{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:22:40Z","timestamp":1767853360834,"version":"3.49.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DE025020"],"award-info":[{"award-number":["R01 DE025020"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 DE024503"],"award-info":[{"award-number":["U01 DE024503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DE21464"],"award-info":[{"award-number":["R01 DE21464"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DE25681"],"award-info":[{"award-number":["R01 DE25681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DE26507"],"award-info":[{"award-number":["R01 DE26507"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771036"],"award-info":[{"award-number":["81771036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271122"],"award-info":[{"award-number":["81271122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s00774-021-01245-y","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T11:04:18Z","timestamp":1625051058000},"page":"962-973","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["6-Shogaol promotes bone resorption and accelerates orthodontic tooth movement through the JNK-NFATc1 signaling axis"],"prefix":"10.1007","volume":"39","author":[{"given":"Xiaofang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ouyang","family":"Ningjuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carroll Ann","family":"Trotman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake Jinkun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guofang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"1245_CR1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/B978-0-323-05460-7.00025-9","volume-title":"Current therapy in orthodontics","author":"H \u0130\u015feri","year":"2010","unstructured":"\u0130\u015feri H, Kurt G, Ki\u015fni\u015fci R (2010) Chapter 25\u2014Biomechanics of rapid tooth movement by dentoalveolar distraction osteogenesis. In: Nanda R, Kapila S (eds) Current therapy in orthodontics. Mosby, Saint Louis, pp 321\u2013337"},{"key":"1245_CR2","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.ajodo.2005.10.003","volume":"129","author":"KJ Skidmore","year":"2006","unstructured":"Skidmore KJ, Brook KJ, Thomson WM, Harding WJ (2006) Factors influencing treatment time in orthodontic patients. Am J Orthod Dentofac Orthop 129:230\u2013238. https:\/\/doi.org\/10.1016\/j.ajodo.2005.10.003","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"1245_CR3","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/jor.1100110216","volume":"11","author":"E Bogoch","year":"1993","unstructured":"Bogoch E, Gschwend N, Rahn B et al (1993) Healing of cancellous bone osteotomy in rabbits\u2014Part I: regulation of bone volume and the regional acceleratory phenomenon in normal bone. J Orthop Res 11:285\u2013291. https:\/\/doi.org\/10.1002\/jor.1100110216","journal-title":"J Orthop Res"},{"key":"1245_CR4","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/jor.1100110217","volume":"11","author":"E Bogoch","year":"1993","unstructured":"Bogoch E, Gschwend N, Rahn B et al (1993) Healing of cancellous bone osteotomy in rabbits\u2014Part II: local reversal of arthritis-induced osteopenia after osteotomy. J Orthop Res 11:292\u2013298. https:\/\/doi.org\/10.1002\/jor.1100110217","journal-title":"J Orthop Res"},{"key":"1245_CR5","unstructured":"The Complete Medicinal Herbal. Penelope Ody (1993). Alternative health practitioner, vol 3, no. 2. SAGE publications, pp 140\u2013140. ISBN 1-56458-187-X"},{"key":"1245_CR6","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1158\/1055-9965.EPI-07-2934","volume":"17","author":"SM Zick","year":"2008","unstructured":"Zick SM, Djuric Z, Ruffin MT et al (2008) Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev 17:1930\u20131936. https:\/\/doi.org\/10.1158\/1055-9965.EPI-07-2934","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"1245_CR7","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1039\/C7FO01354J","volume":"9","author":"X Kou","year":"2018","unstructured":"Kou X, Wang X, Ji R et al (2018) Occurrence, biological activity and metabolism of 6-shogaol. Food Funct 9:1310\u20131327. https:\/\/doi.org\/10.1039\/C7FO01354J","journal-title":"Food Funct"},{"key":"1245_CR8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.0c00364","author":"Y Zhu","year":"2020","unstructured":"Zhu Y, Zhang G, Li M et al (2020) Ultrasound-augmented phase transition nanobubbles for targeted treatment of paclitaxel-resistant cancer. Bioconjugate Chem. https:\/\/doi.org\/10.1021\/acs.bioconjchem.0c00364","journal-title":"Bioconjugate Chem"},{"key":"1245_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-02913-8","author":"M Wo\u017aniak","year":"2020","unstructured":"Wo\u017aniak M, Makuch S, Winograd K et al (2020) 6-Shogaol enhances the anticancer effect of 5-fluorouracil, oxaliplatin, and irinotecan via increase of apoptosis and autophagy in colon cancer cells in hypoxic\/aglycemic conditions. BMC Complement Med Ther. https:\/\/doi.org\/10.1186\/s12906-020-02913-8","journal-title":"BMC Complement Med Ther"},{"key":"1245_CR10","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.foodchem.2012.04.145","volume":"135","author":"F Li","year":"2012","unstructured":"Li F, Nitteranon V, Tang X et al (2012) In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin. Food Chem 135:332\u2013337. https:\/\/doi.org\/10.1016\/j.foodchem.2012.04.145","journal-title":"Food Chem"},{"key":"1245_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103537","author":"L Yang","year":"2020","unstructured":"Yang L, Yang F, Teng L, Katayama I (2020) 6-Shogaol protects human melanocytes against oxidative stress through activation of the Nrf2-antioxidant response element signaling pathway. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21103537","journal-title":"Int J Mol Sci"},{"key":"1245_CR12","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.neuropharm.2012.03.016","volume":"63","author":"SK Ha","year":"2012","unstructured":"Ha SK, Moon E, Ju MS et al (2012) 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. Neuropharmacology 63:211\u2013223. https:\/\/doi.org\/10.1016\/j.neuropharm.2012.03.016","journal-title":"Neuropharmacology"},{"key":"1245_CR13","doi-asserted-by":"publisher","first-page":"5054395","DOI":"10.1155\/2019\/5054395","volume":"2019","author":"NFN Mohd Sahardi","year":"2019","unstructured":"Mohd Sahardi NFN, Makpol S (2019) Ginger (Zingiber officinale Roscoe) in the prevention of ageing and degenerative diseases: review of current evidence. Evid Based Complement Alternat Med 2019:5054395","journal-title":"Evid Based Complement Alternat Med"},{"key":"1245_CR14","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.pharmthera.2017.08.010","volume":"182","author":"JG Choi","year":"2018","unstructured":"Choi JG, Kim SY, Jeong M, Oh MS (2018) Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders. Pharmacol Ther 182:56\u201369. https:\/\/doi.org\/10.1016\/j.pharmthera.2017.08.010","journal-title":"Pharmacol Ther"},{"key":"1245_CR15","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1093\/ecco-jcc\/jjx115","volume":"12","author":"M Zhang","year":"2018","unstructured":"Zhang M, Xu C, Liu D et al (2018) Oral delivery of nanoparticles loaded with ginger active compound, 6-shogaol, attenuates ulcerative colitis and promotes wound healing in a murine model of ulcerative colitis. J Crohns Colitis 12:217\u2013229. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjx115","journal-title":"J Crohns Colitis"},{"key":"1245_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29894","author":"X Zhu","year":"2020","unstructured":"Zhu X, Li X, Wang X et al (2020) Irisin deficiency disturbs bone metabolism. J Cell Physiol. https:\/\/doi.org\/10.1002\/jcp.29894","journal-title":"J Cell Physiol"},{"key":"1245_CR17","doi-asserted-by":"publisher","first-page":"6299","DOI":"10.1016\/j.biomaterials.2014.04.044","volume":"35","author":"Z Zhai","year":"2014","unstructured":"Zhai Z, Qu X, Li H et al (2014) The effect of metallic magnesium degradation products on osteoclast-induced osteolysis and attenuation of NF-\u03baB and NFATc1 signaling. Biomaterials 35:6299\u20136310. https:\/\/doi.org\/10.1016\/j.biomaterials.2014.04.044","journal-title":"Biomaterials"},{"key":"1245_CR18","doi-asserted-by":"publisher","first-page":"16056","DOI":"10.1038\/boneres.2016.56","volume":"5","author":"J Zhang","year":"2017","unstructured":"Zhang J, Valverde P, Zhu X et al (2017) Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism. Bone Res 5:16056. https:\/\/doi.org\/10.1038\/boneres.2016.56","journal-title":"Bone Res"},{"key":"1245_CR19","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.bbrc.2013.12.029","volume":"443","author":"X Qu","year":"2014","unstructured":"Qu X, Zhai Z, Liu X et al (2014) Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades. Biochem Biophys Res Commun 443:658\u2013665. https:\/\/doi.org\/10.1016\/j.bbrc.2013.12.029","journal-title":"Biochem Biophys Res Commun"},{"key":"1245_CR20","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.joms.2013.09.007","volume":"72","author":"H Yuan","year":"2014","unstructured":"Yuan H, Zhu X, Lu J et al (2014) Accelerated orthodontic tooth movement following Le Fort I osteotomy in a rodent model. J Oral Maxillofac Surg 72:764\u2013772. https:\/\/doi.org\/10.1016\/j.joms.2013.09.007","journal-title":"J Oral Maxillofac Surg"},{"key":"1245_CR21","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.bonr.2016.07.002","volume":"5","author":"A Roscher","year":"2016","unstructured":"Roscher A, Hasegawa T, Dohnke S et al (2016) The F-actin modulator SWAP-70 controls podosome patterning in osteoclasts. Bone Reports 5:214\u2013221. https:\/\/doi.org\/10.1016\/j.bonr.2016.07.002","journal-title":"Bone Reports"},{"key":"1245_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103004","author":"K Lee","year":"2018","unstructured":"Lee K, Seo I, Choi MH, Jeong D (2018) Roles of mitogen-activated protein kinases in osteoclast biology. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms19103004","journal-title":"Int J Mol Sci"},{"key":"1245_CR23","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1359\/jbmr.080211","volume":"23","author":"F Ikeda","year":"2008","unstructured":"Ikeda F, Matsubara T, Tsurukai T et al (2008) JNK\/c-Jun signaling mediates an anti-apoptotic effect of RANKL in osteoclasts. J Bone Miner Res 23:907\u2013914. https:\/\/doi.org\/10.1359\/jbmr.080211","journal-title":"J Bone Miner Res"},{"key":"1245_CR24","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1172\/JCI19657","volume":"114","author":"F Ikeda","year":"2004","unstructured":"Ikeda F, Nishimura R, Matsubara T et al (2004) Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest 114:475\u2013484. https:\/\/doi.org\/10.1172\/JCI19657","journal-title":"J Clin Invest"},{"key":"1245_CR25","doi-asserted-by":"publisher","first-page":"233","DOI":"10.11005\/jbm.2014.21.4.233","volume":"21","author":"JH Kim","year":"2014","unstructured":"Kim JH, Kim N (2014) Regulation of NFATc1 in osteoclast differentiation. J Bone Metab 21:233\u2013241. https:\/\/doi.org\/10.11005\/jbm.2014.21.4.233","journal-title":"J Bone Metab"},{"key":"1245_CR26","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1601-6343.2009.01444.x","volume":"12","author":"M Yamaguchi","year":"2009","unstructured":"Yamaguchi M (2009) RANK\/RANKL\/OPG during orthodontic tooth movement. Orthod Craniofac Res 12:113\u2013119. https:\/\/doi.org\/10.1111\/j.1601-6343.2009.01444.x","journal-title":"Orthod Craniofac Res"},{"key":"1245_CR27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","volume":"473","author":"BF Boyce","year":"2008","unstructured":"Boyce BF, Xing L (2008) Functions of RANKL\/RANK\/OPG in bone modeling and remodeling. Arch Biochem Biophys 473:139\u2013146. https:\/\/doi.org\/10.1016\/j.abb.2008.03.018","journal-title":"Arch Biochem Biophys"},{"key":"1245_CR28","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jds.2016.02.006","volume":"11","author":"M Ueda","year":"2016","unstructured":"Ueda M, Kuroishi KN, Gunjigake KK et al (2016) Expression of SOST\/sclerostin in compressed periodontal ligament cells. J Dent Sci 11:272\u2013278. https:\/\/doi.org\/10.1016\/j.jds.2016.02.006","journal-title":"J Dent Sci"},{"key":"1245_CR29","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1034\/j.1601-0825.2001.00663.x","volume":"7","author":"T Hatai","year":"2001","unstructured":"Hatai T, Yokozeki M, Funato N et al (2001) Apoptosis of periodontal ligament cells induced by mechanical stress during tooth movement. Oral Dis 7:287\u2013290. https:\/\/doi.org\/10.1034\/j.1601-0825.2001.00663.x","journal-title":"Oral Dis"},{"key":"1245_CR30","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.2319\/110713-813.1","volume":"84","author":"S Moin","year":"2014","unstructured":"Moin S, Kalajzic Z, Utreja A et al (2014) Osteocyte death during orthodontic tooth movement in mice. Angle Orthod 84:1086\u20131092. https:\/\/doi.org\/10.2319\/110713-813.1","journal-title":"Angle Orthod"},{"key":"1245_CR31","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1177\/0022034513476037","volume":"92","author":"T Matsumoto","year":"2013","unstructured":"Matsumoto T, Iimura T, Ogura K et al (2013) The role of osteocytes in bone resorption during orthodontic tooth movement. J Dent Res 92:340\u2013345. https:\/\/doi.org\/10.1177\/0022034513476037","journal-title":"J Dent Res"},{"key":"1245_CR32","unstructured":"Darnay BG, Besse A, Poblenz AT et al (2013) TRAFs in rank signaling. Madame Curie Bioscience Database. Landes Bioscience.\u00a0http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6222\/"},{"key":"1245_CR33","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1101\/gad.13.8.1015","volume":"13","author":"MA Lomaga","year":"1999","unstructured":"Lomaga MA, Yeh WC, Sarosi I et al (1999) TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev 13:1015\u20131024. https:\/\/doi.org\/10.1101\/gad.13.8.1015","journal-title":"Genes Dev"},{"key":"1245_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-019-1353-3","volume":"10","author":"H-J Liao","year":"2019","unstructured":"Liao H-J, Tsai H-F, Wu C-S et al (2019) TRAIL inhibits RANK signaling and suppresses osteoclast activation via inhibiting lipid raft assembly and TRAF6 recruitment. Cell Death Dis 10:1\u201311. https:\/\/doi.org\/10.1038\/s41419-019-1353-3","journal-title":"Cell Death Dis"},{"key":"1245_CR35","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.molcel.2008.09.002","volume":"31","author":"M Yamashita","year":"2008","unstructured":"Yamashita M, Fatyol K, Jin C et al (2008) TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. Mol Cell 31:918\u2013924. https:\/\/doi.org\/10.1016\/j.molcel.2008.09.002","journal-title":"Mol Cell"},{"key":"1245_CR36","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gad.13.10.1297","volume":"13","author":"V Baud","year":"1999","unstructured":"Baud V, Liu Z-G, Bennett B et al (1999) Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev 13:1297\u20131308","journal-title":"Genes Dev"},{"key":"1245_CR37","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1172\/JCI200422644","volume":"114","author":"SL Teitelbaum","year":"2004","unstructured":"Teitelbaum SL (2004) RANKing c-Jun in osteoclast development. J Clin Invest 114:463\u2013465. https:\/\/doi.org\/10.1172\/JCI200422644","journal-title":"J Clin Invest"},{"key":"1245_CR38","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.1242\/jcs.170738","volume":"128","author":"J-T Yeon","year":"2015","unstructured":"Yeon J-T, Kim K-J, Chun SW et al (2015) KCNK1 inhibits osteoclastogenesis by blocking the Ca2+ oscillation and JNK-NFATc1 signaling axis. J Cell Sci 128:3411\u20133419. https:\/\/doi.org\/10.1242\/jcs.170738","journal-title":"J Cell Sci"},{"key":"1245_CR39","doi-asserted-by":"publisher","first-page":"6295","DOI":"10.1021\/jm200662c","volume":"54","author":"M Okamoto","year":"2011","unstructured":"Okamoto M, Irii H, Tahara Y et al (2011) Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet. J Med Chem 54:6295\u20136304. https:\/\/doi.org\/10.1021\/jm200662c","journal-title":"J Med Chem"},{"key":"1245_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13098-019-0407-0","volume":"11","author":"J-K Yi","year":"2019","unstructured":"Yi J-K, Ryoo Z-Y, Ha J-J et al (2019) Beneficial effects of 6-shogaol on hyperglycemia, islet morphology and apoptosis in some tissues of streptozotocin-induced diabetic mice. Diabetol Metab Syndr 11:15. https:\/\/doi.org\/10.1186\/s13098-019-0407-0","journal-title":"Diabetol Metab Syndr"},{"key":"1245_CR41","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/B978-0-12-416015-6.00004-6","volume":"19","author":"E Seeman","year":"2009","unstructured":"Seeman E (2009) Bone modeling and remodeling. Crit Rev Eukaryot Gene Expr 19:219\u2013233. https:\/\/doi.org\/10.1016\/B978-0-12-416015-6.00004-6","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"1245_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/bonekey.2013.215","author":"NA Sims","year":"2014","unstructured":"Sims NA, Martin TJ (2014) Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. Bonekey Rep. https:\/\/doi.org\/10.1038\/bonekey.2013.215","journal-title":"Bonekey Rep"},{"key":"1245_CR43","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700023","author":"P Wang","year":"2017","unstructured":"Wang P, Zhao Y, Zhu Y, Sang S (2017) Glucuronidation and its impact on the bioactivity of [6]-shogaol. Mol Nutr Food Res. https:\/\/doi.org\/10.1002\/mnfr.201700023","journal-title":"Mol Nutr Food Res"},{"key":"1245_CR44","first-page":"9","volume":"21","author":"WM Wilcko","year":"2001","unstructured":"Wilcko WM, Wilcko T, Bouquot JE, Ferguson DJ (2001) Rapid orthodontics with alveolar reshaping: two case reports of decrowding. Int J Periodontics Restorative Dent 21:9\u201319","journal-title":"Int J Periodontics Restorative Dent"},{"key":"1245_CR45","volume-title":"A textbook of orthodontics","author":"TD Foster","year":"1991","unstructured":"Foster TD (1991) A textbook of orthodontics. Wiley"},{"key":"1245_CR46","doi-asserted-by":"crossref","unstructured":"Zou M, Li C, Zheng Z (2019) Remote corticotomy accelerates orthodontic tooth movement in a rat model. In: BioMed research international. https:\/\/www.hindawi.com\/journals\/bmri\/2019\/4934128\/. Accessed 28 Jun 2019","DOI":"10.1155\/2019\/4934128"},{"key":"1245_CR47","doi-asserted-by":"publisher","first-page":"S83","DOI":"10.1016\/j.ajodo.2010.09.026","volume":"139","author":"SS Baloul","year":"2011","unstructured":"Baloul SS, Gerstenfeld LC, Morgan EF et al (2011) Mechanism of action and morphologic changes in the alveolar bone in response to selective alveolar decortication\u2013facilitated tooth movement. Am J Orthod Dentofac Orthop 139:S83\u2013S101. https:\/\/doi.org\/10.1016\/j.ajodo.2010.09.026","journal-title":"Am J Orthod Dentofac Orthop"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-021-01245-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00774-021-01245-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-021-01245-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T04:44:17Z","timestamp":1636778657000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00774-021-01245-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["1245"],"URL":"https:\/\/doi.org\/10.1007\/s00774-021-01245-y","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]},"assertion":[{"value":"28 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors state that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}