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This systematic review and individual participant data (IPD) meta-analysis examined the comparative efficacy of antidepressant medication (ADM) and interpersonal psychotherapy (IPT) for MAW (aged 40\u201364) versus other adults (men and non-MAW) on depression, quality of life, and interpersonal problem measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, PsycINFO, Embase, and the Cochrane Library were searched January 1, 2025 to identify randomized trials comparing ADM and IPT for adults with depression. IPD were requested and analyzed using mixed-effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IPD were obtained from 9 of the 15 (60%) identified studies, comprising 1,490 participants (527 MAW, 963 other adults). MAW status did not significantly moderate ADM versus IPT comparative efficacy on depression (\n                      <jats:italic>p<\/jats:italic>\n                      = .10) and interpersonal problems (\n                      <jats:italic>p<\/jats:italic>\n                      = .29) outcomes. The two treatments did not significantly differ in treatment effect in the MAW group (depression:\n                      <jats:italic>b<\/jats:italic>\n                      = -0.03,\n                      <jats:italic>p<\/jats:italic>\n                      = .76; interpersonal problems:\n                      <jats:italic>b<\/jats:italic>\n                      = -0.20,\n                      <jats:italic>p<\/jats:italic>\n                      = .31). MAW status significantly moderated comparative efficacy on quality of life measures (\n                      <jats:italic>b\u00a0<\/jats:italic>\n                      =\u20090.37,\n                      <jats:italic>p<\/jats:italic>\n                      = .02). Whereas IPT was non-significantly more efficacious than ADM for MAW (\n                      <jats:italic>b<\/jats:italic>\n                      = -0.18,\n                      <jats:italic>p<\/jats:italic>\n                      = .15), ADM were non-significantly more efficacious than IPT for other adults (\n                      <jats:italic>b<\/jats:italic>\n                      \u2009=\u20090.19,\n                      <jats:italic>p<\/jats:italic>\n                      = .051).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first IPD meta-analysis directly comparing depression treatments in MAW. The absence of treatment effect differences indicates that other factors (e.g., patient preference) may guide choice between IPT and ADM in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00737-026-01730-1","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T05:21:00Z","timestamp":1784524860000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The efficacy of antidepressant medication versus interpersonal psychotherapy for depression in middle-aged women: a systematic review and individual participant data meta-analysis"],"prefix":"10.1007","volume":"29","author":[{"given":"Sanne N.E.","family":"van Haaren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmijn","family":"Breunese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik J.","family":"Wienicke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Markowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica S.","family":"Weitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Hollon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dillon T.","family":"Browne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Rucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Corda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Menchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrna M.","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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The original investigators might have required IRB approval to share their IPD, depending on their institution\u2019s policies; if so, it was their responsibility to obtain it. By signing the data sharing agreement, the authors who shared their IPD declared that those data were collected and transferred according to all applicable local and international laws and regulations, including but not limited to local IRB approval.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Dr Cohen previously held stock options in AbleTo, which he received as compensation for advice on the clinical content of Joyable\u2019s digital cognitive therapy for depression. Dr Markowitz reports salary support from New York State Psychiatric Institute, research grant support from the Columbia Velocity Fund, National Institute of Mental Health, and Department of Defense, and minor book royalties, some related to interpersonal psychotherapy. Dr Hollon reports grant funding from the National Institute of Mental Health and minor book royalties. Dr Weissman reports grants from National Institute of Mental Health, Brain and Behavior Foundation, Templeton Foundation, and Sackler Foundation, and royalties from Perseus Press, Oxford Press, APA Publishing, and Multihealth Systems. Dr Blom reports personal fees from \u2018Leerboek Interpersoonlijke psychotherapie\u2019 outside the submitted work. Dr Driessen reports a grant from the Netherlands Organisation of Scientific Research (NWO) during the conduct of the study. Drs Weitz, Browne, Rucci, Corda, Menchetti, Bagby, Quilty, Altamura, Zobel, Schramm, Gois, Twisk and Cuijpers, Mrs van Haaren and Breunese, and Mr Wienicke have nothing to disclose.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"110"}}