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This study evaluated the duodenal mucosa of rats with Walker-256 tumor administered with 1% <jats:sc>l<\/jats:sc>-glutathione, intending to evaluate the damage caused by cancer-associated cachexia in the gastrointestinal tract and the effects of antioxidant administration on mucosal protection. Twenty-four 55-day-old male Wistar rats were distributed into four groups: control (C); control administered with 1% <jats:sc>l<\/jats:sc>-glutathione (C-GSH); Walker-256 tumor (W) and Walker-256 tumor administered with 1% <jats:sc>l<\/jats:sc>-glutathione (W-GSH). After 14\u00a0days of treatment, the duodenum was harvested for morphometric analysis of the mucosa, proliferation, apoptosis, immunostaining of varicosities immunoreactive (IR) to vasoactive intestinal peptide (VIP) and 5-HT-IR cells, and quantification of mast cells and goblet cells. Walker-256 tumor-bearing rats showed cachexia syndrome, mucosal atrophy, reduced cell proliferation, reduced 5-HT-IR cells, and increased goblet cells and VIPergic varicosities, which were not reversed by <jats:sc>l<\/jats:sc>-glutathione. On the other hand, <jats:sc>l<\/jats:sc>-glutathione caused a reduction of cells in apoptosis and mast cell recruitment, demonstrating a partial recovery of the damage detected in the intestinal mucosa.<\/jats:p>","DOI":"10.1007\/s00726-024-03391-9","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T09:01:57Z","timestamp":1712912517000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of cancer-induced cachexia and administration of l-glutathione on the intestinal mucosa in rat"],"prefix":"10.1007","volume":"56","author":[{"given":"Sabrina Silva","family":"Sestak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Galv\u00e3o","family":"da Motta Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Ganem Rillo Paz","family":"Barateiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Cristina","family":"Vieira-Frez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Raquel Garcia","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Alessandra","family":"Guarnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Vanessa Colombo Martins","family":"Perles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-5123","authenticated-orcid":false,"given":"Jacqueline Nelisis","family":"Zanoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"3391_CR1","first-page":"36","volume":"25","author":"HRS Angelo","year":"2009","unstructured":"Angelo HRS, Oliveira GG (2009) Caquexia e altera\u00e7\u00f5es bioqu\u00edmicas em ratos com tumor de walker 256. 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