{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:03:58Z","timestamp":1789603438788,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":83,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23K24589"],"award-info":[{"award-number":["23K24589"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"DOI":"10.1007\/s00726-026-03542-0","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:35:22Z","timestamp":1782459322000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of taurine on skeletal muscle in senescence-accelerated mice and C2C12 myoblasts and myotubes"],"prefix":"10.1007","volume":"58","author":[{"given":"Yiying","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatasu","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiya","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kawanokuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Midorikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Oikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"issue":"4","key":"3542_CR1","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1093\/ajcn\/64.4.552","volume":"64","author":"RN Baumgartner","year":"1996","unstructured":"Baumgartner RN, Koehler KM, Romero L, Garry PJ (1996) Serum albumin is associated with skeletal muscle in elderly men and women. Am J Clin Nutr 64(4):552\u2013558. https:\/\/doi.org\/10.1093\/ajcn\/64.4.552","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"3542_CR2","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.exger.2005.05.005","volume":"40","author":"W Derave","year":"2005","unstructured":"Derave W, Eijnde BO, Ramaekers M, Hespel P (2005) Soleus muscles of samp8 mice provide an accelerated model of skeletal muscle senescence. Exp Gerontol 40(7):562\u2013572. https:\/\/doi.org\/10.1016\/j.exger.2005.05.005","journal-title":"Exp Gerontol"},{"issue":"3","key":"3542_CR3","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1089\/rej.2008.0699","volume":"11","author":"W Derave","year":"2008","unstructured":"Derave W, Jones G, Hespel P, Harris RC (2008) Creatine supplementation augments skeletal muscle carnosine content in senescence-accelerated mice (samp8). Rejuvenation Res 11(3):641\u2013647. https:\/\/doi.org\/10.1089\/rej.2008.0699","journal-title":"Rejuvenation Res"},{"key":"3542_CR4","doi-asserted-by":"publisher","first-page":"111595","DOI":"10.1016\/j.mad.2021.111595","volume":"200","author":"DA Englund","year":"2021","unstructured":"Englund DA, Zhang X, Aversa Z, LeBrasseur NK (2021) Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions. Mech Ageing Dev 200:111595. https:\/\/doi.org\/10.1016\/j.mad.2021.111595","journal-title":"Mech Ageing Dev"},{"issue":"6751","key":"3542_CR5","doi-asserted-by":"publisher","first-page":"eadl2116","DOI":"10.1126\/science.adl2116","volume":"388","author":"ME Fernandez","year":"2025","unstructured":"Fernandez ME, Bernier M, Price NL, Camandola S, Aon MA, Vaughan K, Mattison JA, Preston JD, Jones DP, Tanaka T, Tian Q, Gonzalez-Freire M, Ferrucci L, de Cabo R (2025) Is taurine an aging biomarker? Science 388(6751):eadl2116. https:\/\/doi.org\/10.1126\/science.adl2116","journal-title":"Science"},{"issue":"1","key":"3542_CR6","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.devcel.2009.11.013","volume":"18","author":"P Hasson","year":"2010","unstructured":"Hasson P, DeLaurier A, Bennett M, Grigorieva E, Naiche LA, Papaioannou VE, Mohun TJ, Logan MP (2010) Tbx4 and tbx5 acting in connective tissue are required for limb muscle and tendon patterning. Dev Cell 18(1):148\u2013156. https:\/\/doi.org\/10.1016\/j.devcel.2009.11.013","journal-title":"Dev Cell"},{"issue":"13","key":"3542_CR7","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1080\/10408398.2024.2348549","volume":"65","author":"W He","year":"2025","unstructured":"He W, Connolly ED, Cross HR, Wu G (2025) Dietary protein and amino acid intakes for mitigating sarcopenia in humans. Crit Rev Food Sci Nutr 65(13):2538\u20132561. https:\/\/doi.org\/10.1080\/10408398.2024.2348549","journal-title":"Crit Rev Food Sci Nutr"},{"key":"3542_CR8","doi-asserted-by":"publisher","first-page":"101528","DOI":"10.1016\/j.arr.2021.101528","volume":"73","author":"X Hong","year":"2022","unstructured":"Hong X, Campanario S, Ramirez-Pardo I, Grima-Terren M, Isern J, Munoz-Canoves P (2022) Stem cell aging in the skeletal muscle: The importance of communication. Ageing Res Rev 73:101528. https:\/\/doi.org\/10.1016\/j.arr.2021.101528","journal-title":"Ageing Res Rev"},{"issue":"2","key":"3542_CR9","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.ydbio.2017.03.028","volume":"429","author":"AH Huang","year":"2017","unstructured":"Huang AH (2017) Coordinated development of the limb musculoskeletal system: Tendon and muscle patterning and integration with the skeleton. Dev Biol 429(2):420\u2013428. https:\/\/doi.org\/10.1016\/j.ydbio.2017.03.028","journal-title":"Dev Biol"},{"issue":"9","key":"3542_CR10","doi-asserted-by":"publisher","first-page":"e107409","DOI":"10.1371\/journal.pone.0107409","volume":"9","author":"T Ito","year":"2014","unstructured":"Ito T, Yoshikawa N, Inui T, Miyazaki N, Schaffer SW, Azuma J (2014) Tissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice. PLoS ONE 9(9):e107409. https:\/\/doi.org\/10.1371\/journal.pone.0107409","journal-title":"PLoS ONE"},{"issue":"10","key":"3542_CR11","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1016\/j.ymthe.2021.07.014","volume":"29","author":"K Kaur","year":"2021","unstructured":"Kaur K, Hadas Y, Kurian AA, Zak MM, Yoo J, Mahmood A, Girard H, Komargodski R, Io T, Santini MP, Sultana N, Sharkar MTK, Magadum A, Fargnoli A, Yoon S, Chepurko E, Chepurko V, Eliyahu E, Pinto D, Lebeche D, Kovacic JC, Hajjar RJ, Rafii S, Zangi L (2021) Direct reprogramming induces vascular regeneration post muscle ischemic injury. Mol Ther 29(10):3042\u20133058. https:\/\/doi.org\/10.1016\/j.ymthe.2021.07.014","journal-title":"Mol Ther"},{"issue":"1","key":"3542_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/ng0197-21","volume":"15","author":"QY Li","year":"1997","unstructured":"Li QY, Newbury-Ecob RA, Terrett JA, Wilson DI, Curtis AR, Yi CH, Gebuhr T, Bullen PJ, Robson SC, Strachan T, Bonnet D, Lyonnet S, Young ID, Raeburn JA, Buckler AJ, Law DJ, Brook JD (1997) Holt-oram syndrome is caused by mutations in tbx5, a member of the brachyury (t) gene family. Nat Genet 15(1):21\u201329. https:\/\/doi.org\/10.1038\/ng0197-21","journal-title":"Nat Genet"},{"key":"3542_CR13","doi-asserted-by":"publisher","unstructured":"Liu X, Chen Y, Zhang L, Qi Z, Yang L, Huang C, Wang L, Lin D (2025) Taurine attenuates disuse muscle atrophy through modulation of the xct-gsh-gpx4 and ampk-acc-acsl4 pathways. Antioxid (Basel) 14(7). https:\/\/doi.org\/10.3390\/antiox14070847","DOI":"10.3390\/antiox14070847"},{"issue":"2","key":"3542_CR14","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/(SICI)1097-0185(199810)252:2<311::AID-AR17>3.0.CO;2-Q","volume":"252","author":"LM McIntosh","year":"1998","unstructured":"McIntosh LM, Garrett KL, Megeney L, Rudnicki MA, Anderson JE (1998) Regeneration and myogenic cell proliferation correlate with taurine levels in dystrophin- and myod-deficient muscles. Anat Rec 252(2):311\u2013324. https:\/\/doi.org\/10.1002\/(SICI)1097-0185(199810)252:2%3C311::AID-AR17%3E3.0.CO;2-Q","journal-title":"Anat Rec"},{"issue":"1","key":"3542_CR15","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1248\/bpb.b20-00555","volume":"44","author":"Y Morita","year":"2021","unstructured":"Morita Y, Ishida T, Morisawa S, Jobu K, Ou Y, Fujita H, Hanazaki K, Miyamura M (2021) Juzentaihoto suppresses muscle atrophy and decreased motor function in samp8 mice. Biol Pharm Bull 44(1):32\u201338. https:\/\/doi.org\/10.1248\/bpb.b20-00555","journal-title":"Biol Pharm Bull"},{"issue":"4","key":"3542_CR16","doi-asserted-by":"publisher","first-page":"dmm050540","DOI":"10.1242\/dmm.050540","volume":"17","author":"S Mughal","year":"2024","unstructured":"Mughal S, Sabater-Arcis M, Artero R, Ramon-Azcon J, Fernandez-Costa JM (2024) Taurine activates the akt-mtor axis to restore muscle mass and contractile strength in human 3d in vitro models of steroid myopathy. Dis Model Mech 17(4):dmm050540. https:\/\/doi.org\/10.1242\/dmm.050540","journal-title":"Dis Model Mech"},{"issue":"7","key":"3542_CR17","doi-asserted-by":"publisher","first-page":"673","DOI":"10.2174\/1389203718666161122113609","volume":"19","author":"BM Scicchitano","year":"2018","unstructured":"Scicchitano BM, Sica G (2018) The beneficial effects of taurine to counteract sarcopenia. Curr Protein Pept Sci 19(7):673\u2013680. https:\/\/doi.org\/10.2174\/1389203718666161122113609","journal-title":"Curr Protein Pept Sci"},{"issue":"3","key":"3542_CR18","doi-asserted-by":"publisher","first-page":"590","DOI":"10.7705\/biomedica.5765","volume":"41","author":"JR Silva-Fhon","year":"2021","unstructured":"Silva-Fhon JR, Rojas-Huayta VM, Aparco-Balboa JP, C\u00e9spedes-Panduro B, Partezani-Rodrigues RA (2021) Sarcopenia and blood albumin: A systematic review with meta-analysis. Biomedica 41(3):590\u2013603. https:\/\/doi.org\/10.7705\/biomedica.5765","journal-title":"Biomedica"},{"issue":"6649","key":"3542_CR19","doi-asserted-by":"publisher","first-page":"eabn9257","DOI":"10.1126\/science.abn9257","volume":"380","author":"P Singh","year":"2023","unstructured":"Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, Shi SL, Lopes Bastos B, Nair T, Riermeier A, Vayndorf EM, Wu JZ, Nilakhe A, Nguyen CQ, Muir M, Kiflezghi MG, Foulger A, Junker A, Devine J, Sharan K, Chinta SJ, Rajput S, Rane A, Baumert P, Schonfelder M, Iavarone F, di Lorenzo G, Kumari S, Gupta A, Sarkar R, Khyriem C, Chawla AS, Sharma A, Sarper N, Chattopadhyay N, Biswal BK, Settembre C, Nagarajan P, Targoff KL, Picard M, Gupta S, Velagapudi V, Papenfuss AT, Kaya A, Ferreira MG, Kennedy BK, Andersen JK, Lithgow GJ, Ali AM, Mukhopadhyay A, Palotie A, Kastenmuller G, Kaeberlein M, Wackerhage H, Pal B, Yadav VK (2023) Taurine deficiency as a driver of aging. Science 380(6649):eabn9257. https:\/\/doi.org\/10.1126\/science.abn9257","journal-title":"Science"},{"issue":"31","key":"3542_CR21","doi-asserted-by":"publisher","first-page":"23639","DOI":"10.1074\/jbc.M110.101063","volume":"285","author":"M Snyder","year":"2010","unstructured":"Snyder M, Huang XY, Zhang JJ (2010) Stat3 directly controls the expression of tbx5, nkx2.5, and gata4 and is essential for cardiomyocyte differentiation of p19cl6 cells. J Biol Chem 285(31):23639\u201323646. https:\/\/doi.org\/10.1074\/jbc.M110.101063","journal-title":"J Biol Chem"},{"issue":"9","key":"3542_CR20","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1111\/j.1532-5415.2012.04115.x","volume":"60","author":"CK Snyder","year":"2012","unstructured":"Snyder CK, Lapidus JA, Cawthon PM, Dam TT, Sakai LY, Marshall LM, Osteoporotic Fractures in Men Research G (2012) Serum albumin in relation to change in muscle mass, muscle strength, and muscle power in older men. J Am Geriatr Soc 60(9):1663\u20131672. https:\/\/doi.org\/10.1111\/j.1532-5415.2012.04115.x","journal-title":"J Am Geriatr Soc"},{"key":"3542_CR22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/bs.ctdb.2016.08.008","volume":"122","author":"JD Steimle","year":"2017","unstructured":"Steimle JD, Moskowitz IP (2017) Tbx5: A key regulator of heart development. Curr Top Dev Biol 122:195\u2013221. https:\/\/doi.org\/10.1016\/bs.ctdb.2016.08.008","journal-title":"Curr Top Dev Biol"},{"issue":"11","key":"3542_CR23","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1113\/JP271418","volume":"594","author":"JR Terrill","year":"2016","unstructured":"Terrill JR, Pinniger GJ, Graves JA, Grounds MD, Arthur PG (2016) Increasing taurine intake and taurine synthesis improves skeletal muscle function in the mdx mouse model for duchenne muscular dystrophy. J Physiol 594(11):3095\u20133110. https:\/\/doi.org\/10.1113\/JP271418","journal-title":"J Physiol"},{"key":"3542_CR24","doi-asserted-by":"publisher","first-page":"582449","DOI":"10.3389\/fphys.2020.582449","volume":"11","author":"A Thirupathi","year":"2020","unstructured":"Thirupathi A, Pinho RA, Baker JS, Istvan B, Gu Y (2020) Taurine reverses oxidative damages and restores the muscle function in overuse of exercised muscle. Front Physiol 11:582449. https:\/\/doi.org\/10.3389\/fphys.2020.582449","journal-title":"Front Physiol"},{"key":"3542_CR25","doi-asserted-by":"publisher","unstructured":"Wu W, Zhang L, Chen Y, Huang C, Yang L, Lin D (2025) Exercise attenuates skeletal muscle atrophy in senescent samp8 mice: Metabolic insights from nmr-based metabolomics. Molecules 30(9). https:\/\/doi.org\/10.3390\/molecules30092003","DOI":"10.3390\/molecules30092003"},{"issue":"11","key":"3542_CR26","doi-asserted-by":"publisher","first-page":"6844","DOI":"10.1074\/jbc.M114.634451","volume":"290","author":"A Yamak","year":"2015","unstructured":"Yamak A, Georges RO, Sheikh-Hassani M, Morin M, Komati H, Nemer M (2015) Novel exons in the tbx5 gene locus generate protein isoforms with distinct expression domains and function. J Biol Chem 290(11):6844\u20136856. https:\/\/doi.org\/10.1074\/jbc.M114.634451","journal-title":"J Biol Chem"},{"issue":"5","key":"3542_CR27","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.3390\/ijms21051830","volume":"21","author":"H Yamakawa","year":"2020","unstructured":"Yamakawa H, Kusumoto D, Hashimoto H, Yuasa S (2020) Stem cell aging in skeletal muscle regeneration and disease. Int J Mol Sci 21(5):1830. https:\/\/doi.org\/10.3390\/ijms21051830","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3542_CR28","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1186\/1423-0127-17-S1-S9","volume":"17","author":"J Yang","year":"2010","unstructured":"Yang J, Wu G, Feng Y, Lv Q, Lin S, Hu J (2010) Effects of taurine on male reproduction in rats of different ages. J Biomed Sci 17(1):S9. https:\/\/doi.org\/10.1186\/1423-0127-17-S1-S9","journal-title":"J Biomed Sci"},{"key":"3542_CR29","doi-asserted-by":"publisher","first-page":"8884283","DOI":"10.1155\/2021\/8884283","volume":"2021","author":"D Yu","year":"2021","unstructured":"Yu D, Cai Z, Li D, Zhang Y, He M, Yang Y, Liu D, Xie W, Li Y, Xiao W (2021) Myogenic differentiation of stem cells for skeletal muscle regeneration. Stem Cells Int 2021:8884283. https:\/\/doi.org\/10.1155\/2021\/8884283","journal-title":"Stem Cells Int"},{"key":"3542_CR30","doi-asserted-by":"publisher","first-page":"685362","DOI":"10.3389\/fmolb.2021.685362","volume":"8","author":"L Zhou","year":"2021","unstructured":"Zhou L, Lu R, Huang C, Lin D (2021) Taurine protects c2c12 myoblasts from impaired cell proliferation and myotube differentiation under cisplatin-induced ros exposure. Front Mol Biosci 8:685362. https:\/\/doi.org\/10.3389\/fmolb.2021.685362","journal-title":"Front Mol Biosci"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00726-026-03542-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-026-03542-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-026-03542-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:37:43Z","timestamp":1789601863000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00726-026-03542-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3542"],"URL":"https:\/\/doi.org\/10.1007\/s00726-026-03542-0","relation":{},"ISSN":["1438-2199"],"issn-type":[{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"assertion":[{"value":"27 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"49"}}