{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:27:04Z","timestamp":1786980424134,"version":"build-2736575974"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:00:00Z","timestamp":1473811200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271107"],"award-info":[{"award-number":["81271107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470718"],"award-info":[{"award-number":["81470718"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100736"],"award-info":[{"award-number":["81100736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s00774-016-0773-8","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T08:53:58Z","timestamp":1473843238000},"page":"355-365","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Platelet-derived growth factor\u00a0BB enhances osteoclast formation and osteoclast precursor cell chemotaxis"],"prefix":"10.1007","volume":"35","author":[{"given":"Dian-qi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-long","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janak L.","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu-bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,14]]},"reference":[{"key":"773_CR1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","volume":"423","author":"WJ Boyle","year":"2003","unstructured":"Boyle WJ, Simonet WS, Lacey DL (2003) Osteoclast differentiation and activation. Nature 423:337\u2013342","journal-title":"Nature"},{"key":"773_CR2","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1111\/j.1365-2362.2012.02717.x","volume":"42","author":"BF Boyce","year":"2012","unstructured":"Boyce BF, Rosenberg E, de Papp AE, Duong LT (2012) The osteoclast, bone remodelling and treatment of metabolic bone disease. Eur J Clin Invest 42:1332\u20131341","journal-title":"Eur J Clin Invest"},{"key":"773_CR3","doi-asserted-by":"crossref","first-page":"34120","DOI":"10.1074\/jbc.273.51.34120","volume":"273","author":"L Galibert","year":"1998","unstructured":"Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC (1998) The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-\u03baB, a member of the TNFR superfamily. J Biol Chem 273:34120\u201334127","journal-title":"J Biol Chem"},{"key":"773_CR4","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","volume":"95","author":"H Yasuda","year":"1998","unstructured":"Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T (1998) Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL. Proc Natl Acad Sci U S A 95:3597\u20133602","journal-title":"Proc Natl Acad Sci U S A"},{"key":"773_CR5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","volume":"397","author":"YY Kong","year":"1999","unstructured":"Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM (1999) OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397:315\u2013323","journal-title":"Nature"},{"key":"773_CR6","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1007\/s00198-014-2779-1","volume":"25","author":"JL Pathak","year":"2014","unstructured":"Pathak JL, Bravenboer N, Verschueren P, Lems WF, Luyten FP, Klein-Nulend J, Bakker AD (2014) Inflammatory factors in the circulation of patients with active rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts. Osteoporos Int 25:2453\u20132463","journal-title":"Osteoporos Int"},{"key":"773_CR7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.6844921","volume":"220","author":"HN Antoniades","year":"1983","unstructured":"Antoniades HN, Hunkapiller MW (1983) Human platelet-derived growth factor (PDGF): amino-terminal amino acid sequence. Science 220:963\u2013965","journal-title":"Science"},{"issue":"Suppl 1","key":"773_CR8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2106\/JBJS.G.01231","volume":"90","author":"JO Hollinger","year":"2008","unstructured":"Hollinger JO, Hart CE, Hirsch SN, Lynch S, Friedlaender GE (2008) Recombinant human platelet-derived growth factor: biology and clinical applications. J Bone Joint Surg Am 90(Suppl 1):48\u201354","journal-title":"J Bone Joint Surg Am"},{"key":"773_CR9","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.2106\/JBJS.H.00540","volume":"91","author":"DC Moore","year":"2009","unstructured":"Moore DC, Ehrlich MG, McAllister SC, Machan JT, Hart CE, Voigt C, Lesieur-Brooks AM, Weber EW (2009) Recombinant human platelet-derived growth factor-BB augmentation of new-bone formation in a rat model of distraction osteogenesis. J Bone Joint Surg Am 91:1973\u20131984","journal-title":"J Bone Joint Surg Am"},{"key":"773_CR10","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/nm.3668","volume":"20","author":"H Xie","year":"2014","unstructured":"Xie H, Cui Z, Wang L, Xia Z, Hu Y, Xian L, Li C, Xie L, Crane J, Wan M, Zhen G, Bian Q, Yu B, Chang W, Qiu T, Pickarski M, Duong LT, Windle JJ, Luo X, Liao E, Cao X (2014) PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis. Nat Med 20:1270\u20131278","journal-title":"Nat Med"},{"key":"773_CR11","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bone.2009.01.377","volume":"44","author":"R Chung","year":"2009","unstructured":"Chung R, Foster BK, Zannettino AC, Xian CJ (2009) Potential roles of growth factor PDGF-BB in the bony repair of injured growth plate. Bone 44:878\u2013885","journal-title":"Bone"},{"key":"773_CR12","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.2174\/1381612811319190005","volume":"19","author":"GE Friedlaender","year":"2013","unstructured":"Friedlaender GE, Lin S, Solchaga LA, Snel LB, Lynch SE (2013) The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration. Curr Pharm Des 19:3384\u20133390","journal-title":"Curr Pharm Des"},{"key":"773_CR13","doi-asserted-by":"crossref","first-page":"e3537","DOI":"10.1371\/journal.pone.0003537","volume":"3","author":"MA Sanchez-Fernandez","year":"2008","unstructured":"Sanchez-Fernandez MA, Gallois A, Riedl T, Jurdic P, Hoflack B (2008) Osteoclasts control osteoblast chemotaxis via PDGF-BB\/PDGF receptor beta signaling. PLoS One 3:e3537","journal-title":"PLoS One"},{"key":"773_CR14","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/bbrc.1998.9412","volume":"251","author":"Z Zhang","year":"1998","unstructured":"Zhang Z, Chen J, Jin D (1998) Platelet-derived growth factor (PDGF)-BB stimulates osteoclastic bone resorption directly: the role of receptor beta. Biochem Biophys Res Commun 251:190\u2013194","journal-title":"Biochem Biophys Res Commun"},{"key":"773_CR15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1126\/science.7939685","volume":"266","author":"AE Grigoriadis","year":"1994","unstructured":"Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EF (1994) c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266:443\u2013448","journal-title":"Science"},{"key":"773_CR16","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","volume":"3","author":"H Takayanagi","year":"2002","unstructured":"Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3:889\u2013901","journal-title":"Dev Cell"},{"key":"773_CR17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1359\/jbmr.071211","volume":"23","author":"J Yamashita","year":"2008","unstructured":"Yamashita J, Datta NS, Chun YH, Yang DY, Carey AA, Kreider JM, Goldstein SA, McCauley LK (2008) Role of Bcl2 in osteoclastogenesis and PTH anabolic actions in bone. J Bone Miner Res 23:621\u2013632","journal-title":"J Bone Miner Res"},{"key":"773_CR18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/jcp.22012","volume":"223","author":"KA Mensah","year":"2010","unstructured":"Mensah KA, Ritchlin CT, Schwarz EM (2010) RANKL induces heterogeneous DC-STAMPlo and DC-STAMPhi osteoclast precursors of which the DC-STAMPlo precursors are the master fusogens. J Cell Physiol 223:76\u201383","journal-title":"J Cell Physiol"},{"key":"773_CR19","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.4049\/jimmunol.178.9.5588","volume":"178","author":"K Kim","year":"2007","unstructured":"Kim K, Lee J, Kim JH, Jin HM, Zhou B, Lee SY, Kim N (2007) Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor. J Immunol 178:5588\u20135594","journal-title":"J Immunol"},{"key":"773_CR20","doi-asserted-by":"crossref","first-page":"e24780","DOI":"10.1371\/journal.pone.0024780","volume":"6","author":"Y He","year":"2011","unstructured":"He Y, Staser K, Rhodes SD, Liu Y, Wu X, Park SJ, Yuan J, Yang X, Li X, Jiang L, Chen S, Yang FC (2011) Erk1 positively regulates osteoclast differentiation and bone resorptive activity. PLoS One 6:e24780","journal-title":"PLoS One"},{"key":"773_CR21","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bbrc.2013.04.084","volume":"435","author":"CH Li","year":"2013","unstructured":"Li CH, Zhao JX, Sun L, Yao ZQ, Deng XL, Liu R, Liu XY (2013) AG490 inhibits NFATc1 expression and STAT3 activation during RANKL induced osteoclastogenesis. Biochem Biophys Res Commun 435:533\u2013539","journal-title":"Biochem Biophys Res Commun"},{"key":"773_CR22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1423-0127-21-10","volume":"21","author":"M Tsubaki","year":"2014","unstructured":"Tsubaki M, Komai M, Itoh T, Imano M, Sakamoto K, Shimaoka H, Takeda T, Ogawa N, Mashimo K, Fujiwara D, Mukai J, Sakaguchi K, Satou T, Nishida S (2014) Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1\/2 and Akt activation. J Biomed Sci 21:10","journal-title":"J Biomed Sci"},{"key":"773_CR23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-61779-415-5_13","volume-title":"Bone research protocols methods in molecular medicine","author":"P Collin-Osdoby","year":"2012","unstructured":"Collin-Osdoby P, Osdoby P (2012) RANKL-mediated osteoclast formation from murine RAW 264.7 cells. In: Helfrich MH, Ralston SH (eds) Bone research protocols methods in molecular medicine. Humana, New York, p 187"},{"key":"773_CR24","doi-asserted-by":"publisher","first-page":"e59171","DOI":"10.1371\/journal.pone.0059171","volume":"8","author":"ZF Wei","year":"2013","unstructured":"Wei ZF, Tong B, Xia YF, Lu Q, Chou GX, Wang ZT, Dai Y (2013) Norisoboldine suppresses osteoclast differentiation through preventing the accumulation of TRAF6-TAK1 complexes and activation of MAPKs\/NF-\u03baB\/c-Fos\/NFATc1 pathways. PLoS One 8:e59171. doi: 10.1371\/journal.pone.0059171","journal-title":"PLoS One"},{"key":"773_CR25","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1083\/jcb.143.6.1749","volume":"143","author":"KL O\u2019Connor","year":"1998","unstructured":"O\u2019Connor KL, Shaw LM, Mercurio AM (1998) Release of cAMP gating by the \u02516\u03b24 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells. J Cell Biol 143:1749\u20131760","journal-title":"J Cell Biol"},{"key":"773_CR26","first-page":"689","volume":"32","author":"K Thakare","year":"2012","unstructured":"Thakare K, Deo V (2012) Randomized controlled clinical study of rhPDGF-BB\u00a0+\u00a0\u03b2-TCP versus HA\u00a0+\u00a0\u03b2-TCP for the treatment of infrabony periodontal defects: clinical and radiographic results. Int J Periodontics Restorative Dent 32:689\u2013696","journal-title":"Int J Periodontics Restorative Dent"},{"key":"773_CR27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13018-015-0174-z","volume":"10","author":"A Christersson","year":"2015","unstructured":"Christersson A, Sanden B, Larsson S (2015) Prospective randomized feasibility trial to assess the use of rhPDGF-BB in treatment of distal radius fractures. J Orthop Surg Res 10:37","journal-title":"J Orthop Surg Res"},{"key":"773_CR28","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1177\/1071100715576370","volume":"36","author":"TR Daniels","year":"2015","unstructured":"Daniels TR, Younger AS, Penner MJ, Wing KJ, Le IL, Russell IS, Lalonde KA, Evangelista PT, Quiton JD, Glazebrook M, DiGiovanni CW (2015) Prospective randomized controlled trial of hindfoot and ankle fusions treated with rhPDGF-BB in combination with a \u03b2-TCP-collagen matrix. Foot Ankle Int 36:739\u2013748","journal-title":"Foot Ankle Int"},{"key":"773_CR29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s10856-015-5626-9","volume":"27","author":"TT Demirtas","year":"2016","unstructured":"Demirtas TT, Goz E, Karakecili A, Gumusderelioglu M (2016) Combined delivery of PDGF-BB and BMP-6 for enhanced osteoblastic differentiation. J Mater Sci Mater Med 27:12","journal-title":"J Mater Sci Mater Med"},{"key":"773_CR30","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1210\/endo.134.3.8119182","volume":"134","author":"JM Hock","year":"1994","unstructured":"Hock JM, Canalis E (1994) Platelet-derived growth factor enhances bone cell replication, but not differentiated function of osteoblasts. Endocrinology 134:1423\u20131428","journal-title":"Endocrinology"},{"key":"773_CR31","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.148.2.333","volume":"148","author":"T Miyazaki","year":"2000","unstructured":"Miyazaki T, Katagiri H, Kanegae Y, Takayanagi H, Sawada Y, Yamamoto A, Pando MP, Asano T, Verma IM, Oda H, Nakamura K, Tanaka S (2000) Reciprocal role of ERK and NF-\u03baB pathways in survival and activation of osteoclasts. J Cell Biol 148:333\u2013342","journal-title":"J Cell Biol"},{"key":"773_CR32","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1126\/science.1071545","volume":"296","author":"DS Aaronson","year":"2002","unstructured":"Aaronson DS, Horvath CM (2002) A road map for those who don\u2019t know JAK-STAT. Science 296:1653\u20131655","journal-title":"Science"},{"key":"773_CR33","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/sj.emboj.7600564","volume":"24","author":"J Gohda","year":"2005","unstructured":"Gohda J, Akiyama T, Koga T, Takayanagi H, Tanaka S, Inoue J (2005) RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis. EMBO J 24:790\u2013799","journal-title":"EMBO J"},{"key":"773_CR34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","volume":"40","author":"M Asagiri","year":"2007","unstructured":"Asagiri M, Takayanagi H (2007) The molecular understanding of osteoclast differentiation. Bone 40:251\u2013264","journal-title":"Bone"},{"key":"773_CR35","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.4049\/jimmunol.1300514","volume":"192","author":"JS Park","year":"2014","unstructured":"Park JS, Lee J, Lim MA, Kim EK, Kim SM, Ryu JG, Lee JH, Kwok SK, Park KS, Kim HY, Park SH, Cho ML (2014) JAK2-STAT3 blockade by AG490 suppresses autoimmune arthritis in mice via reciprocal regulation of regulatory T cells and Th17 cells. J Immunol 192:4417\u20134424","journal-title":"J Immunol"},{"key":"773_CR36","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1138\/20100459","volume":"7","author":"T Ishii","year":"2010","unstructured":"Ishii T, Kikuta J, Kubo A, Ishii M (2010) Control of osteoclast precursor migration: a novel point of control for osteoclastogenesis and bone homeostasis. IBMS Bonekey 7:279\u2013286","journal-title":"IBMS Bonekey"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00774-016-0773-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-016-0773-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-016-0773-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T06:32:20Z","timestamp":1718778740000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00774-016-0773-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,14]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["773"],"URL":"https:\/\/doi.org\/10.1007\/s00774-016-0773-8","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,14]]}}}