{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:55:21Z","timestamp":1771260921029,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T00:00:00Z","timestamp":1618099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T00:00:00Z","timestamp":1618099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s00774-021-01227-0","type":"journal-article","created":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T13:02:21Z","timestamp":1618146141000},"page":"757-768","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The effect of aging on the nanostructure of murine alveolar bone and dentin"],"prefix":"10.1007","volume":"39","author":[{"given":"Chika","family":"Akabane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Pabisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Wagermaier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Roschger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Tobori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomichi","family":"Okano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Fratzl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Weinkamer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,11]]},"reference":[{"key":"1227_CR1","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1016\/j.archoralbio.2012.07.006","volume":"57","author":"GRS Naveh","year":"2012","unstructured":"Naveh GRS, Chattah NLT, Zaslansky P, Shahar R, Weiner S (2012) Tooth-PDL-bone complex: response to compressive loads encountered during mastication\u2014a review. Arch Oral Biol 57:1575\u20131584","journal-title":"Arch Oral Biol"},{"key":"1227_CR2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/S1369-7021(11)70056-6","volume":"14","author":"JW Dunlop","year":"2011","unstructured":"Dunlop JW, Weinkamer R, Fratzl P (2011) Artful interfaces within biological materials. Mater Today 14:70\u201378","journal-title":"Mater Today"},{"key":"1227_CR3","doi-asserted-by":"publisher","first-page":"5238","DOI":"10.1016\/j.biomaterials.2007.08.031","volume":"28","author":"SP Ho","year":"2007","unstructured":"Ho SP, Marshall SJ, Ryder MI, Marshall GW (2007) The tooth attachment mechanism defined by structure, chemical composition and mechanical properties of collagen fibers in the periodontium. Biomaterials 28:5238\u20135245","journal-title":"Biomaterials"},{"key":"1227_CR4","doi-asserted-by":"publisher","first-page":"6635","DOI":"10.1016\/j.biomaterials.2010.05.024","volume":"31","author":"SP Ho","year":"2010","unstructured":"Ho SP, Kurylo MP, Fong TK, Lee SS, Wagner HD, Ryder MI, Marshall GW (2010) The biomechanical characteristics of the bone-periodontal ligament\u2013cementum complex. Biomaterials 31:6635\u20136646","journal-title":"Biomaterials"},{"key":"1227_CR5","doi-asserted-by":"publisher","first-page":"9008","DOI":"10.1073\/pnas.1807324115","volume":"115","author":"GR Naveh","year":"2018","unstructured":"Naveh GR, Foster JE, Santisteban TMS, Yang X, Olsen BR (2018) Nonuniformity in ligaments is a structural strategy for optimizing functionality. Proc Natl Acad Sci 115:9008\u20139013","journal-title":"Proc Natl Acad Sci"},{"key":"1227_CR6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jmbbm.2016.11.020","volume":"67","author":"A Nikolaus","year":"2017","unstructured":"Nikolaus A, Currey JD, Lindtner T, Fleck C, Zaslansky P (2017) Importance of the variable periodontal ligament geometry for whole tooth mechanical function: a validated numerical study. J Mech Behav Biomed 67:61\u201373","journal-title":"J Mech Behav Biomed"},{"key":"1227_CR7","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.bone.2013.09.007","volume":"57","author":"SP Ho","year":"2013","unstructured":"Ho SP, Kurylo MP, Grandfield K, Hurng J, Herber R-P, Ryder MI, Altoe V, Aloni S, Feng JQ, Webb S (2013) The plastic nature of the human bone\u2013periodontal ligament\u2013tooth fibrous joint. Bone 57:455\u2013467","journal-title":"Bone"},{"key":"1227_CR8","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.msec.2010.12.002","volume":"31","author":"R Weinkamer","year":"2011","unstructured":"Weinkamer R, Fratzl P (2011) Mechanical adaptation of biological materials\u2014the examples of bone and wood. Mater Sci Eng C 31:1164\u20131173","journal-title":"Mater Sci Eng C"},{"key":"1227_CR9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1093\/ejo\/cjl001","volume":"28","author":"MC Meikle","year":"2006","unstructured":"Meikle MC (2006) The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100 years after Carl Sandstedt. Eur J Orthod 28:221\u2013240","journal-title":"Eur J Orthod"},{"key":"1227_CR10","doi-asserted-by":"publisher","first-page":"711","DOI":"10.2741\/e281","volume":"3","author":"M Goldberg","year":"2011","unstructured":"Goldberg M, Kulkarni AB, Young M, Boskey A (2011) Dentin: structure, composition and mineralization: the role of dentin ECM in dentin formation and mineralization. Front Biosci (Elite Ed) 3:711","journal-title":"Front Biosci (Elite Ed)"},{"key":"1227_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1601-1546.2012.00269.x","volume":"20","author":"L Tj\u00e4derhane","year":"2009","unstructured":"Tj\u00e4derhane L, Carrilho MR, Breschi L, Tay FR, Pashley DH (2009) Dentin basic structure and composition\u2014an overview. Endod Top 20:3\u201329","journal-title":"Endod Top"},{"key":"1227_CR12","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/j.1601-1546.2012.00266.x","volume":"20","author":"L Tj\u00e4derhane","year":"2012","unstructured":"Tj\u00e4derhane L, Haapasalo M (2012) The dentin\u2013pulp border: a dynamic interface between hard and soft tissues. Endod Top 20:52\u201384","journal-title":"Endod Top"},{"key":"1227_CR13","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/j.1601-1546.2010.00248.x","volume":"17","author":"D Tziafas","year":"2007","unstructured":"Tziafas D (2007) Dentinogenic potential of the dental pulp: facts and hypotheses. Endod Top 17:42\u201364","journal-title":"Endod Top"},{"key":"1227_CR14","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1016\/j.archoralbio.2015.10.002","volume":"60","author":"C Montoya","year":"2015","unstructured":"Montoya C, Arango-Santander S, Pel\u00e1ez-Vargas A, Arola D, Ossa E (2015) Effect of aging on the microstructure, hardness and chemical composition of dentin. Arch Oral Biol 60:1811\u20131820","journal-title":"Arch Oral Biol"},{"key":"1227_CR15","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/j.bone.2004.07.016","volume":"35","author":"RK Nalla","year":"2004","unstructured":"Nalla RK, Kruzic JJ, Kinney JH, Ritchie RO (2004) Effect of aging on the toughness of human cortical bone: evaluation by R-curves. Bone 35:1240\u20131246","journal-title":"Bone"},{"key":"1227_CR16","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1177\/0022034510377791","volume":"89","author":"AL Boskey","year":"2010","unstructured":"Boskey AL, Coleman R (2010) Aging and bone. J Dent Res 89:1333\u20131348","journal-title":"J Dent Res"},{"key":"1227_CR17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S8756-3282(97)00228-7","volume":"22","author":"P Zioupos","year":"1998","unstructured":"Zioupos P, Currey J (1998) Changes in the stiffness, strength, and toughness of human cortical bone with age. Bone 22:57\u201366","journal-title":"Bone"},{"key":"1227_CR18","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1359\/jbmr.060816","volume":"21","author":"JW Ager III","year":"2006","unstructured":"Ager JW III, Nalla RK, Balooch G, Kim G, Pugach M, Habelitz S, Marshall GW, Kinney JH, Ritchie RO (2006) On the increasing fragility of human teeth with age: a deep-UV resonance Raman study. J Bone Miner Res 21:1879\u20131887","journal-title":"J Bone Miner Res"},{"key":"1227_CR19","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.jmbbm.2009.01.008","volume":"2","author":"A Nazari","year":"2009","unstructured":"Nazari A, Bajaj D, Zhang D, Romberg E, Arola D (2009) Aging and the reduction in fracture toughness of human dentin. J Mech Behav Biomed 2:550\u2013559","journal-title":"J Mech Behav Biomed"},{"key":"1227_CR20","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/ger.12321","volume":"35","author":"C Montoya","year":"2018","unstructured":"Montoya C, Arola D, Ossa EA (2018) Deformation behaviour of aged coronal dentin. Gerodontology 35:95\u2013100","journal-title":"Gerodontology"},{"key":"1227_CR21","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s00198-009-1066-z","volume":"21","author":"M Saito","year":"2010","unstructured":"Saito M, Marumo K (2010) Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporosis Int 21:195\u2013214","journal-title":"Osteoporosis Int"},{"key":"1227_CR22","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.bone.2003.11.003","volume":"34","author":"O Akkus","year":"2004","unstructured":"Akkus O, Adar F, Schaffler MB (2004) Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone. Bone 34:443\u2013453","journal-title":"Bone"},{"key":"1227_CR23","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1016\/S0006-3495(00)76426-5","volume":"79","author":"I J\u00e4ger","year":"2000","unstructured":"J\u00e4ger I, Fratzl P (2000) Mineralized collagen fibrils: a mechanical model with a staggered arrangement of mineral particles. Biophys J 79:1737\u20131746","journal-title":"Biophys J"},{"key":"1227_CR24","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S1047-8477(02)00635-4","volume":"141","author":"I Zizak","year":"2003","unstructured":"Zizak I, Roschger P, Paris O, Misof BM, Berzlanovich A, Bernstorff S, Amenitsch H, Klaushofer K, Fratzl P (2003) Characteristics of mineral particles in the human bone\/cartilage interface. J Struct Biol 141:208\u2013217","journal-title":"J Struct Biol"},{"key":"1227_CR25","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.actbio.2019.03.020","volume":"89","author":"T Tang","year":"2019","unstructured":"Tang T, Wagermaier W, Schuetz R, Wang Q, Eltit F, Fratzl P, Wang R (2019) Hypermineralization in the femoral neck of the elderly. Acta Biomater 89:330\u2013342","journal-title":"Acta Biomater"},{"key":"1227_CR26","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/BF02409493","volume":"33","author":"S Chatterji","year":"1981","unstructured":"Chatterji S, Wall JC, Jeffery JW (1981) Age-related changes in the orientation and particle size of the mineral phase in human femoral cortical bone. Calcif Tissue Int 33:567\u2013574","journal-title":"Calcif Tissue Int"},{"key":"1227_CR27","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1039\/B402005G","volume":"14","author":"P Fratzl","year":"2004","unstructured":"Fratzl P, Gupta H, Paschalis E, Roschger P (2004) Structure and mechanical quality of the collagen\u2013mineral nano-composite in bone. J Mater Chem 14:2115\u20132123","journal-title":"J Mater Chem"},{"key":"1227_CR28","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1002\/jbmr.2528","volume":"30","author":"H Razi","year":"2015","unstructured":"Razi H, Birkhold AI, Weinkamer R, Duda GN, Willie BM, Checa S (2015) Aging leads to a dysregulation in mechanically driven bone formation and resorption. J Bone Miner Res 30:1864\u20131873","journal-title":"J Bone Miner Res"},{"key":"1227_CR29","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/B978-0-12-416617-2.00018-7","volume":"532","author":"S Pabisch","year":"2013","unstructured":"Pabisch S, Wagermaier W, Zander T, Li CH, Fratzl P (2013) Imaging the nanostructure of bone and dentin through small- and wide-angle X-ray scattering. Method Enzymol 532:391\u2013413","journal-title":"Method Enzymol"},{"key":"1227_CR30","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jsb.2016.09.007","volume":"196","author":"S Pabisch","year":"2016","unstructured":"Pabisch S, Akabane C, Wagermaier W, Roschger A, Ogura T, Hyodo R, Kataoka S, Tobori N, Okano T, Murakami S, Fratzl P, Weinkamer R (2016) The nanostructure of murine alveolar bone and its changes due to type 2 diabetes. J Struct Biol 196:223\u2013231","journal-title":"J Struct Biol"},{"key":"1227_CR31","doi-asserted-by":"publisher","first-page":"5479","DOI":"10.1016\/j.biomaterials.2010.03.030","volume":"31","author":"A M\u00e4rten","year":"2010","unstructured":"M\u00e4rten A, Fratzl P, Paris O, Zaslansky P (2010) On the mineral in collagen of human crown dentine. Biomaterials 31:5479\u20135490","journal-title":"Biomaterials"},{"key":"1227_CR32","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jmbbm.2013.12.014","volume":"32","author":"T Sui","year":"2014","unstructured":"Sui T, Sandholzer MA, Le Bourhis E, Baimpas N, Landini G, Korsunsky AM (2014) Structure-mechanical function relations at nano-scale in heat-affected human dental tissue. J Mech Behav Biomed Mater 32:113\u2013124","journal-title":"J Mech Behav Biomed Mater"},{"key":"1227_CR33","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00223-001-2012-z","volume":"69","author":"W Tesch","year":"2001","unstructured":"Tesch W, Eidelman N, Roschger P, Goldenberg F, Klaushofer K, Fratzl P (2001) Graded microstructure and mechanical properties of human crown dentin. Calcified Tissue Int 69:147\u2013157","journal-title":"Calcified Tissue Int"},{"key":"1227_CR34","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1111\/1556-4029.12400","volume":"59","author":"MA Sandholzer","year":"2014","unstructured":"Sandholzer MA, Sui T, Korsunsky AM, Walmsley AD, Lumley PJ, Landini G (2014) X-ray scattering evaluation of ultrastructural changes in human dental tissues with thermal treatment. J Forensic Sci 59:769\u2013774","journal-title":"J Forensic Sci"},{"key":"1227_CR35","doi-asserted-by":"publisher","first-page":"3363","DOI":"10.1016\/j.biomaterials.2004.09.004","volume":"26","author":"JH Kinney","year":"2005","unstructured":"Kinney JH, Nalla RK, Pople JA, Breunig TM, Ritchie RO (2005) Age-related transparent root dentin: mineral concentration, crystallite size, and mechanical properties. Biomaterials 26:3363\u20133376","journal-title":"Biomaterials"},{"key":"1227_CR36","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S8756-3282(98)00112-4","volume":"23","author":"P Roschger","year":"1998","unstructured":"Roschger P, Fratzl P, Eschberger J, Klaushofer K (1998) Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 23:319\u2013326","journal-title":"Bone"},{"key":"1227_CR37","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S8756-3282(97)00015-X","volume":"20","author":"RD Bloebaum","year":"1997","unstructured":"Bloebaum RD, Skedros JG, Vajda EG, Bachus KN, Constantz BR (1997) Determining mineral content variations in bone using backscattered electron imaging. Bone 20:485\u2013490","journal-title":"Bone"},{"key":"1227_CR38","doi-asserted-by":"publisher","first-page":"S466","DOI":"10.1107\/S0021889806045444","volume":"40","author":"O Paris","year":"2007","unstructured":"Paris O, Li CH, Siegel S, Weseloh G, Emmerling F, Riesemeier H, Erko A, Fratzl P (2007) A new experimental station for simultaneous X-ray microbeam scanning for small- and wide-angle scattering and fluorescence at BESSY II. J Appl Crystallogr 40:S466\u2013S470","journal-title":"J Appl Crystallogr"},{"key":"1227_CR39","first-page":"9","volume":"35","author":"P Fratzl","year":"1996","unstructured":"Fratzl P, Schreiber S, Klaushofer K (1996) Bone mineralization as studied by small-angle X-ray scattering. Connect Tissue Res 35:9\u201316","journal-title":"Connect Tissue Res"},{"key":"1227_CR40","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/BF02556454","volume":"48","author":"P Fratzl","year":"1991","unstructured":"Fratzl P, Fratzl-Zelman N, Klaushofer K, Vogl G, Koller K (1991) Nucleation and growth of mineral crystals in bone studied by small-angle X-ray-scattering. Calcified Tissue Int 48:407\u2013413","journal-title":"Calcified Tissue Int"},{"key":"1227_CR41","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1107\/S1600576714019773","volume":"47","author":"G Benecke","year":"2014","unstructured":"Benecke G, Wagermaier W, Li C, Schwartzkopf M, Flucke G, Hoerth R, Zizak I, Burghammer M, Metwalli E, M\u00fcller-Buschbaum P (2014) A customizable software for fast reduction and analysis of large X-ray scattering data sets: applications of the new DPDAK package to small-angle X-ray scattering and grazing-incidence small-angle X-ray scattering. J Appl Crystallogr 47:1797\u20131803","journal-title":"J Appl Crystallogr"},{"key":"1227_CR42","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jsb.2019.02.010","volume":"206","author":"R Maria","year":"2019","unstructured":"Maria R, Ben-Zvi Y, Rechav K, Klein E, Shahar R, Weiner S (2019) An unusual disordered alveolar bone material in the upper furcation region of minipig mandibles: a 3D hierarchical structural study. J Struct Biol 206:128\u2013137","journal-title":"J Struct Biol"},{"key":"1227_CR43","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0003-9969(61)90001-2","volume":"5","author":"L Johannessen","year":"1961","unstructured":"Johannessen L (1961) Dentine apposition in the mandibular first molars of albino rats. Arch Oral Biol 5:81\u201391","journal-title":"Arch Oral Biol"},{"key":"1227_CR44","doi-asserted-by":"publisher","first-page":"7650","DOI":"10.1016\/j.biomaterials.2005.05.059","volume":"26","author":"AE Porter","year":"2005","unstructured":"Porter AE, Nalla RK, Minor A, Jinschek JR, Kisielowski C, Radmilovic V, Kinney JH, Tomsia AP, Ritchie RO (2005) A transmission electron microscopy study of mineralization in age-induced transparent dentin. Biomaterials 26:7650\u20137660","journal-title":"Biomaterials"},{"key":"1227_CR45","doi-asserted-by":"publisher","first-page":"5576","DOI":"10.1002\/anie.200500496","volume":"44","author":"H C\u00f6lfen","year":"2005","unstructured":"C\u00f6lfen H, Antonietti M (2005) Mesocrystals: inorganic superstructures made by highly parallel crystallization and controlled alignment. Angew Chem Int Ed 44:5576\u20135591","journal-title":"Angew Chem Int Ed"},{"key":"1227_CR46","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/978-3-319-45669-0_8","volume-title":"New perspectives on mineral nucleation and growth","author":"A Rao","year":"2017","unstructured":"Rao A, C\u00f6lfen H (2017) Mineralization schemes in the living world: mesocrystals. New perspectives on mineral nucleation and growth. Springer, pp 155\u2013183"},{"key":"1227_CR47","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jsb.2013.05.012","volume":"183","author":"B Bar-On","year":"2013","unstructured":"Bar-On B, Wagner DH (2013) Structural motifs and elastic properties of hierarchical biological tissues\u2014a review. J Struct Biol 183:149\u2013164","journal-title":"J Struct Biol"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-021-01227-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00774-021-01227-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-021-01227-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T04:14:59Z","timestamp":1630296899000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00774-021-01227-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,11]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["1227"],"URL":"https:\/\/doi.org\/10.1007\/s00774-021-01227-0","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,11]]},"assertion":[{"value":"27 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"CA, NT, and TO are employees of Lion Corporation. All other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental procedures were approved by the Animal Care and Use Committee of LION Corporation (Protocol Number: 2014-246, 2015-045).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}