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Since 2022, the duration of antibiotic administration during extractions in such patients has been intentionally shortened to prevent antimicrobial resistance at our hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study involved 160 patients on low-dose bisphosphonates (BPs) requiring tooth extractions between 2019 and 2024 at four Japanese institutions. In 2019\u20132021, patients received amoxicillin (AMPC) 500\u00a0mg 1\u00a0h before and 750\u00a0mg per day for 2\u00a0days post-extraction. In 2022\u20132024, a single 500\u00a0mg dose of AMPC was administered 1\u00a0h pre-extraction. Patients were managed with tension-free wound suturing and regular follow-up. The rates of MRONJ development were compared between the two periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MRONJ developed in 3 out of 170 teeth (1.76%) in 2019\u20132021, and in 2 out of 147 teeth (1.36%) in 2022\u20132024, with no significant difference (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20091.000). All MRONJ cases were low-stage (Stage 1) and healed completely within 12\u201316\u00a0weeks. Four out of five MRONJ cases (80%) exhibited radiopaque changes around the root. When all teeth in both groups were surveyed, MRONJ development was significantly higher in teeth with such changes compared to those without (4\/58 vs. 1\/259;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A single preoperative dose of AMPC may be sufficient for tooth extractions in patients on low-dose BPs. However, teeth with radiopaque changes around the root require careful monitoring postextraction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00774-025-01617-8","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T08:35:40Z","timestamp":1751445340000},"page":"525-534","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["What is the appropriate antibiotic administration to prevent MRONJ development after tooth extraction?"],"prefix":"10.1007","volume":"43","author":[{"given":"Eiji","family":"Iwata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Ohori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Susukida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanae","family":"Yatagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Kashin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Miyai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"1617_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2022.103859","volume":"107","author":"M Ashrafi","year":"2022","unstructured":"Ashrafi M, Gholamian F, Doblare M (2022) A comparison between the effect of systemic and coated drug delivery in osteoporotic bone after dental implantation. 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