{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:26:57Z","timestamp":1786606017685,"version":"build-2736575974"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Xinjiang Uygur Autonomous Region Tianshan Talents Medical and Health High-Level Personnel Training Program","award":["TSYC202301B026"],"award-info":[{"award-number":["TSYC202301B026"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00774-026-01710-6","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T07:32:12Z","timestamp":1774251132000},"page":"469-481","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of potential diagnostic and therapeutic apoptosis-related casual targets for osteoporosis: an integrated multi-omics analysis"],"prefix":"10.1007","volume":"44","author":[{"given":"Yixi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lintao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5889-0179","authenticated-orcid":false,"given":"Paerhati","family":"Rexiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"1710_CR1","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/S0140-6736(21)02646-5","volume":"399","author":"IR Reid","year":"2022","unstructured":"Reid IR, Billington EO (2022) Drug therapy for osteoporosis in older adults. Lancet 399:1080\u20131092. https:\/\/doi.org\/10.1016\/S0140-6736(21)02646-5","journal-title":"Lancet"},{"key":"1710_CR2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3760\/cma.j.cn311282-20230321-00122","volume":"39","author":"Chineses Society of Osteoporosis And Bone Mineral Research","year":"2023","unstructured":"Chineses Society of Osteoporosis And Bone Mineral Research (2023) Guidelines for the diagnosis and treatment of primary osteoporosis (2022). Chin J Endocrinol Metab 39:377\u2013406. https:\/\/doi.org\/10.3760\/cma.j.cn311282-20230321-00122","journal-title":"Chin J Endocrinol Metab"},{"key":"1710_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-022-01092-y","volume":"17","author":"ARB da Silva","year":"2022","unstructured":"da Silva ARB, Martinez LC, de Meiros Pinheiro M, Szejnfeld VL (2022) Secular trends in hip fractures in adults over 50 years old: a retrospective analysis of hospital admissions to the Brazilian Public Health System from 2004 to 2013. Arch Osteoporos 17:50. https:\/\/doi.org\/10.1007\/s11657-022-01092-y","journal-title":"Arch Osteoporos"},{"key":"1710_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108168","volume":"237","author":"S Song","year":"2022","unstructured":"Song S, Guo Y, Yang Y, Fu D (2022) Advances in pathogenesis and therapeutic strategies for osteoporosis. Pharmacol Ther 237:108168. https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108168","journal-title":"Pharmacol Ther"},{"key":"1710_CR5","doi-asserted-by":"publisher","first-page":"106635","DOI":"10.1016\/j.phrs.2022.106635","volume":"187","author":"Z Li","year":"2023","unstructured":"Li Z, Li D, Chen R, Gao S, Xu Z, Li N\u00a0(2023) Cell death regulation: a new way for natural products to treat osteoporosis. Pharmacol Res 187:106635. https:\/\/doi.org\/10.1016\/j.phrs.2022.106635","journal-title":"Pharmacol Res"},{"key":"1710_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122045","volume":"17","author":"T Komori","year":"2016","unstructured":"Komori T (2016) Cell death in chondrocytes, osteoblasts, and osteocytes. Int J Mol Sci 17:2045. https:\/\/doi.org\/10.3390\/ijms17122045","journal-title":"Int J Mol Sci"},{"key":"1710_CR7","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1002\/jbmr.2808","volume":"31","author":"T Moriishi","year":"2016","unstructured":"Moriishi T, Fukuyama R, Miyazaki T, Furuichi T, Ito M, Komori T (2016) Overexpression of BCLXL in osteoblasts inhibits osteoblast apoptosis and increases bone volume and strength. J Bone Miner Res 31:1366\u20131380. https:\/\/doi.org\/10.1002\/jbmr.2808","journal-title":"J Bone Miner Res"},{"key":"1710_CR8","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1196\/annals.1346.020","volume":"1068","author":"S Tanaka","year":"2006","unstructured":"Tanaka S, Miyazaki T, Fukuda A, Akiyama T, Kadono Y, Wakeyama H, Kono S, Hoshikawa S, Nakamura M, Ohshima Y, Hikita A, Nakamura I, Nakamura K (2006) Molecular mechanism of the life and death of the osteoclast. Ann N Y Acad Sci 1068:180\u2013186. https:\/\/doi.org\/10.1196\/annals.1346.020","journal-title":"Ann N Y Acad Sci"},{"key":"1710_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41413-020-0102-7","volume":"8","author":"AMJ M\u00f8ller","year":"2020","unstructured":"M\u00f8ller AMJ, Delaiss\u00e9 J-M, Olesen JB, Madsen JS, Canto LM, Bechmann T, Rogatto SR, S\u00f8e K (2020) Aging and menopause reprogram osteoclast precursors for aggressive bone resorption. Bone Res 8:27. https:\/\/doi.org\/10.1038\/s41413-020-0102-7","journal-title":"Bone Res"},{"key":"1710_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101943","volume":"88","author":"L Gerosa","year":"2023","unstructured":"Gerosa L, Malvandi AM, Malavolta M, Provinciali M, Lombardi G (2023) Exploring cellular senescence in the musculoskeletal system: any insights for biomarkers discovery? Ageing Res Rev 88:101943. https:\/\/doi.org\/10.1016\/j.arr.2023.101943","journal-title":"Ageing Res Rev"},{"key":"1710_CR11","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1210\/endrev\/bnaa016","volume":"41","author":"MCK Severinsen","year":"2020","unstructured":"Severinsen MCK, Pedersen BK (2020) Muscle-organ crosstalk: the emerging roles of myokines. Endocr Rev 41:594\u2013609. https:\/\/doi.org\/10.1210\/endrev\/bnaa016","journal-title":"Endocr Rev"},{"key":"1710_CR12","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1159\/000528585","volume":"79","author":"L Chen","year":"2023","unstructured":"Chen L, Wu J, Ren W, Li X, Luo M, Hu Y (2023) The relationship between skeletal muscle mass and bone mass at different sites in older adults. Ann Nutr Metab 79:256\u2013262. https:\/\/doi.org\/10.1159\/000528585","journal-title":"Ann Nutr Metab"},{"key":"1710_CR13","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12916-023-02878-8","volume":"21","author":"S Xu","year":"2023","unstructured":"Xu S, Li X, Zhang S, Qi C, Zhang Z, Ma R, Xiang L, Chen L, Zhu Y, Tang C, Bourgonje AR, Li M, He Y, Zeng Z, Hu S, Feng R, Chen M (2023) Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn\u2019s disease: a multi-omics Mendelian randomization study. BMC Med 21:179. https:\/\/doi.org\/10.1186\/s12916-023-02878-8","journal-title":"BMC Med"},{"key":"1710_CR14","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/s41467-017-00108-3","volume":"8","author":"C Medina-Gomez","year":"2017","unstructured":"Medina-Gomez C, Kemp JP, Dimou NL, Kreiner E, Chesi A et al (2017) Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1\/TOM1L2 locus. Nat Commun 8:121. https:\/\/doi.org\/10.1038\/s41467-017-00108-3","journal-title":"Nat Commun"},{"key":"1710_CR15","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1038\/s41588-021-00923-x","volume":"53","author":"JL Min","year":"2021","unstructured":"Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J et al (2021) Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nat Genet 53:1311\u20131321. https:\/\/doi.org\/10.1038\/s41588-021-00923-x","journal-title":"Nat Genet"},{"key":"1710_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779","volume":"12","author":"C Sudlow","year":"2015","unstructured":"Sudlow C, Gallacher J, Allen N, Beral V, Burton P et al (2015) UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med 12:e1001779. https:\/\/doi.org\/10.1371\/journal.pmed.1001779","journal-title":"PLoS Med"},{"key":"1710_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.783322","author":"M Huang","year":"2021","unstructured":"Huang M, Xu S, Liu L, Zhang M, Guo J, Yuan Y, Xu J, Chen X, Zou J (2021) M6A methylation regulates osteoblastic differentiation and bone remodeling. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2021.783322","journal-title":"Front Cell Dev Biol"},{"key":"1710_CR18","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.canlet.2015.05.023","volume":"365","author":"D Douchi","year":"2015","unstructured":"Douchi D, Ohtsuka H, Ariake K, Masuda K, Kawasaki S, Kawaguchi K, Fukase K, Oikawa M, Motoi F, Naitoh T, Katayose Y, Egawa S, Unno M (2015) Silencing of LRRFIP1 reverses the epithelial\u2013mesenchymal transition via inhibition of the Wnt\/\u03b2-catenin signaling pathway. Cancer Lett 365:132\u2013140. https:\/\/doi.org\/10.1016\/j.canlet.2015.05.023","journal-title":"Cancer Lett"},{"key":"1710_CR19","doi-asserted-by":"publisher","first-page":"3450","DOI":"10.4049\/jimmunol.0802260","volume":"182","author":"P Dai","year":"2009","unstructured":"Dai P, Jeong SY, Yu Y, Leng T, Wu W, Xie L, Chen X (2009) Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. J Immunol 182:3450\u20133460. https:\/\/doi.org\/10.4049\/jimmunol.0802260","journal-title":"J Immunol"},{"key":"1710_CR20","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1021\/pr050031z","volume":"4","author":"T Wang","year":"2005","unstructured":"Wang T, Gu S, Ronni T, Du Y-C, Chen X (2005) In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. J Proteome Res 4:941\u2013949. https:\/\/doi.org\/10.1021\/pr050031z","journal-title":"J Proteome Res"},{"key":"1710_CR21","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/labinvest.3700545","volume":"87","author":"Y Duan","year":"2007","unstructured":"Duan Y, Liao AP, Kuppireddi S, Ye Z, Ciancio MJ, Sun J (2007) \u03b2-catenin activity negatively regulates bacteria-induced inflammation. Lab Invest 87:613\u2013624. https:\/\/doi.org\/10.1038\/labinvest.3700545","journal-title":"Lab Invest"},{"key":"1710_CR22","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1074\/mcp.M114.043836","volume":"14","author":"M Rotival","year":"2015","unstructured":"Rotival M, Ko J-H, Srivastava PK, Kerloc\u2019h A, Montoya A, Mauro C, Faull P, Cutillas PR, Petretto E, Behmoaras J (2015) Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation. Mol Cell Proteomics 14:484\u2013498. https:\/\/doi.org\/10.1074\/mcp.M114.043836","journal-title":"Mol Cell Proteomics"},{"key":"1710_CR23","doi-asserted-by":"publisher","unstructured":"Labb\u00e9 P, Faure E, Lecointe S, Le Scouarnec S, Kyndt F, Marrec M, Le Tourneau T, Offmann B, Dupla\u00e0 C, Zaffran S, Schott JJ, Merot J (2017) The alternatively spliced LRRFIP1 isoform-1 is a key regulator of the Wnt\/\u03b2-catenin transcription pathway. Biochimica et Biophysica Acta (BBA) - Mol Cell Res 1864:1142\u20131152. https:\/\/doi.org\/10.1016\/j.bbamcr.2017.03.008","DOI":"10.1016\/j.bbamcr.2017.03.008"},{"key":"1710_CR24","doi-asserted-by":"publisher","unstructured":"Becker IC, Barrachina MN, Lykins J, Camacho V, Stone AP, Chua BA, Signer RAJ, Machlus KR, Whiteheart SW, Roweth HG, Italiano JE (2024) Inhibition of RhoA-mediated secretory autophagy in megakaryocytes mitigates myelofibrosis in mice. bioRxiv. https:\/\/doi.org\/10.1101\/2024.12.04.626665","DOI":"10.1101\/2024.12.04.626665"},{"key":"1710_CR25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3390\/cells8020108","volume":"8","author":"M Takimoto","year":"2019","unstructured":"Takimoto M (2019) Multidisciplinary roles of LRRFIP1\/GCF2 in human biological systems and diseases. Cells 8:108. https:\/\/doi.org\/10.3390\/cells8020108","journal-title":"Cells"},{"key":"1710_CR26","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.7150\/ijms.27333","volume":"15","author":"P Wang","year":"2018","unstructured":"Wang P, Cao Y, Zhan D, Wang D, Wang B, Liu Y, Li G, He W, Wang H, Xu L (2018) Influence of DNA methylation on the expression of OPG\/RANKL in primary osteoporosis. Int J Med Sci 15:1480\u20131485. https:\/\/doi.org\/10.7150\/ijms.27333","journal-title":"Int J Med Sci"},{"key":"1710_CR27","doi-asserted-by":"publisher","unstructured":"Wang Y, Sun L, Kan T, Xue W, Wang H, Xu P, Zhang L, Yan M, Li H, Yu Z (2024) Hypermethylation of Bmp2 and Fgfr2 Promoter Regions in Bone Marrow Mesenchymal Stem Cells Leads to Bone Loss in Prematurely Aged Mice. Aging Dis 16:1149\u20131168. https:\/\/doi.org\/10.14336\/AD.2024.0324","DOI":"10.14336\/AD.2024.0324"},{"key":"1710_CR28","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.ajhg.2023.12.017","volume":"111","author":"L Romo","year":"2024","unstructured":"Romo L, Findlay SD, Burge CB (2024) Regulatory features aid interpretation of 3\u2032UTR variants. Am J Hum Genet 111:350\u2013363. https:\/\/doi.org\/10.1016\/j.ajhg.2023.12.017","journal-title":"Am J Hum Genet"},{"key":"1710_CR29","doi-asserted-by":"publisher","unstructured":"Rodr\u00edguez-Ruiz L, Lozano-Gil JM, Naranjo-S\u00e1nchez E, Mart\u00ednez-Balsalobre E, Mart\u00ednez-L\u00f3pez A, Lachaud C, Blanquer M, Phung TK, Garc\u00eda-Moreno D, Cayuela ML, Tyrkalska SD, P\u00e9rez-Oliva AB, Mulero V (2023) ZAK\u03b1 \/ P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome. EMBO Mol Med. https:\/\/doi.org\/10.15252\/emmm.202318142","DOI":"10.15252\/emmm.202318142"},{"key":"1710_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901412","author":"Y Lv","year":"2020","unstructured":"Lv Y, Huang Y, Xu M, Heng BC, Yang C, Cao C, Hu Z, Liu W, Chi X, Gao M, Zhang X, Wei Y, Deng X (2020) The miR-193a-3p-MAP3k3 signaling axis regulates substrate topography-induced osteogenesis of bone marrow stem cells. Adv Sci. https:\/\/doi.org\/10.1002\/advs.201901412","journal-title":"Adv Sci"},{"key":"1710_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04902-w","volume":"13","author":"W-Z He","year":"2022","unstructured":"He W-Z, Yang M, Jiang Y, He C, Sun Y-C et al (2022) miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing. Cell Death Dis 13:494. https:\/\/doi.org\/10.1038\/s41419-022-04902-w","journal-title":"Cell Death Dis"},{"key":"1710_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115679","volume":"142","author":"ML Potter","year":"2021","unstructured":"Potter ML, Hill WD, Isales CM, Hamrick MW, Fulzele S (2021) MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells. Bone 142:115679. https:\/\/doi.org\/10.1016\/j.bone.2020.115679","journal-title":"Bone"},{"key":"1710_CR33","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/s41419-021-04110-y","volume":"12","author":"B Zhang","year":"2021","unstructured":"Zhang B, Yuan P, Xu G, Chen Z, Li Z, Ye H, Wang J, Shi P, Sun X (2021) DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2\/Smad2 signaling. Cell Death Dis 12:825. https:\/\/doi.org\/10.1038\/s41419-021-04110-y","journal-title":"Cell Death Dis"},{"key":"1710_CR34","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/nm.3917","volume":"21","author":"B Dankbar","year":"2015","unstructured":"Dankbar B, Fennen M, Brunert D, Hayer S, Frank S, Wehmeyer C, Beckmann D, Paruzel P, Bertrand J, Redlich K, Koers-Wunrau C, Stratis A, Korb-Pap A, Pap T (2015) Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice. Nat Med 21:1085\u20131090. https:\/\/doi.org\/10.1038\/nm.3917","journal-title":"Nat Med"},{"key":"1710_CR35","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007764","author":"A Bozec","year":"2014","unstructured":"Bozec A, Zaiss MM, Kagwiria R, Voll R, Rauh M, Chen Z, Mueller-Schmucker S, Kroczek RA, Heinzerling L, Moser M, Mellor AL, David J-P, Schett G (2014) T cell costimulation molecules CD80\/86 inhibit osteoclast differentiation by inducing the IDO\/tryptophan pathway. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.3007764","journal-title":"Sci Transl Med"},{"key":"1710_CR36","doi-asserted-by":"publisher","first-page":"38369","DOI":"10.1038\/srep38369","volume":"6","author":"A Russo","year":"2016","unstructured":"Russo A, Saide A, Cagliani R, Cantile M, Botti G, Russo G (2016) RpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NF\u03baB upon 5-FU treatment. Sci Rep 6:38369. https:\/\/doi.org\/10.1038\/srep38369","journal-title":"Sci Rep"},{"key":"1710_CR37","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1152\/japplphysiol.00946.2018","volume":"127","author":"T Chaillou","year":"2019","unstructured":"Chaillou T (2019) Ribosome specialization and its potential role in the control of protein translation and skeletal muscle size. J Appl Physiol 127:599\u2013607. https:\/\/doi.org\/10.1152\/japplphysiol.00946.2018","journal-title":"J Appl Physiol"},{"key":"1710_CR38","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/jcp.24250","volume":"228","author":"H Okamura","year":"2013","unstructured":"Okamura H, Yoshida K, Yang D, Haneji T (2013) Protein phosphatase 2A C\u03b1 regulates osteoblast differentiation and the expressions of bone sialoprotein and osteocalcin via osterix transcription factor. J Cell Physiol 228:1031\u20131037. https:\/\/doi.org\/10.1002\/jcp.24250","journal-title":"J Cell Physiol"},{"key":"1710_CR39","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1038\/bjc.2014.141","volume":"110","author":"A Bhardwaj","year":"2014","unstructured":"Bhardwaj A, Singh S, Srivastava SK, Arora S, Hyde SJ, Andrews J, Grizzle WE, Singh AP (2014) Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model. Br J Cancer 110:2000\u20132010. https:\/\/doi.org\/10.1038\/bjc.2014.141","journal-title":"Br J Cancer"},{"key":"1710_CR40","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.tips.2021.04.003","volume":"42","author":"SA Serapian","year":"2021","unstructured":"Serapian SA, Sanchez-Mart\u00edn C, Moroni E, Rasola A, Colombo G (2021) Targeting the mitochondrial chaperone TRAP1: strategies and therapeutic perspectives. Trends Pharmacol Sci 42:566\u2013576. https:\/\/doi.org\/10.1016\/j.tips.2021.04.003","journal-title":"Trends Pharmacol Sci"},{"key":"1710_CR41","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.3390\/clinpract14060216","volume":"14","author":"GN Iaconisi","year":"2024","unstructured":"Iaconisi GN, Mancini R, Ricci V, Donati D, Sconza C, Marvulli R, Ranieri M, Megna M, Varrassi G, Della Tommasa S, Bernetti A, Capobianco L, Far\u00ec G (2024) Biochemical mechanisms and rehabilitation strategies in osteoporosis-related pain: a systematic review. Clin Pract 14:2737\u20132758. https:\/\/doi.org\/10.3390\/clinpract14060216","journal-title":"Clin Pract"},{"key":"1710_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1002871","author":"C Cui","year":"2022","unstructured":"Cui C, Tian X, Wei L, Wang Y, Wang K, Fu R (2022) New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2022.1002871","journal-title":"Front Pharmacol"},{"key":"1710_CR43","doi-asserted-by":"publisher","first-page":"4632","DOI":"10.3390\/jcm12144632","volume":"12","author":"B Torrecillas-Baena","year":"2023","unstructured":"Torrecillas-Baena B, Camacho-Cardenosa M, Quesada-G\u00f3mez JM, Moreno-Moreno P, Dorado G, G\u00e1lvez-Moreno M\u00c1, Casado-D\u00edaz A (2023) Non-specific inhibition of dipeptidyl peptidases 8\/9 by dipeptidyl peptidase 4 inhibitors negatively affects mesenchymal stem cell differentiation. J Clin Med 12:4632. https:\/\/doi.org\/10.3390\/jcm12144632","journal-title":"J Clin Med"},{"key":"1710_CR44","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1038\/ncomms4351","volume":"5","author":"H Kim","year":"2014","unstructured":"Kim H, Lee H-J, Oh Y, Choi S-G, Hong S-H, Kim H-J, Lee S-Y, Choi J-W, Su Hwang D, Kim K-S, Kim H-J, Zhang J, Youn H-J, Noh D-Y, Jung Y-K (2014) The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth. Nat Commun 5:3351. https:\/\/doi.org\/10.1038\/ncomms4351","journal-title":"Nat Commun"},{"key":"1710_CR45","doi-asserted-by":"publisher","unstructured":"Ahmad SS, Ahmed F, Ahmad S, Krishnan A, Khan MA (2025) Targeting dipeptidyl peptidase-8\/9 to combat inflammation-induced osteoclastogenesis in RAW264.7 macrophages and analysis of anti-osteoclastogenesis potential of chrysin. Iran J Basic Med Sci 28:516\u2013526. https:\/\/doi.org\/10.22038\/ijbms.2025.82219.17784","DOI":"10.22038\/ijbms.2025.82219.17784"},{"key":"1710_CR46","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/jpp\/rgae109","volume":"77","author":"SS Ahmad","year":"2025","unstructured":"Ahmad SS, Ahmed F, Alam MM, Ahmad S, Khan MA (2025) Unravelling the role of dipeptidyl peptidases-8\/9 (DPP-8\/9) in inflammatory osteoporosis: a comprehensive study investigating chrysin as a potential anti-osteoporotic agent. J Pharm Pharmacol 77:249\u2013263. https:\/\/doi.org\/10.1093\/jpp\/rgae109","journal-title":"J Pharm Pharmacol"},{"key":"1710_CR47","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/1471-213X-10-104","volume":"10","author":"T Camarata","year":"2010","unstructured":"Camarata T, Snyder D, Schwend T, Klosowiak J, Holtrup B, Simon H-G (2010) Pdlim7 is required for maintenance of the mesenchymal\/epidermal Fgf signaling feedback loop during zebrafish pectoral fin development. BMC Dev Biol 10:104. https:\/\/doi.org\/10.1186\/1471-213X-10-104","journal-title":"BMC Dev Biol"},{"key":"1710_CR48","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1042\/BJ20150222","volume":"473","author":"R D'Cruz","year":"2016","unstructured":"D'Cruz R, Plant PJ, Pablo LA, Lin S, Chackowicz J, Correa J, Bain J, Batt J (2016) PDLIM7 is a novel target of the ubiquitin ligase Nedd4-1 in skeletal muscle. Biochem J 473:267\u2013276. https:\/\/doi.org\/10.1042\/BJ20150222","journal-title":"Biochem J"},{"key":"1710_CR49","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.celrep.2017.10.001","volume":"21","author":"AR Sonawane","year":"2017","unstructured":"Sonawane AR, Platig J, Fagny M, Chen C-Y, Paulson JN, Lopes-Ramos CM, DeMeo DL, Quackenbush J, Glass K, Kuijjer ML (2017) Understanding tissue-specific gene regulation. Cell Rep 21:1077\u20131088. https:\/\/doi.org\/10.1016\/j.celrep.2017.10.001","journal-title":"Cell Rep"}],"container-title":["Journal of Bone and Mineral Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-026-01710-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00774-026-01710-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00774-026-01710-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:29:02Z","timestamp":1786602542000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00774-026-01710-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["1710"],"URL":"https:\/\/doi.org\/10.1007\/s00774-026-01710-6","relation":{},"ISSN":["0914-8779","1435-5604"],"issn-type":[{"value":"0914-8779","type":"print"},{"value":"1435-5604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"6 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors have no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study design was approved by the Ethics Committee of Xinjiang Medical University before data collection and analysis (Approval No. 20210401\u201301).","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}