{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T19:55:12Z","timestamp":1785614112361,"version":"3.56.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1007\/s00774-024-01528-0","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T23:03:22Z","timestamp":1722035002000},"page":"463-469","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Crosstalk between kidney and bone: insights from CKD-MBD"],"prefix":"10.1007","volume":"42","author":[{"given":"Kodai","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Soeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-4507","authenticated-orcid":false,"given":"Hirotaka","family":"Komaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"1528_CR1","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1007\/s00774-006-0719-7","volume":"24","author":"M Fukagawa","year":"2006","unstructured":"Fukagawa M, Hamada Y, Nakanishi S, Tanaka M (2006) The kidney and bone metabolism: nephrologists\u2019 point of view. J Bone Miner Metab 24:434\u2013438","journal-title":"J Bone Miner Metab"},{"key":"1528_CR2","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1359\/JBMR.0301264","volume":"19","author":"T Shimada","year":"2004","unstructured":"Shimada T, Hasegawa H, Yamazaki Y, Muto T, Hino R, Takeuchi Y, Fujita T, Nakahara K, Fukumoto S, Yamashita T (2004) FGF-23 is a potent regulator of Vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 19:429\u2013435","journal-title":"J Bone Miner Res"},{"key":"1528_CR3","unstructured":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) (2009) (in eng). Kidney Int Suppl:S1\u2013130"},{"key":"1528_CR4","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1681\/ASN.2005010052","volume":"16","author":"O Gutierrez","year":"2005","unstructured":"Gutierrez O, Isakova T, Rhee E, Shah A, Holmes J, Collerone G, Juppner H, Wolf M (2005) Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J Am Soc Nephrol 16:2205\u20132215","journal-title":"J Am Soc Nephrol"},{"key":"1528_CR5","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/ki.2010.313","volume":"78","author":"H Hasegawa","year":"2010","unstructured":"Hasegawa H, Nagano N, Urakawa I, Yamazaki Y, Iijima K, Fujita T, Yamashita T, Fukumoto S, Shimada T (2010) Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease. Kidney Int 78:975\u2013980","journal-title":"Kidney Int"},{"key":"1528_CR6","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/ki.2009.466","volume":"77","author":"H Komaba","year":"2010","unstructured":"Komaba H, Fukagawa M (2010) FGF23\u2013parathyroid interaction: implications in chronic kidney disease. Kidney Int 77:292\u2013298","journal-title":"Kidney Int"},{"key":"1528_CR7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.xkme.2019.09.007","volume":"2","author":"C Kawabata","year":"2020","unstructured":"Kawabata C, Komaba H, Ishida H, Nakagawa Y, Hamano N, Koizumi M, Kanai G, Wada T, Nakamura M, Fukagawa M (2020) Changes in fibroblast growth factor 23 and soluble klotho levels after hemodialysis initiation. Kidney Med 2:59\u201367","journal-title":"Kidney Med"},{"key":"1528_CR8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/sj.ki.5001542","volume":"70","author":"ML Melamed","year":"2006","unstructured":"Melamed ML, Eustace JA, Plantinga L, Jaar BG, Fink NE, Coresh J, Klag MJ, Powe NR (2006) Changes in serum calcium, phosphate, and PTH and the risk of death in incident dialysis patients: a longitudinal study. Kidney Int 70:351\u2013357","journal-title":"Kidney Int"},{"key":"1528_CR9","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/(SICI)1098-2388(199703\/04)13:2<78::AID-SSU3>3.0.CO;2-Z","volume":"13","author":"Y Tominaga","year":"1997","unstructured":"Tominaga Y, Tanaka Y, Sato K, Nagasaka T, Takagi H (1997) Histopathology, pathophysiology, and indications for surgical treatment of renal hyperparathyroidism (in eng). Semin Surg Oncol 13:78\u201386","journal-title":"Semin Surg Oncol"},{"key":"1528_CR10","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/ki.1997.41","volume":"51","author":"J Gogusev","year":"1997","unstructured":"Gogusev J, Duchambon P, Hory B, Giovannini M, Goureau Y, Sarfati E, Dr\u00fceke TB (1997) Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. Kidney Int 51:328\u2013336","journal-title":"Kidney Int"},{"key":"1528_CR11","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1172\/JCI116720","volume":"92","author":"N Fukuda","year":"1993","unstructured":"Fukuda N, Tanaka H, Tominaga Y, Fukagawa M, Kurokawa K, Seino Y (1993) Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients. J Clin Invest 92:1436\u20131443","journal-title":"J Clin Invest"},{"key":"1528_CR12","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/ki.2009.414","volume":"77","author":"H Komaba","year":"2010","unstructured":"Komaba H, Goto S, Fujii H, Hamada Y, Kobayashi A, Shibuya K, Tominaga Y, Otsuki N, Nibu K-I, Nakagawa K, Tsugawa N, Okano T, Kitazawa R, Fukagawa M (2010) Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients. Kidney Int 77:232\u2013238","journal-title":"Kidney Int"},{"key":"1528_CR13","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s10157-023-02336-y","volume":"27","author":"H Komaba","year":"2023","unstructured":"Komaba H (2023) Roles of PTH and FGF23 in kidney failure: a focus on nonclassical effects. Clin Exp Nephrol 27:395\u2013401","journal-title":"Clin Exp Nephrol"},{"key":"1528_CR14","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/1744-9987.12030","volume":"17","author":"M Taniguchi","year":"2013","unstructured":"Taniguchi M, Fukagawa M, Fujii N, Hamano T, Shoji T, Yokoyama K, Nakai S, Shigematsu T, Iseki K, Tsubakihara Y (2013) Serum phosphate and calcium should be primarily and consistently controlled in prevalent hemodialysis patients. Ther Apher Dial 17:221\u2013228","journal-title":"Ther Apher Dial"},{"key":"1528_CR15","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1097\/01.ASN.0000133041.27682.A2","volume":"15","author":"GA Block","year":"2004","unstructured":"Block GA, Klassen PS, Lazarus JM, Ofsthun N, Lowrie EG, Chertow GM (2004) Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 15:2208\u20132218","journal-title":"J Am Soc Nephrol"},{"key":"1528_CR16","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1053\/j.ajkd.2008.03.020","volume":"52","author":"F Tentori","year":"2008","unstructured":"Tentori F, Blayney MJ, Albert JM, Gillespie BW, Kerr PG, Bommer J, Young EW, Akizawa T, Akiba T, Pisoni RL, Robinson BM, Port FK (2008) Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: The Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis 52:519\u2013530","journal-title":"Am J Kidney Dis"},{"key":"1528_CR17","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1056\/NEJMoa1205624","volume":"367","author":"EVOLVE Trial Investigators","year":"2012","unstructured":"EVOLVE Trial Investigators (2012) Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. N Engl J Med 367:2482\u20132494","journal-title":"N Engl J Med"},{"key":"1528_CR18","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1111\/j.1523-1755.2004.00972.x","volume":"66","author":"B Kestenbaum","year":"2004","unstructured":"Kestenbaum B, Andress DL, Schwartz SM, Gillen DL, Seliger SL, Jadav PR, Sherrard DJ, Stehman-Breen C (2004) Survival following parathyroidectomy among United States dialysis patients. Kidney Int 66:2010\u20132016","journal-title":"Kidney Int"},{"key":"1528_CR19","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/ki.2015.72","volume":"88","author":"H Komaba","year":"2015","unstructured":"Komaba H, Taniguchi M, Wada A, Iseki K, Tsubakihara Y, Fukagawa M (2015) Parathyroidectomy and survival among Japanese hemodialysis patients with secondary hyperparathyroidism. Kidney Int 88:350\u2013359","journal-title":"Kidney Int"},{"key":"1528_CR20","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1210\/clinem\/dgac142","volume":"107","author":"H Komaba","year":"2022","unstructured":"Komaba H, Hamano T, Fujii N, Moriwaki K, Wada A, Masakane I, Nitta K, Fukagawa M (2022) Parathyroidectomy vs cinacalcet among patients undergoing hemodialysis. J Clin Endocr Metab 107:2016\u20132025","journal-title":"J Clin Endocr Metab"},{"key":"1528_CR21","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1093\/ndt\/gfaa054","volume":"35","author":"MB Lopes","year":"2020","unstructured":"Lopes MB, Karaboyas A, Bieber B, Pisoni RL, Walpen S, Fukagawa M, Christensson A, Evenepoel P, Pegoraro M, Robinson BM, Pecoits-Filho R (2020) Impact of longer term phosphorus control on cardiovascular mortality in hemodialysis patients using an area under the curve approach: results from the DOPPS. Nephrol Dial Transplant 35:1794\u20131801","journal-title":"Nephrol Dial Transplant"},{"key":"1528_CR22","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1161\/01.RES.87.7.e10","volume":"87","author":"S Jono","year":"2000","unstructured":"Jono S, McKee MD, Murry CE, Shioi A, Nishizawa Y, Mori K, Morii H, Giachelli CM (2000) Phosphate regulation of vascular smooth muscle cell calcification. Circ Res 87:e10\u2013e17","journal-title":"Circ Res"},{"key":"1528_CR23","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1681\/ASN.2020050598","volume":"32","author":"Y Isaka","year":"2021","unstructured":"Isaka Y, Hamano T, Fujii H, Tsujimoto Y, Koiwa F, Sakaguchi Y, Tanaka R, Tomiyama N, Tatsugami F, Teramukai S (2021) Optimal phosphate control related to coronary artery calcification in dialysis patients. J Am Soc Nephrol 32:723\u2013735","journal-title":"J Am Soc Nephrol"},{"key":"1528_CR24","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","volume":"69","author":"S Moe","year":"2006","unstructured":"Moe S, Dr\u00fceke T, Cunningham J, Goodman W, Martin K, Olgaard K, Ott S, Sprague S, Lameire N, Eknoyan G (2006) Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 69:1945\u20131953","journal-title":"Kidney Int"},{"key":"1528_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/endocr\/bqad022","volume":"164","author":"T Hasegawa","year":"2023","unstructured":"Hasegawa T, Tokunaga S, Yamamoto T, Sakai M, Hongo H, Kawata T, Amizuka N (2023) Evocalcet rescues secondary hyperparathyroidism-driven cortical porosity in CKD male rats. Endocrinology 164:1\u201317","journal-title":"Endocrinology"},{"key":"1528_CR26","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1038\/ki.2008.60","volume":"73","author":"DL Andress","year":"2008","unstructured":"Andress DL (2008) Adynamic bone in patients with chronic kidney disease. Kidney Int 73:1345\u20131354","journal-title":"Kidney Int"},{"key":"1528_CR27","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1038\/sj.ki.5001754","volume":"70","author":"M Jadoul","year":"2006","unstructured":"Jadoul M, Albert JM, Akiba T, Akizawa T, Arab L, Bragg-Gresham JL, Mason N, Prutz KG, Young EW, Pisoni RL (2006) Incidence and risk factors for hip or other bone fractures among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study. Kidney Int 70:1358\u20131366","journal-title":"Kidney Int"},{"key":"1528_CR28","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/kisup.2013.93","volume":"3","author":"JJ Kazama","year":"2013","unstructured":"Kazama JJ, Iwasaki Y, Fukagawa M (2013) Uremic osteoporosis. Kidney Int Suppl 3:446\u2013450","journal-title":"Kidney Int Suppl"},{"key":"1528_CR29","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s11914-017-0364-1","volume":"15","author":"SM Moe","year":"2017","unstructured":"Moe SM (2017) Renal osteodystrophy or kidney-induced osteoporosis? Curr Osteoporos Rep 15:194\u2013197","journal-title":"Curr Osteoporos Rep"},{"key":"1528_CR30","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.bone.2015.07.015","volume":"81","author":"Y Iwasaki","year":"2015","unstructured":"Iwasaki Y, Kazama JJ, Yamato H, Matsugaki A, Nakano T, Fukagawa M (2015) Altered material properties are responsible for bone fragility in rats with chronic kidney injury. Bone 81:247\u2013254","journal-title":"Bone"},{"key":"1528_CR31","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1096\/fj.07-098954","volume":"22","author":"H Shimizu","year":"2008","unstructured":"Shimizu H, Nakagami H, Osako MK, Hanayama R, Kunugiza Y, Kizawa T, Tomita T, Yoshikawa H, Ogihara T, Morishita R (2008) Angiotensin II accelerates osteoporosis by activating osteoclasts. FASEB J 22:2465\u20132475","journal-title":"FASEB J"},{"key":"1528_CR32","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/jcsm.12421","volume":"10","author":"L Koppe","year":"2019","unstructured":"Koppe L, Fouque D, Kalantar-Zadeh K (2019) Kidney cachexia or protein-energy wasting in chronic kidney disease: facts and numbers. J Cachexia Sarcopenia Muscle 10:479\u2013484","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"1528_CR33","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s13539-011-0019-5","volume":"2","author":"RH Mak","year":"2011","unstructured":"Mak RH, Ikizler AT, Kovesdy CP, Raj DS, Stenvinkel P, Kalantar-Zadeh K (2011) Wasting in chronic kidney disease. J Cachexia Sarcopenia Muscle 2:9\u201325","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"1528_CR34","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1046\/j.1523-1755.2002.00658.x","volume":"62","author":"TB Pifer","year":"2002","unstructured":"Pifer TB, McCullough KP, Port FK, Goodkin DA, Maroni BJ, Held PJ, Young EW (2002) Mortality risk in hemodialysis patients and changes in nutritional indicators: DOPPS. Kidney Int 62:2238\u20132245","journal-title":"Kidney Int"},{"key":"1528_CR35","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1053\/j.ajkd.2005.05.020","volume":"46","author":"K Kalantar-Zadeh","year":"2005","unstructured":"Kalantar-Zadeh K, Kopple JD, Kilpatrick RD, McAllister CJ, Shinaberger CS, Gjertson DW, Greenland S (2005) Association of morbid obesity and weight change over time with cardiovascular survival in hemodialysis population. Am J Kidney Dis 46:489\u2013500","journal-title":"Am J Kidney Dis"},{"key":"1528_CR36","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.cmet.2015.11.003","volume":"23","author":"S Kir","year":"2016","unstructured":"Kir S, Komaba H, Garcia Ana P, Economopoulos Konstantinos P, Liu W, Lanske B, Hodin Richard A, Spiegelman Bruce M (2016) PTH\/PTHrP receptor mediates cachexia in models of kidney failure and cancer. Cell Metab 23:315\u2013323","journal-title":"Cell Metab"},{"key":"1528_CR37","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1097\/01.ASN.0000141961.49723.BC","volume":"15","author":"L Cuppari","year":"2004","unstructured":"Cuppari L, de Carvalho AB, Avesani CM, Kamimura MA, Dos Santos Lob\u00e3o RR, Draibe SA (2004) Increased resting energy expenditure in hemodialysis patients with severe hyperparathyroidism. J Am Soc Nephrol 15:2933\u20132939","journal-title":"J Am Soc Nephrol"},{"key":"1528_CR38","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/jcsm.12722","volume":"12","author":"H Komaba","year":"2021","unstructured":"Komaba H, Zhao J, Yamamoto S, Nomura T, Fuller DS, McCullough KP, Evenepoel P, Christensson A, Zhao X, Alrukhaimi M, Al-Ali F, Young EW, Robinson BM, Fukagawa M (2021) Secondary hyperparathyroidism, weight loss, and longer term mortality in haemodialysis patients: results from the DOPPS. J Cachexia Sarcopenia Muscle 12:855\u2013865","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"1528_CR39","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/ki.2013.150","volume":"84","author":"M Christov","year":"2013","unstructured":"Christov M, Waikar SS, Pereira RC et al (2013) Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney Int 84:776\u2013785","journal-title":"Kidney Int"},{"key":"1528_CR40","doi-asserted-by":"publisher","first-page":"4693","DOI":"10.1038\/s41467-019-12399-9","volume":"10","author":"PP Centeno","year":"2019","unstructured":"Centeno PP, Herberger A, Mun HC et al (2019) Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion. Nat Commun 10:4693","journal-title":"Nat Commun"},{"key":"1528_CR41","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/ki.2014.215","volume":"86","author":"T Meir","year":"2014","unstructured":"Meir T, Durlacher K, Pan Z, Amir G et al (2014) Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription. Kidney Int 86:1106\u20131115","journal-title":"Kidney Int"},{"key":"1528_CR42","doi-asserted-by":"publisher","first-page":"E652","DOI":"10.1210\/jc.2013-4050","volume":"99","author":"H Takahashi","year":"2014","unstructured":"Takahashi H, Komaba H, Takahashi Y et al (2014) Impact of parathyroidectomy on serum FGF23 and soluble Klotho in hemodialysis patients with severe secondary hyperparathyroidism. J Clin Endocrinol Metab 99:E652\u2013E658","journal-title":"J Clin Endocrinol Metab"},{"key":"1528_CR43","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1093\/ndt\/gfr384","volume":"27","author":"M Koizumi","year":"2012","unstructured":"Koizumi M, Komaba H, Nakanishi S, Fujimori A, Fukagawa M (2012) Cinacalcet treatment and serum FGF23 levels in haemodialysis patients with secondary hyperparathyroidism. Nephrol Dial Transplant 27:784\u2013790","journal-title":"Nephrol Dial Transplant"},{"key":"1528_CR44","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/ki.2011.47","volume":"79","author":"T Isakova","year":"2011","unstructured":"Isakova T, Wahl P, Vargas GS et al (2011) Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int 79:1370\u20131378","journal-title":"Kidney Int"},{"key":"1528_CR45","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.molmet.2018.02.007","volume":"11","author":"N Bon","year":"2018","unstructured":"Bon N, Frangi G, Sourice S, Guicheux J, Beck-Cormier S, Beck L (2018) Phosphate-dependent FGF23 secretion is modulated by PiT2\/Slc20a2. Mol Metab 11:197\u2013204","journal-title":"Mol Metab"},{"key":"1528_CR46","doi-asserted-by":"publisher","first-page":"11418","DOI":"10.1073\/pnas.1815166116","volume":"116","author":"Y Takashi","year":"2019","unstructured":"Takashi Y, Kosako H, Sawatsubashi S et al (2019) Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation. Proc Natl Acad Sci U S A 116:11418\u201311427","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1528_CR47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI164610","volume":"133","author":"W Zhou","year":"2023","unstructured":"Zhou W, Simic P, Zhou IY et al (2023) Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis. J Clin Invest 133:e164610","journal-title":"J Clin Invest"},{"key":"1528_CR48","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1172\/JCI131190","volume":"130","author":"P Simic","year":"2020","unstructured":"Simic P, Kim W, Zhou W et al (2020) Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. J Clin Invest 130:1513\u20131526","journal-title":"J Clin Invest"},{"key":"1528_CR49","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1093\/ndt\/gfs160","volume":"27","author":"MC Hu","year":"2012","unstructured":"Hu MC, Kuro-o M, Moe OW (2012) The emerging role of Klotho in clinical nephrology. Nephrol Dial Transplant 27:2650\u20132657","journal-title":"Nephrol Dial Transplant"},{"key":"1528_CR50","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/nature05315","volume":"444","author":"I Urakawa","year":"2006","unstructured":"Urakawa I, Yamazaki Y, Shimada T et al (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444:770\u2013774","journal-title":"Nature"},{"key":"1528_CR51","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1006\/bbrc.2000.4226","volume":"280","author":"N Koh","year":"2001","unstructured":"Koh N, Fujimori T, Nishiguchi S et al (2001) Severely reduced production of klotho in human chronic renal failure kidney. Biochem Biophys Res Commun 280:1015\u20131020","journal-title":"Biochem Biophys Res Commun"},{"key":"1528_CR52","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1159\/000346778","volume":"180","author":"MC Hu","year":"2013","unstructured":"Hu MC, Kuro-o M, Moe OW (2013) Klotho and chronic kidney disease. Contrib Nephrol 180:47\u201363","journal-title":"Contrib Nephrol"},{"key":"1528_CR53","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.1096\/fj.201700006R","volume":"31","author":"JR Mu\u00f1oz-Casta\u00f1eda","year":"2017","unstructured":"Mu\u00f1oz-Casta\u00f1eda JR, Herencia C, Pend\u00f3n-Ruiz de Mier MV et al (2017) Differential regulation of renal Klotho and FGFR1 in normal and uremic rats. FASEB J 31:3858\u20133867","journal-title":"FASEB J"},{"key":"1528_CR54","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature25451","volume":"553","author":"G Chen","year":"2018","unstructured":"Chen G, Liu Y, Goetz R et al (2018) \u03b1-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling. Nature 553:461\u2013466","journal-title":"Nature"},{"key":"1528_CR55","doi-asserted-by":"publisher","first-page":"4710","DOI":"10.1172\/JCI64986","volume":"122","author":"RC Smith","year":"2012","unstructured":"Smith RC, O\u2019Bryan LM, Farrow EG et al (2012) Circulating \u03b1Klotho influences phosphate handling by controlling FGF23 production. J Clin Invest 122:4710\u20134715","journal-title":"J Clin Invest"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-024-01528-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00774-024-01528-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-024-01528-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T09:07:06Z","timestamp":1726823226000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00774-024-01528-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["1528"],"URL":"https:\/\/doi.org\/10.1007\/s00774-024-01528-0","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"13 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"HK has received honoraria, consulting fees, and\/or grant support from Chugai Pharmaceutical, Kissei Pharmaceutical, Kyowa Kirin, Ono Pharmaceutical, Sanwa Kagaku Kenkyusho, and Torii Pharmaceutical. The remaining authors have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}