{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:14:42Z","timestamp":1792782882196,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"State of Nebraska","award":["2019-01"],"award-info":[{"award-number":["2019-01"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL144125"],"award-info":[{"award-number":["R01HL144125"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s00774-019-01013-z","type":"journal-article","created":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T09:52:44Z","timestamp":1559382764000},"page":"759-767","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Therapeutic potential of exosomes in rotator cuff tendon healing"],"prefix":"10.1007","volume":"37","author":[{"given":"Denton E.","family":"Connor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan A.","family":"Paulus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parinaz Jila","family":"Dabestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finosh K.","family":"Thankam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F.","family":"Dilisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Michael","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-0013","authenticated-orcid":false,"given":"Devendra K.","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,1]]},"reference":[{"key":"1013_CR1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.colsurfb.2017.06.004","volume":"157","author":"S Zhao","year":"2017","unstructured":"Zhao S, Su W, Shah V et al (2017) Biomaterials based strategies for rotator cuff repair. Colloids Surf B 157:407\u2013416. \n                    https:\/\/doi.org\/10.1016\/j.colsurfb.2017.06.004","journal-title":"Colloids Surf B"},{"key":"1013_CR2","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1186\/s12891-017-1694-y","volume":"18","author":"JE Gold","year":"2017","unstructured":"Gold JE, Hallman DM, Hellstr\u00f6m F et al (2017) Systematic review of quantitative imaging biomarkers for neck and shoulder musculoskeletal disorders. BMC Musculoskelet Disorders 18:395. \n                    https:\/\/doi.org\/10.1186\/s12891-017-1694-y","journal-title":"BMC Musculoskelet Disorders"},{"key":"1013_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2474-15-4","volume":"15","author":"NB Jain","year":"2014","unstructured":"Jain NB, Higgins LD, Losina E, Collins J, Blazar PE, Katz JN (2014) Epidemiology of musculoskeletal upper extremity ambulatory surgery in the United States. BMC Musculoskelet Disorders 15:4. \n                    https:\/\/doi.org\/10.1186\/1471-2474-15-4","journal-title":"BMC Musculoskelet Disorders"},{"key":"1013_CR4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1097\/JSA.0b013e318213bccb","volume":"19","author":"UG Longo","year":"2011","unstructured":"Longo UG, Berton A, Khan WS, Maffulli N, Denaro V (2011) Histopathology of rotator cuff tears. Sports Med Arthrosc Rev 19:227\u2013236. \n                    https:\/\/doi.org\/10.1097\/JSA.0b013e318213bccb","journal-title":"Sports Med Arthrosc Rev"},{"key":"1013_CR5","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1080\/17453674.2017.1370844","volume":"88","author":"MS Rashid","year":"2017","unstructured":"Rashid MS, Cooper C, Cook J et al (2017) Increasing age and tear size reduce rotator cuff repair healing rate at 1 year. Acta Orthop 88:606\u2013611. \n                    https:\/\/doi.org\/10.1080\/17453674.2017.1370844","journal-title":"Acta Orthop"},{"key":"1013_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23810","author":"S Patel","year":"2017","unstructured":"Patel S, Caldwell J\u2010M, Doty SB et al (2017) Integrating soft and hard tissues via interface tissue engineering. J Orthop Res. \n                    https:\/\/doi.org\/10.1002\/jor.23810","journal-title":"J Orthop Res"},{"key":"1013_CR7","doi-asserted-by":"publisher","first-page":"e000482","DOI":"10.1136\/rmdopen-2017-000482","volume":"3","author":"A Ruyssen-Witrand","year":"2017","unstructured":"Ruyssen-Witrand A, Jamard B, Cantagrel A et al (2017) Relationships between ultrasound enthesitis, disease activity and axial radiographic structural changes in patients with early spondyloarthritis: data from DESIR cohort. RMD Open 3:e000482. \n                    https:\/\/doi.org\/10.1136\/rmdopen-2017-000482","journal-title":"RMD Open"},{"key":"1013_CR8","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1002\/ar.23684","volume":"300","author":"Takahashi Hideaki","year":"2017","unstructured":"Hideaki Takahashi, Hiroyuki Tamaki, Mineo Oyama, Noriaki Yamamoto, Hideaki Onishi (2017) Time-dependent changes in the structure of calcified fibrocartilage in the rat achilles tendon-bone interface with sciatic denervation. Anat Rec 300:2166\u20132174. \n                    https:\/\/doi.org\/10.1002\/ar.23684","journal-title":"Anat Rec"},{"key":"1013_CR9","doi-asserted-by":"publisher","DOI":"10.1177\/2325967117734517","author":"AT Hexter","year":"2017","unstructured":"Hexter AT, Pendegrass C, Haddad F, Blunn G (2017) Demineralized bone matrix to augment tendon-bone healing: a systematic review. Orthop J Sports Med. \n                    https:\/\/doi.org\/10.1177\/2325967117734517","journal-title":"Orthop J Sports Med"},{"key":"1013_CR10","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1016\/j.arthro.2017.03.031","volume":"33","author":"H Nakagawa","year":"2017","unstructured":"Nakagawa H, Morihara T, Fujiwara H et al (2017) Effect of footprint preparation on tendon-to-bone healing a histologic and biomechanical study in a rat rotator cuff repair model. Arthrosc J Arthroscopic Relat Surg 33:1482\u20131492. \n                    https:\/\/doi.org\/10.1016\/j.arthro.2017.03.031","journal-title":"Arthrosc J Arthroscopic Relat Surg"},{"key":"1013_CR11","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1007\/s00264-014-2391-1","volume":"38","author":"P Hernigou","year":"2014","unstructured":"Hernigou P, Flouzat Lachaniette CH, Delambre J et al (2014) Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop 38:1811\u20131818. \n                    https:\/\/doi.org\/10.1007\/s00264-014-2391-1","journal-title":"Int Orthop"},{"key":"1013_CR12","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.actbio.2017.11.017","volume":"65","author":"JL Zitnay","year":"2018","unstructured":"Zitnay JL, Reese SP, Tran G, Farhang N, Bowles RD, Weiss JA (2018) Fabrication of dense anisotropic collagen scaffolds using biaxial compression. Acta Biomater 65:76\u201387. \n                    https:\/\/doi.org\/10.1016\/j.actbio.2017.11.017","journal-title":"Acta Biomater"},{"key":"1013_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2016.00213","author":"CR Fellows","year":"2016","unstructured":"Fellows CR, Matta C, Zakany R, Khan IM, Mobasheri A (2016) Adipose, bone marrow and synovial joint-derived mesenchymal stem cells for cartilage repair. Front Genet. \n                    https:\/\/doi.org\/10.3389\/fgene.2016.00213","journal-title":"Front Genet"},{"key":"1013_CR14","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1177\/0363546509360924","volume":"38","author":"AD Mazzocca","year":"2010","unstructured":"Mazzocca AD, McCarthy MBR, Chowaniec DM, Cote MP, Arciero RA, Drissi H (2010) Rapid isolation of human stem cells (connective tissue progenitor cells) from the proximal humerus during arthroscopic rotator cuff surgery. Am J Sports Med 38:1438\u20131447. \n                    https:\/\/doi.org\/10.1177\/0363546509360924","journal-title":"Am J Sports Med"},{"key":"1013_CR15","doi-asserted-by":"publisher","first-page":"3322","DOI":"10.1177\/0363546517720199","volume":"45","author":"H Honda","year":"2017","unstructured":"Honda H, Gotoh M, Kanazawa T et al (2017) Hyaluronic acid accelerates tendon-to-bone healing after rotator cuff repair. Am J Sports Med 45:3322\u20133330. \n                    https:\/\/doi.org\/10.1177\/0363546517720199","journal-title":"Am J Sports Med"},{"key":"1013_CR16","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1177\/0363546517735850","volume":"46","author":"N Sevivas","year":"2018","unstructured":"Sevivas N, Teixeira FG, Portugal R et al (2018) Mesenchymal stem cell secretome improves tendon cell viability in vitro and tendon-bone healing in vivo when a tissue engineering strategy is used in a rat model of chronic massive rotator cuff tear. Am J Sports Med 46:449\u2013459. \n                    https:\/\/doi.org\/10.1177\/0363546517735850","journal-title":"Am J Sports Med"},{"key":"1013_CR17","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1177\/0363546517702863","volume":"45","author":"YS Kim","year":"2017","unstructured":"Kim YS, Sung CH, Chung SH, Kwak SJ, Koh YG (2017) Does an injection of adipose-derived mesenchymal stem cells loaded in fibrin glue influence rotator cuff repair outcomes? A clinical and magnetic resonance imaging study. Am J Sports Med 45:2010\u20132018. \n                    https:\/\/doi.org\/10.1177\/0363546517702863","journal-title":"Am J Sports Med"},{"key":"1013_CR18","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1038\/nm1630","volume":"13","author":"Y Bi","year":"2007","unstructured":"Bi Y, Ehirchiou D, Kilts TM et al (2007) Identification of tendon stem\/progenitor cells and the role of the extracellular matrix in their niche. Nat Med 13:1219\u20131227. \n                    https:\/\/doi.org\/10.1038\/nm1630","journal-title":"Nat Med"},{"key":"1013_CR19","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1002\/jor.21123","volume":"28","author":"J Zhang","year":"2010","unstructured":"Zhang J, Pan T, Liu Y, Wang JH-C (2010) Mouse treadmill running enhances tendons by expanding the pool of tendon stem cells (TSCs) and TSC-related cellular production of collagen. J Orthop Res 28:1178\u20131183. \n                    https:\/\/doi.org\/10.1002\/jor.21123","journal-title":"J Orthop Res"},{"key":"1013_CR20","doi-asserted-by":"publisher","first-page":"20677","DOI":"10.3402\/jev.v2i0.20677","volume":"2","author":"R Crescitelli","year":"2013","unstructured":"Crescitelli R, L\u00e4sser C, Szab\u00f3 TG et al (2013) Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes. J Extracell Vesicles 2:20677. \n                    https:\/\/doi.org\/10.3402\/jev.v2i0.20677","journal-title":"J Extracell Vesicles"},{"key":"1013_CR21","doi-asserted-by":"publisher","first-page":"24215","DOI":"10.3402\/jev.v3.24215","volume":"3","author":"MI Zonneveld","year":"2014","unstructured":"Zonneveld MI, Brisson AR, van Herwijnen MJC et al (2014) Recovery of extracellular vesicles from human breast milk is influenced by sample collection and vesicle isolation procedures. J Extracell Vesicles 3:24215. \n                    https:\/\/doi.org\/10.3402\/jev.v3.24215","journal-title":"J Extracell Vesicles"},{"key":"1013_CR22","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jse.2012.02.007","volume":"22","author":"Y Kida","year":"2013","unstructured":"Kida Y, Morihara T, Matsuda K-I et al (2013) Bone marrow\u2013derived cells from the footprint infiltrate into the repaired rotator cuff. J Shoulder Elbow Surg 22:197\u2013205. \n                    https:\/\/doi.org\/10.1016\/j.jse.2012.02.007","journal-title":"J Shoulder Elbow Surg"},{"key":"1013_CR23","doi-asserted-by":"publisher","first-page":"12888","DOI":"10.1038\/s41598-017-13105-9","volume":"7","author":"RD Gasperi","year":"2017","unstructured":"Gasperi RD, Hamidi S, Harlow LM, Ksiezak-Reding H, Bauman WA, Cardozo CP (2017) Denervation-related alterations and biological activity of miRNAs contained in exosomes released by skeletal muscle fibers. Sci Rep 7:12888. \n                    https:\/\/doi.org\/10.1038\/s41598-017-13105-9","journal-title":"Sci Rep"},{"key":"1013_CR24","doi-asserted-by":"publisher","first-page":"e126","DOI":"10.1038\/mtna.2013.60","volume":"2","author":"JL Munoz","year":"2013","unstructured":"Munoz JL, Bliss SA, Greco SJ, Ramkissoon SH, Ligon KL, Rameshwar P (2013) Delivery of functional anti-mir-9 by mesenchymal stem cell\u2013derived exosomes to glioblastoma multiforme cells conferred chemosensitivity. Mol Ther Nucleic Acids 2:e126. \n                    https:\/\/doi.org\/10.1038\/mtna.2013.60","journal-title":"Mol Ther Nucleic Acids"},{"key":"1013_CR25","doi-asserted-by":"publisher","first-page":"956","DOI":"10.3390\/ijms18050956","volume":"18","author":"UTT Than","year":"2017","unstructured":"Than UTT, Guanzon D, Leavesley D, Parker T (2017) Association of extracellular membrane vesicles with cutaneous wound healing. Int J Mol Sci 18:956. \n                    https:\/\/doi.org\/10.3390\/ijms18050956","journal-title":"Int J Mol Sci"},{"key":"1013_CR26","first-page":"4341","volume":"9","author":"MB Fouda","year":"2017","unstructured":"Fouda MB, Thankam FG, Dilisio MF, Agrawal DK (2017) Alterations in tendon microenvironment in response to mechanical load: potential molecular targets for treatment strategies. Am J Transl Res. 9:4341\u20134360","journal-title":"Am J Transl Res."},{"key":"1013_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/srep32993","author":"L Hu","year":"2016","unstructured":"Hu L, Wang J, Zhou X et al (2016) Exosomes derived from human adipose mesenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts. Sci Rep. \n                    https:\/\/doi.org\/10.1038\/srep32993","journal-title":"Sci Rep"},{"key":"1013_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12967-014-0365-0","volume":"13","author":"J Zhang","year":"2015","unstructured":"Zhang J, Guan J, Niu X et al (2015) Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis. J Transl Med 13:1\u20132. \n                    https:\/\/doi.org\/10.1186\/s12967-015-0417-0","journal-title":"J Transl Med"},{"key":"1013_CR29","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13451","author":"EW Choi","year":"2017","unstructured":"Choi EW, Seo MK, Woo EY, Kim SH, Park EJ, Kim S (2017) Exosomes from human adipose-derived stem cells promote proliferation and migration of skin fibroblasts. Exp Dermatol. \n                    https:\/\/doi.org\/10.1111\/exd.13451","journal-title":"Exp Dermatol"},{"key":"1013_CR30","doi-asserted-by":"publisher","first-page":"144","DOI":"10.15283\/ijsc17043","volume":"10","author":"OS El-Tookhy","year":"2017","unstructured":"El-Tookhy OS, Shamaa AA, Shehab GG, Abdallah AN, Azzam OM (2017) Histological evaluation of experimentally induced critical size defect skin wounds using exosomal solution of mesenchymal stem cells derived microvesicles. Int J Stem Cells 10:144\u2013153. \n                    https:\/\/doi.org\/10.15283\/ijsc17043","journal-title":"Int J Stem Cells"},{"key":"1013_CR31","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1089\/wound.2011.0294","volume":"1","author":"AM Hocking","year":"2012","unstructured":"Hocking AM (2012) Mesenchymal stem cell therapy for cutaneous wounds. Adv Wound Care (New Rochelle) 1:166\u2013171. \n                    https:\/\/doi.org\/10.1089\/wound.2011.0294","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"1013_CR32","doi-asserted-by":"publisher","first-page":"13321","DOI":"10.1038\/s41598-017-12919-x","volume":"7","author":"L Wang","year":"2017","unstructured":"Wang L, Hu L, Zhou X et al (2017) Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling. Sci Rep 7:13321. \n                    https:\/\/doi.org\/10.1038\/s41598-017-12919-x","journal-title":"Sci Rep"},{"key":"1013_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0660-9","author":"M Komaki","year":"2017","unstructured":"Komaki M, Numata Y, Morioka C et al (2017) Exosomes of human placenta-derived mesenchymal stem cells stimulate angiogenesis. Stem Cell Res Ther. \n                    https:\/\/doi.org\/10.1186\/s13287-017-0660-9","journal-title":"Stem Cell Res Ther"},{"key":"1013_CR34","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1002\/stem.2575","volume":"35","author":"DG Phinney","year":"2017","unstructured":"Phinney DG, Pittenger MF (2017) MSC-derived exosomes for cell-free therapy. Stem Cells 35:851\u2013858","journal-title":"Stem Cells"},{"key":"1013_CR35","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1089\/wound.2013.0485","volume":"4","author":"M Xue","year":"2015","unstructured":"Xue M, Jackson CJ (2015) Extracellular matrix reorganization during wound healing and its impact on abnormal scarring. Adv Wound Care (New Rochelle). 4:119\u2013136. \n                    https:\/\/doi.org\/10.1089\/wound.2013.0485","journal-title":"Adv Wound Care (New Rochelle)."},{"key":"1013_CR36","doi-asserted-by":"publisher","DOI":"10.1177\/1849454416663660","author":"V Laghezza Masci","year":"2016","unstructured":"Laghezza Masci V, Taddei AR, Gambellini G, Giorgi F, Fausto AM (2016) Microvesicles shed from fibroblasts act as metalloproteinase carriers in a 3-D collagen matrix. J Circ Biomark. \n                    https:\/\/doi.org\/10.1177\/1849454416663660","journal-title":"J Circ Biomark"},{"key":"1013_CR37","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jdermsci.2016.06.013","volume":"84","author":"K Nakamura","year":"2016","unstructured":"Nakamura K, Jinnin M, Harada M et al (2016) Altered expression of CD63 and exosomes in scleroderma dermal fibroblasts. J Dermatol Sci 84:30\u201339. \n                    https:\/\/doi.org\/10.1016\/j.jdermsci.2016.06.013","journal-title":"J Dermatol Sci"},{"key":"1013_CR38","doi-asserted-by":"publisher","first-page":"836","DOI":"10.7150\/ijbs.14809","volume":"12","author":"X Qi","year":"2016","unstructured":"Qi X, Zhang J, Yuan H et al (2016) Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells repair critical-sized bone defects through enhanced angiogenesis and osteogenesis in osteoporotic rats. Int J Biol Sci 12:836\u2013849. \n                    https:\/\/doi.org\/10.7150\/ijbs.14809","journal-title":"Int J Biol Sci"},{"key":"1013_CR39","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13287-017-0632-0","volume":"8","author":"Y Wang","year":"2017","unstructured":"Wang Y, Yu D, Liu Z et al (2017) Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix. Stem Cell Res Ther 8:189. \n                    https:\/\/doi.org\/10.1186\/s13287-017-0632-0","journal-title":"Stem Cell Res Ther"},{"key":"1013_CR40","doi-asserted-by":"publisher","first-page":"180","DOI":"10.7150\/thno.17133","volume":"7","author":"S-C Tao","year":"2017","unstructured":"Tao S-C, Yuan T, Zhang Y-L, Yin W-J, Guo S-C, Zhang C-Q (2017) Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model. Theranostics 7:180\u2013195. \n                    https:\/\/doi.org\/10.7150\/thno.17133","journal-title":"Theranostics"},{"key":"1013_CR41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.biomaterials.2018.04.055","volume":"174","author":"A Bier","year":"2018","unstructured":"Bier A, Berenstein P, Kronfeld N et al (2018) Placenta-derived mesenchymal stromal cells and their exosomes exert therapeutic effects in Duchenne Muscular Dystrophy. Biomaterials 174:67\u201378. \n                    https:\/\/doi.org\/10.1016\/j.biomaterials.2018.04.055","journal-title":"Biomaterials"},{"key":"1013_CR42","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/B978-0-12-381510-1.00081-8","volume-title":"Muscle","author":"E McNally","year":"2012","unstructured":"McNally E (2012) Chapter 81\u2014novel targets and approaches to treating skeletal muscle disease. In: Hill JA, Olson EN (eds) Muscle. Academic Press, Boston\/Waltham, pp 1095\u20131103. \n                    https:\/\/doi.org\/10.1016\/b978-0-12-381510-1.00081-8"},{"key":"1013_CR43","doi-asserted-by":"publisher","first-page":"e88685","DOI":"10.1371\/journal.pone.0088685","volume":"9","author":"Y Feng","year":"2014","unstructured":"Feng Y, Huang W, Wani M, Yu X, Ashraf M (2014) Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS One 9:e88685. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0088685","journal-title":"PLoS One"},{"key":"1013_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19581-x","author":"SW Ferguson","year":"2018","unstructured":"Ferguson SW, Wang J, Lee CJ et al (2018) The microRNA regulatory landscape of MSC-derived exosomes: a systems view. Sci Rep. \n                    https:\/\/doi.org\/10.1038\/s41598-018-19581-x","journal-title":"Sci Rep"},{"key":"1013_CR45","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10616-018-0264-y","volume":"71","author":"T Xu","year":"2019","unstructured":"Xu T, Xu M, Bai J et al (2019) Tenocyte-derived exosomes induce the tenogenic differentiation of mesenchymal stem cells through TGF-\u03b2. Cytotechnology 71:57\u201365. \n                    https:\/\/doi.org\/10.1007\/s10616-018-0264-y","journal-title":"Cytotechnology"},{"key":"1013_CR46","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1177\/0363546515597488","volume":"43","author":"T Tokunaga","year":"2015","unstructured":"Tokunaga T, Shukunami C, Okamoto N et al (2015) FGF-2 stimulates the growth of tenogenic progenitor cells to facilitate the generation of tenomodulin-positive tenocytes in a rat rotator cuff healing model. Am J Sports Med 43:2411\u20132422. \n                    https:\/\/doi.org\/10.1177\/0363546515597488","journal-title":"Am J Sports Med"},{"key":"1013_CR47","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1016\/j.jse.2017.03.020","volume":"26","author":"T Tokunaga","year":"2017","unstructured":"Tokunaga T, Karasugi T, Arimura H et al (2017) Enhancement of rotator cuff tendon\u2013bone healing with fibroblast growth factor 2 impregnated in gelatin hydrogel sheets in a rabbit model. J Shoulder Elbow Surg 26:1708\u20131717. \n                    https:\/\/doi.org\/10.1016\/j.jse.2017.03.020","journal-title":"J Shoulder Elbow Surg"},{"key":"1013_CR48","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.omtn.2018.11.006","volume":"14","author":"H Cui","year":"2018","unstructured":"Cui H, He Y, Chen S, Zhang D, Yu Y, Fan C (2018) Macrophage-derived miRNA-containing exosomes induce peritendinous fibrosis after tendon injury through the miR-21-5p\/Smad7 pathway. Mol Ther Nucleic Acids 14:114\u2013130. \n                    https:\/\/doi.org\/10.1016\/j.omtn.2018.11.006","journal-title":"Mol Ther Nucleic Acids"},{"key":"1013_CR49","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/j.jtcvs.2015.07.035","volume":"150","author":"AC Gaffey","year":"2015","unstructured":"Gaffey AC, Chen MH, Venkataraman CM et al (2015) Injectable shear-thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium. J Thorac Cardiovasc Surg 150:1268\u20131277. \n                    https:\/\/doi.org\/10.1016\/j.jtcvs.2015.07.035","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1013_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.08.076","author":"DK Agrawal","year":"2018","unstructured":"Agrawal DK, Siddique A (2018) Rejuvenation of \u201cbroken heart\u201d with bioengineered gel. J Thorac Cardiovasc Surg. \n                    https:\/\/doi.org\/10.1016\/j.jtcvs.2018.08.076","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1013_CR51","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s10237-014-0628-y","volume":"14","author":"HY Nam","year":"2015","unstructured":"Nam HY, Pingguan-Murphy B, Abbas AA, Merican AM, Kamarul T (2015) The proliferation and tenogenic differentiation potential of bone marrow-derived mesenchymal stromal cell are influenced by specific uniaxial cyclic tensile loading conditions. Biomech Model Mechanobiol 14:649\u2013663. \n                    https:\/\/doi.org\/10.1007\/s10237-014-0628-y","journal-title":"Biomech Model Mechanobiol"},{"key":"1013_CR52","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.clinbiomech.2017.10.014","volume":"50","author":"H Miyamoto","year":"2017","unstructured":"Miyamoto H, Aoki M, Hidaka E, Fujimiya M, Uchiyama E (2017) Measurement of strain and tensile force of the Supraspinatus tendon under conditions that simulates low angle isometric elevation of the gleno-humeral joint: influence of adduction torque and joint positioning. Clin Biomech 50:92\u201398. \n                    https:\/\/doi.org\/10.1016\/j.clinbiomech.2017.10.014","journal-title":"Clin Biomech"},{"key":"1013_CR53","doi-asserted-by":"publisher","first-page":"e0178117","DOI":"10.1371\/journal.pone.0178117","volume":"12","author":"HY Nam","year":"2017","unstructured":"Nam HY, Raghavendran HRB, Pingguan-Murphy B, Abbas AA, Merican AM, Kamarul T (2017) Fate of tenogenic differentiation potential of human bone marrow stromal cells by uniaxial stretching affected by stretch-activated calcium channel agonist gadolinium. PLoS One 12:e0178117. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0178117","journal-title":"PLoS One"},{"key":"1013_CR54","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/aps.2017.162","volume":"39","author":"S Samanta","year":"2018","unstructured":"Samanta S, Rajasingh S, Drosos N, Zhou Z, Dawn B, Rajasingh J (2018) Exosomes: new molecular targets of diseases. Acta Pharmacol Sin 39:501\u2013513. \n                    https:\/\/doi.org\/10.1038\/aps.2017.162","journal-title":"Acta Pharmacol Sin"},{"key":"1013_CR55","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jpedsurg.2018.10.020","volume":"54","author":"SA Tracy","year":"2019","unstructured":"Tracy SA, Ahmed A, Tigges JC et al (2019) A comparison of clinically relevant sources of mesenchymal stem cell-derived exosomes: bone marrow and amniotic fluid. J Pediatr Surg 54:86\u201390. \n                    https:\/\/doi.org\/10.1016\/j.jpedsurg.2018.10.020","journal-title":"J Pediatr Surg"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-019-01013-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00774-019-01013-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-019-01013-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T19:27:43Z","timestamp":1590866863000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00774-019-01013-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,1]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["1013"],"URL":"https:\/\/doi.org\/10.1007\/s00774-019-01013-z","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,1]]},"assertion":[{"value":"30 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors have read the journal\u2019s policy on disclosure of potential conflicts of interest. The authors have no other relevant affiliations or financial or non-financial involvement with any organization or entity with financial or non-financial interest or conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}