{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:52:26Z","timestamp":1791089546138,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bone Miner Metab"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Rapid bone mineral density (BMD) loss and fracture risk are major complications of kidney transplantation (KTx), partly attributed to glucocorticoid-impaired bone remodeling. We investigated associations between early postoperative femoral neck BMD (BMD-FN) decline and single nucleotide polymorphisms (SNPs) in genes related to glucocorticoid sensitivity and bone metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Sixty-nine adult patients who underwent living-donor KTx in 2015\u20132024 were investigated. The primary endpoint was annualized BMD-FN change (%) between preoperative and 12 \u00b1 6\u00a0months postoperative DXA. Patients with significant prior glucocorticoid exposure, postoperative pulse therapy, or anti-osteoporotic treatment were excluded. Four SNPs (\n                      <jats:italic>NR3C1<\/jats:italic>\n                      [rs41423247],\n                      <jats:italic>TNFRSF11A<\/jats:italic>\n                      [rs1805034, rs884205], and\n                      <jats:italic>LRP5<\/jats:italic>\n                      [rs3736228]) were genotyped and analyzed using multiple linear regression adjusted for age and sex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median annualized BMD-FN change was \u2212\u20093.4% (IQR \u2212\u20096.6 to \u2212\u20090.7). Among the four SNPs, only\n                      <jats:italic>TNFRSF11A<\/jats:italic>\n                      rs884205 was significantly associated with greater BMD loss; A risk allele carriers showed greater decline than the CC genotype (\u03b2 = \u2212\u20092.75; 95% CI, \u2212\u20094.82 to \u2212\u20090.68; P = 0.010). No significant associations were observed for\n                      <jats:italic>NR3C1<\/jats:italic>\n                      (rs41423247),\n                      <jats:italic>TNFRSF11A<\/jats:italic>\n                      (rs1805034), and\n                      <jats:italic>LRP5<\/jats:italic>\n                      (rs3736228). However, after adjustment for baseline BMD-FN, which was higher in risk-allele carriers, the rs884205 association was attenuated and no longer significant (\u03b2 = \u22121.92%; 95% CI, \u22123.94 to 0.09; P = 0.062).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In the early post-KTx period, the\n                      <jats:italic>TNFRSF11A<\/jats:italic>\n                      rs884205 risk allele may be associated with greater annualized BMD-FN decline, although this did not persist after baseline BMD-FN adjustment. These findings are preliminary and warrant confirmation in larger cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00774-026-01765-5","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:06:46Z","timestamp":1791043606000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between RANK gene polymorphism and early femoral neck bone loss in kidney transplant recipients"],"prefix":"10.1007","author":[{"given":"Satoshi","family":"Kitamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9553-0981","authenticated-orcid":false,"given":"Yoji","family":"Hyodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuto","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"1765_CR1","doi-asserted-by":"publisher","first-page":"01","DOI":"10.31579\/2834-5142\/030","volume":"4","author":"MGMG Penido","year":"2022","unstructured":"Penido MGMG (2022) Mineral and bone disease after kidney transplantation: risk of fracture, graft dysfunction and mortality - a review. 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