{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:40:09Z","timestamp":1751517609038,"version":"3.41.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00774-018-0920-5","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T09:23:34Z","timestamp":1522401814000},"page":"319-326","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serum homocysteine levels are affected by renal function during a 3-year period of minodronate therapy in female osteoporotic patients"],"prefix":"10.1007","volume":"37","author":[{"given":"Tsuyoshi","family":"Ohishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomotada","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Asukai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"920_CR1","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/BF03026321","volume":"23","author":"T Mashiba","year":"2005","unstructured":"Mashiba T, Mori S, Burr DB, Komatsubara S, Cao Y, Manabe T, Norimatsu H (2005) The effects of suppressed bone remodeling by bisphosphonates on microdamage accumulation and degree of mineralization in the cortical bone of dog rib. J Bone Miner Metab 23:36\u201342","journal-title":"J Bone Miner Metab"},{"key":"920_CR2","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1007\/s00198-008-0585-3","volume":"19","author":"M Saito","year":"2008","unstructured":"Saito M, Mori S, Mashiba T, Komatsubara S, Marumo K (2008) Collagen maturity, glycation induced-pentosidine, and mineralization are increased following 3-year treatment with incadronate in dogs. Osteoporos Int 19:1343\u20131354","journal-title":"Osteoporos Int"},{"key":"920_CR3","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/jbmr.1501","volume":"27","author":"Y Bala","year":"2012","unstructured":"Bala Y, Depalle B, Farlay D, Douillard T, Meille S, Follet H, Chapurlat R, Chevalier J, Boivin G (2012) Bone micromechanical properties are compromised during long-term alendronate therapy independently of mineralization. J Bone Miner Res 27:825\u2013834","journal-title":"J Bone Miner Res"},{"key":"920_CR4","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s00198-009-1066-z","volume":"21","author":"M Saito","year":"2010","unstructured":"Saito M, Marumo K (2010) Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int 21:195\u2013214","journal-title":"Osteoporos Int"},{"key":"920_CR5","first-page":"232","volume":"42","author":"T Ohishi","year":"2017","unstructured":"Ohishi T, Fujita T, Suzuki D, Nishida T, Yamamoto K, Okabayashi R, Ushirozako H, Banno T, Matsuyama Y (2017) Changes of bone mineral density and serum pentosidine during a 27-month follow-up of monthly minodronate in osteoporotic patients. Endocr Res 42:232\u2013240","journal-title":"Endocr Res"},{"key":"920_CR6","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1007\/s00726-011-1180-z","volume":"44","author":"M Nakano","year":"2013","unstructured":"Nakano M, Kubota M, Owada S, Nagai R (2013) The pentosidine concentration in human blood specimens is affected by heating. Amino Acids 44:1451\u20131456","journal-title":"Amino Acids"},{"key":"920_CR7","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","volume":"288","author":"Homocysteine Studies Collaboration","year":"2002","unstructured":"Homocysteine Studies Collaboration (2002) Homocysteine and risk of ischemic heart disease and stroke; a meta-analysis. JAMA 288:2015\u20132022","journal-title":"JAMA"},{"key":"920_CR8","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.bone.2008.12.023","volume":"44","author":"S Blouin","year":"2009","unstructured":"Blouin S, Thaler HW, Korninger C, Schmid R, Hofstaetter JG, Zoehrer R, Phipps R, Klaushofer K, Roschqer P, Paschalis EP (2009) Bone matrix quality and plasma homocysteine levels. Bone 44:959\u2013964","journal-title":"Bone"},{"key":"920_CR9","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1515\/cclm-2012-0605","volume":"51","author":"TP Vacek","year":"2013","unstructured":"Vacek TP, Kalani A, Voor MJ, Tyagi SC, Tyagi N (2013) The role of homocysteine in bone remodeling. Clin Chem Lab Med 51:579\u2013590","journal-title":"Clin Chem Lab Med"},{"key":"920_CR10","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.bone.2014.03.002","volume":"63","author":"AW Enneman","year":"2014","unstructured":"Enneman AW, Swart KMA, Zillikens MC, van Dijk SC, van Wijingaarden PJ, Brouwer-Brolsma EM, Dhonukshe-Rutten RAM, Hofman A, Rivadeneira F, van der Cammen TJM, Lips P, de Groot CPGM, Uitterlinden AG, van Meurs JBJ, van Scoor NM, van der Velde N (2014) The association between plasma homocysteine levels and bone quality and bone mineral density parameters in older persons. Bone 63:141\u2013146","journal-title":"Bone"},{"key":"920_CR11","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1056\/NEJMoa032739","volume":"350","author":"RR McLean","year":"2004","unstructured":"McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP (2004) Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 350:2042\u20132049","journal-title":"N Engl J Med"},{"key":"920_CR12","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s00774-010-0191-2","volume":"29","author":"M Shiraki","year":"2011","unstructured":"Shiraki M, Kuroda T, Shiraki Y, Tanaka S, Higuchi T, Saito M (2011) Urinary pentosidine and plasma homocysteine levels at baseline predict future fractures in osteoporosis patients under bisphosphonate treatment. J Bone Miner Metab 29:62\u201370","journal-title":"J Bone Miner Metab"},{"key":"920_CR13","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.bone.2012.05.024","volume":"51","author":"J Yang","year":"2012","unstructured":"Yang J, Hu X, Zhang Q, Cao H, Wang J, Liu B (2012) Homocysteine level and risk of fracture: a meta-analysis and systematic review. Bone 51:376\u2013382","journal-title":"Bone"},{"key":"920_CR14","first-page":"9","volume":"15","author":"Y Chatani","year":"2005","unstructured":"Chatani Y (2005) Minodronic acid hydrate as a new therapeutic agent for osteoporosis. Clin Calcium 15:9\u201314 (article in Japanese)","journal-title":"Clin Calcium"},{"key":"920_CR15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0022-3565(24)38786-5","volume":"296","author":"JE Dunford","year":"2001","unstructured":"Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ (2001) Structure\u2013activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonate. J Pharmacol Exp Ther 296:235\u2013242","journal-title":"J Pharmacol Exp Ther"},{"key":"920_CR16","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s00774-011-0332-2","volume":"30","author":"H Hagino","year":"2012","unstructured":"Hagino H, Shiraki M, Fukunaga M, Nakano T, Takaoka K, Ohashi Y, Nakamura T, Matsumoto T (2012) Three years of treatment with minodronate in patients with postmenopausal osteoporosis. J Bone Miner Metab 30:439\u2013446","journal-title":"J Bone Miner Metab"},{"key":"920_CR17","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s007740170001","volume":"19","author":"H Orimo","year":"2001","unstructured":"Orimo H, Hayashi Y, Fukunaga M, Sone T, Fujiwara S, Shiraki M, Kushida K, Miyamoto S, Soen S, Nishimura J, Oh-hashi Y, Hosoi T, Gorai I, Tanaka H, Igai T, Kishimoto H (2001) Osteoporosis diagnostic criteria for primary osteoporosis: year 2000 revision. J Bone Miner Metab 19:331\u2013337","journal-title":"J Bone Miner Metab"},{"key":"920_CR18","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0378-4347(87)80438-3","volume":"422","author":"A Araki","year":"1987","unstructured":"Araki A, Sako Y (1987) Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 422:43\u201352","journal-title":"J Chromatogr"},{"key":"920_CR19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000180580","volume":"12","author":"DW Cockcroft","year":"1976","unstructured":"Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 12:31\u201341","journal-title":"Nephron"},{"key":"920_CR20","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.bone.2013.02.013","volume":"55","author":"A Kimoto","year":"2013","unstructured":"Kimoto A, Tanaka M, Nozaki Mori M, Fukushima S, Mori H, Ahioya T, Nakamura T (2013) Intermittent minodronic acid treatment with sufficient bone resorption inhibition prevents reduction in bone mass and strength in ovariectomized rats with established osteopenia comparable with daily treatment. Bone 55:189\u2013197","journal-title":"Bone"},{"key":"920_CR21","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.bone.2012.11.026","volume":"53","author":"K Nagira","year":"2013","unstructured":"Nagira K, Hagino H, Kameyama Y, Teshima R (2013) Effects of minodronate on cortical bone response to mechanical loading in rats. Bone 53:277\u2013283","journal-title":"Bone"},{"key":"920_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bone.2013.01.016","volume":"54","author":"Y Yamagami","year":"2013","unstructured":"Yamagami Y, Mashiba T, Iwata K, Tanaka M, Nozaki K, Yamamoto T (2013) Effects of minodronic acid and alendronate on bone remodeling, microdamage accumulation, degree of mineralization and bone mechanical properties in ovariectomized cynomolgus monkeys. Bone 54:1\u20137","journal-title":"Bone"},{"key":"920_CR23","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1302\/2046-3758.610.BJR-2016-0321.R1","volume":"6","author":"A Jin","year":"2017","unstructured":"Jin A, Cobb J, HansenU Bhattacharya R, Reinhard C, Vo N, Atwood R, Li J, Karunaratne A, Wiles C, Abel R (2017) The effect of long-term bisphosphonate therapy on trabecular bone strength and microcrack density. Bone Joint Res 6:602\u2013609. https:\/\/doi.org\/10.1302\/2046-3758.610.BJR-2016-0321.R1","journal-title":"Bone Joint Res"},{"key":"920_CR24","doi-asserted-by":"publisher","first-page":"43399","DOI":"10.1038\/srep43399","volume":"7","author":"S Ma","year":"2017","unstructured":"Ma S, Goh EL, Jin A, Bhattacharya R, Boughton OR, Patel B, Karunaratne A, Vo NT, Atwood R, Cobb JP, HansenU Abel RL (2017) Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties. Sci Rep 7:43399. https:\/\/doi.org\/10.1038\/srep43399","journal-title":"Sci Rep"},{"key":"920_CR25","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1007\/s00198-014-2909-9","volume":"26","author":"S Tariq","year":"2015","unstructured":"Tariq S, Tariq S, Alam SS, Baig M (2015) Effect of ibandronate therapy on serum homocysteine and leptin in postmenopausal osteoporotic females. Osteoporos Int 26:1187\u20131192","journal-title":"Osteoporos Int"},{"key":"920_CR26","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3109\/00365519609088586","volume":"56","author":"M Arnadottir","year":"1996","unstructured":"Arnadottir M, Hultberg B, Nisson-Ehle P, Thysell H (1996) The effect of reduced glomerular filtration rate on plasma total homocysteine concentration. Scand J Clin Lab Investig 56:41\u201346","journal-title":"Scand J Clin Lab Investig"},{"key":"920_CR27","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1523-1755.2004.00732.x","volume":"66","author":"ME Francis","year":"2004","unstructured":"Francis ME, Eggers PW, Hostetter TH, Briggs JP (2004) Association between serum homocysteine and markers of impaired kidney function in adults in the United States. Kidney Int 66:303\u2013312","journal-title":"Kidney Int"},{"key":"920_CR28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1359\/jbmr.061003","volume":"22","author":"P Gerdhem","year":"2007","unstructured":"Gerdhem P, Ivaska KK, Isaksson A, Pettersson K, V\u00e4\u00e4n\u00e4nen HK, Obrant KJ, \u00c5kesson K (2007) Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women. J Bone Miner Res 22:127\u2013134","journal-title":"J Bone Miner Res"},{"key":"920_CR29","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.bone.2013.05.004","volume":"56","author":"Y Fujita","year":"2013","unstructured":"Fujita Y, Iki M, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N (2013) Renal function and bone mineral density in community-dwelling elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study. Bone 56:61\u201366","journal-title":"Bone"},{"key":"920_CR30","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1210\/jc.2008-1777","volume":"94","author":"MS LeBoff","year":"2009","unstructured":"LeBoff MS, Narweker R, LaCroix A, Wu L, Jackson R, Lee J, Bauer DC, Cauley J, Kooperberg C, Lewis C, Thomas AM, Cummings S (2009) Homocysteine levels and risk of hip fracture in postmenopausal women. J Clin Endocrinol Metab 94:1207\u20131213","journal-title":"J Clin Endocrinol Metab"},{"key":"920_CR31","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bone.2010.12.024","volume":"49","author":"PD Miller","year":"2011","unstructured":"Miller PD (2011) The kidney and bisphosphonates. Bone 49:77\u201381","journal-title":"Bone"},{"key":"920_CR32","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.2040-1124.2010.00088.x","volume":"2","author":"C Yamada","year":"2011","unstructured":"Yamada C, Fujimoto S, Ikeda K, Nomura Y, Matsubara A, Kanno M, Shide K, Tanaka K, Imai E, Fukuwatari T, Shibata K, Inagaki N (2011) Relationship of homocysteine and homocysteine-related vitamins to bone mineral density in Japanese patients with type 2 diabetes. J Diabetes Investig 2:233\u2013239","journal-title":"J Diabetes Investig"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-018-0920-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00774-018-0920-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-018-0920-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:27:02Z","timestamp":1751516822000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00774-018-0920-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,30]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["920"],"URL":"https:\/\/doi.org\/10.1007\/s00774-018-0920-5","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"type":"print","value":"0914-8779"},{"type":"electronic","value":"1435-5604"}],"subject":[],"published":{"date-parts":[[2018,3,30]]},"assertion":[{"value":"15 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors report no conflicts of interest. The authors are responsible for the content and writing of the paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}