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Hypusination of EIF5A plays a key role in translation. Here, we examined the contribution of the epithelial hypusination pathway to gastric inflammation induced by\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    . Immunohistochemical analyses revealed increased expression of DHPS and hypusinated EIF5A (EIF5A\n                    <jats:sup>Hyp<\/jats:sup>\n                    ) in the gastric mucosa of patients with\n                    <jats:italic>H. pylori<\/jats:italic>\n                    gastritis compared to uninfected individuals, notably within gastric epithelial cells (GECs) and immune infiltrates. Then, we created a mouse model with epithelial-specific deletion of Dhps (\n                    <jats:italic>Dhps<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u0394epi<\/jats:italic>\n                    <\/jats:sup>\n                    ) and confirmed the reduction of DHPS and EIF5A\n                    <jats:sup>Hyp<\/jats:sup>\n                    in GECs.\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected\n                    <jats:italic>Dhps<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u0394epi<\/jats:italic>\n                    <\/jats:sup>\n                    mice exhibited an attenuation of gastric histologic inflammation scores compared with infected\n                    <jats:italic>Dhps<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>fl\/+<\/jats:italic>\n                    <\/jats:sup>\n                    controls, without alteration in bacterial colonization levels. Quantitative proteomics of isolated GECs showed that\n                    <jats:italic>Dhps<\/jats:italic>\n                    deletion altered the expression of proteins involved in organismal injury, cancer, and gastrointestinal diseases in na\u00efve mice. Upon\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection, inflammatory and immune response proteins, including signaling factors and immunoglobulin mediators, were less induced in\n                    <jats:italic>Dhps<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u0394epi<\/jats:italic>\n                    <\/jats:sup>\n                    GECs, and pathways linked to tissue injury and inflammation were selectively downregulated. Together, these findings demonstrate that epithelial hypusination supports\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -driven gastric inflammation without affecting bacterial persistence. Targeting DHPS-dependent EIF5A hypusination may thus represent a novel therapeutic strategy to limit\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -associated mucosal injury and disease progression.\n                  <\/jats:p>","DOI":"10.1007\/s00726-026-03496-3","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:16:25Z","timestamp":1770020185000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epithelial hypusination regulates Helicobacter pylori-induced gastric inflammation"],"prefix":"10.1007","volume":"58","author":[{"given":"Alain P.","family":"Gobert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara M.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline V.","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Asim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto G.","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristie L.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purvi","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina N.","family":"Tyree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate S.","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Coburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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