{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:12:23Z","timestamp":1790417543274,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00774-020-01200-3","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T02:30:29Z","timestamp":1613010629000},"page":"631-638","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Plasma periostin as a biomarker of osteoporosis in postmenopausal women with type 2 diabetes"],"prefix":"10.1007","volume":"39","author":[{"given":"Junyan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-996X","authenticated-orcid":false,"given":"Qingzhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"1200_CR1","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/1471-2474-13-163","volume":"13","author":"S Waterloo","year":"2012","unstructured":"Waterloo S, Nguyen T, Ahmed LA, Center JR, Morseth B, Nguyen ND, Eisman JA, S\u00f8gaard AJ, Emaus N (2012) Important risk factors and attributable risk of vertebral fractures in the population-based Troms\u00f8 study. BMC Musculoskelet Disord 13:163","journal-title":"BMC Musculoskelet Disord"},{"key":"1200_CR2","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1001\/jama.2011.715","volume":"305","author":"AV Schwartz","year":"2011","unstructured":"Schwartz AV, Vittinghoff E, Bauer DC, Hillier TA, Strotmeyer ES, Ensrud KE, Donaldson MG, Cauley JA, Harris TB, Koster A (2011) Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes. JAMA 305:2184\u20132192","journal-title":"JAMA"},{"key":"1200_CR3","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1002\/jbmr.3057","volume":"32","author":"AG Nilsson","year":"2017","unstructured":"Nilsson AG, Sundh D, Johansson L, Nilsson M, Mellstr\u00f6m D, Rud\u00e4ng R, Zoulakis M, Wallander M, Darelid A, Lorentzon M (2017) Type 2 diabetes mellitus is associated with better bone microarchitecture but lower bone material strength and poorer physical function in elderly women: a population-based study. J Bone Miner Res 32:1062\u20131071","journal-title":"J Bone Miner Res"},{"key":"1200_CR4","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/jbmr.1763","volume":"28","author":"JM Patsch","year":"2013","unstructured":"Patsch JM, Burghardt AJ, Yap SP, Baum T, Schwartz AV, Joseph GB, Link TM (2013) Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures. J Bone Miner Res 28:313\u2013324","journal-title":"J Bone Miner Res"},{"key":"1200_CR5","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1002\/jbmr.2388","volume":"30","author":"Y Bala","year":"2015","unstructured":"Bala Y, Bui QM, Wang XF, Iuliano S, Wang Q, Ghasem-Zadeh A, Rozental TD, Bouxsein ML, Zebaze RM, Seeman E (2015) Trabecular and cortical microstructure and fragility of the distal radius in women. J Bone Miner Res 30:621\u2013629","journal-title":"J Bone Miner Res"},{"key":"1200_CR6","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00198-014-2927-7","volume":"26","author":"E Yu","year":"2015","unstructured":"Yu E, Putman MS, Derrico N, Abrishamanian-Garcia G, Finkelstein JS, Bouxsein ML (2015) Defects in cortical microarchitecture among African\u2013American women with type 2 diabetes. Osteoporos Int 26:673\u2013679","journal-title":"Osteoporos Int"},{"key":"1200_CR7","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1007\/s00198-016-3614-7","volume":"27","author":"U Heilmeier","year":"2016","unstructured":"Heilmeier U, Cheng K, Pasco C, Parrish R, Nirody J, Patsch J, Zhang C, Joseph G, Burghardt A, Schwartz A (2016) Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics. Osteoporos Int 27:2791\u20132802","journal-title":"Osteoporos Int"},{"key":"1200_CR8","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1359\/jbmr.081108","volume":"24","author":"G Holzer","year":"2009","unstructured":"Holzer G, Von Skrbensky G, Holzer LA, Pichl W (2009) Hip fractures and the contribution of cortical versus trabecular bone to femoral neck strength. J Bone Miner Res 24:468\u2013474","journal-title":"J Bone Miner Res"},{"key":"1200_CR9","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.atherosclerosis.2009.07.046","volume":"208","author":"G Li","year":"2010","unstructured":"Li G, Jin R, Norris RA, Zhang L, Yu S, Wu F, Markwald RR, Nanda A, Conway SJ, Smyth SS (2010) Periostin mediates vascular smooth muscle cell migration through the integrins \u03b1\u03bd\u03b23 and \u03b1\u03bd\u03b25 and focal adhesion kinase (FAK) pathway. Atherosclerosis 208:358\u2013365","journal-title":"Atherosclerosis"},{"key":"1200_CR10","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.1007\/s00018-011-0784-5","volume":"68","author":"A Kudo","year":"2011","unstructured":"Kudo A (2011) Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell. Cell Mol Life Sci 68:3201","journal-title":"Cell Mol Life Sci"},{"key":"1200_CR11","unstructured":"Bonnet N, Rousseau J, Garnero P, Ferrari S (2011) Periostin: a novel serum marker of cortical bone formation. J Bone Miner Res:SU0113"},{"key":"1200_CR12","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.matbio.2010.07.001","volume":"29","author":"D Fortunati","year":"2010","unstructured":"Fortunati D, Reppe S, Fjeldheim \u00c5-K, Nielsen M, Gautvik VT, Gautvik KM (2010) Periostin is a collagen associated bone matrix protein regulated by parathyroid hormone. Matrix Biol 29:594\u2013601","journal-title":"Matrix Biol"},{"key":"1200_CR13","doi-asserted-by":"publisher","first-page":"35939","DOI":"10.1074\/jbc.M109.060335","volume":"284","author":"N Bonnet","year":"2009","unstructured":"Bonnet N, Standley KN, Bianchi EN, Stadelmann V, Foti M, Conway SJ, Ferrari SL (2009) The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity. J Biol Chem 284:35939\u201335950","journal-title":"J Biol Chem"},{"key":"1200_CR14","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.orthres.2003.10.007","volume":"22","author":"T Nakazawa","year":"2004","unstructured":"Nakazawa T, Nakajima A, Seki N, Okawa A, Kato M, Moriya H, Amizuka N, Einhorn TA, Yamazaki M (2004) Gene expression of periostin in the early stage of fracture healing detected by cDNA microarray analysis. J Orthop Res 22:520\u2013525","journal-title":"J Orthop Res"},{"key":"1200_CR15","doi-asserted-by":"publisher","first-page":"e78347","DOI":"10.1371\/journal.pone.0078347","volume":"8","author":"N Bonnet","year":"2013","unstructured":"Bonnet N, Gineyts E, Ammann P, Conway SJ, Garnero P, Ferrari S (2013) Periostin deficiency increases bone damage and impairs injury response to fatigue loading in adult mice. PLoS ONE 8:e78347","journal-title":"PLoS ONE"},{"key":"1200_CR16","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.bone.2017.03.041","volume":"99","author":"JS Walsh","year":"2017","unstructured":"Walsh JS, Gossiel F, Scott JR, Paggiosi MA, Eastell R (2017) Effect of age and gender on serum periostin: relationship to cortical measures, bone turnover and hormones. Bone 99:8\u201313","journal-title":"Bone"},{"key":"1200_CR17","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.bone.2014.10.011","volume":"71","author":"M Gerbaix","year":"2015","unstructured":"Gerbaix M, Vico L, Ferrari SL, Bonnet N (2015) Periostin expression contributes to cortical bone loss during unloading. Bone 71:94\u2013100","journal-title":"Bone"},{"key":"1200_CR18","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00223-010-9391-y","volume":"87","author":"S Conti\u00e9","year":"2010","unstructured":"Conti\u00e9 S, Voorzanger-Rousselot N, Litvin J, Bonnet N, Ferrari S, Cl\u00e9zardin P, Garnero P (2010) Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice. Calcif Tissue Int 87:341\u2013350","journal-title":"Calcif Tissue Int"},{"key":"1200_CR19","first-page":"145","volume":"46","author":"A Anastasilakis","year":"2014","unstructured":"Anastasilakis A, Polyzos S, Makras P, Savvides M, Sakellariou G, Gkiomisi A, Papatheodorou A, Terpos E (2014) Circulating periostin levels do not differ between postmenopausal women with normal and low bone mass and are not affected by zoledronic acid treatment. Horm Metab Res 46:145\u2013149","journal-title":"Horm Metab Res"},{"key":"1200_CR20","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1007\/s00198-011-1892-7","volume":"23","author":"B Merle","year":"2012","unstructured":"Merle B, Garnero P (2012) The multiple facets of periostin in bone metabolism. Osteoporos Int 23:1199\u20131212","journal-title":"Osteoporos Int"},{"key":"1200_CR21","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1007\/s00198-011-1861-1","volume":"23","author":"S-M Xiao","year":"2012","unstructured":"Xiao S-M, Gao Y, Cheung C-L, Bow C, Lau K-S, Sham P, Tan K, Kung A (2012) Association of CDX1 binding site of periostin gene with bone mineral density and vertebral fracture risk. Osteoporos Int 23:1877\u20131887","journal-title":"Osteoporos Int"},{"key":"1200_CR22","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.bone.2015.08.014","volume":"81","author":"B-J Kim","year":"2015","unstructured":"Kim B-J, Rhee Y, Kim CH, Baek KH, Min Y-K, Kim D-Y, Ahn SH, Kim H, Lee SH, Lee S-Y (2015) Plasma periostin associates significantly with non-vertebral but not vertebral fractures in postmenopausal women: clinical evidence for the different effects of periostin depending on the skeletal site. Bone 81:435\u2013441","journal-title":"Bone"},{"key":"1200_CR23","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1007\/s12020-016-1144-x","volume":"56","author":"SA Polyzos","year":"2017","unstructured":"Polyzos SA, Kountouras J, Anastasilakis AD, Papatheodorou A, Kokkoris P, Terpos E (2017) Circulating periostin in patients with nonalcoholic fatty liver disease. Endocrine 56:438\u2013441","journal-title":"Endocrine"},{"key":"1200_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-016-0001-8","volume":"6","author":"Z Yang","year":"2016","unstructured":"Yang Z, Zhang H, Niu Y, Zhang W, Zhu L, Li X, Lu S, Fan J, Li X, Ning G (2016) Circulating periostin in relation to insulin resistance and nonalcoholic fatty liver disease among overweight and obese subjects. Sci Rep 6:1\u20136","journal-title":"Sci Rep"},{"key":"1200_CR25","first-page":"6423637","volume":"2016","author":"Y Luo","year":"2016","unstructured":"Luo Y, Qu H, Wang H, Wei H, Wu J, Duan Y, Liu D, Deng H (2016) Plasma periostin levels are increased in Chinese subjects with obesity and type 2 diabetes and are positively correlated with glucose and lipid parameters. Mediat Inflamm 2016:6423637","journal-title":"Mediat Inflamm"},{"key":"1200_CR26","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1007\/s40618-017-0820-x","volume":"41","author":"Y Ding","year":"2018","unstructured":"Ding Y, Ge Q, Qu H, Feng Z, Long J, Wei Q, Zhou Q, Wu R, Yao L, Deng H (2018) Increased serum periostin concentrations are associated with the presence of diabetic retinopathy in patients with type 2 diabetes mellitus. J Endocrinol Invest 41:937\u2013945","journal-title":"J Endocrinol Invest"},{"key":"1200_CR27","doi-asserted-by":"publisher","first-page":"5670","DOI":"10.1167\/iovs.10-6625","volume":"52","author":"S Yoshida","year":"2011","unstructured":"Yoshida S, Ishikawa K, Asato R, Arima M, Sassa Y, Yoshida A, Yoshikawa H, Narukawa K, Obika S, Ono J (2011) Increased expression of periostin in vitreous and fibrovascular membranes obtained from patients with proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 52:5670\u20135678","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1200_CR28","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1007\/s10157-019-01744-3","volume":"23","author":"NMQ El-Dawla","year":"2019","unstructured":"El-Dawla NMQ, Sallam A-AM, El-Hefnawy MH, El-Mesallamy HO (2019) E-cadherin and periostin in early detection and progression of diabetic nephropathy: epithelial-to-mesenchymal transition. Clin Exp Nephrol 23:1050\u20131057","journal-title":"Clin Exp Nephrol"},{"key":"1200_CR29","doi-asserted-by":"publisher","first-page":"e0124055","DOI":"10.1371\/journal.pone.0124055","volume":"10","author":"B Satirapoj","year":"2015","unstructured":"Satirapoj B, Tassanasorn S, Charoenpitakchai M, Supasyndh O (2015) Periostin as a tissue and urinary biomarker of renal injury in type 2 diabetes mellitus. PLoS ONE 10:e0124055","journal-title":"PLoS ONE"},{"key":"1200_CR30","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1136\/jim-2019-001135","volume":"68","author":"MTA Ghafar","year":"2020","unstructured":"Ghafar MTA, Shalaby KH, Okda HI, Soliman NA, Keshk WA (2020) Assessment of two novel renal tubular proteins in type 2 diabetic patients with nephropathy. J Investig Med 68:748\u2013755","journal-title":"J Investig Med"},{"key":"1200_CR31","first-page":"RC04","volume":"9","author":"S Singh","year":"2015","unstructured":"Singh S, Kumar D, Lal AK (2015) Serum osteocalcin as a diagnostic biomarker for primary osteoporosis in women. J Clin Diagn Res 9:RC04","journal-title":"J Clin Diagn Res"},{"key":"1200_CR32","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1210\/jc.2013-3893","volume":"99","author":"J Rousseau","year":"2014","unstructured":"Rousseau J, Sornay-Rendu E, Bertholon C, Chapurlat R, Garnero P (2014) Serum periostin is associated with fracture risk in postmenopausal women: a 7-year prospective analysis of the OFELY study. J Clin Endocrinol Metabol 99:2533\u20132539","journal-title":"J Clin Endocrinol Metabol"},{"key":"1200_CR33","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.metabol.2014.11.006","volume":"64","author":"T Mehta","year":"2015","unstructured":"Mehta T, B\u016f\u017ekov\u00e1 P, Sarnak MJ, Chonchol M, Cauley JA, Wallace E, Fink HA, Robbins J, Jalal D (2015) Serum urate levels and the risk of hip fractures: data from the Cardiovascular Health Study. Metabolism 64:438\u2013446","journal-title":"Metabolism"},{"key":"1200_CR34","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.molmed.2009.08.004","volume":"15","author":"F Wauquier","year":"2009","unstructured":"Wauquier F, Leotoing L, Coxam V, Guicheux J, Wittrant Y (2009) Oxidative stress in bone remodelling and disease. Trends Mol Med 15:468\u2013477","journal-title":"Trends Mol Med"},{"key":"1200_CR35","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1093\/rheumatology\/keu425","volume":"54","author":"GT Sakellariou","year":"2014","unstructured":"Sakellariou GT, Anastasilakis AD, Bisbinas I, Oikonomou D, Gerou S, Polyzos SA, Sayegh FE (2014) Circulating periostin levels in patients with AS: association with clinical and radiographic variables, inflammatory markers and molecules involved in bone formation. Rheumatology 54:908\u2013914","journal-title":"Rheumatology"},{"key":"1200_CR36","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s11033-011-0746-x","volume":"39","author":"F Wang","year":"2012","unstructured":"Wang F, Yang C, Song Y, Jiang Y, Ding Z (2012) Periostin gene polymorphisms, protein levels and risk of incident coronary artery disease. Mol Biol Rep 39:359\u2013367","journal-title":"Mol Biol Rep"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-020-01200-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00774-020-01200-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-020-01200-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T23:36:42Z","timestamp":1625701002000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00774-020-01200-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,10]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["1200"],"URL":"https:\/\/doi.org\/10.1007\/s00774-020-01200-3","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,10]]},"assertion":[{"value":"21 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Junyan Li, Xiaohong Niu, Qinqin Si, Qi Song, Miaomiao Jin, Ruijun Zhou, Jianbo Li and Qingzhong Wang declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}