{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:20:05Z","timestamp":1790436005055,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T00:00:00Z","timestamp":1308009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1007\/s00774-011-0281-9","type":"journal-article","created":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T01:14:00Z","timestamp":1307927640000},"page":"645-651","source":"Crossref","is-referenced-by-count":20,"title":["Vertebral fracture risk and alendronate effects on osteoporosis assessed by a computed tomography-based nonlinear finite element method"],"prefix":"10.1007","volume":"29","author":[{"given":"Kazuhiro","family":"Imai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,14]]},"reference":[{"key":"281_CR1","doi-asserted-by":"crossref","unstructured":"NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy (2001) Osteoporosis prevention, diagnosis, and therapy. JAMA 285:785\u2013795","DOI":"10.1001\/jama.285.6.785"},{"key":"281_CR2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/BF01623782","volume":"7","author":"JA Kanis","year":"1997","unstructured":"Kanis JA, Delmas P, Burckhardt P, Cooper C, Torgerson D (1997) Guidelines for diagnosis and management of osteoporosis. The European Foundation for Osteoporosis and Bone Disease. Osteoporos Int 7:390\u2013406","journal-title":"Osteoporos Int"},{"key":"281_CR3","first-page":"1","volume":"843","author":"World Health Organization","year":"1994","unstructured":"World Health Organization (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser 843:1\u2013129","journal-title":"World Health Organ Tech Rep Ser"},{"key":"281_CR4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0268-0033(94)90019-1","volume":"9","author":"SJ Edmondston","year":"1994","unstructured":"Edmondston SJ, Singer KP, Day RE, Breidahl PD, Price RI (1994) In vitro relationships between vertebral body density, size and compressive strength in the elderly thoracolumbar spine. Clin Biomech 9:180\u2013186","journal-title":"Clin Biomech"},{"key":"281_CR5","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1359\/jbmr.1997.12.10.1721","volume":"12","author":"XG Cheng","year":"1997","unstructured":"Cheng XG, Nicholson PH, Boonen S, Lowet G, Brys P, Aerssens J, Van der Perre G, Dequeker J (1997) Prediction of vertebral strength in vitro by spinal bone densitometry and calcaneal ultrasound. J Bone Miner Res 12:1721\u20131728","journal-title":"J Bone Miner Res"},{"key":"281_CR6","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/jbmr.5650090514","volume":"9","author":"BS Myers","year":"1994","unstructured":"Myers BS, Arbogast KB, Lobaugh B, Harper KD, Richardson WJ, Drezner MK (1994) Improved assessment of lumbar vertebral body strength using supine lateral dual-energy X-ray absorptiometry. J Bone Miner Res 9:687\u2013693","journal-title":"J Bone Miner Res"},{"key":"281_CR7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF01626536","volume":"6","author":"K Bjarnason","year":"1996","unstructured":"Bjarnason K, Hassager C, Svendsen OL, Stang H, Christiansen C (1996) Anteroposterior and lateral spinal DXA for the assessment of vertebral body strength: comparison with hip and forearm measurement. Osteoporos Int 6:37\u201342","journal-title":"Osteoporos Int"},{"key":"281_CR8","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1136\/bmj.312.7041.1254","volume":"312","author":"D Marshall","year":"1996","unstructured":"Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312:1254\u20131259","journal-title":"BMJ"},{"key":"281_CR9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3109\/17453677208998949","volume":"43","author":"WA Brekelmans","year":"1972","unstructured":"Brekelmans WA, Poort HW, Slooff TJ (1972) A new method to analyse the mechanical behaviour of skeletal parts. Acta Orthop Scand 43:301\u2013317","journal-title":"Acta Orthop Scand"},{"key":"281_CR10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0021-9290(83)90072-6","volume":"16","author":"R Huiskes","year":"1983","unstructured":"Huiskes R, Chao EY (1983) A survey of finite element analysis in orthopedic biomechanics: the first decade. J Biomech 16:385\u2013409","journal-title":"J Biomech"},{"key":"281_CR11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1148\/radiology.179.3.2027972","volume":"179","author":"KG Faulkner","year":"1991","unstructured":"Faulkner KG, Cann CE, Hasegawa BH (1991) Effect of bone distribution on vertebral strength: assessment with patient-specific nonlinear finite element analysis. Radiology 179:669\u2013674","journal-title":"Radiology"},{"key":"281_CR12","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0021-9290(99)00099-8","volume":"32","author":"DD Cody","year":"1999","unstructured":"Cody DD, Gross GJ, Hou FJ, Spencer HJ, Goldstein SA, Fyhrie DP (1999) Femoral strength is better predicted by finite element models than QCT and DXA. J Biomech 32:1013\u20131020","journal-title":"J Biomech"},{"key":"281_CR13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0021-9290(97)00123-1","volume":"31","author":"JH Keyak","year":"1998","unstructured":"Keyak JH, Rossi SA, Jones KA, Skinner HB (1998) Prediction of femoral fracture load using automated finite element modeling. J Biomech 31:125\u2013133","journal-title":"J Biomech"},{"key":"281_CR14","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S1350-4533(01)00094-7","volume":"23","author":"JH Keyak","year":"2001","unstructured":"Keyak JH, Rossi SA, Jones KA, Les CM, Skinner HB (2001) Prediction of fracture location in the proximal femur using finite element models. Med Eng Phys 23:657\u2013664","journal-title":"Med Eng Phys"},{"key":"281_CR15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1350-4533(01)00045-5","volume":"23","author":"JH Keyak","year":"2001","unstructured":"Keyak JH (2001) Improved prediction of proximal femoral fracture load using nonlinear finite element models. Med Eng Phys 23:165\u2013173","journal-title":"Med Eng Phys"},{"key":"281_CR16","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.jbiomech.2006.08.003","volume":"40","author":"M Bessho","year":"2007","unstructured":"Bessho M, Ohnishi I, Matsuyama J, Matsumoto T, Imai K, Nakamura K (2007) Prediction of strength and strain of the proximal femur by a CT-based finite element method. J Biomech 40:1745\u20131753","journal-title":"J Biomech"},{"key":"281_CR17","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/jor.1100160305","volume":"16","author":"MJ Silva","year":"1998","unstructured":"Silva MJ, Keaveny TM, Hayes WC (1998) Computed tomography-based finite element analysis predicts failure loads and fracture patterns for vertebral sections. J Orthop Res 16:300\u2013308","journal-title":"J Orthop Res"},{"key":"281_CR18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1515\/bmte.1998.43.4.82","volume":"43","author":"H Martin","year":"1998","unstructured":"Martin H, Werner J, Andresen R, Schober HC, Schmitz KP (1998) Noninvasive assessment of stiffness and failure load of human vertebrae from CT-data. Biomed Tech 43:82\u201388","journal-title":"Biomed Tech"},{"key":"281_CR19","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.bone.2006.10.025","volume":"40","author":"JM Buckley","year":"2007","unstructured":"Buckley JM, Loo K, Motherway J (2007) Comparison of quantitative computed tomography-based measures in predicting vertebral strength. Bone 40:767\u2013774","journal-title":"Bone"},{"key":"281_CR20","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S8756-3282(03)00210-2","volume":"33","author":"RP Crawford","year":"2003","unstructured":"Crawford RP, Cann CE, Keaveny TM (2003) Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography. Bone 33:744\u2013750","journal-title":"Bone"},{"key":"281_CR21","first-page":"559","volume":"28","author":"MA Liebschner","year":"2003","unstructured":"Liebschner MA, Kopperdahl DL, Rosenberg WS, Keaveny TM (2003) Finite element modeling of the human thoracolumbar spine. Spine 28:559\u2013565","journal-title":"Spine"},{"key":"281_CR22","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1097\/01.brs.0000225993.57349.df","volume":"31","author":"K Imai","year":"2006","unstructured":"Imai K, Ohnishi I, Bessho M, Nakamura K (2006) Nonlinear finite element model predicts vertebral bone strength and fracture site. Spine 31:1789\u20131794","journal-title":"Spine"},{"key":"281_CR23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/BRS.0b013e31815e3993","volume":"33","author":"K Imai","year":"2008","unstructured":"Imai K, Ohnishi I, Yamamoto S, Nakamura K (2008) In vivo assessment of lumbar vertebral strength in elderly women using computed tomography-based nonlinear finite element model. Spine 33:27\u201332","journal-title":"Spine"},{"key":"281_CR24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s007740170001","volume":"19","author":"H Orimo","year":"2001","unstructured":"Orimo H, Hayashi Y, Fukunaga M, Sone T, Fujiwara S, Shiraki M, Kushida K, Miyamoto S, Soen S, Nishimura J, Oh-Hashi Y, Hosoi T, Gorai I, Tanaka H, Igai T, Kishimoto H (2001) Diagnostic criteria for primary osteoporosis: year 2000 revision. J Bone Miner Metab 19:331\u2013337","journal-title":"J Bone Miner Metab"},{"key":"281_CR25","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00198-008-0750-8","volume":"20","author":"K Imai","year":"2009","unstructured":"Imai K, Ohnishi I, Matsumoto T, Yamamoto S, Nakamura K (2009) Assessment of vertebral fracture risk and therapeutic effects of alendronate in postmenopausal women using a quantitative computed tomography-based nonlinear finite element method. Osteoporosis Int 20:801\u2013810","journal-title":"Osteoporosis Int"},{"key":"281_CR26","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1359\/jbmr.070728","volume":"22","author":"LJ Melton III","year":"2007","unstructured":"Melton LJ III, Riggs BL, Keaveny TM, Achenbach SJ, Hoffmann PF, Camp JJ, Rouleau PA, Bouxsein ML, Amin S, Atkinson EJ, Robb RA, Khosla S (2007) Structural determinants of vertebral fracture risk. J Bone Miner Res 22:1885\u20131892","journal-title":"J Bone Miner Res"},{"key":"281_CR27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1359\/jbmr.061011","volume":"22","author":"TM Keaveny","year":"2007","unstructured":"Keaveny TM, Donley DW, Hoffmann PF, Mitlak BH, Glass EV, San Martin JA (2007) Effects of teriparatide and alendronate on vertebral strength as assessed by finite element modeling of QCT scans in women with osteoporosis. J Bone Miner Res 22:149\u2013157","journal-title":"J Bone Miner Res"},{"key":"281_CR28","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1001\/archinte.165.15.1762","volume":"165","author":"MR McClung","year":"2005","unstructured":"McClung MR, San Martin J, Miller PD, Civitelli R, Bandeira F, Omizo M, Donley DW, Dalsky GP, Eriksen EF (2005) Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass. Arch Intern Med 165:1762\u20131768","journal-title":"Arch Intern Med"},{"key":"281_CR29","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMoa031975","volume":"349","author":"DM Black","year":"2003","unstructured":"Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, Garnero P, Bouxsein ML, Bilezikian JP, Rosen CJ (2003) The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 349:1207\u20131215","journal-title":"N Engl J Med"},{"key":"281_CR30","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1118\/1.598629","volume":"26","author":"G Dougherty","year":"1999","unstructured":"Dougherty G, Newman D (1999) Measurement of thickness and density of thin structures by computed tomography: a simulation study. Med Phys 26:1341\u20131348","journal-title":"Med Phys"},{"key":"281_CR31","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1088\/0031-9155\/44\/3\/017","volume":"44","author":"S Prevrhal","year":"1999","unstructured":"Prevrhal S, Engelke K, Kalender WA (1999) Accuracy limits for the determination of cortical width and density: the influence of object size and CT imaging parameters. Phys Med Biol 44:751\u2013764","journal-title":"Phys Med Biol"},{"key":"281_CR32","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0002-9343(01)01124-X","volume":"112","author":"SR Cummings","year":"2002","unstructured":"Cummings SR, Karpf DB, Harris F, Genant HK, Ensrud K, LaCroix AZ, Black DM (2002) Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs. Am J Med 112:281\u2013289","journal-title":"Am J Med"},{"key":"281_CR33","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1097\/BRS.0b013e3181a55636","volume":"34","author":"T Matsumoto","year":"2009","unstructured":"Matsumoto T, Ohnishi I, Bessho M, Imai K, Ohashi S, Nakamura K (2009) Prediction of vertebral strength under loading conditions occurring in activities of daily living using a computed tomography-based nonlinear finite element method. Spine 34:1464\u20131469","journal-title":"Spine"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-011-0281-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00774-011-0281-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-011-0281-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T17:30:49Z","timestamp":1560274249000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00774-011-0281-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,14]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["281"],"URL":"https:\/\/doi.org\/10.1007\/s00774-011-0281-9","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,14]]}}}