{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:26:19Z","timestamp":1775784379181,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,8,7]],"date-time":"2010-08-07T00:00:00Z","timestamp":1281139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1007\/s00774-010-0211-2","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T02:18:04Z","timestamp":1281061084000},"page":"201-206","source":"Crossref","is-referenced-by-count":31,"title":["Serum concentrations of carboxylated osteocalcin are increased and associated with several components of the polycystic ovarian syndrome"],"prefix":"10.1007","volume":"29","author":[{"given":"Evanthia","family":"Diamanti-Kandarakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarantis","family":"Livadas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Katsikis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Piperi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mantziou","family":"Aimilia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios G.","family":"Papavassiliou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Panidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,8,7]]},"reference":[{"key":"211_CR1","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1210\/jc.84.11.4006","volume":"84","author":"E Diamanti-Kandarakis","year":"1999","unstructured":"Diamanti-Kandarakis E, Kouli CR, Bergiele AT, Filandra FA, Tsianateli TC, Spina GG, Zapanti ED, Bartzis MI (1999) A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile. J Clin Endocr Metab 84:4006\u20134011","journal-title":"J Clin Endocr Metab"},{"key":"211_CR2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1210\/jc.2004-1006","volume":"90","author":"MO Goodarzi","year":"2005","unstructured":"Goodarzi MO, Erickson S, Port SC, Jennrich RI, Korenman SG (2005) Beta-cell function: a key pathological determinant in polycystic ovary syndrome. J Clin Endocrinol Metab 90:310\u2013315","journal-title":"J Clin Endocrinol Metab"},{"key":"211_CR3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.tem.2008.02.006","volume":"19","author":"NK Lee","year":"2008","unstructured":"Lee NK, Karsenty G (2008) Reciprocal regulation of bone and energy metabolism. Trends Endocr Metab 19:161\u2013166","journal-title":"Trends Endocr Metab"},{"key":"211_CR4","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1073\/pnas.0711119105","volume":"105","author":"M Ferron","year":"2008","unstructured":"Ferron M, Hinoi E, Karsenty G, Ducy P (2008) Osteocalcin differentially regulates beta-cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA 105:5266\u20135270","journal-title":"Proc Natl Acad Sci USA"},{"key":"211_CR5","doi-asserted-by":"crossref","first-page":"36088","DOI":"10.1074\/jbc.M801698200","volume":"283","author":"A Cassese","year":"2008","unstructured":"Cassese A, Esposito I, Fiory F, Barbagallo AP, Paturzo F, Mirra P, Ulianich L, Giacco F, Iadicicco C, Lombardi A, Oriente F, Van Obberghen E, Beguinot F, Formisano P, Miele C (2008) In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs. J Biol Chem 283:36088\u201336099","journal-title":"J Biol Chem"},{"key":"211_CR6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/13813450701602523","volume":"113","author":"S Franke","year":"2007","unstructured":"Franke S, Siggelkow H, Wolf G, Hein G (2007) Advanced glycation end products influence the mRNA expression of RAGE, RANKL and various osteoblastic genes in human osteoblasts. Arch Phys Biochem 113:154\u2013161","journal-title":"Arch Phys Biochem"},{"key":"211_CR7","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/BF03345631","volume":"31","author":"E Diamanti-Kandarakis","year":"2008","unstructured":"Diamanti-Kandarakis E, Livadas S, Kandarakis SA, Margeli A, Papasotiriou I (2008) Low free plasma levels of retinol-binding protein 4 in insulin-resistant subjects with polycystic ovary syndrome. J Endocrinol Invest 31:950\u2013954","journal-title":"J Endocrinol Invest"},{"key":"211_CR8","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1373\/clinchem.2005.052761","volume":"51","author":"D Panidis","year":"2005","unstructured":"Panidis D, Balaris C, Farmakiotis D, Rousso D, Kourtis A, Balaris V, Katsikis I, Zournatzi V, Diamanti-Kandarakis E (2005) Serum parathyroid hormone concentrations are increased in women with polycystic ovary syndrome. Clin Chem 51:1691\u20131697","journal-title":"Clin Chem"},{"key":"211_CR9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1530\/EJE-07-0822","volume":"158","author":"E Diamanti-Kandarakis","year":"2008","unstructured":"Diamanti-Kandarakis E, Piouka A, Livadas S, Piperi C, Katsikis I, Papavassiliou AG, Panidis D (2008) Antimullerian hormone is associated with advanced glycosylated end products in women with polycystic ovary syndrome. Eur J Endocr 158:525\u2013531","journal-title":"Eur J Endocr"},{"key":"211_CR10","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1007\/s00198-002-1342-7","volume":"14","author":"MF Young","year":"2003","unstructured":"Young MF (2003) Bone matrix proteins: their function, regulation, and relationship to osteoporosis. Osteoporos Int 14:S35\u2013S42","journal-title":"Osteoporos Int"},{"key":"211_CR11","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","volume":"130","author":"NK Lee","year":"2007","unstructured":"Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130:456\u2013469","journal-title":"Cell"},{"key":"211_CR12","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00774-003-0473-z","volume":"22","author":"T Horiuchi","year":"2004","unstructured":"Horiuchi T, Kazama H, Araki A, Inoue J, Hosoi T, Onouchi T, Mizuno S, Ito H, Orimo H (2004) Impaired gamma carboxylation of osteocalcin in elderly women with type II diabetes mellitus: relationship between increase in undercarboxylated osteocalcin levels and low bone mineral density. J Bone Miner Metab 22:236\u2013240","journal-title":"J Bone Miner Metab"},{"key":"211_CR13","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1359\/jbmr.081234","volume":"24","author":"JM Kindblom","year":"2009","unstructured":"Kindblom JM, Ohlsson C, Ljunggren O, Karlsson MK, Tivesten A, Smith U, Mellstr\u00f6m D (2009) Plasma osteocalcin is inversely related to fat mass and glucose in elderly Swedish men. J Bone Miner Res 24:785\u2013791","journal-title":"J Bone Miner Res"},{"key":"211_CR14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cca.2008.07.001","volume":"396","author":"JA Im","year":"2008","unstructured":"Im JA, Yu BP, Jeon JY, Kim SH (2008) Relationship between osteocalcin and glucose metabolism in postmenopausal women. Clin Chim Acta 396:66\u201369","journal-title":"Clin Chim Acta"},{"key":"211_CR15","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/dmrr.1045","volume":"25","author":"YC Hwang","year":"2009","unstructured":"Hwang YC, Jeong IK, Kyu JA, Chung HO (2009) The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced \u03b2-cell function in middle-aged male subjects. Diabetes Metab Res Rev 25:768\u2013772","journal-title":"Diabetes Metab Res Rev"},{"key":"211_CR16","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.3945\/ajcn.2009.28151","volume":"90","author":"MK Shea","year":"2009","unstructured":"Shea MK, Gundberg CM, Meigs JB, Dallal GE, Saltzman E, Yoshida M, Jacques PF, Booth SL (2009) \u03b3-Carboxylation of osteocalcin and insulin resistance in older men and women. Am J Clin Nutr 90:1230\u20131235","journal-title":"Am J Clin Nutr"},{"key":"211_CR17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1210\/jc.2008-1455","volume":"94","author":"I Kanazawa","year":"2009","unstructured":"Kanazawa I, Yamaguchi T, Yamamoto M, Kurioka S, Yano S, Sugimoto T (2009) Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocr Metab 94:45\u201349","journal-title":"J Clin Endocr Metab"},{"key":"211_CR18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1055\/s-2007-992786","volume":"116","author":"L Schurman","year":"2008","unstructured":"Schurman L, McCarthy AD, Sedlinsky C, Gangoiti MV, Arnol V, Bruzzone L, Cortizo AM (2008) Metformin reverts deleterious effects of advanced glycation end-products (AGEs) on osteoblastic cells. Exp Clin Endocr Diabetes 116:333\u2013340","journal-title":"Exp Clin Endocr Diabetes"},{"key":"211_CR19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1530\/EJE-08-0107","volume":"159","author":"HF Escobar-Morreale","year":"2008","unstructured":"Escobar-Morreale HF, Botella-Carretero JI, Martinez-Garcia MA, Luque-Ram\u00edrez M, Alvarez-Blasco F, San Mill\u00e1n JL (2008) Serum osteoprotegerin concentrations are decreased in women with the polycystic ovary syndrome. Eur J Endocrinol 159:225\u2013232","journal-title":"Eur J Endocrinol"},{"key":"211_CR20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2265.1998.3691182.x","volume":"48","author":"S Adami","year":"1998","unstructured":"Adami S, Zamberlan N, Castello R, Tosi F, Gatti D, Moghetti P (1998) Effect of hyperandrogenism and menstrual cycle abnormalities on bone mass and bone turnover in young women. Clin Endocr (Oxf) 48:169\u2013173","journal-title":"Clin Endocr (Oxf)"},{"key":"211_CR21","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1210\/jc.2007-2249","volume":"93","author":"D Glintborg","year":"2008","unstructured":"Glintborg D, Andersen M, Hagen C, Heickendorff L, Hermann AP (2008) Association of pioglitazone treatment with decreased bone mineral density in obese premenopausal patients with polycystic ovary syndrome: a randomized, placebo-controlled trial. J Clin Endocr Metab 93:1696\u20131701","journal-title":"J Clin Endocr Metab"},{"key":"211_CR22","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1210\/jc.2007-0646","volume":"92","author":"D Vega","year":"2007","unstructured":"Vega D, Maalouf NM, Sakhaee K (2007) Clinical review #: the role of receptor activator of nuclear factor-kappaB (RANK)\/RANK ligand\/osteoprotegerin: clinical implications. J Clin Endocr Metab 92:4514\u20134521","journal-title":"J Clin Endocr Metab"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-010-0211-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00774-010-0211-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-010-0211-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T06:16:41Z","timestamp":1559110601000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00774-010-0211-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,7]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["211"],"URL":"https:\/\/doi.org\/10.1007\/s00774-010-0211-2","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,7]]}}}