{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:18:31Z","timestamp":1790914711101,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T00:00:00Z","timestamp":1365724800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1007\/s00774-013-0452-y","type":"journal-article","created":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T09:10:40Z","timestamp":1365671440000},"page":"637-643","source":"Crossref","is-referenced-by-count":16,"title":["Effects of total bilirubin on the prevalence of osteoporosis in postmenopausal women without potential liver disease"],"prefix":"10.1007","volume":"31","author":[{"given":"Lu-Qin","family":"Bian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ji","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Wook","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Zhu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn-Soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,12]]},"reference":[{"key":"452_CR1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0016-5085(95)90033-0","volume":"108","author":"JE Hay","year":"1995","unstructured":"Hay JE (1995) Bone disease in cholestatic liver disease. Gastroenterology 108:276\u2013283","journal-title":"Gastroenterology"},{"key":"452_CR2","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0016-5085(03)01062-X","volume":"125","author":"WD Leslie","year":"2003","unstructured":"Leslie WD, Bernstein CD, Leboff MS (2003) AGA technical review on osteoporosis in hepatic disorders. Gastroenterology 125:941\u2013966","journal-title":"Gastroenterology"},{"key":"452_CR3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/hep.1840010617","volume":"1","author":"HO Conn","year":"1981","unstructured":"Conn HO (1981) A peek at the Child-Turcotte classification. Hepatology 1:673\u2013676","journal-title":"Hepatology"},{"key":"452_CR4","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1053\/he.2000.5852","volume":"31","author":"M Malinchoc","year":"2000","unstructured":"Malinchoc M, Kamath PS, Gordon FD, Peine CJ, Rank J, ter Borg PCJ (2000) A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology 31:864\u2013871","journal-title":"Hepatology"},{"key":"452_CR5","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1089-3261(03)00100-4","volume":"7","author":"A Pares","year":"2003","unstructured":"Pares A, Rodes J (2003) Natural history of primary biliary cirrhosis. Clin Liver Dis 7:779\u2013794","journal-title":"Clin Liver Dis"},{"key":"452_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM198301063080101","volume":"308","author":"J Roll","year":"1983","unstructured":"Roll J, Boyer JL, Barry D, GB Klatskin (1983) The prognostic importance of clinical and histologic features in asymptomatic and symptomatic primary biliary cirrhosis. N Engl J Med 308:1\u20137","journal-title":"N Engl J Med"},{"key":"452_CR7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/hep.510290140","volume":"29","author":"AM Bonnand","year":"1999","unstructured":"Bonnand AM, Heathcote EJ, Lindor KD, Poupon RE (1999) Clinical significance of serum bilirubin levels under ursodeoxycholic acid therapy in patients with primary biliary cirrhosis. Hepatology 29:39\u201343","journal-title":"Hepatology"},{"key":"452_CR8","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0168-8278(01)00144-1","volume":"35","author":"KVN Menon","year":"2001","unstructured":"Menon KVN, Angulo P, Weston S, Dickson ER, Lindor KD (2001) Bone disease in primary biliary cirrhosis: independent indicators and rate of progression. J Hepatol 35:316\u2013323","journal-title":"J Hepatol"},{"key":"452_CR9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00042737-200201000-00008","volume":"14","author":"S Ormarsd\u00f3ttir","year":"2002","unstructured":"Ormarsd\u00f3ttir S, Ljunggren O, Mallmin H, Micha\u00eblsson K, L\u00f6\u00f6f L (2002) Increased rate of bone loss at the femoral neck in patients with chronic liver disease. Eur J Gastroenterol Hepatol 14:43\u201348","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"452_CR10","first-page":"389","volume":"21","author":"KD Lindor","year":"1995","unstructured":"Lindor KD, Janes CH, Crippin JS, Jorgensen RA, Dickson ER (1995) Bone disease in primary biliary cirrhosis: does ursodeoxycholic acid make a difference? Hepatology 21:389\u2013392","journal-title":"Hepatology"},{"key":"452_CR11","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1002\/hep.24605","volume":"54","author":"S Ruiz-Gasp\u00e0","year":"2011","unstructured":"Ruiz-Gasp\u00e0 S, Martinez-Ferrer A, Gua\u00f1abens N, Dubreuil M, Peris P, Enjuanes A, Martinez de Osaba MJ, Alvarez L, Monegal A, Combalia A, Par\u00e9s A (2011) Effects of bilirubin and sera from jaundiced patients on osteoblasts: contribution to the development of osteoporosis in liver diseases. Hepatology 54:2104\u20132113","journal-title":"Hepatology"},{"key":"452_CR12","unstructured":"World Health Organization (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Technical Report no. 843. World Health Organization, Geneva"},{"key":"452_CR13","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","volume":"9","author":"JA Kanis","year":"1994","unstructured":"Kanis JA, Melton LJ 3rd, Christiansen C, Johnson CC, Khaltaev N (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137\u20131141","journal-title":"J Bone Miner Res"},{"key":"452_CR14","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/01.CIR.97.23.2302","volume":"97","author":"AW van \u2018t Hof","year":"1998","unstructured":"van \u2018t Hof AW, Liem A, Suryapranata H, Hoorntje JC, de Boer MJ, Zijlstra F (1998) Angiographic assessment of myocardial reperfusion in patients treated with primary angioplasty for acute myocardial infarction: myocardial blush grade. Zwolle Myocardial Infarction Study Group. Circulation 97:2302\u20132306","journal-title":"Circulation"},{"key":"452_CR15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1136\/gut.49.2.282","volume":"49","author":"J Newton","year":"2001","unstructured":"Newton J, Francis R, Prince M, James O, Bassendine M, Rawlings D, Jones D (2001) Osteoporosis in primary biliary cirrhosis revisited. Gut 49:282\u2013287","journal-title":"Gut"},{"key":"452_CR16","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.archger.2012.05.004","volume":"55","author":"ME Kuyumcu","year":"2012","unstructured":"Kuyumcu ME, Yesil Y, Ozt\u00fcrk ZA, C\u0131nar E, K\u0131z\u0131larslanoglu C, Halil M, Ulger Z, Yesil NK, Cankurtaran M, Ar\u0131o\u011ful S (2012) The association between homocysteine (hcy) and serum natural antioxidants in elderly bone mineral densitometry (BMD). Arch Gerontol Geriatr 55:739\u2013743","journal-title":"Arch Gerontol Geriatr"},{"key":"452_CR17","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(94)92211-X","volume":"344","author":"B Halliwell","year":"1994","unstructured":"Halliwell B (1994) Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 344:721\u2013724","journal-title":"Lancet"},{"key":"452_CR18","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1210\/jc.2002-021496","volume":"88","author":"D Maggio","year":"2003","unstructured":"Maggio D, Barabani M, Pierandrei M, Polidori MC, Catani M, Mecocci P, Senin U, Pacifici R, Cherubini A (2003) Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab 88:1523\u20131527","journal-title":"J Clin Endocrinol Metab"},{"key":"452_CR19","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/j.jss.2011.02.033","volume":"169","author":"YB Zhang","year":"2011","unstructured":"Zhang YB, Zhong ZM, Hou G, Jiang H, Chen JT (2011) Involvement of oxidative stress in age-related bone loss. J Surg Res 169:e37\u2013e42","journal-title":"J Surg Res"},{"key":"452_CR20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1471-2474-8-124","volume":"8","author":"MA S\u00e1nchez-Rodr\u00edguez","year":"2007","unstructured":"S\u00e1nchez-Rodr\u00edguez MA, Ruiz-Ramos M, Correa-Mu\u00f1oz E, Mendoza-N\u00fa\u00f1ez VM (2007) Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes. BMC Musculoskelet Disord 8:124","journal-title":"BMC Musculoskelet Disord"},{"key":"452_CR21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1161\/hq1201.100456","volume":"22","author":"N Weiss","year":"2002","unstructured":"Weiss N, Heydrick S, Zhang YY, Bierl C, Cap A, Loscalzo J (2002) Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine betasynthase-deficient mice. Arterioscler Thromb Vasc Biol 22:34\u201341","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"452_CR22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2003.12.073","volume":"314","author":"XC Bai","year":"2004","unstructured":"Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, Luo SQ (2004) Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun 314:197\u2013207","journal-title":"Biochem Biophys Res Commun"},{"key":"452_CR23","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1172\/JCI200318859","volume":"112","author":"JM Lean","year":"2003","unstructured":"Lean JM, Davies JT, Fuller K, Jagger CJ, Kirstein B, Partington GA, Urry ZL, Chambers TJ (2003) A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest 112:915\u2013923","journal-title":"J Clin Invest"},{"key":"452_CR24","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1210\/en.2004-1021","volume":"146","author":"JM Lean","year":"2005","unstructured":"Lean JM, Jagger CJ, Kirstein B, Fuller K, Chambers TJ (2005) Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. Endocrinology 146:728\u2013735","journal-title":"Endocrinology"},{"key":"452_CR25","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","volume":"235","author":"R Stocker","year":"1987","unstructured":"Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN (1987) Bilirubin is an antioxidant of possible physiological importance. Science 235:1043\u20131046","journal-title":"Science"},{"key":"452_CR26","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1073\/pnas.84.16.5918","volume":"84","author":"R Stocker","year":"1987","unstructured":"Stocker R, Glazer AN, Ames BN (1987) Antioxidant activity of albumin-bound bilirubin. Proc Natl Acad Sci USA 84:5918\u20135922","journal-title":"Proc Natl Acad Sci USA"},{"key":"452_CR27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/10715768909073428","volume":"6","author":"R Stocker","year":"1989","unstructured":"Stocker R, Peterhans E (1989) Antioxidant properties of conjugated bilirubin and biliverdin: biologically relevant scavenging of hypochlorous acid. Free Radic Res Commun 6:57\u201366","journal-title":"Free Radic Res Commun"},{"key":"452_CR28","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0006-2952(95)02395-X","volume":"51","author":"TW Wu","year":"1996","unstructured":"Wu TW, Fung KP, Wu J, Yang CC, Weisel RD (1996) Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins. Biochem Pharmacol 51:859\u2013862","journal-title":"Biochem Pharmacol"},{"key":"452_CR29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/abbi.1998.0584","volume":"352","author":"M Minetti","year":"1998","unstructured":"Minetti M, Mallozzi C, Di Stasi AM, Pietraforte D (1998) Bilirubin is an effective antioxidant of peroxynitrite-mediated protein oxidation in human blood plasma. Arch Biochem Biophys 352:165\u2013174","journal-title":"Arch Biochem Biophys"},{"key":"452_CR30","doi-asserted-by":"crossref","first-page":"16093","DOI":"10.1073\/pnas.252626999","volume":"99","author":"DE Baranano","year":"2002","unstructured":"Baranano DE, Rao M, Ferris CD, Snyder SH (2002) Biliverdin reductase: a major physiologic cytoprotectant. Proc Natl Acad Sci USA 99:16093\u201316098","journal-title":"Proc Natl Acad Sci USA"},{"key":"452_CR31","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1373\/clinchem.2010.151043","volume":"56","author":"JP Lin","year":"2010","unstructured":"Lin JP, Vitek L, Schwertner HA (2010) Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease. Clin Chem 56:1535\u20131543","journal-title":"Clin Chem"},{"key":"452_CR32","doi-asserted-by":"crossref","first-page":"F563","DOI":"10.1152\/ajprenal.00220.2005","volume":"290","author":"KA Kirkby","year":"2006","unstructured":"Kirkby KA, Adin CA (2006) Products of heme oxygenase and their potential therapeutic applications. Am J Physiol Renal Physiol 290:F563\u2013F571","journal-title":"Am J Physiol Renal Physiol"},{"key":"452_CR33","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/0961203309355301","volume":"19","author":"JM Sabio","year":"2010","unstructured":"Sabio JM, Vargas-Hitos JA, Mediavilla JD, Navarrete-Navarrete N, Zamora-Posadas M, P\u00e9rez-Vicente S, Hidalgo-Tenorio C, D\u00edaz-Chamorro A, J\u00e1imez L, Jim\u00e9nez-Alonso J, Grupo Lupus Virgen de las Nieves (2010) Correlation of asymptomatic hyperuricaemia and serum uric acid levels with arterial stiffness in women with systemic lupus erythematosus without clinically evident atherosclerotic cardiovascular disease. Lupus 19:591\u2013598","journal-title":"Lupus"},{"key":"452_CR34","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1177\/0003319711423806","volume":"63","author":"Z Zhang","year":"2012","unstructured":"Zhang Z, Bian L, Choi Y (2012) Serum uric acid: a marker of metabolic syndrome and subclinical atherosclerosis in Korean men. Angiology 63:420\u2013428","journal-title":"Angiology"},{"key":"452_CR35","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.bone.2012.10.025","volume":"52","author":"J Makovey","year":"2013","unstructured":"Makovey J, Macara M, Chen JS, Hayward CS, March L, Seibel MJ, Sambrook PN (2013) Serum uric acid plays a protective role for bone loss in peri-and postmenopausal women: a longitudinal study. Bone 52:400\u2013406","journal-title":"Bone"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-013-0452-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00774-013-0452-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-013-0452-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T02:16:49Z","timestamp":1559096209000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00774-013-0452-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["452"],"URL":"https:\/\/doi.org\/10.1007\/s00774-013-0452-y","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,12]]}}}