{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:19:58Z","timestamp":1780085998821,"version":"3.54.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006396","name":"qazvin university of medical sciences","doi-asserted-by":"publisher","award":["IR.QUMS.Rec.1399.565"],"award-info":[{"award-number":["IR.QUMS.Rec.1399.565"]}],"id":[{"id":"10.13039\/501100006396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00774-022-01330-w","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T20:02:50Z","timestamp":1654027370000},"page":"663-669","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hypocalcemia in hospitalized patients with COVID-19: roles of hypovitaminosis D and functional hypoparathyroidism"],"prefix":"10.1007","volume":"40","author":[{"given":"Sima","family":"Hashemipour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8775-9241","authenticated-orcid":false,"given":"Somaieh","family":"Kiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouria","family":"Shahsavari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabereh","family":"Afshar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arefeh","family":"Ghobadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Mohammad Reza Hadizadeh","family":"Khairkhahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milad","family":"Badri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Saeed","family":"Farzam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Sohrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahyar","family":"Seddighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozita","family":"Bahadori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"1330_CR1","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1186\/s12879-021-06625-3","volume":"21","author":"F Mohammadi","year":"2021","unstructured":"Mohammadi F, Badri M, Safari S, Hemmat N et al (2021) A case report of rhino-facial mucormycosis in a non-diabetic patient with COVID-19: a systematic review of literature and current update. BMC Infect Dis 21:906. https:\/\/doi.org\/10.1186\/s12879-021-06625-3","journal-title":"BMC Infect Dis"},{"key":"1330_CR2","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1056\/NEJMc2018688","volume":"383","author":"F Rubino","year":"2020","unstructured":"Rubino F, Amiel SA, Zimmet P, Alberti G, Bornstein S et al (2020) New-onset diabetes in Covid-19. N Engl J Med 383:789\u2013790","journal-title":"N Engl J Med"},{"key":"1330_CR3","doi-asserted-by":"publisher","first-page":"E882","DOI":"10.1152\/ajpendo.00178.2020","volume":"318","author":"Z Yousaf","year":"2020","unstructured":"Yousaf Z, Al-Shokri SD, Al-Soub H, Mohamed MF (2020) COVID-19-associated SIADH: a clue in the times of pandemic! Am J Physiol-Endocrinol Metab 318:E882\u2013E885","journal-title":"Am J Physiol-Endocrinol Metab"},{"key":"1330_CR4","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s11154-020-09569-2","volume":"21","author":"M Marazuela","year":"2020","unstructured":"Marazuela M, Giustina A, Puig-Domingo M (2020) Endocrine and metabolic aspects of the COVID-19 pandemic. Rev Endocr Metab Disord 21:495\u2013507","journal-title":"Rev Endocr Metab Disord"},{"key":"1330_CR5","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s12020-020-02383-5","volume":"68","author":"L Di Filippo","year":"2020","unstructured":"Di Filippo L, Formenti AM, Rovere-Querini P, Carlucci M, Conte C et al (2020) Hypocalcemia is highly prevalent and predicts hospitalization in patients with COVID-19. Endocrine 68:475\u2013478","journal-title":"Endocrine"},{"key":"1330_CR6","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1016\/j.jiph.2020.05.029","volume":"13","author":"J Liu","year":"2020","unstructured":"Liu J, Han P, Wu J, Gong J, Tian D (2020) Prevalence and predictive value of hypocalcemia in severe COVID-19 patients. J Infect Public Health 13:1224\u20131228","journal-title":"J Infect Public Health"},{"key":"1330_CR7","doi-asserted-by":"publisher","first-page":"11287","DOI":"10.18632\/aging.103526","volume":"12","author":"J-K Sun","year":"2020","unstructured":"Sun J-K, Zhang W-H, Zou L, Liu Y, Li J-J et al (2020) Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019. Aging (Albany NY) 12:11287","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"1330_CR8","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1080\/07315724.2020.1856013","volume":"40","author":"S Bennouar","year":"2020","unstructured":"Bennouar S, Cherif AB, Kessira A, Bennouar D-E, Abdi S (2020) Vitamin D deficiency and low serum calcium as predictors of poor prognosis in patients with severe COVID-19. J Am Coll Nutr 40:104\u2013110","journal-title":"J Am Coll Nutr"},{"key":"1330_CR9","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1001\/jama.1986.03380140094029","volume":"256","author":"GP Zaloga","year":"1986","unstructured":"Zaloga GP, Chernow B (1986) Hypocalcemia in critical illness. JAMA 256:1924\u20131929","journal-title":"JAMA"},{"key":"1330_CR10","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0002-9343(88)90415-9","volume":"84","author":"TK Desai","year":"1988","unstructured":"Desai TK, Carlson RW, Geheb MA (1988) Prevalence and clinical implications of hypocalcemia in acutely III patients in a medical intensive care setting. Am J Med 84:209\u2013214","journal-title":"Am J Med"},{"key":"1330_CR11","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1177\/0885066611411543","volume":"28","author":"A Kelly","year":"2013","unstructured":"Kelly A, Levine MA (2013) Hypocalcemia in the critically ill patient. J Intensive Care Med 28:166\u2013177","journal-title":"J Intensive Care Med"},{"key":"1330_CR12","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.beem.2011.03.001","volume":"25","author":"P Lee","year":"2011","unstructured":"Lee P (2011) Vitamin D metabolism and deficiency in critical illness. Best Pract Res Clin Endocrinol Metab 25:769\u2013781","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"1330_CR13","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1097\/MCO.0b013e328358fc2b","volume":"15","author":"SA Quraishi","year":"2012","unstructured":"Quraishi SA, Camargo CA Jr (2012) Vitamin D in acute stress and critical illness. Curr Opin Clin Nutr Metab Care 15:625","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"1330_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s12020-020-02541-9","volume":"71","author":"L di Filippo","year":"2021","unstructured":"di Filippo L, Formenti AM, Doga M, Frara S, Rovere-Querini P et al (2021) Hypocalcemia is a distinctive biochemical feature of hospitalized COVID-19 patients. Endocrine 71:9\u201313","journal-title":"Endocrine"},{"key":"1330_CR15","first-page":"1057","volume":"7","author":"R Pal","year":"2020","unstructured":"Pal R, Ram S, Zohmangaihi D, Biswas I, Suri V et al (2020) High prevalence of hypocalcemia in non-severe COVID-19 patients: a retrospective case-control study. Front Med 7:1057","journal-title":"Front Med"},{"key":"1330_CR16","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1002\/jbmr.483","volume":"26","author":"JP Bilezikian","year":"2011","unstructured":"Bilezikian JP, Khan A, Potts JT Jr, Brandi ML, Clarke BL et al (2011) Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. J Bone Miner Res 26:2317\u20132337","journal-title":"J Bone Miner Res"},{"key":"1330_CR17","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1177\/0260106018802968","volume":"24","author":"S Vatandost","year":"2018","unstructured":"Vatandost S, Jahani M, Afshari A, Amiri MR, Heidarimoghadam R, Mohammadi Y (2018) Prevalence of vitamin D deficiency in Iran: a systematic review and meta-analysis. Nutr Health 24:269\u2013278","journal-title":"Nutr Health"},{"key":"1330_CR18","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s11154-021-09655-z","volume":"23","author":"L di Filippo","year":"2021","unstructured":"di Filippo L, Doga M, Frara S, Giustina A (2021) Hypocalcemia in COVID-19: prevalence, clinical significance and therapeutic implications. Rev Endocr Metab Disord 23:299\u2013308","journal-title":"Rev Endocr Metab Disord"},{"key":"1330_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceca.2009.05.005","volume":"46","author":"Y Zhou","year":"2009","unstructured":"Zhou Y, Frey TK, Yang JJ (2009) Viral calciomics: interplays between Ca2+ and virus. Cell Calcium 46:1\u201317","journal-title":"Cell Calcium"},{"key":"1330_CR20","doi-asserted-by":"publisher","first-page":"R304","DOI":"10.1530\/EC-18-0184","volume":"7","author":"K Amrein","year":"2018","unstructured":"Amrein K, Papinutti A, Mathew E, Vila G, Parekh D (2018) Vitamin D and critical illness: what endocrinology can learn from intensive care and vice versa. Endocr Connect 7:R304\u2013R315","journal-title":"Endocr Connect"},{"key":"1330_CR21","doi-asserted-by":"publisher","first-page":"e1343","DOI":"10.1210\/clinem\/dgaa733","volume":"106","author":"JL Hern\u00e1ndez","year":"2021","unstructured":"Hern\u00e1ndez JL, Nan D, Fernandez-Ayala M, Garc\u00eda-Unzueta M, Hern\u00e1ndez-Hern\u00e1ndez MA et al (2021) Vitamin D status in hospitalized patients with SARS-CoV-2 infection. J Clin Endocrinol Metab 106:e1343\u2013e1353","journal-title":"J Clin Endocrinol Metab"},{"key":"1330_CR22","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.ijid.2021.04.050","volume":"107","author":"W Osman","year":"2021","unstructured":"Osman W, Al Fahdi F, Al Salmi I, Al Khalili H, Gokhale A, Khamis F (2021) Serum calcium and vitamin D levels: correlation with severity of COVID-19 in hospitalized patients in Royal Hospital. Oman Int J Infect Dis 107:153\u2013163","journal-title":"Oman Int J Infect Dis"},{"key":"1330_CR23","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00134-012-2713-y","volume":"39","author":"P Nair","year":"2013","unstructured":"Nair P, Lee P, Reynolds C, Nguyen ND, Myburgh J et al (2013) Significant perturbation of vitamin D\u2013parathyroid\u2013calcium axis and adverse clinical outcomes in critically ill patients. Intensive Care Med 39:267\u2013274","journal-title":"Intensive Care Med"},{"key":"1330_CR24","doi-asserted-by":"publisher","first-page":"14177","DOI":"10.1074\/jbc.M408587200","volume":"280","author":"L Canaff","year":"2005","unstructured":"Canaff L, Hendy GN (2005) Calcium-sensing receptor gene transcription Is up-regulated by the proinflammatory cytokine, interleukin-1\u03b2: role of the NF-\u03baB pathway and \u03baB elements. J Biol Chem 280:14177\u201314188","journal-title":"J Biol Chem"},{"key":"1330_CR25","doi-asserted-by":"publisher","first-page":"13586","DOI":"10.1074\/jbc.M708087200","volume":"283","author":"L Canaff","year":"2008","unstructured":"Canaff L, Zhou X, Hendy GN (2008) The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1\/3 and Sp1\/3. J Biol Chem 283:13586\u201313600","journal-title":"J Biol Chem"},{"key":"1330_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0885066604271539","volume":"20","author":"GM Tong","year":"2005","unstructured":"Tong GM, Rude RK (2005) Magnesium deficiency in critical illness. J Intensive Care Med 20:3\u201317","journal-title":"J Intensive Care Med"},{"key":"1330_CR27","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/00003246-200001000-00015","volume":"28","author":"L Lind","year":"2000","unstructured":"Lind L, Carlstedt F, Rastad J, Stiernstr\u00f6m H, Stridsberg M et al (2000) Hypocalcemia and parathyroid hormone secretion in critically ill patients. Crit Care Med 28:93\u201399","journal-title":"Crit Care Med"},{"key":"1330_CR28","doi-asserted-by":"publisher","first-page":"e75441","DOI":"10.1371\/journal.pone.0075441","volume":"8","author":"J Hu","year":"2013","unstructured":"Hu J, Luo Z, Zhao X, Chen Q, Chen Z et al (2013) Changes in the calcium-parathyroid hormone-vitamin d axis and prognosis for critically ill patients: a prospective observational study. PLoS ONE 8:e75441","journal-title":"PLoS ONE"},{"key":"1330_CR29","first-page":"47","volume":"24","author":"R Swaminathan","year":"2003","unstructured":"Swaminathan R (2003) Magnesium metabolism and its disorders. Clin Biochem Rev 24:47","journal-title":"Clin Biochem Rev"},{"key":"1330_CR30","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1177\/0148607104028003133","volume":"28","author":"RN Dickerson","year":"2004","unstructured":"Dickerson RN, Alexander KH, Minard G, Croce MA, Brown RO (2004) Accuracy of methods to estimate ionized and \u201ccorrected\u201d serum calcium concentrations in critically ill multiple trauma patients receiving specialized nutrition support. J Parenter Enter Nutr 28:133\u2013141","journal-title":"J Parenter Enter Nutr"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-022-01330-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00774-022-01330-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-022-01330-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T03:30:47Z","timestamp":1657078247000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00774-022-01330-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,31]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["1330"],"URL":"https:\/\/doi.org\/10.1007\/s00774-022-01330-w","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,31]]},"assertion":[{"value":"23 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared no potential conflicts of interest with respect to the research, authorship and\/or publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The research protocols used in this research were approved by the ethics committee and the research council of Qazvin University of Medical Sciences, Qazvin, Iran (The ethical cod: IR.QUMS.Rec.1399.565).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}