{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:44:58Z","timestamp":1761864298964,"version":"3.37.3"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T00:00:00Z","timestamp":1622937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T00:00:00Z","timestamp":1622937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81672133"],"award-info":[{"award-number":["81672133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81874010"],"award-info":[{"award-number":["81874010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s00774-021-01235-0","type":"journal-article","created":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T05:02:18Z","timestamp":1622955738000},"page":"925-933","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long-term pretreatment with alendronate inhibits calvarial defect healing in an osteoporotic rat model"],"prefix":"10.1007","volume":"39","author":[{"given":"Chenggui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxiong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqiong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3690-9457","authenticated-orcid":false,"given":"Chunli","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,6]]},"reference":[{"key":"1235_CR1","doi-asserted-by":"publisher","first-page":"S90","DOI":"10.1016\/j.injury.2007.02.014","volume":"38","author":"P Giannoudis","year":"2007","unstructured":"Giannoudis P, Tzioupis C, Almalki T, Buckley R (2007) Fracture healing in osteoporotic fractures: is it really different? A basic science perspective. Injury 38:S90-99","journal-title":"Injury"},{"key":"1235_CR2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s11914-009-0003-6","volume":"7","author":"P Geusens","year":"2009","unstructured":"Geusens P (2009) Bisphosphonates for postmenopausal osteoporosis: determining duration of treatment. Curr Osteoporos Rep 7:12\u201317","journal-title":"Curr Osteoporos Rep"},{"key":"1235_CR3","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1517\/14656566.2013.822861","volume":"14","author":"G Duque","year":"2013","unstructured":"Duque G (2013) Osteoporosis in older persons: current pharmacotherapy and future directions. Expert Opin Pharmacother 14:1949\u20131958","journal-title":"Expert Opin Pharmacother"},{"key":"1235_CR4","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/aps.2012.170","volume":"34","author":"LJ Fu","year":"2013","unstructured":"Fu LJ, Tang TT, Hao YQ, Dai KR (2013) Long-term effects of alendronate on fracture healing and bone remodeling of femoral shaft in ovariectomized rats. Acta Pharmacol Sin 34:387\u2013392","journal-title":"Acta Pharmacol Sin"},{"key":"1235_CR5","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.60B2.350882","author":"B McKibbin","year":"1978","unstructured":"McKibbin B (1978) The biology of fracture healing in long bones. J Bone Joint Surg Br. https:\/\/doi.org\/10.1302\/0301-620X.60B2.350882","journal-title":"J Bone Joint Surg Br"},{"key":"1235_CR6","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1007\/s00784-018-2670-0","volume":"23","author":"N de Oliveira","year":"2019","unstructured":"de Oliveira N, Oliveira J, de Souza ML, Weiss SG, Chaves LH, Casagrande TC, Deliberador TM, Giovanini AF, Zielak JC, Scariot R (2019) Bone repair in craniofacial defects treated with different doses of alendronate: a histological, histomorphometric, and immunohistochemical study. Clin Oral Investig 23:2355\u20132364","journal-title":"Clin Oral Investig"},{"key":"1235_CR7","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1016\/j.joms.2017.03.050","volume":"75","author":"JS Vieira","year":"2017","unstructured":"Vieira JS, Giovanini A, G\u00f6rhinger I, Gonzaga CC, Costa-Casagrande TA, Deliberador TM (2017) Use of low-dose alendronate improves cranial bone repair and is associated with an increase of osteocalcin: an experimental study. J Oral Maxillofac Surg 75:1873\u20131881","journal-title":"J Oral Maxillofac Surg"},{"key":"1235_CR8","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1111\/j.1601-0825.2010.01677.x","volume":"16","author":"JI Aguirre","year":"2010","unstructured":"Aguirre JI, Altman MK, Vanegas SM, Franz SE, Bassit AC, Wronski TJ (2010) Effects of alendronate on bone healing after tooth extraction in rats. Oral Dis 16:674\u2013685","journal-title":"Oral Dis"},{"key":"1235_CR9","doi-asserted-by":"publisher","first-page":"103635","DOI":"10.1016\/j.jmbbm.2020.103635","volume":"104","author":"C Koyama","year":"2020","unstructured":"Koyama C, Hirota M, Okamoto Y, Iwai T, Ogawa T, Hayakawa T, Mitsudo K (2020) A nitrogen-containing bisphosphonate inhibits osteoblast attachment and impairs bone healing in bone-compatible scaffold. J Mech Behav Biomed Mater 104:103635","journal-title":"J Mech Behav Biomed Mater"},{"key":"1235_CR10","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s00223-008-9104-y","volume":"82","author":"AI Idris","year":"2008","unstructured":"Idris AI, Rojas J, Greig IR, Van\u2019t Hof RJ, Ralston SH (2008) Aminobisphosphonates cause osteoblast apoptosis and inhibit bone nodule formation in vitro. Calcif Tissue Int 82:191\u2013201","journal-title":"Calcif Tissue Int"},{"key":"1235_CR11","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s11914-008-0005-9","volume":"6","author":"JP Bilezikian","year":"2008","unstructured":"Bilezikian JP (2008) Combination anabolic and antiresorptive therapy for osteoporosis: opening the anabolic window. Curr Osteoporos Rep 6:24\u201330","journal-title":"Curr Osteoporos Rep"},{"key":"1235_CR12","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/jbmr.5650110402","volume":"11","author":"XW Meng","year":"1996","unstructured":"Meng XW, Liang XG, Birchman R, Wu DD, Dempster DW, Lindsay R, Shen V (1996) Temporal expression of the anabolic action of PTH in cancellous bone of ovariectomized rats. J Bone Miner Res 11:421\u2013429","journal-title":"J Bone Miner Res"},{"key":"1235_CR13","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1016\/j.jse.2010.05.005","volume":"19","author":"A Oteo-Alvaro","year":"2010","unstructured":"Oteo-Alvaro A, Moreno E (2010) Atrophic humeral shaft nonunion treated with teriparatide (rh PTH 1\u201334): a case report. J Shoulder Elbow Surg 19:e22-28","journal-title":"J Shoulder Elbow Surg"},{"key":"1235_CR14","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1093\/rheumatology\/kes319","volume":"52","author":"RA Corrigan","year":"2013","unstructured":"Corrigan RA, Miller A, McNally MA, Javaid MK (2013) Treatment of fracture non-union in a young adult with combination anabolic and anti-resorptive bone therapy. Rheumatology (Oxford) 52:1147\u20131149","journal-title":"Rheumatology (Oxford)"},{"key":"1235_CR15","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s00774-017-0893-9","volume":"36","author":"H Li","year":"2018","unstructured":"Li H, Zhou Q, Bai BL, Weng SJ, Wu ZY, Xie ZJ, Feng ZH, Cheng L, Boodhun V, Yang L (2018) Effects of combined human parathyroid hormone (1\u201334) and menaquinone-4 treatment on the interface of hydroxyapatite-coated titanium implants in the femur of osteoporotic rats. J Bone Miner Metab 36:691\u2013699","journal-title":"J Bone Miner Metab"},{"key":"1235_CR16","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1002\/jbmr.3178","volume":"32","author":"L Zhang","year":"2017","unstructured":"Zhang L, Wang T, Chang M, Kaiser C, Kim JD, Wu T, Cao X, Zhang X, Schwarz EM (2017) Teriparatide treatment improves bone defect healing via anabolic effects on new bone formation and non-anabolic effects on inhibition of mast cells in a murine cranial window model. J Bone Miner Res 32:1870\u20131883","journal-title":"J Bone Miner Res"},{"key":"1235_CR17","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.bone.2016.08.012","volume":"92","author":"M Casanova","year":"2016","unstructured":"Casanova M, Herelle J, Thomas M, Softley R, Schindeler A, Little D, Schneider P, Muller R (2016) Effect of combined treatment with zoledronic acid and parathyroid hormone on mouse bone callus structure and composition. Bone 92:70\u201378","journal-title":"Bone"},{"key":"1235_CR18","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1007\/s00198-011-1751-6","volume":"23","author":"YF Li","year":"2012","unstructured":"Li YF, Zhou CC, Li JH, Luo E, Zhu SS, Feng G, Hu J (2012) The effects of combined human parathyroid hormone (1\u201334) and zoledronic acid treatment on fracture healing in osteoporotic rats. Osteoporos Int 23:1463\u20131474","journal-title":"Osteoporos Int"},{"key":"1235_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24953","author":"C Zhang","year":"2020","unstructured":"Zhang C, Zhu J, Jia J, Guan Z, Sun T, Zhang W, Yuan W, Wang H, Leng H, Song C (2020) Once-weekly parathyroid hormone combined with ongoing long-term alendronate treatment promotes osteoporotic fracture healing in ovariectomized rats. J Orthop Res. https:\/\/doi.org\/10.1002\/jor.24953","journal-title":"J Orthop Res"},{"key":"1235_CR20","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1080\/21691401.2018.1453825","volume":"46","author":"X Wang","year":"2018","unstructured":"Wang X, Zeng D, Weng W, Huang Q, Zhang X, Wen J, Wu J, Jiang X (2018) Alendronate delivery on amino modified mesoporous bioactive glass scaffolds to enhance bone regeneration in osteoporosis rats. Artif Cells Nanomed Biotechnol 46:171\u2013181","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"1235_CR21","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/jbmr.5650060405","volume":"6","author":"JG Seedor","year":"1991","unstructured":"Seedor JG, Quartuccio HA, Thompson DD (1991) The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in rats. J Bone Miner Res 6:339\u2013346","journal-title":"J Bone Miner Res"},{"key":"1235_CR22","doi-asserted-by":"publisher","first-page":"9955","DOI":"10.1021\/am501048n","volume":"6","author":"S Tarafder","year":"2014","unstructured":"Tarafder S, Bose S (2014) Polycaprolactone-coated 3D printed tricalcium phosphate scaffolds for bone tissue engineering: in vitro alendronate release behavior and local delivery effect on in vivo osteogenesis. ACS Appl Mater Interfaces 6:9955\u20139965","journal-title":"ACS Appl Mater Interfaces"},{"key":"1235_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36997","author":"Y Zeng","year":"2020","unstructured":"Zeng Y, Zhou M, Mou S, Yang J, Yuan Q, Guo L, Zhong A, Wang J, Sun J, Wang Z (2020) Sustained delivery of alendronate by engineered collagen scaffold for the repair of osteoporotic bone defects and resistance to bone loss. J Biomed Mater Res A. https:\/\/doi.org\/10.1002\/jbm.a.36997","journal-title":"J Biomed Mater Res A"},{"key":"1235_CR24","doi-asserted-by":"publisher","first-page":"055005","DOI":"10.1088\/1748-6041\/11\/5\/055005","volume":"11","author":"SE Kim","year":"2016","unstructured":"Kim SE, Yun YP, Shim KS, Kim HJ, Park K, Song HR (2016) 3D printed alendronate-releasing poly(caprolactone) porous scaffolds enhance osteogenic differentiation and bone formation in rat tibial defects. Biomed Mater 11:055005","journal-title":"Biomed Mater"},{"key":"1235_CR25","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/j.archoralbio.2012.06.013","volume":"57","author":"H Toker","year":"2012","unstructured":"Toker H, Ozdemir H, Ozer H, Eren K (2012) Alendronate enhances osseous healing in a rat calvarial defect model. Arch Oral Biol 57:1545\u20131550","journal-title":"Arch Oral Biol"},{"key":"1235_CR26","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1597\/15-356","volume":"54","author":"N Cheng","year":"2017","unstructured":"Cheng N, Park J, Olson J, Kwon T, Lee D, Lim R, Ha S, Kim R, Zhang X, Ting K, Tetradis S, Hong C (2017) Effects of bisphosphonate administration on cleft bone graft in a rat model. Cleft Palate Craniofac J 54:687\u2013698","journal-title":"Cleft Palate Craniofac J"},{"key":"1235_CR27","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.oooo.2016.08.009","volume":"123","author":"SS Lim","year":"2017","unstructured":"Lim SS, Lee B, Kim IS, Hwang SJ (2017) Differential modulation of zoledronate and etidronate in osseous healing of an extracted socket and tibia defect. Oral Surg Oral Med Oral Pathol Oral Radiol 123:8\u201319","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"1235_CR28","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1359\/jbmr.070318","volume":"22","author":"N Amanat","year":"2007","unstructured":"Amanat N, McDonald M, Godfrey C, Bilston L, Little D (2007) Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair. J Bone Miner Res 22:867\u2013876","journal-title":"J Bone Miner Res"},{"key":"1235_CR29","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.95B9.31562","author":"T Savaridas","year":"2013","unstructured":"Savaridas T, Wallace RJ, Salter DM, Simpson AH (2013) Do bisphosphonates inhibit direct fracture healing? A laboratory investigation using an animal model. Bone Joint J. https:\/\/doi.org\/10.1302\/0301-620X.95B9.31562","journal-title":"Bone Joint J"},{"key":"1235_CR30","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1007\/s00784-017-2292-y","volume":"22","author":"AF Giovanini","year":"2018","unstructured":"Giovanini AF, de Sousa Passoni GN, G\u00f6hringer I, Deliberador TM, Zielak JC, Storrer CLM, Costa-Casagrande TA, Scariot R (2018) Prolonged use of alendronate alters the biology of cranial repair in estrogen-deficient rats\u2019 associated simultaneous immunohistochemical expression of TGF-\u03b21+, \u03b1-ER+, and BMPR1B. Clin Oral Investig 22:1959\u20131971","journal-title":"Clin Oral Investig"},{"key":"1235_CR31","doi-asserted-by":"publisher","first-page":"74","DOI":"10.17925\/USE.2016.12.02.74","volume":"12","author":"P Camacho","year":"2016","unstructured":"Camacho P (2016) 2016 American Association of Clinical Endocrinologists\/American College of Endocrinology Clinical Practice guidelines on postmenopausal osteoporosis. US Endocrinol 12:74","journal-title":"US Endocrinol"},{"key":"1235_CR32","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3109\/17453674.2011.566138","volume":"82","author":"O Belfrage","year":"2011","unstructured":"Belfrage O, Flivik G, Sundberg M, Kesteris U, Tagil M (2011) Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density: a bone chamber study in rats. Acta Orthop 82:228\u2013233","journal-title":"Acta Orthop"},{"key":"1235_CR33","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1002\/jor.20625","volume":"26","author":"AK Harding","year":"2008","unstructured":"Harding AK, Aspenberg P, Kataoka M, Bylski D, Tagil M (2008) Manipulating the anabolic and catabolic response in bone graft remodeling: synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate. J Orthop Res 26:1245\u20131249","journal-title":"J Orthop Res"},{"key":"1235_CR34","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1359\/jbmr.2003.18.12.2116","volume":"18","author":"CH Kim","year":"2003","unstructured":"Kim CH, Takai E, Zhou H, von Stechow D, M\u00fcller R, Dempster DW, Guo XE (2003) Trabecular bone response to mechanical and parathyroid hormone stimulation: the role of mechanical microenvironment. J Bone Miner Res 18:2116\u20132125","journal-title":"J Bone Miner Res"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-021-01235-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00774-021-01235-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-021-01235-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T04:41:48Z","timestamp":1636778508000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00774-021-01235-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["1235"],"URL":"https:\/\/doi.org\/10.1007\/s00774-021-01235-0","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"type":"print","value":"0914-8779"},{"type":"electronic","value":"1435-5604"}],"subject":[],"published":{"date-parts":[[2021,6,6]]},"assertion":[{"value":"28 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Chenggui Zhang, Junxiong Zhu, Jialin Jia, Zhiyuan Guan, Tiantong Sun, Wang Zhang, Wanqiong Yuan, Hong Wang and Chunli Song declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental procedures and protocols were approved by the Peking University Third Hospital Committee on Ethics for the Care and Use of Laboratory Animals (A2020258).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}