dai ZL, Li XL, Xi PB, Zhang J, Wu G, Zhu WY (2012) Metabolism of select amino acids in bacteria from the pig small intestine. Amino Acids 42(5):1597\u20131608. https:\/\/doi.org\/10.1007\/s00726-011-0846-x","journal-title":"Amino Acids"},{"key":"3179_CR12","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/978-1-4939-9639-1_11","volume":"2030","author":"Z Dai","year":"2019","unstructured":"Dai Z, Sun S, Chen H, Liu M, Zhang L, Wu Z, Li J, Wu G (2019) Analysis of tryptophan and its metabolites by high-performance liquid chromatography. Methods Mol Biol 2030:131\u2013142. https:\/\/doi.org\/10.1007\/978-1-4939-9639-1_11","journal-title":"Methods Mol Biol"},{"key":"3179_CR13","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/978-3-030-85686-1_7","volume":"1354","author":"Z Dai","year":"2022","unstructured":"Dai Z, Wu Z, Zhu W, Wu G (2022) Amino acids in microbial metabolism and function. Adv Exp Med Biol 1354:127\u2013143. https:\/\/doi.org\/10.1007\/978-3-030-85686-1_7","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"3179_CR14","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/j.1365-2672.1960.tb00188.x","volume":"23","author":"J De Man","year":"1960","unstructured":"De Man J, Rogosa M, Sharpe M (1960) A medium for the cultivation of lactobacilli. J Appl Bacteriol 23(1):130\u2013135. https:\/\/doi.org\/10.1111\/j.1365-2672.1960.tb00188.x","journal-title":"J Appl Bacteriol"},{"issue":"7682","key":"3179_CR15","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/nature24661","volume":"551","author":"D Dodd","year":"2017","unstructured":"Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL (2017) A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. Nature 551(7682):648\u2013652. https:\/\/doi.org\/10.1038\/nature24661","journal-title":"Nature"},{"key":"3179_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-020-02023-y","author":"A Ehrlich","year":"2020","unstructured":"Ehrlich A, Pacheco A, Henrick B, Taft D, Xu G, Huda M, Mishchuk D, Goodson M, Slupsky C, Barile D, Lebrilla C, Stephensen C, Mills D, Raybould H (2020) Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells. BMC Microbiol. https:\/\/doi.org\/10.1186\/s12866-020-02023-y","journal-title":"BMC Microbiol"},{"issue":"4","key":"3179_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094891","volume":"9","author":"A Finamore","year":"2014","unstructured":"Finamore A, Roselli M, Imbinto A, Seeboth J, Oswald IP, Mengheri E (2014) Lactobacillus amylovorus inhibits the TLR4 inflammatory signaling triggered by enterotoxigenic Escherichia coli via modulation of the negative regulators and involvement of TLR2 in intestinal Caco-2 cells and pig explants. PLoS ONE 9(4):e94891. https:\/\/doi.org\/10.1371\/journal.pone.0094891","journal-title":"PLoS ONE"},{"issue":"10","key":"3179_CR18","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrgastro.2012.156","volume":"9","author":"HJ Flint","year":"2012","unstructured":"Flint HJ, Scott KP, Louis P, Duncan SH (2012) The role of the gut microbiota in nutrition and health. Nat Rev Gastroenterol Hepatol 9(10):577\u2013589. https:\/\/doi.org\/10.1038\/nrgastro.2012.156","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"Suppl 1","key":"3179_CR19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4137\/IJTR.S11588","volume":"6","author":"T Fukuwatari","year":"2013","unstructured":"Fukuwatari T, Shibata K (2013) Nutritional aspect of tryptophan metabolism. Int J Tryptophan Res 6(Suppl 1):3\u20138. https:\/\/doi.org\/10.4137\/IJTR.S11588","journal-title":"Int J Tryptophan Res"},{"issue":"8","key":"3179_CR20","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1136\/gutjnl-2018-317232","volume":"68","author":"T Hendrikx","year":"2019","unstructured":"Hendrikx T, Duan Y, Wang Y, Oh J, Alexander L, Huang W, Starkel P, Ho S, Gao B, Fiehn O, Emond P, Sokol H, van Pijkeren J, Schnabl B (2019) Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice. Gut 68(8):1504\u20131515. https:\/\/doi.org\/10.1136\/gutjnl-2018-317232","journal-title":"Gut"},{"issue":"8","key":"3179_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135494","volume":"10","author":"JL Hoeflinger","year":"2015","unstructured":"Hoeflinger JL, Kashtanov DO, Cox SB, Dowd SE, Jouni ZE, Donovan SM, Miller MJ (2015) Characterization of the intestinal lactobacilli community following galactooligosaccharides and polydextrose supplementation in the neonatal piglet. PLoS ONE 10(8):e0135494. https:\/\/doi.org\/10.1371\/journal.pone.0135494","journal-title":"PLoS ONE"},{"issue":"1","key":"3179_CR22","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00216-015-9103-6","volume":"408","author":"A Honore","year":"2016","unstructured":"Honore A, Aunsbjerg S, Ebrahimi P, Thorsen M, Benfeldt C, Knochel S, Skov T (2016) Metabolic footprinting for investigation of antifungal properties of Lactobacillus paracasei. Anal Bioanal Chem 408(1):83\u201396. https:\/\/doi.org\/10.1007\/s00216-015-9103-6","journal-title":"Anal Bioanal Chem"},{"issue":"9","key":"3179_CR23","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1038\/s41418-018-0070-2","volume":"25","author":"Q Hou","year":"2018","unstructured":"Hou Q, Ye L, Liu H, Huang L, Yang Q, Turner J, Yu Q (2018) Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22. Cell Death Differ 25(9):1657\u20131670. https:\/\/doi.org\/10.1038\/s41418-018-0070-2","journal-title":"Cell Death Differ"},{"issue":"4","key":"3179_CR24","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/BF01361659","volume":"17","author":"RI Khan","year":"1999","unstructured":"Khan RI, Onodera R, Amin MR, Mohammed N (1999) Production of tyrosine and other aromatic compounds from phenylalanine by rumen microorganisms. Amino Acids 17(4):335\u2013346. https:\/\/doi.org\/10.1007\/BF01361659","journal-title":"Amino Acids"},{"issue":"11","key":"3179_CR25","doi-asserted-by":"publisher","first-page":"7578","DOI":"10.1128\/AEM.71.11.7578-7581.2005","volume":"71","author":"S Konstantinov","year":"2005","unstructured":"Konstantinov S, Smidt H, de Vos W (2005) Representational difference analysis and real-time PCR for strain-specific quantification of Lactobacillus sobrius sp nov. Appl Environ Microbiol 71(11):7578\u20137581. https:\/\/doi.org\/10.1128\/AEM.71.11.7578-7581.2005","journal-title":"Appl Environ Microbiol"},{"issue":"6","key":"3179_CR26","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/nm.4102","volume":"22","author":"B Lamas","year":"2016","unstructured":"Lamas B, Richard M, Leducq V, Pham H, Michel M, Da Costa G, Bridonneau C, Jegou S, Hoffmann T, Natividad J, Brot L, Taleb S, Couturier-Maillard A, Nion-Larmurier I, Merabtene F, Seksik P, Bourrier A, Cosnes J, Ryffel B, Beaugerie L, Launay J, Langella P, Xavier R, Sokol H (2016) CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nat Med 22(6):598\u2013605. https:\/\/doi.org\/10.1038\/nm.4102","journal-title":"Nat Med"},{"issue":"4","key":"3179_CR27","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1124\/pr.113.008201","volume":"66","author":"T Li","year":"2014","unstructured":"Li T, Chiang JY (2014) Bile acid signaling in metabolic disease and drug therapy. Pharmacol Rev 66(4):948\u2013983. https:\/\/doi.org\/10.1124\/pr.113.008201","journal-title":"Pharmacol Rev"},{"key":"3179_CR28","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/978-3-030-85686-1_13","volume":"1354","author":"P Li","year":"2022","unstructured":"Li P, Wu G (2022) Functional molecules of intestinal mucosal products and peptones in animal nutrition and health. Adv Exp Med Biol 1354:263\u2013277. https:\/\/doi.org\/10.1007\/978-3-030-85686-1_13","journal-title":"Adv Exp Med Biol"},{"key":"3179_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01736","author":"H Liang","year":"2018","unstructured":"Liang H, Dai Z, Liu N, Ji Y, Chen J, Zhang Y, Yang Y, Li J, Wu Z, Wu G (2018) Dietary L-tryptophan modulates the structural and functional composition of the intestinal microbiome in weaned piglets. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2018.01736","journal-title":"Front Microbiol"},{"key":"3179_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20010020","author":"H Liang","year":"2019","unstructured":"Liang H, Dai Z, Kou J, Sun K, Chen J, Yang Y, Wu G, Wu Z (2019) Dietary L-tryptophan supplementation enhances the intestinal mucosal barrier function in weaned piglets: implication of tryptophan-metabolizing microbiota. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20010020","journal-title":"Int J Mol Sci"},{"issue":"6","key":"3179_CR31","doi-asserted-by":"publisher","first-page":"G824","DOI":"10.1152\/ajpgi.00107.2019","volume":"317","author":"Y Liu","year":"2019","unstructured":"Liu Y, Tian X, He B, Hoang TK, Taylor CM, Blanchard E, Freeborn J, Park S, Luo M, Couturier J, Tran DQ, Roos S, Wu G, Rhoads JM (2019) Lactobacillus reuteri DSM 17938 feeding of healthy newborn mice regulates immune responses while modulating gut microbiota and boosting beneficial metabolites. Am J Physiol Gastrointest Liver Physiol 317(6):G824\u2013G838. https:\/\/doi.org\/10.1152\/ajpgi.00107.2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"2","key":"3179_CR32","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41390-019-0740-x","volume":"88","author":"D Meng","year":"2020","unstructured":"Meng D, Sommella E, Salviati E, Campiglia P, Ganguli K, Djebali K, Zhu W, Walker W (2020) Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine. Pediatr Res 88(2):209\u2013217. https:\/\/doi.org\/10.1038\/s41390-019-0740-x","journal-title":"Pediatr Res"},{"issue":"9","key":"3179_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043928","volume":"7","author":"JM Neal-McKinney","year":"2012","unstructured":"Neal-McKinney JM, Lu X, Duong T, Larson CL, Call DR, Shah DH, Konkel ME (2012) Production of organic acids by probiotic lactobacilli can be used to reduce pathogen load in poultry. PLoS ONE 7(9):e43928. https:\/\/doi.org\/10.1371\/journal.pone.0043928","journal-title":"PLoS ONE"},{"issue":"8","key":"3179_CR34","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1128\/AEM.64.8.3009-3013.1998","volume":"64","author":"MN Nierop Groot","year":"1998","unstructured":"Nierop Groot MN, de Bont JAM (1998) Conversion of phenylalanine to benzaldehyde initiated by an aminotransferase in Lactobacillus plantarum. Appl Environ Microbiol 64(8):3009\u20133013. https:\/\/doi.org\/10.1128\/AEM.64.8.3009-3013.1998","journal-title":"Appl Environ Microbiol"},{"issue":"W1","key":"3179_CR35","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1093\/nar\/gkab382","volume":"49","author":"Z Pang","year":"2021","unstructured":"Pang Z, Chong J, Zhou G, Morais D, Chang L, Barrette M, Gauthier C, Jacques P, Li S, Xia J (2021) MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights. Nucleic Acids Res 49(W1):388\u2013396. https:\/\/doi.org\/10.1093\/nar\/gkab382","journal-title":"Nucleic Acids Res"},{"key":"3179_CR36","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","volume":"10","author":"D Parada Venegas","year":"2019","unstructured":"Parada Venegas D, De la Fuente MK, Landskron G, Gonz\u00e1lez MJ, Quera R, Dijkstra G, Harmsen HJM, Faber KN, Hermoso MA (2019) Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Front Immunol 10:277. https:\/\/doi.org\/10.3389\/fimmu.2019.00277","journal-title":"Front Immunol"},{"key":"3179_CR37","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1128\/AEM.01148-17","volume":"83","author":"R Peixoto","year":"2017","unstructured":"Peixoto R, Alves E, Wang M, Ferreira R, Granato A, Han J, Gill H, Jacobson K, Lobo L, Domingues R, Borchers C, Davies J, Finlay B, Antunes L (2017) Repression of Salmonella host cell invasion by aromatic small molecules from the human fecal metabolome. Appl Environ Microbiol 83:19. https:\/\/doi.org\/10.1128\/AEM.01148-17","journal-title":"Appl Environ Microbiol"},{"key":"3179_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58069-5","author":"R Prete","year":"2020","unstructured":"Prete R, Long S, Gallardo A, Gahan C, Corsetti A, Joyce S (2020) Beneficial bile acid metabolism from Lactobacillus plantarum of food origin. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-020-58069-5","journal-title":"Sci Rep"},{"issue":"3","key":"3179_CR39","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1080\/19490976.2016.1150414","volume":"7","author":"JM Ridlon","year":"2016","unstructured":"Ridlon JM, Wolf PG, Gaskins HR (2016) Taurocholic acid metabolism by gut microbes and colon cancer. Gut Microbes 7(3):201\u2013215. https:\/\/doi.org\/10.1080\/19490976.2016.1150414","journal-title":"Gut Microbes"},{"issue":"1","key":"3179_CR40","doi-asserted-by":"publisher","first-page":"3294","DOI":"10.1038\/s41467-018-05470-4","volume":"9","author":"HM Roager","year":"2018","unstructured":"Roager HM, Licht TR (2018) Microbial tryptophan catabolites in health and disease. Nat Commun 9(1):3294. https:\/\/doi.org\/10.1038\/s41467-018-05470-4","journal-title":"Nat Commun"},{"issue":"2","key":"3179_CR41","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2307\/3579575","volume":"148","author":"P Scanff","year":"1997","unstructured":"Scanff P, Grison S, Monti P, Joubert C, Griffiths N, Gourmelon P (1997) Whole-body gamma irradiation modifies bile composition in the pig. Radiat Res 148(2):175\u2013180. https:\/\/doi.org\/10.2307\/3579575","journal-title":"Radiat Res"},{"issue":"32","key":"3179_CR42","doi-asserted-by":"publisher","first-page":"19376","DOI":"10.1073\/pnas.2000047117","volume":"117","author":"S Scott","year":"2020","unstructured":"Scott S, Fu J, Chang P (2020) Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor. Proc Natl Acad Sci U S A 117(32):19376\u201319387. https:\/\/doi.org\/10.1073\/pnas.2000047117","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"3179_CR43","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.cmet.2020.02.001","volume":"31","author":"I Shats","year":"2020","unstructured":"Shats I, Williams J, Liu J, Makarov M, Wu X, Lih F, Deterding L, Lim C, Xu X, Randall T, Lee E, Li W, Fan W, Li J, Sokolsky M, Kabanov A, Li L, Migaud M, Locasale J, Li X (2020) Bacteria boost mammalian host NAD metabolism by engaging the deamidated biosynthesis pathway. Cell Metab 31(3):564\u2013579. https:\/\/doi.org\/10.1016\/j.cmet.2020.02.001","journal-title":"Cell Metab"},{"issue":"6","key":"3179_CR44","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1271\/bbb.121006","volume":"77","author":"Y Suzuki","year":"2013","unstructured":"Suzuki Y, Kosaka M, Shindo K, Kawasumi T, Kimoto-Nira H, Suzuki C (2013) Identification of antioxidants produced by Lactobacillus plantarum. Biosci Biotechnol Biochem 77(6):1299\u20131302. https:\/\/doi.org\/10.1271\/bbb.121006","journal-title":"Biosci Biotechnol Biochem"},{"issue":"19","key":"3179_CR45","doi-asserted-by":"publisher","first-page":"5815","DOI":"10.1128\/JB.185.19.5815-5821.2003","volume":"185","author":"M Teresa Pellicer","year":"2003","unstructured":"Teresa Pellicer M, Felisa Nu\u00f1ez M, Aguilar J, Badia J, Baldoma L (2003) Role of 2-phosphoglycolate phosphatase of Escherichia coli in metabolism of the 2-phosphoglycolate formed in DNA repair. J Bacteriol 185(19):5815\u20135821. https:\/\/doi.org\/10.1128\/JB.185.19.5815-5821.2003","journal-title":"J Bacteriol"},{"issue":"32","key":"3179_CR46","doi-asserted-by":"publisher","first-page":"14390","DOI":"10.1073\/pnas.1005399107","volume":"107","author":"R Teufel","year":"2010","unstructured":"Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G (2010) Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proc Natl Acad Sci U S A 107(32):14390\u201314395. https:\/\/doi.org\/10.1073\/pnas.1005399107","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"3179_CR47","doi-asserted-by":"publisher","first-page":"7253","DOI":"10.1128\/AEM.71.11.7253-7262.2005","volume":"71","author":"B Teusink","year":"2005","unstructured":"Teusink B, van Enckevort F, Francke C, Wiersma A, Wegkamp A, Smid E, Siezen R (2005) In silico reconstruction of the metabolic pathways of Lactobacillus plantarum: comparing predictions of nutrient requirements with those from growth experiments. Appl Environ Microbiol 71(11):7253\u20137262. https:\/\/doi.org\/10.1128\/AEM.71.11.7253-7262.2005","journal-title":"Appl Environ Microbiol"},{"key":"3179_CR48","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3389\/fmed.2017.00163","volume":"4","author":"V Urdaneta","year":"2017","unstructured":"Urdaneta V, Casades\u00fas J (2017) Interactions between bacteria and bile salts in the gastrointestinal and hepatobiliary tracts. Front Med (lausanne) 4:163. https:\/\/doi.org\/10.3389\/fmed.2017.00163","journal-title":"Front Med (lausanne)"},{"key":"3179_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9100219","author":"J Wandy","year":"2019","unstructured":"Wandy J, Davies V, van der Hooft J, Weidt S, Daly R, Rogers S (2019) In silico optimization of mass spectrometry fragmentation strategies in metabolomics. Metabolites. https:\/\/doi.org\/10.3390\/metabo9100219","journal-title":"Metabolites"},{"issue":"6","key":"3179_CR50","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.3945\/jn.114.209817","volume":"145","author":"H Wang","year":"2015","unstructured":"Wang H, Ji Y, Wu G, Sun K, Sun Y, Li W, Wang B, He B, Zhang Q, Dai Z, Wu Z (2015) l-Tryptophan activates mammalian target of rapamycin and enhances expression of tight junction proteins in intestinal porcine epithelial cells. J Nutr 145(6):1156\u20131162. https:\/\/doi.org\/10.3945\/jn.114.209817","journal-title":"J Nutr"},{"key":"3179_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01953","author":"J Wang","year":"2018","unstructured":"Wang J, Ji H, Wang S, Liu H, Zhang W, Zhang D, Wang Y (2018) Probiotic Lactobacillus plantarum promotes intestinal barrier function by strengthening the epithelium and modulating gut microbiota. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2018.01953","journal-title":"Front Microbiol"},{"issue":"7","key":"3179_CR52","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1093\/jn\/nxaa129","volume":"150","author":"B Wang","year":"2020","unstructured":"Wang B, Sun S, Liu M, Chen H, Liu N, Wu Z, Wu G, Dai Z (2020) Dietary L-tryptophan regulates colonic serotonin homeostasis in mice with dextran sodium sulfate-induced colitis. J Nutr 150(7):1966\u20131976. https:\/\/doi.org\/10.1093\/jn\/nxaa129","journal-title":"J Nutr"},{"issue":"7682","key":"3179_CR53","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nature24628","volume":"551","author":"N Wilck","year":"2017","unstructured":"Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, Haase S, M\u00e4hler A, Balogh A, Mark\u00f3 L, Vvedenskaya O, Kleiner FH, Tsvetkov D, Klug L, Costea PI, Sunagawa S, Maier L, Rakova N, Schatz V, Neubert P, Fr\u00e4tzer C, Krannich A, Gollasch M, Grohme DA, C\u00f4rte-Real BF, Gerlach RG, Basic M, Typas A, Wu C, Titze JM, Jantsch J, Boschmann M, Dechend R, Kleinewietfeld M, Kempa S, Bork P, Linker RA, Alm EJ, M\u00fcller DN (2017) Salt-responsive gut commensal modulates TH17 axis and disease. Nature 551(7682):585\u2013589. https:\/\/doi.org\/10.1038\/nature24628","journal-title":"Nature"},{"key":"3179_CR54","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.anifeedsci.2005.04.031","volume":"123","author":"B Williams","year":"2005","unstructured":"Williams B, Bosch M, Boer H, Verstegen M, Tamminga S (2005) An in vitro batch culture method to assess potential fermentability of feed ingredients for monogastric diets. Anim Feed Sci Technol 123:445\u2013462. https:\/\/doi.org\/10.1016\/j.anifeedsci.2005.04.031","journal-title":"Anim Feed Sci Technol"},{"key":"3179_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-030-85686-1_1","volume":"1354","author":"G Wu","year":"2022","unstructured":"Wu G (2022) Nutrition and metabolism: foundations for animal growth, development, reproduction, and health. Adv Exp Med Biol 1354:1\u201324. https:\/\/doi.org\/10.1007\/978-3-030-85686-1_1","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"3179_CR56","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1007\/s00253-021-11099-z","volume":"105","author":"J Xia","year":"2021","unstructured":"Xia J, Jiang S, Lv L, Wu W, Wang Q, Xu Q, Ye J, Fang D, Li Y, Wu J, Bian X, Yang L, Jiang H, Wang K, Yan R, Li L (2021) Modulation of the immune response and metabolism in germ-free rats colonized by the probiotic Lactobacillus salivarius LI01. Appl Microbiol Biotechnol 105(4):1629\u20131645. https:\/\/doi.org\/10.1007\/s00253-021-11099-z","journal-title":"Appl Microbiol Biotechnol"},{"issue":"3","key":"3179_CR57","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1248\/cpb.45.464","volume":"45","author":"M Yoshikawa","year":"1997","unstructured":"Yoshikawa M, Shimada H, Saka M, Yoshizumi S, Yamahara J, Matsuda H (1997) Medicinal foodstuffs. 5. Moroheiya. 1. Absolute stereostructures of corchoionosides A, B, and C, histamine release inhibitors from the leaves of Vietnamese Corchorus olitorius L (Tiliaceae). Chem Pharm Bull (tokyo) 45(3):464\u2013469","journal-title":"Chem Pharm Bull (tokyo)"},{"issue":"2","key":"3179_CR58","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.immuni.2013.08.003","volume":"39","author":"T Zelante","year":"2013","unstructured":"Zelante T, Iannitti RG, Cunha C, De Luca A, Giovannini G, Pieraccini G, Zecchi R, D\u2019Angelo C, Massi-Benedetti C, Fallarino F, Carvalho A, Puccetti P, Romani L (2013) Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity 39(2):372\u2013385. https:\/\/doi.org\/10.1016\/j.immuni.2013.08.003","journal-title":"Immunity"},{"key":"3179_CR59","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.630294","volume":"8","author":"H Zhang","year":"2021","unstructured":"Zhang H, HuangFu H, Wang X, Zhao S, Liu Y, Lv H, Qin G, Tan Z (2021) Antibacterial activity of lactic acid producing Leuconostoc mesenteroides QZ1178 against pathogenic Gallibacterium anatis. Front Vet Sci 8:630294. https:\/\/doi.org\/10.3389\/fvets.2021.630294","journal-title":"Front Vet Sci"},{"issue":"7","key":"3179_CR60","doi-asserted-by":"publisher","first-page":"3191","DOI":"10.1007\/s00253-014-6294-2","volume":"99","author":"A Zhao","year":"2015","unstructured":"Zhao A, Hu X, Pan L, Wang X (2015) Isolation and characterization of a gamma-aminobutyric acid producing strain Lactobacillus buchneri WPZ001 that could efficiently utilize xylose and corncob hydrolysate. Appl Microbiol Biotechnol 99(7):3191\u20133200. https:\/\/doi.org\/10.1007\/s00253-014-6294-2","journal-title":"Appl Microbiol Biotechnol"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-022-03179-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00726-022-03179-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-022-03179-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T07:05:26Z","timestamp":1667718326000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00726-022-03179-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["3179"],"URL":"https:\/\/doi.org\/10.1007\/s00726-022-03179-9","relation":{},"ISSN":["0939-4451","1438-2199"],"issn-type":[{"value":"0939-4451","type":"print"},{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,15]]},"assertion":[{"value":"1 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No human participants and\/or animals were involved in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}