{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:19:19Z","timestamp":1760645959970},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T00:00:00Z","timestamp":1346803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s00774-012-0383-z","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T05:56:50Z","timestamp":1346738210000},"page":"96-101","source":"Crossref","is-referenced-by-count":11,"title":["Association between estrogen receptor-\u03b2 dinucleotide repeat polymorphism and incidence of femoral fracture"],"prefix":"10.1007","volume":"31","author":[{"given":"Naoko","family":"Honma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seijiro","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko Naka","family":"Mieno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyo","family":"Takubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomio","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoji","family":"Sawabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,9,5]]},"reference":[{"key":"383_CR1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s007740170001","volume":"19","author":"H Orimo","year":"2001","unstructured":"Orimo H, Hayashi Y, Fukunaga M, Sone T, Fujiwara S, Shiraki M, Kushida K, Miyamoto S, Soen S, Nishimura J, Oh-Hashi Y, Hosoi T, Gorai I, Tanaka H, Igai T, Kishimoto H (2001) Diagnostic criteria for primary osteoporosis: year 2000 revision. J Bone Miner Metab 19:331\u2013337","journal-title":"J Bone Miner Metab"},{"key":"383_CR2","doi-asserted-by":"crossref","unstructured":"Albagha OM, Ralston SH (2003) Genetic determinants of susceptibility to osteoporosis. Endocrinol Metab Clin N Am 32:65\u201381, vi","DOI":"10.1016\/S0889-8529(02)00059-2"},{"key":"383_CR3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1210\/er.23.3.303","volume":"23","author":"M Peacock","year":"2002","unstructured":"Peacock M, Turner CH, Econs MJ, Foroud T (2002) Genetics of osteoporosis. Endocr Rev 23:303\u2013326","journal-title":"Endocr Rev"},{"key":"383_CR4","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1056\/NEJMe0803046","volume":"358","author":"JN Hirschhorn","year":"2008","unstructured":"Hirschhorn JN, Gennari L (2008) Bona fide genetic associations with bone mineral density. N Engl J Med 358:2403\u20132405","journal-title":"N Engl J Med"},{"key":"383_CR5","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1101\/gad.1449506","volume":"20","author":"SH Ralston","year":"2006","unstructured":"Ralston SH, de Crombrugghe B (2006) Genetic regulation of bone mass and susceptibility to osteoporosis. Genes Dev 20:2492\u20132506","journal-title":"Genes Dev"},{"key":"383_CR6","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1210\/jc.86.8.3555","volume":"86","author":"S Khosla","year":"2001","unstructured":"Khosla S, Melton LJ 3rd, Atkinson EJ, O\u2019Fallon WM (2001) Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab 86:3555\u20133561","journal-title":"J Clin Endocrinol Metab"},{"key":"383_CR7","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1172\/JCI119701","volume":"100","author":"CW Slemenda","year":"1997","unstructured":"Slemenda CW, Longcope C, Zhou L, Hui SL, Peacock M, Johnston CC (1997) Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens. J Clin Invest 100:1755\u20131759","journal-title":"J Clin Invest"},{"key":"383_CR8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.7326\/0003-4819-102-3-319","volume":"102","author":"B Ettinger","year":"1985","unstructured":"Ettinger B, Genant HK, Cann CE (1985) Long-term estrogen replacement therapy prevents bone loss and fractures. Ann Intern Med 102:319\u2013324","journal-title":"Ann Intern Med"},{"key":"383_CR9","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S0140-6736(76)92217-0","volume":"1","author":"R Lindsay","year":"1976","unstructured":"Lindsay R, Hart DM, Aitken JM, MacDonald EB, Anderson JB, Clarke AC (1976) Long-term prevention of postmenopausal osteoporosis by oestrogen. Evidence for an increased bone mass after delayed onset of oestrogen treatment. Lancet 1:1038\u20131041","journal-title":"Lancet"},{"key":"383_CR10","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1073\/pnas.93.12.5925","volume":"93","author":"GG Kuiper","year":"1996","unstructured":"Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925\u20135930","journal-title":"Proc Natl Acad Sci USA"},{"key":"383_CR11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0014-5793(96)00782-X","volume":"392","author":"S Mosselman","year":"1996","unstructured":"Mosselman S, Polman J, Dijkema R (1996) ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett 392:49\u201353","journal-title":"FEBS Lett"},{"key":"383_CR12","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.1210\/en.138.11.5067","volume":"138","author":"J Arts","year":"1997","unstructured":"Arts J, Kuiper GG, Janssen JM, Gustafsson JA, Lowik CW, Pols HA, van Leeuwen JP (1997) Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology 138:5067\u20135070","journal-title":"Endocrinology"},{"key":"383_CR13","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1210\/en.138.10.4509","volume":"138","author":"Y Onoe","year":"1997","unstructured":"Onoe Y, Miyaura C, Ohta H, Nozawa S, Suda T (1997) Expression of estrogen receptor beta in rat bone. Endocrinology 138:4509\u20134512","journal-title":"Endocrinology"},{"key":"383_CR14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s100380050043","volume":"43","author":"K Tsukamoto","year":"1998","unstructured":"Tsukamoto K, Inoue S, Hosoi T, Orimo H, Emi M (1998) Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human estrogen receptor beta locus. J Hum Genet 43:73\u201374","journal-title":"J Hum Genet"},{"key":"383_CR15","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S1673-8527(07)60098-8","volume":"34","author":"L Geng","year":"2007","unstructured":"Geng L, Yao Z, Yang H, Luo J, Han L, Lu Q (2007) Association of CA repeat polymorphism in estrogen receptor beta gene with postmenopausal osteoporosis in Chinese. J Genet Genomics 34:868\u2013876","journal-title":"J Genet Genomics"},{"key":"383_CR16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S8756-3282(02)00827-X","volume":"31","author":"HH Lau","year":"2002","unstructured":"Lau HH, Ho AY, Luk KD, Kung AW (2002) Estrogen receptor beta gene polymorphisms are associated with higher bone mineral density in premenopausal, but not postmenopausal southern Chinese women. Bone 31:276\u2013281","journal-title":"Bone"},{"key":"383_CR17","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1006\/bbrc.2000.2285","volume":"269","author":"S Ogawa","year":"2000","unstructured":"Ogawa S, Hosoi T, Shiraki M, Orimo H, Emi M, Muramatsu M, Ouchi Y, Inoue S (2000) Association of estrogen receptor beta gene polymorphism with bone mineral density. Biochem Biophys Res Commun 269:537\u2013541","journal-title":"Biochem Biophys Res Commun"},{"key":"383_CR18","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00223-003-0170-x","volume":"74","author":"JK Scariano","year":"2004","unstructured":"Scariano JK, Simplicio SG, Montoya GD, Garry PJ, Baumgartner RN (2004) Estrogen receptor beta dinucleotide (CA) repeat polymorphism is significantly associated with bone mineral density in postmenopausal women. Calcif Tissue Int 74:501\u2013508","journal-title":"Calcif Tissue Int"},{"key":"383_CR19","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1359\/jbmr.0301258","volume":"19","author":"AM Shearman","year":"2004","unstructured":"Shearman AM, Karasik D, Gruenthal KM, Demissie S, Cupples LA, Housman DE, Kiel DP (2004) Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham Study. J Bone Miner Res 19:773\u2013781","journal-title":"J Bone Miner Res"},{"key":"383_CR20","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.bbrc.2008.07.017","volume":"374","author":"C Takeo","year":"2008","unstructured":"Takeo C, Ugai K, Araki J, Zhang L, Baba M, Ohashi W, Ueno K, Suzuki Y, Amano K, Hirai A, Muramatsu M (2008) Pharmacogenetics of hormone replacement therapy for climacteric symptoms. Biochem Biophys Res Commun 374:604\u2013608","journal-title":"Biochem Biophys Res Commun"},{"key":"383_CR21","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/sj.ejhg.5200714","volume":"9","author":"C Forsell","year":"2001","unstructured":"Forsell C, Enmark E, Axelman K, Blomberg M, Wahlund LO, Gustafsson JA, Lannfelt L (2001) Investigations of a CA repeat in the oestrogen receptor beta gene in patients with Alzheimer\u2019s disease. Eur J Hum Genet 9:802\u2013804","journal-title":"Eur J Hum Genet"},{"key":"383_CR22","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1158\/1055-9965.EPI-05-0514","volume":"14","author":"ML Slattery","year":"2005","unstructured":"Slattery ML, Sweeney C, Murtaugh M, Ma KN, Wolff RK, Potter JD, Caan BJ, Samowitz W (2005) Associations between ERalpha, ERbeta, and AR genotypes and colon and rectal cancer. Cancer Epidemiol Biomarkers Prev 14:2936\u20132942","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"383_CR23","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1210\/jc.86.6.2562","volume":"86","author":"L Westberg","year":"2001","unstructured":"Westberg L, Baghaei F, Rosmond R, Hellstrand M, Landen M, Jansson M, Holm G, Bjorntorp P, Eriksson E (2001) Polymorphisms of the androgen receptor gene and the estrogen receptor beta gene are associated with androgen levels in women. J Clin Endocrinol Metab 86:2562\u20132568","journal-title":"J Clin Endocrinol Metab"},{"key":"383_CR24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00774-007-0841-1","volume":"26","author":"M Sakuma","year":"2008","unstructured":"Sakuma M, Endo N, Oinuma T, Endo E, Yazawa T, Watanabe K, Watanabe S (2008) Incidence and outcome of osteoporotic fractures in 2004 in Sado City, Niigata Prefecture, Japan. J Bone Miner Metab 26:373\u2013378","journal-title":"J Bone Miner Metab"},{"key":"383_CR25","first-page":"121","volume":"62","author":"H Shimokata","year":"2004","unstructured":"Shimokata H (2004) Epidemiological statistics of dementia in Japan. Nihon Rinsho 62:121\u2013126","journal-title":"Nihon Rinsho"},{"key":"383_CR26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2131\/jts.33.237","volume":"33","author":"K Ugai","year":"2008","unstructured":"Ugai K, Nishimura K, Fukino K, Nakamura T, Ueno K (2008) Functional analysis of transcriptional activity of cytosine and adenine (CA) repeats polymorphism in the estrogen receptor beta gene. J Toxicol Sci 33:237\u2013240","journal-title":"J Toxicol Sci"},{"key":"383_CR27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0014-5793(02)02521-8","volume":"516","author":"I Poola","year":"2002","unstructured":"Poola I, Abraham J, Baldwin K (2002) Identification of ten exon deleted ERbeta mRNAs in human ovary, breast, uterus and bone tissues: alternate splicing pattern of estrogen receptor beta mRNA is distinct from that of estrogen receptor alpha. FEBS Lett 516:133\u2013138","journal-title":"FEBS Lett"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-012-0383-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00774-012-0383-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-012-0383-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T06:16:47Z","timestamp":1559110607000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00774-012-0383-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,5]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["383"],"URL":"https:\/\/doi.org\/10.1007\/s00774-012-0383-z","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,5]]}}}