{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:57:59Z","timestamp":1792126679552,"version":"4.4.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s00774-011-0346-9","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T02:03:59Z","timestamp":1325815439000},"page":"474-484","source":"Crossref","is-referenced-by-count":41,"title":["Involvement of endoplasmic reticulum stress in homocysteine-induced apoptosis of osteoblastic cells"],"prefix":"10.1007","volume":"30","author":[{"given":"Su-Jung","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Jo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Uk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Hoan","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul-Soo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"346_CR1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrrheum.2009.139","volume":"5","author":"JA Kanis","year":"2009","unstructured":"Kanis JA, McCloskey EV, Johansson H, Oden A (2009) Approaches to the targeting of treatment for osteoporosis. Nat Rev Rheumatol 5:425\u2013431","journal-title":"Nat Rev Rheumatol"},{"key":"346_CR2","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/S0140-6736(02)08706-8","volume":"359","author":"E Seeman","year":"2002","unstructured":"Seeman E (2002) Pathogenesis of bone fragility in women and men. Lancet 359:1841\u20131850","journal-title":"Lancet"},{"key":"346_CR3","first-page":"182","volume":"10","author":"SC Manolagas","year":"1998","unstructured":"Manolagas SC (1998) Cellular and molecular mechanisms of osteoporosis. Aging (Milano) 10:182\u2013190","journal-title":"Aging (Milano)"},{"key":"346_CR4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0002-9343(99)00420-9","volume":"108","author":"RS Weinstein","year":"2000","unstructured":"Weinstein RS, Manolagas SC (2000) Apoptosis and osteoporosis. Am J Med 108:153\u2013164","journal-title":"Am J Med"},{"key":"346_CR5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrrheum.2009.260","volume":"6","author":"N Harvey","year":"2010","unstructured":"Harvey N, Dennison E, Cooper C (2010) Osteoporosis: impact on health and economics. Nat Rev Rheumatol 6:99\u2013105","journal-title":"Nat Rev Rheumatol"},{"key":"346_CR6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jbspin.2008.11.002","volume":"76","author":"R Levasseur","year":"2009","unstructured":"Levasseur R (2009) Bone tissue and hyperhomocysteinemia. Jt Bone Spine 76:234\u2013240","journal-title":"Jt Bone Spine"},{"key":"346_CR7","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1023\/A:1005445132327","volume":"21","author":"S Yap","year":"1998","unstructured":"Yap S, Naughten E (1998) Homocystinuria due to cystathionine beta-synthase deficiency in Ireland: 25\u00a0years\u2019 experience of a newborn screened and treated population with reference to clinical outcome and biochemical control. J Inherit Metab Dis 21:738\u2013747","journal-title":"J Inherit Metab Dis"},{"key":"346_CR8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1001\/archneurol.2009.333","volume":"67","author":"FD Testai","year":"2010","unstructured":"Testai FD, Gorelick PB (2010) Inherited metabolic disorders and stroke part 2: homocystinuria, organic acidurias, and urea cycle disorders. Arch Neurol 67:148\u2013153","journal-title":"Arch Neurol"},{"key":"346_CR9","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1056\/NEJMoa032546","volume":"350","author":"JB Meurs van","year":"2004","unstructured":"van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM et al (2004) Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 350:2033\u20132041","journal-title":"N Engl J Med"},{"key":"346_CR10","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMoa032739","volume":"350","author":"RR McLean","year":"2004","unstructured":"McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP (2004) Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 350:2042\u20132049","journal-title":"N Engl J Med"},{"key":"346_CR11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1359\/jbmr.070210","volume":"22","author":"CG Gjesdal","year":"2007","unstructured":"Gjesdal CG, Vollset SE, Ueland PM, Refsum H, Meyer HE, Tell GS (2007) Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the hordaland homocysteine study. J Bone Miner Res 22:747\u2013756","journal-title":"J Bone Miner Res"},{"key":"346_CR12","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1373\/clinchem.2007.086272","volume":"53","author":"M Herrmann","year":"2007","unstructured":"Herrmann M, Wildemann B, Claes L, Klohs S, Ohnmacht M, Taban-Shomal O, Hubner U, Pexa A, Umanskaya N, Herrmann W (2007) Experimental hyperhomocysteinemia reduces bone quality in rats. Clin Chem 53:1455\u20131461","journal-title":"Clin Chem"},{"key":"346_CR13","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1096\/fj.08-120584","volume":"23","author":"S Gupta","year":"2009","unstructured":"Gupta S, Kuhnisch J, Mustafa A, Lhotak S, Schlachterman A, Slifker MJ, Klein-Szanto A, High KA, Austin RC, Kruger WD (2009) Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia. FASEB J 23:883\u2013893","journal-title":"FASEB J"},{"key":"346_CR14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00198-008-0648-5","volume":"20","author":"P Anagnostis","year":"2009","unstructured":"Anagnostis P, Karagiannis A, Kakafika AI, Tziomalos K, Athyros VG, Mikhailidis DP (2009) Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities? Osteoporos Int 20:197\u2013207","journal-title":"Osteoporos Int"},{"key":"346_CR15","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","volume":"454","author":"K Zhang","year":"2008","unstructured":"Zhang K, Kaufman RJ (2008) From endoplasmic-reticulum stress to the inflammatory response. Nature 454:455\u2013462","journal-title":"Nature"},{"key":"346_CR16","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/S0016-5085(03)00276-2","volume":"124","author":"C Ji","year":"2003","unstructured":"Ji C, Kaplowitz N (2003) Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124:1488\u20131499","journal-title":"Gastroenterology"},{"key":"346_CR17","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jnutbio.2007.09.009","volume":"19","author":"HJ Kim","year":"2008","unstructured":"Kim HJ, Cho HK, Kwon YH (2008) Synergistic induction of ER stress by homocysteine and beta-amyloid in SH-SY5Y cells. J Nutr Biochem 19:754\u2013761","journal-title":"J Nutr Biochem"},{"key":"346_CR18","doi-asserted-by":"crossref","first-page":"18323","DOI":"10.1074\/jbc.M109.020891","volume":"284","author":"S Chigurupati","year":"2009","unstructured":"Chigurupati S, Wei Z, Belal C, Vandermey M, Kyriazis GA, Arumugam TV, Chan SL (2009) The homocysteine-inducible endoplasmic reticulum stress protein counteracts calcium store depletion and induction of CCAAT enhancer-binding protein homologous protein in a neurotoxin model of Parkinson disease. J Biol Chem 284:18323\u201318333","journal-title":"J Biol Chem"},{"key":"346_CR19","doi-asserted-by":"crossref","first-page":"35867","DOI":"10.1074\/jbc.M100747200","volume":"276","author":"C Zhang","year":"2001","unstructured":"Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, Kitajima S (2001) Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. J Biol Chem 276:35867\u201335874","journal-title":"J Biol Chem"},{"key":"346_CR20","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.1128\/MCB.02429-05","volume":"26","author":"K Shirakawa","year":"2006","unstructured":"Shirakawa K, Maeda S, Gotoh T et al (2006) CCAAT\/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation. Mol Cell Biol 26:6105\u20136116","journal-title":"Mol Cell Biol"},{"key":"346_CR21","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.bone.2006.09.028","volume":"40","author":"RC Pereira","year":"2007","unstructured":"Pereira RC, Stadmeyer LE, Smith DL, Rydziel S, Canalis E (2007) CCAAT\/enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia. Bone 40:619\u2013626","journal-title":"Bone"},{"key":"346_CR22","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.4049\/jimmunol.177.4.2681","volume":"177","author":"SA Yoo","year":"2006","unstructured":"Yoo SA, Park BH, Park GS, Koh HS, Lee MS, Ryu SH, Miyazawa K, Park SH, Cho CS, Kim WU (2006) Calcineurin is expressed and plays a critical role in inflammatory arthritis. J Immunol 177:2681\u20132690","journal-title":"J Immunol"},{"key":"346_CR23","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1074\/jbc.M411224200","volume":"280","author":"SJ Lee","year":"2005","unstructured":"Lee SJ, Kim KM, Namkoong S et al (2005) Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine. J Biol Chem 280:5781\u20135788","journal-title":"J Biol Chem"},{"key":"346_CR24","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.bbrc.2007.03.067","volume":"356","author":"Q Yuan","year":"2007","unstructured":"Yuan Q, Jiang DJ, Chen QQ, Wang S, Xin HY, Deng HW, Li YJ (2007) Role of asymmetric dimethylarginine in homocysteine-induced apoptosis of vascular smooth muscle cells. Biochem Biophys Res Commun 356:880\u2013885","journal-title":"Biochem Biophys Res Commun"},{"key":"346_CR25","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bone.2006.03.004","volume":"39","author":"DJ Kim","year":"2006","unstructured":"Kim DJ, Koh JM, Lee O, Kim NJ, Lee YS, Kim YS, Park JY, Lee KU, Kim GS (2006) Homocysteine enhances apoptosis in human bone marrow stromal cells. Bone 39:582\u2013590","journal-title":"Bone"},{"key":"346_CR26","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrm1150","volume":"4","author":"S Orrenius","year":"2003","unstructured":"Orrenius S, Zhivotovsky B, Nicotera P (2003) Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 4:552\u2013565","journal-title":"Nat Rev Mol Cell Biol"},{"key":"346_CR27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1042\/bst0320493","volume":"32","author":"M Degli Esposti","year":"2004","unstructured":"Degli Esposti M (2004) Mitochondria in apoptosis: past, present and future. Biochem Soc Trans 32:493\u2013495","journal-title":"Biochem Soc Trans"},{"key":"346_CR28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nrc2663","volume":"9","author":"TG Cotter","year":"2009","unstructured":"Cotter TG (2009) Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer 9:501\u2013507","journal-title":"Nat Rev Cancer"},{"key":"346_CR29","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","volume":"407","author":"MO Hengartner","year":"2000","unstructured":"Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770\u2013776","journal-title":"Nature"},{"key":"346_CR30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0169-328X(00)00208-4","volume":"84","author":"S Althausen","year":"2000","unstructured":"Althausen S, Paschen W (2000) Homocysteine-induced changes in mRNA levels of genes coding for cytoplasmic- and endoplasmic reticulum-resident stress proteins in neuronal cell cultures. Brain Res Mol Brain Res 84:32\u201340","journal-title":"Brain Res Mol Brain Res"},{"key":"346_CR31","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0092-8674(01)00612-2","volume":"107","author":"X Shen","year":"2001","unstructured":"Shen X, Ellis RE, Lee K et al (2001) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107:893\u2013903","journal-title":"Cell"},{"key":"346_CR32","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0092-8674(93)90648-A","volume":"73","author":"JS Cox","year":"1993","unstructured":"Cox JS, Shamu CE, Walter P (1993) Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 73:1197\u20131206","journal-title":"Cell"},{"key":"346_CR33","doi-asserted-by":"crossref","first-page":"50259","DOI":"10.1074\/jbc.M307444200","volume":"278","author":"T Bellido","year":"2003","unstructured":"Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O\u2019Brien CA, Manolagas SC, Jilka RL (2003) Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem 278:50259\u201350272","journal-title":"J Biol Chem"},{"key":"346_CR34","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0022-2143(99)90201-9","volume":"134","author":"M Tsuboi","year":"1999","unstructured":"Tsuboi M, Kawakami A, Nakashima T et al (1999) Tumor necrosis factor-alpha and interleukin-1beta increase the Fas-mediated apoptosis of human osteoblasts. J Lab Clin Med 134:222\u2013231","journal-title":"J Lab Clin Med"},{"key":"346_CR35","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/01.HYP.0000127914.94292.76","volume":"43","author":"T Suhara","year":"2004","unstructured":"Suhara T, Fukuo K, Yasuda O, Tsubakimoto M, Takemura Y, Kawamoto H, Yokoi T, Mogi M, Kaimoto T, Ogihara T (2004) Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways. Hypertension 43:1208\u20131213","journal-title":"Hypertension"},{"key":"346_CR36","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.embor.7400779","volume":"7","author":"E Szegezdi","year":"2006","unstructured":"Szegezdi E, Logue SE, Gorman AM, Samali A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7:880\u2013885","journal-title":"EMBO Rep"},{"key":"346_CR37","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1212\/01.wnl.0000192306.98198.ec","volume":"66","author":"K Zhang","year":"2006","unstructured":"Zhang K, Kaufman RJ (2006) The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 66:S102\u2013S109","journal-title":"Neurology"},{"key":"346_CR38","doi-asserted-by":"crossref","first-page":"34287","DOI":"10.1074\/jbc.M204973200","volume":"277","author":"N Morishima","year":"2002","unstructured":"Morishima N, Nakanishi K, Takenouchi H, Shibata T, Yasuhiko Y (2002) An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 277:34287\u201334294","journal-title":"J Biol Chem"},{"key":"346_CR39","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1182\/blood.V96.6.2140","volume":"96","author":"Y Cai","year":"2000","unstructured":"Cai Y, Zhang C, Nawa T, Aso T, Tanaka M, Oshiro S, Ichijo H, Kitajima S (2000) Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element. Blood 96:2140\u20132148","journal-title":"Blood"},{"key":"346_CR40","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1006\/bbrc.2001.6044","volume":"289","author":"C Zhang","year":"2001","unstructured":"Zhang C, Kawauchi J, Adachi MT, Hashimoto Y, Oshiro S, Aso T, Kitajima S (2001) Activation of JNK and transcriptional repressor ATF3\/LRF1 through the IRE1\/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine. Biochem Biophys Res Commun 289:718\u2013724","journal-title":"Biochem Biophys Res Commun"},{"key":"346_CR41","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1074\/jbc.271.2.631","volume":"271","author":"YR Chen","year":"1996","unstructured":"Chen YR, Meyer CF, Tan TH (1996) Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J Biol Chem 271:631\u2013634","journal-title":"J Biol Chem"},{"key":"346_CR42","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","volume":"8","author":"D Ron","year":"2007","unstructured":"Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519\u2013529","journal-title":"Nat Rev Mol Cell Biol"},{"key":"346_CR43","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1101\/gad.12.7.982","volume":"12","author":"H Zinszner","year":"1998","unstructured":"Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, Stevens JL, Ron D (1998) CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 12:982\u2013995","journal-title":"Genes Dev"},{"key":"346_CR44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0092-8674(04)00344-7","volume":"117","author":"X Yang","year":"2004","unstructured":"Yang X, Matsuda K, Bialek P et al (2004) ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin\u2013Lowry syndrome. Cell 117:387\u2013398","journal-title":"Cell"},{"key":"346_CR45","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1128\/MCB.22.11.3864-3874.2002","volume":"22","author":"P Zhang","year":"2002","unstructured":"Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR (2002) The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol 22:3864\u20133874","journal-title":"Mol Cell Biol"},{"key":"346_CR46","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1371\/journal.pgen.0040007","volume":"4","author":"TS Lisse","year":"2008","unstructured":"Lisse TS, Thiele F, Fuchs H et al (2008) ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta. PLoS Genet 4:e7","journal-title":"PLoS Genet"},{"key":"346_CR47","first-page":"822","volume":"27","author":"S Berglund","year":"2009","unstructured":"Berglund S, Sodergren A, Wallberg Jonsson S, Rantapaa Dahlqvist S (2009) Atherothrombotic events in rheumatoid arthritis are predicted by homocysteine\u2014a six-year follow-up study. Clin Exp Rheumatol 27:822\u2013825","journal-title":"Clin Exp Rheumatol"},{"key":"346_CR48","first-page":"387","volume":"24","author":"PE Lazzerini","year":"2006","unstructured":"Lazzerini PE, Selvi E, Lorenzini S, Capecchi PL, Ghittoni R, Bisogno S, Catenaccio M, Marcolongo R, Galeazzi M, Laghi-Pasini F (2006) Homocysteine enhances cytokine production in cultured synoviocytes from rheumatoid arthritis patients. Clin Exp Rheumatol 24:387\u2013393","journal-title":"Clin Exp Rheumatol"},{"key":"346_CR49","doi-asserted-by":"crossref","first-page":"29659","DOI":"10.1074\/jbc.271.47.29659","volume":"271","author":"K Kokame","year":"1996","unstructured":"Kokame K, Kato H, Miyata T (1996) Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78\/BiP and novel genes. J Biol Chem 271:29659\u201329665","journal-title":"J Biol Chem"},{"key":"346_CR50","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/1529-0131(200104)44:4<761::AID-ANR132>3.0.CO;2-S","volume":"44","author":"S Blass","year":"2001","unstructured":"Blass S, Union A, Raymackers J, Schumann F, Ungethum U, Muller-Steinbach S, De Keyser F, Engel JM, Burmester GR (2001) The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis. Arthritis Rheum 44:761\u2013771","journal-title":"Arthritis Rheum"},{"key":"346_CR51","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0955-0674(02)00358-7","volume":"14","author":"RY Hampton","year":"2002","unstructured":"Hampton RY (2002) ER-associated degradation in protein quality control and cellular regulation. Curr Opin Cell Biol 14:476\u2013482","journal-title":"Curr Opin Cell Biol"},{"key":"346_CR52","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1101\/gad.1096603","volume":"17","author":"T Amano","year":"2003","unstructured":"Amano T, Yamasaki S, Yagishita N et al (2003) Synoviolin\/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev 17:2436\u20132449","journal-title":"Genes Dev"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-011-0346-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00774-011-0346-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-011-0346-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T06:11:25Z","timestamp":1593497485000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00774-011-0346-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,6]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["346"],"URL":"https:\/\/doi.org\/10.1007\/s00774-011-0346-9","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,6]]}}}