{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:57:39Z","timestamp":1775019459161,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["77847"],"award-info":[{"award-number":["77847"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"DOI":"10.1007\/s00726-026-03516-2","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:49:03Z","timestamp":1774360143000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Taurine supplementation and systemic lupus erythematosus in preclinical studies: a systematic review of clinical outcomes and underlying mechanisms"],"prefix":"10.1007","volume":"58","author":[{"given":"Aida","family":"Malek Mahdavi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeinab","family":"Javadivala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloufar","family":"Orooji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"issue":"10","key":"3516_CR1","first-page":"e30330","volume":"14","author":"MA Ameer","year":"2022","unstructured":"Ameer MA, Chaudhry H, Mushtaq J, Khan OS, Babar M, Hashim T, Zeb S, Tariq MA, Patlolla SR, Ali J, Hashim SN, Hashim S (2022) An Overview of Systemic Lupus Erythematosus (SLE) Pathogenesis, Classification, and Management. Cureus 14(10):e30330","journal-title":"Cureus"},{"issue":"1","key":"3516_CR2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/rheumatology\/keaa267","volume":"60","author":"IEM Bultink","year":"2021","unstructured":"Bultink IEM, de Vries F, van Vollenhoven RF, Lalmohamed A (2021) Mortality, causes of death and influence of medication use in patients with systemic lupus erythematosus vs matched controls. Rheumatology (Oxford) 60(1):207\u2013216","journal-title":"Rheumatology (Oxford)"},{"issue":"9","key":"3516_CR3","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1002\/art.42920","volume":"76","author":"G Figueroa-Parra","year":"2024","unstructured":"Figueroa-Parra G, Cu\u00e9llar-Guti\u00e9rrez MC, Gonz\u00e1lez-Trevi\u00f1o M, Sanchez-Rodriguez A, Flores-Gouyonnet J, Meade-Aguilar JA, Prokop LJ, Murad MH, Dall\u2019Era M, Rovin BH, Houssiau F, Tamirou F, Fervenza FC, Crowson CS, Putman MS, Duarte-Garc\u00eda A (2024) Impact of Glucocorticoid Dose on Complete Response, Serious Infections, and Mortality During the Initial Therapy of Lupus Nephritis: A Systematic Review and Meta-Analysis of the Control Arms of Randomized Controlled Trials. Arthritis Rheumatol 76(9):1408\u20131418","journal-title":"Arthritis Rheumatol"},{"issue":"20","key":"3516_CR5","doi-asserted-by":"publisher","first-page":"9685","DOI":"10.1021\/jf8020255","volume":"56","author":"TC Hsu","year":"2008","unstructured":"Hsu TC, Chiang SY, Wu JH, Tsai CC, Huang CY, Chen YC, Tzang BS (2008) Treatment with taurine attenuates hepatic apoptosis in NZB\/W F1 mice fed with a high-cholesterol diet. J Agric Food Chem 56(20):9685\u20139691","journal-title":"J Agric Food Chem"},{"issue":"1","key":"3516_CR4","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.foodchem.2009.05.088","volume":"119","author":"TC Hsu","year":"2010","unstructured":"Hsu TC, Chen YC, Tsai CC, Wu JH, Li SL, Tzang BS (2010) Protective effects of taurine against hepatic abnormality in NZB\/W F1 mice fed a hypercholesterolemic diet. Food Chem 119(1):62\u201368","journal-title":"Food Chem"},{"issue":"18","key":"3516_CR7","doi-asserted-by":"publisher","first-page":"8635","DOI":"10.1021\/jf9020625","volume":"57","author":"CY Huang","year":"2009","unstructured":"Huang CY, Hsu TC, Kuo WW, Wu SP, Lin YM, Yen CY, Wu JH, Tzang BS (2009) Beneficial effects of taurine on cardiac abnormality in NZB\/W F1 mice fed with a high-cholesterol diet. J Agric Food Chem 57(18):8635\u20138642","journal-title":"J Agric Food Chem"},{"issue":"1","key":"3516_CR6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12986-025-00936-x","volume":"22","author":"S Huang","year":"2025","unstructured":"Huang S, Cui Y, Zhang Y, Deng H, Liu S, Feng X (2025) Taurine corrects lupus CD4+ T cell imbalance through inhibition of mTORC1 signaling. Nutr Metab (Lond) 22(1):41","journal-title":"Nutr Metab (Lond)"},{"issue":"4","key":"3516_CR8","first-page":"287","volume":"54","author":"OM Ighodaro","year":"2018","unstructured":"Ighodaro OM, Akinloye OA (2018) First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alex J Med 54(4):287\u2013293","journal-title":"Alex J Med"},{"issue":"8","key":"3516_CR9","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1007\/s00296-023-05306-5","volume":"43","author":"PB Katarzyna","year":"2023","unstructured":"Katarzyna PB, Wiktor S, Ewa D, Piotr L (2023) Current treatment of systemic lupus erythematosus: a clinician\u2019s perspective. Rheumatol Int 43(8):1395\u20131407","journal-title":"Rheumatol Int"},{"issue":"12","key":"3516_CR10","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1002\/art.41419","volume":"72","author":"J Li","year":"2020","unstructured":"Li J, Ding H, Meng Y, Li G, Fu Q, Guo Q, Yin Z, Ye Z, Zhou H, Shen N (2020) Taurine Metabolism Aggravates the Progression of Lupus by Promoting the Function of Plasmacytoid Dendritic Cells. Arthritis Rheumatol 72(12):2106\u20132117","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"3516_CR11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.21037\/apm-20-2087","volume":"10","author":"H Luo","year":"2021","unstructured":"Luo H, Geng CJ, Miao SM, Wang LH, Li Q (2021) Taurine attenuates the damage of lupus nephritis mouse via inactivation of the NF-\u03baB pathway. Ann Palliat Med 10(1):137\u2013147","journal-title":"Ann Palliat Med"},{"issue":"6","key":"3516_CR12","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00726-021-02988-8","volume":"53","author":"A Malek Mahdavi","year":"2021","unstructured":"Malek Mahdavi A, Javadivala Z (2021) A systematic review of preclinical studies on the efficacy of taurine for the treatment of rheumatoid arthritis. Amino Acids 53(6):783\u2013800","journal-title":"Amino Acids"},{"issue":"5","key":"3516_CR13","doi-asserted-by":"publisher","first-page":"F1088","DOI":"10.1152\/ajprenal.90746.2008","volume":"296","author":"C Meyer-Schwesinger","year":"2009","unstructured":"Meyer-Schwesinger C, Dehde S, von Ruffer C, Gatzemeier S, Klug P, Wenzel UO, Stahl RA, Thaiss F, Meyer TN (2009) Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling. Am J Physiol Ren Physiol 296(5):F1088\u20131099","journal-title":"Am J Physiol Ren Physiol"},{"issue":"1","key":"3516_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2046-4053-4-1","volume":"4","author":"D Moher","year":"2015","unstructured":"Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, PRISMA-P Group (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 4(1):1","journal-title":"Syst Rev"},{"issue":"6662","key":"3516_CR15","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/34214","volume":"391","author":"H Sakahira","year":"1998","unstructured":"Sakahira H, Enari M, Nagata S (1998) Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391(6662):96\u201399","journal-title":"Nature"},{"issue":"3","key":"3516_CR16","doi-asserted-by":"publisher","first-page":"225","DOI":"10.4062\/biomolther.2017.251","volume":"26","author":"S Schaffer","year":"2018","unstructured":"Schaffer S, Kim HW (2018) Effects and Mechanisms of Taurine as a Therapeutic Agent. Biomol Ther (Seoul) 26(3):225\u2013241","journal-title":"Biomol Ther (Seoul)"},{"issue":"1","key":"3516_CR17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1423-0127-21-23","volume":"21","author":"D Shah","year":"2014","unstructured":"Shah D, Mahajan N, Sah S, Nath SK, Paudyal B (2014) Oxidative stress and its biomarkers in systemic lupus erythematosus. J Biomed Sci 21(1):23","journal-title":"J Biomed Sci"},{"issue":"3","key":"3516_CR18","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.bbrc.2016.11.088","volume":"482","author":"H Vakifahmetoglu-Norberg","year":"2017","unstructured":"Vakifahmetoglu-Norberg H, Ouchida AT, Norberg E (2017) The role of mitochondria in metabolism and cell death. Biochem Biophys Res Commun 482(3):426\u2013431","journal-title":"Biochem Biophys Res Commun"},{"key":"3516_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/2526174","volume":"2016","author":"J Yang","year":"2016","unstructured":"Yang J, Yang X, Zou H, Li M (2016) Oxidative stress and Treg and Th17 dysfunction in systemic lupus erythematosus. Oxid Med Cell Longev 2016:1\u201310","journal-title":"Oxid Med Cell Longev"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00726-026-03516-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-026-03516-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-026-03516-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:01:32Z","timestamp":1775012492000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00726-026-03516-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3516"],"URL":"https:\/\/doi.org\/10.1007\/s00726-026-03516-2","relation":{},"ISSN":["1438-2199"],"issn-type":[{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]},"assertion":[{"value":"24 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"24"}}