{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:06:36Z","timestamp":1791417996043,"version":"4.3.3"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1007\/s00774-009-0121-3","type":"journal-article","created":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T03:19:49Z","timestamp":1254280789000},"page":"139-148","source":"Crossref","is-referenced-by-count":33,"title":["Effects of transgenic Pit-1 overexpression on calcium phosphate and bone metabolism"],"prefix":"10.1007","volume":"28","author":[{"given":"Atsushi","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Ammann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Nishiwaki-Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahoko","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuko","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"Hirabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Oiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyasu","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Caverzasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,10,1]]},"reference":[{"key":"121_CR1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1172\/JCI111006","volume":"72","author":"BD Hettleman","year":"1983","unstructured":"Hettleman BD, Sabina RL, Drezner MK, Holmes EW, Swain JL (1983) Defective adenosine triphosphate synthesis. An explanation for skeletal muscle dysfunction in phosphate-deficient mice. J Clin Invest 72:582\u2013589","journal-title":"J Clin Invest"},{"key":"121_CR2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0005-2736(93)90167-X","volume":"1148","author":"PJ Butterworth","year":"1993","unstructured":"Butterworth PJ, Younus MJ (1993) Uptake of phosphate by rat hepatocytes in primary culture: a sodium-dependent system that is stimulated by insulin. Biochim Biophys Acta 1148:117\u2013122","journal-title":"Biochim Biophys Acta"},{"key":"121_CR3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0167-4889(94)90238-0","volume":"1223","author":"KE Polgreen","year":"1994","unstructured":"Polgreen KE, Kemp GJ, Leighton B, Radda GK (1994) Modulation of Pi transport in skeletal muscle by insulin and IGF-1. Biochim Biophys Acta 1223:279\u2013284","journal-title":"Biochim Biophys Acta"},{"key":"121_CR4","volume-title":"The importance of the kidney in phosphate homeostasis","author":"OLM Bijvoet","year":"1976","unstructured":"Bijvoet OLM (1976) The importance of the kidney in phosphate homeostasis. Armour Montagru, Paris"},{"key":"121_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4684-4259-5_1","volume":"151","author":"JP Bonjour","year":"1982","unstructured":"Bonjour JP, Caverzasio J, Fleisch H, Muhlbauer R, Troehler U (1982) The adaptive system of the tubular transport of phosphate. Adv Exp Med Biol 151:1\u201311","journal-title":"Adv Exp Med Biol"},{"key":"121_CR6","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4615-9152-8_9","volume-title":"Tubular adaptation to the supply and requirement of phosphate","author":"JP Bonjour","year":"1980","unstructured":"Bonjour JP, Fleisch H (1980) Tubular adaptation to the supply and requirement of phosphate. Plenum Press, New York"},{"key":"121_CR7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1582-4934.2004.tb00274.x","volume":"8","author":"E Takeda","year":"2004","unstructured":"Takeda E, Yamamoto H, Nashiki K, Sato T, Arai H, Taketani Y (2004) Inorganic phosphate homeostasis and the role of dietary phosphorus. J Cell Mol Med 8:191\u2013200","journal-title":"J Cell Mol Med"},{"key":"121_CR8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/01.mnh.0000172716.41853.1e","volume":"14","author":"D Prie","year":"2005","unstructured":"Prie D, Beck L, Urena P, Friedlander G (2005) Recent findings in phosphate homeostasis. Curr Opin Nephrol Hypertens 14:318\u2013324","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"121_CR9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2169\/internalmedicine.47.0730","volume":"47","author":"S Fukumoto","year":"2008","unstructured":"Fukumoto S (2008) Physiological regulation and disorders of phosphate metabolism: pivotal role of fibroblast growth factor 23. Int Med 47:337\u2013343","journal-title":"Int Med"},{"key":"121_CR10","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1074\/jbc.M408903200","volume":"280","author":"H Saito","year":"2005","unstructured":"Saito H, Maeda A, Ohtomo S, Hirata M, Kusano K, Kato S, Ogata E, Segawa H, Miyamoto K, Fukushima N (2005) Circulating FGF-23 is regulated by 1-alpha, 25-dihydroxyvitamin D3 and phosphorus in vivo. J Biol Chem 280:2543\u20132549","journal-title":"J Biol Chem"},{"key":"121_CR11","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.bone.2004.06.014","volume":"35","author":"M Mirams","year":"2004","unstructured":"Mirams M, Robinson BG, Mason RS, Nelson AE (2004) Bone as a source of FGF23: regulation by phosphate? Bone (NY) 35:1192\u20131199","journal-title":"Bone (NY)"},{"key":"121_CR12","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.bone.2007.01.017","volume":"40","author":"Y Yoshiko","year":"2007","unstructured":"Yoshiko Y, Wang H, Minamizaki T, Ijuin C, Yamamoto R, Suemune S, Kozai K, Tanne K, Aubin JE, Maeda N (2007) Mineralized tissue cells are a principal source of FGF23. Bone (NY) 40:1565\u20131573","journal-title":"Bone (NY)"},{"key":"121_CR13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF02555151","volume":"43","author":"J Caverzasio","year":"1988","unstructured":"Caverzasio J, Selz T, Bonjour JP (1988) Characteristics of phosphate transport in osteoblast-like cells. Calcif Tissue Int 43:83\u201387","journal-title":"Calcif Tissue Int"},{"key":"121_CR14","doi-asserted-by":"crossref","first-page":"17791","DOI":"10.1016\/S0021-9258(18)55196-6","volume":"266","author":"C Montessuit","year":"1991","unstructured":"Montessuit C, Caverzasio J, Bonjour JP (1991) Characterization of a Pi transport system in cartilage matrix vesicles. Potential role in the calcification process. J Biol Chem 266:17791\u201317797","journal-title":"J Biol Chem"},{"key":"121_CR15","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1210\/endo.138.12.5561","volume":"138","author":"G Palmer","year":"1997","unstructured":"Palmer G, Bonjour JP, Caverzasio J (1997) Expression of a newly identified phosphate transporter\/retrovirus receptor in human SaOS-2 osteoblast-like cells and its regulation by insulin-like growth factor I. Endocrinology 138:5202\u20135209","journal-title":"Endocrinology"},{"key":"121_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S8756-3282(98)00151-3","volume":"24","author":"G Palmer","year":"1999","unstructured":"Palmer G, Zhao J, Bonjour J, Hofstetter W, Caverzasio J (1999) In vivo expression of transcripts encoding the Glvr-1 phosphate transporter\/retrovirus receptor during bone development. Bone (NY) 24:1\u20137","journal-title":"Bone (NY)"},{"key":"121_CR17","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/01.RES.0000161997.24797.c0","volume":"96","author":"CM Giachelli","year":"2005","unstructured":"Giachelli CM, Speer MY, Li X, Rajachar RM, Yang H (2005) Regulation of vascular calcification: roles of phosphate and osteopontin. Circ Res 96:717\u2013722","journal-title":"Circ Res"},{"key":"121_CR18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/art.20748","volume":"52","author":"DL Cecil","year":"2005","unstructured":"Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R (2005) Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. Arthritis Rheum 52:144\u2013154","journal-title":"Arthritis Rheum"},{"key":"121_CR19","first-page":"119","volume":"11","author":"J Caverzasio","year":"1996","unstructured":"Caverzasio J, Montessuit C, Bonjour JP (1996) Functional role of Pi transport in osteogenic cells. News Physiol Sci 11:119\u2013125","journal-title":"News Physiol Sci"},{"key":"121_CR20","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/ki.1996.138","volume":"49","author":"J Caverzasio","year":"1996","unstructured":"Caverzasio J, Bonjour JP (1996) Characteristics and regulation of Pi transport in osteogenic cells for bone metabolism. Kidney Int 49:975\u2013980","journal-title":"Kidney Int"},{"key":"121_CR21","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1359\/jbmr.020603","volume":"21","author":"A Suzuki","year":"2006","unstructured":"Suzuki A, Ghayor C, Guicheux J, Magne D, Quillard S, Kakita A, Ono Y, Miura Y, Oiso Y, Itoh M, Caverzasio J (2006) Enhanced expression of the inorganic phosphate transporter Pit-1 is involved in BMP-2-induced matrix mineralization in osteoblast-like cells. J Bone Miner Res 21:674\u2013683","journal-title":"J Bone Miner Res"},{"key":"121_CR22","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1128\/JVI.66.3.1635-1640.1992","volume":"66","author":"SV Johann","year":"1992","unstructured":"Johann SV, Gibbons JJ, O\u2019Hara B (1992) GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus. J Virol 66:1635\u20131640","journal-title":"J Virol"},{"key":"121_CR23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","volume":"108","author":"H Niwa","year":"1991","unstructured":"Niwa H, Yamamura K, Miyazaki J (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene (Amst) 108:193\u2013199","journal-title":"Gene (Amst)"},{"key":"121_CR24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1023\/A:1008910629235","volume":"8","author":"R Takahashi","year":"1999","unstructured":"Takahashi R, Hirabayashi M, Ueda M (1999) Production of transgenic rats using cryopreserved pronuclear-stage zygotes. Transgenic Res 8:397\u2013400","journal-title":"Transgenic Res"},{"key":"121_CR25","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1021\/ac60119a033","volume":"28","author":"PS Chen","year":"1956","unstructured":"Chen PS, Toribara TY, Warner H (1956) Microdetermination of phosphorus. Anal Chem 28:1756\u20131758","journal-title":"Anal Chem"},{"key":"121_CR26","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(75)92736-1","volume":"2","author":"RJ Walton","year":"1975","unstructured":"Walton RJ, Bijvoet OL (1975) Nomogram for derivation of renal threshold phosphate concentration. Lancet 2:309\u2013310","journal-title":"Lancet"},{"key":"121_CR27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF02563795","volume":"41","author":"PR Elford","year":"1987","unstructured":"Elford PR, Felix R, Cecchini M, Trechsel U, Fleisch H (1987) Murine osteoblast-like cells and the osteogenic cell MC3T3\u2013E1 release a macrophage colony-stimulating activity in culture. Calcif Tissue Int 41:151\u2013156","journal-title":"Calcif Tissue Int"},{"key":"121_CR28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0021-9258(18)71242-8","volume":"207","author":"OH Lowry","year":"1954","unstructured":"Lowry OH, Roberts NR, Wu ML, Hixon WS, Crawford EJ (1954) The quantitative histomorphometry of brain. II. Enzyme measurements. J Biol Chem 207:19\u201337","journal-title":"J Biol Chem"},{"issue":"pt A","key":"121_CR29","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0076-6879(82)82074-0","volume":"82","author":"RA Berg","year":"1982","unstructured":"Berg RA (1982) Determination of 3- and 4-hydroxyproline. Methods Enzymol 82(pt A):372\u2013398","journal-title":"Methods Enzymol"},{"key":"121_CR30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1359\/jbmr.2000.15.1.95","volume":"15","author":"A Suzuki","year":"2000","unstructured":"Suzuki A, Palmer G, Bonjour JP, Caverzasio J (2000) Stimulation of sodium-dependent phosphate transport and signaling mechanisms induced by basic fibroblast growth factor in MC3T3-E1 osteoblast-like cells. J Bone Miner Res 15:95\u2013102","journal-title":"J Bone Miner Res"},{"key":"121_CR31","first-page":"E93","volume":"256","author":"T Selz","year":"1989","unstructured":"Selz T, Caverzasio J, Bonjour JP (1989) Regulation of Na-dependent Pi transport by parathyroid hormone in osteoblast-like cells. Am J Physiol 256:E93\u2013E100","journal-title":"Am J Physiol"},{"key":"121_CR32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1359\/jbmr.1997.12.1.36","volume":"12","author":"X Zhen","year":"1997","unstructured":"Zhen X, Bonjour JP, Caverzasio J (1997) Platelet-derived growth factor stimulates sodium-dependent Pi transport in osteoblastic cells via phospholipase C-gamma and phosphatidylinositol 3\u2032-kinase. J Bone Miner Res 12:36\u201344","journal-title":"J Bone Miner Res"},{"key":"121_CR33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF01622738","volume":"6","author":"P Ammann","year":"1996","unstructured":"Ammann P, Rizzoli R, Meyer JM, Bonjour JP (1996) Bone density and shape as determinants of bone strength in IGF-I and\/or pamidronate-treated ovariectomized rats. Osteoporosis Int 6:219\u2013227","journal-title":"Osteoporosis Int"},{"key":"121_CR34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3233\/THC-1996-4112","volume":"4","author":"R Muller","year":"1996","unstructured":"Muller R, Koller B, Hildebrand T, Laib A, Gianolini S, Ruegsegger P (1996) Resolution dependency of microstructural properties of cancellous bone based on three-dimensional mu-tomography. Technol Health Care 4:113\u2013119","journal-title":"Technol Health Care"},{"key":"121_CR35","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF02347054","volume":"38","author":"A Laib","year":"2000","unstructured":"Laib A, Barou O, Vico L, Lafage-Proust MH, Alexandre C, Rugsegger P (2000) 3D micro-computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilisation osteoporosis. Med Biol Eng Comput 38:326\u2013332","journal-title":"Med Biol Eng Comput"},{"key":"121_CR36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3109\/10520299209110002","volume":"67","author":"HE Gruber","year":"1992","unstructured":"Gruber HE (1992) Adaptations of Goldner\u2019s Masson trichrome stain for the study of undecalcified plastic embedded bone. Biotech Histochem 67:30\u201334","journal-title":"Biotech Histochem"},{"key":"121_CR37","first-page":"226","volume-title":"Theory and practice of histopathology","author":"D Sheehan","year":"1980","unstructured":"Sheehan D, Hrapchak B (1980) Theory and practice of histopathology. Battelle Press, Columbus, OH, pp 226\u2013227"},{"key":"121_CR38","doi-asserted-by":"crossref","first-page":"8352","DOI":"10.1073\/pnas.140021997","volume":"97","author":"GR Beck Jr","year":"2000","unstructured":"Beck GR Jr, Zerler B, Moran E (2000) Phosphate is a specific signal for induction of osteopontin gene expression. Proc Natl Acad Sci USA 97:8352\u20138357","journal-title":"Proc Natl Acad Sci USA"},{"key":"121_CR39","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1161\/01.RES.0000218859.90970.8d","volume":"98","author":"BK Son","year":"2006","unstructured":"Son BK, Kozaki K, Iijima K, Eto M, Kojima T, Ota H, Senda Y, Maemura K, Nakano T, Akishita M, Ouchi Y (2006) Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway. Circ Res 98:1024\u20131031","journal-title":"Circ Res"},{"key":"121_CR40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1507\/endocrj.K06-093","volume":"54","author":"K Nishiwaki-Yasuda","year":"2007","unstructured":"Nishiwaki-Yasuda K, Suzuki A, Kakita A, Sekiguchi S, Asano S, Nishii K, Nagao S, Oiso Y, Itoh M (2007) Vasopressin stimulates Na-dependent phosphate transport and calcification in rat aortic smooth muscle cells. Endocr J 54:103\u2013112","journal-title":"Endocr J"},{"key":"121_CR41","first-page":"F122","volume":"248","author":"J Caverzasio","year":"1985","unstructured":"Caverzasio J, Brown CD, Biber J, Bonjour JP, Murer H (1985) Adaptation of phosphate transport in phosphate-deprived LLC-PK1 cells. Am J Physiol 248:F122\u2013F127","journal-title":"Am J Physiol"},{"key":"121_CR42","first-page":"F712","volume":"257","author":"J Caverzasio","year":"1989","unstructured":"Caverzasio J, Bonjour JP (1989) Insulin-like growth factor I stimulates Na-dependent Pi transport in cultured kidney cells. Am J Physiol 257:F712\u2013F717","journal-title":"Am J Physiol"},{"key":"121_CR43","first-page":"E24","volume":"267","author":"C Montessuit","year":"1994","unstructured":"Montessuit C, Bonjour JP, Caverzasio J (1994) Pi transport regulation by chicken growth plate chondrocytes. Am J Physiol 267:E24\u2013E31","journal-title":"Am J Physiol"},{"key":"121_CR44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mce.2008.08.031","volume":"310","author":"S Fukumoto","year":"2009","unstructured":"Fukumoto S (2009) The role of bone in phosphate metabolism. Mol Cell Endocrinol 310:63\u201370","journal-title":"Mol Cell Endocrinol"},{"key":"121_CR45","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1359\/jbmr.080220","volume":"23","author":"H Wang","year":"2008","unstructured":"Wang H, Yoshiko Y, Yamamoto R, Minamizaki T, Kozai K, Tanne K, Aubin JE, Maeda N (2008) Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro. J Bone Miner Res 23:939\u2013948","journal-title":"J Bone Miner Res"},{"key":"121_CR46","doi-asserted-by":"crossref","first-page":"F527","DOI":"10.1152\/ajpcell.1998.275.2.C527","volume":"275","author":"HS Tenenhouse","year":"1998","unstructured":"Tenenhouse HS, Roy S, Martel J, Gauthier C (1998) Differential expression, abundance, and regulation of Na+-phosphate cotransporter genes in murine kidney. Am J Physiol 275:F527\u2013F534","journal-title":"Am J Physiol"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-009-0121-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00774-009-0121-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-009-0121-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T13:11:22Z","timestamp":1633957882000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00774-009-0121-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,1]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["121"],"URL":"https:\/\/doi.org\/10.1007\/s00774-009-0121-3","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,1]]}}}